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61. 发明申请

US20160281068A1 BIOCATALYSTS FOR EZETIMIBE SYNTHESIS 审中-公开
公开(公告)号：US20160281068A1
公开(公告)日：2016-09-29
申请号：US15179503
申请日：2016-06-10
申请人： Codexis Inc.
发明人： Michael A. Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga K. Modukuru , Emily Mundorff , Derek J. Smith , Shiwei Song , Wan Lin Yeo
IPC分类号： C12N9/04 , C12P17/10
CPC分类号： C12N9/0006 , A61K38/00 , C07K14/47 , C12P17/10 , C12P17/14 , C12Y101/00 , C12Y101/01184
摘要： The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

62. 发明授权

US09139820B2 Ketoreductase polypeptides 有权
标题翻译：酮还原酶多肽
公开(公告)号：US09139820B2
公开(公告)日：2015-09-22
申请号：US14606127
申请日：2015-01-27
申请人： Codexis, Inc.
发明人： Emily Mundorff , Erik Jan De Vries
IPC分类号： C12N9/00 , C12P7/02 , C12N9/04 , C12P17/14 , C12P17/10
CPC分类号： C12N9/0006 , C12N15/00 , C12N15/75 , C12P7/02 , C12P17/10 , C12P17/14 , C12P41/002 , C12Y101/01184 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4S)-2-oxo-4-phenyl(1,3-oxazolidin-3-yl))-1-(4-fluorophenyl)pentane-1,5-dione to (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize the intermediate (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one in a process for making Ezetimibe.
摘要翻译：本发明提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶，其包括还原5 - （（4S）-2-氧代-4-苯基（1,3-恶唑烷-3-基））） - 1-（4-氟苯基）戊烷-1,5-二酮转化为（4S）-3 - [（5S）-5-（4-氟苯基）-5-羟基戊酰基] -4-苯基-1,3- 恶唑烷-2-酮。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞和使用工程化酮还原酶合成中间体（4S）-3 - [（5S）-5-（4-氟苯基） -5-羟基戊酰基] -4-苯基-1,3-恶唑烷-2-酮在制备依泽替米贝的方法中。

63. 发明申请

US20150132806A1 KETOREDUCTASE POLYPEPTIDES 审中-公开
标题翻译：甜菜糖多糖
公开(公告)号：US20150132806A1
公开(公告)日：2015-05-14
申请号：US14606127
申请日：2015-01-27
申请人： Codexis, Inc.
发明人： Emily Mundorff , Erik Jan De Vries
IPC分类号： C12N9/04 , C12P17/14 , C12P17/10 , C12P7/02
CPC分类号： C12N9/0006 , C12N15/00 , C12N15/75 , C12P7/02 , C12P17/10 , C12P17/14 , C12P41/002 , C12Y101/01184 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4S)-2-oxo-4-phenyl(1,3-oxazolidin-3-yl))-1-(4-fluorophenyl)pentane-1,5-dione to (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize the intermediate (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one in a process for making Ezetimibe.
摘要翻译：本发明提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶，其包括还原5 - （（4S）-2-氧代-4-苯基（1,3-恶唑烷-3-基））） - 1-（4-氟苯基）戊烷-1,5-二酮转化为（4S）-3 - [（5S）-5-（4-氟苯基）-5-羟基戊酰基] -4-苯基-1,3- 恶唑烷-2-酮。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞和使用工程化酮还原酶合成中间体（4S）-3 - [（5S）-5-（4-氟苯基） -5-羟基戊酰基] -4-苯基-1,3-恶唑烷-2-酮在制备依泽替米贝的方法中。

64. 发明授权

US08980605B2 Ketoreductases and uses thereof 有权
标题翻译：酮还原酶及其用途
公开(公告)号：US08980605B2
公开(公告)日：2015-03-17
申请号：US13793158
申请日：2013-03-11
申请人： Codexis, Inc.
发明人： Charlene Ching , John M. Gruber , Gjalt W. Huisman , Emily Mundorff , Lisa M. Newman
IPC分类号： C12N9/04 , C12Q1/00 , C12N1/20 , C12N15/00 , C12P21/04 , C12Q1/34 , C07H21/04 , C12N15/70
CPC分类号： C12N9/0006 , C12N15/00 , C12N15/70 , C12Y101/01184
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译：本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。

65. 发明申请

US20130344552A1 KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES 有权
公开(公告)号：US20130344552A1
公开(公告)日：2013-12-26
申请号：US13970284
申请日：2013-08-19
申请人： Codexis, Inc.
发明人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Charlene Ching , John M. Gruber , Anke Krebber , Gjalt W. Huisman
IPC分类号： C12N9/04
CPC分类号： C12N9/0006 , C12P7/22 , C12Y101/01 , C12Y101/01184 , Y02E50/17 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

66. 发明授权

US08512973B2 Methods of using engineered ketoreductase polypeptides for the stereoselective reduction of acetophenones 有权
标题翻译：使用工程化酮还原酶多肽进行苯乙酮立体选择性还原的方法
公开(公告)号：US08512973B2
公开(公告)日：2013-08-20
申请号：US13682600
申请日：2012-11-20
申请人： Codexis, Inc.
发明人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Charlene Ching , John M. Gruber , Anke Krebber , Gjalt W. Huisman
IPC分类号： C12Q1/26 , C12P7/02 , C07K14/00 , C12N9/02 , C12P21/00
CPC分类号： C12N9/0006 , C12P7/22 , C12Y101/01 , C12Y101/01184 , Y02E50/17 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译：本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。

67. 发明申请

US20130177962A1 KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF A 3-ARYL-3 HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE 有权
标题翻译：用于生产3-亚氨基-3-羟基丙酰胺的3-氨基-3-羟基丙酰胺的甜菜碱多糖
公开(公告)号：US20130177962A1
公开(公告)日：2013-07-11
申请号：US13796985
申请日：2013-03-12
申请人： Codexis, Inc.
发明人： Christopher Savile , John M. Gruber , Emily Mundorff , Gjalt W. Huisman , Steven James Collier
IPC分类号： C12N9/00
CPC分类号： C12N9/0006 , C12P13/001 , C12P17/00 , C12P41/002
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N,N-dimethyl-3-keto-3-(2-thienyl)-1-ketopropanamine to (S)—N,N-dimethyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
摘要翻译：本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。优化了工程化酮还原酶多肽，用于催化N，N-二甲基-3-酮-3-（2-噻吩基）-1-酮基丙胺转化为（S）-N，N-二甲基-3-羟基-3-（ 2-噻吩基）-1-丙胺。

68. 发明授权

US12049649B2 Ketoreductase polypeptides for the production of azetidinone 有权
公开(公告)号：US12049649B2
公开(公告)日：2024-07-30
申请号：US17357673
申请日：2021-06-24
申请人： CODEXIS, INC.
发明人： Onorato Campopiano , Emily Mundorff , Birthe Borup , Rama Voladri
IPC分类号： C12N9/04 , C12P17/10
CPC分类号： C12N9/0006 , C12P17/10 , C12Y101/01184 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

69. 发明公开

US20240229091A1 KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (R)-3-HYDROXYTHIOLANE 审中-公开
公开(公告)号：US20240229091A1
公开(公告)日：2024-07-11
申请号：US18614099
申请日：2024-03-22
申请人： Codexis, Inc.
发明人： Jack S. Liang , Stephan Jenne , Emily Mundorff , Rama Voladri , James J. Lalonde , Gjalt W. Huisman
IPC分类号： C12P17/00 , C12N9/04 , C12P17/16
CPC分类号： C12P17/00 , C12N9/0006 , C12P17/167 , C12Y101/01184 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.

70. 发明授权

US11965194B2 Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane 有权
公开(公告)号：US11965194B2
公开(公告)日：2024-04-23
申请号：US17813950
申请日：2022-07-21
申请人： Codexis, Inc.
发明人： Jack S. Liang , Stephan Jenne , Emily Mundorff , Rama Voladri , James J. Lalonde , Gjalt W. Huisman
IPC分类号： C12P17/00 , C12N9/04 , C12P17/16
CPC分类号： C12P17/00 , C12N9/0006 , C12P17/167 , C12Y101/01184 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.

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