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61. 发明授权

US08761866B2 Examination and imaging of brain cognitive functions 失效
标题翻译：大脑认知功能的检查和成像
公开(公告)号：US08761866B2
公开(公告)日：2014-06-24
申请号：US13135969
申请日：2011-07-18
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0035 , A61B5/0042 , A61B5/6834
摘要： A system for examining biological tissue of a subject includes a wireless optical probe, electronics and a processor. The wireless optical probe includes a light source connected to receive signals from a wireless receiver, and a light detector coupled to provide data to a wireless transmitter constructed to transfer data wirelessly. The wireless optical probe is powered by a battery. The light source is constructed and arranged to introduce optical radiation in the visible to infra-red range into the examined biological tissue of a subject, and the light detector is constructed and arranged to detect radiation that has migrated in the examined biological tissue of the subject. The electronics is constructed and arranged to communicate wirelessly with the optical probe, to store the transferred data, and to create optical data. The processor is constructed and arranged to evaluate the optical data. The system may also provide brain stimulation and evaluate the detected radiation to determine a brain cognitive function of the subject. One embodiment of the system can detect a brain disorder. Another embodiment of the system can detect “deceit.” In addition to the optical module, the system may include other optional modules such as an EEG module, an MEG module, a thermography module, a respiratory module, a skin conductivity module, and a blood pressure module.
摘要翻译：用于检查对象的生物组织的系统包括无线光学探针，电子设备和处理器。无线光学探头包括连接到从无线接收器接收信号的光源，以及被耦合以向无线发射机提供数据的光检测器，该无线发射机被构造成以无线方式传送数据。无线光探头由电池供电。光源被构造和布置成将可见光到红外范围的光辐射引入受检者的经检查的生物组织中，并且构建并布置光检测器以检测已经在被检查的被检查的生物组织中迁移的辐射。电子设备被构造和布置成与光学探头无线通信，以存储传送的数据，并且创建光学数据。处理器被构造和布置以评估光学数据。该系统还可以提供脑刺激并评估所检测的辐射以确定受试者的脑认知功能。该系统的一个实施例可以检测脑障碍。该系统的另一实施例可以检测“欺骗”。除了光学模块之外，系统还可以包括其他可选模块，例如EEG模块，MEG模块，热成像模块，呼吸模块，皮肤电导率模块和血压模块

62. 发明申请

US20120035433A1 Examination and imaging of brain cognitive functions 失效
标题翻译：大脑认知功能的检查和成像
公开(公告)号：US20120035433A1
公开(公告)日：2012-02-09
申请号：US13135969
申请日：2011-07-18
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B6/00 , A61B5/053 , A61B5/01 , A61B5/08 , A61B5/1455 , A61B5/0476
CPC分类号： A61B5/0059 , A61B5/0035 , A61B5/0042 , A61B5/6834
摘要： A system for examining biological tissue of a subject includes a wireless optical probe, electronics and a processor. The wireless optical probe includes a light source connected to receive signals from a wireless receiver, and a light detector coupled to provide data to a wireless transmitter constructed to transfer data wirelessly. The wireless optical probe is powered by a battery. The light source is constructed and arranged to introduce optical radiation in the visible to infra-red range into the examined biological tissue of a subject, and the light detector is constructed and arranged to detect radiation that has migrated in the examined biological tissue of the subject. The electronics is constructed and arranged to communicate wirelessly with the optical probe, to store the transferred data, and to create optical data. The processor is constructed and arranged to evaluate the optical data. The system may also provide brain stimulation and evaluate the detected radiation to determine a brain cognitive function of the subject. One embodiment of the system can detect a brain disorder. Another embodiment of the system can detect “deceit.” In addition to the optical module, the system may include other optional modules such as an EEG module, an MEG module, a thermography module, a respiratory module, a skin conductivity module, and a blood pressure module.
摘要翻译：用于检查对象的生物组织的系统包括无线光学探针，电子设备和处理器。无线光学探头包括连接到从无线接收器接收信号的光源，以及被耦合以向无线发射机提供数据的光检测器，该无线发射机被构造成以无线方式传送数据。无线光探头由电池供电。光源被构造和布置成将可见光到红外范围的光辐射引入受检者的经检查的生物组织中，并且构建并布置光检测器以检测已经在被检查的被检查的生物组织中迁移的辐射。电子设备被构造和布置成与光学探头无线通信，以存储传送的数据，并且创建光学数据。处理器被构造和布置以评估光学数据。该系统还可以提供脑刺激并评估所检测的辐射以确定受试者的脑认知功能。该系统的一个实施例可以检测脑障碍。该系统的另一实施例可以检测“欺骗”。除了光学模块之外，系统还可以包括其他可选模块，例如EEG模块，MEG模块，热成像模块，呼吸模块，皮肤电导率模块和血压模块

63. 发明授权

US08060189B2 System and method for detection of hematoma 有权
标题翻译：用于血肿检测的系统和方法
公开(公告)号：US08060189B2
公开(公告)日：2011-11-15
申请号：US11919851
申请日：2006-05-05
申请人： Baruch Ben Dor , Britton Chance
发明人： Baruch Ben Dor , Britton Chance
IPC分类号： A61B5/1455
CPC分类号： A61B5/0059 , A61B5/4076
摘要： A system and method for determining brain hematoma including a handheld device for emitting and detecting radiation with a removable light guide assembly. A method for determining a brain hematoma condition that includes determining optical density of various regions of the brain using near infrared spectroscopy.
摘要翻译：一种用于确定脑血肿的系统和方法，包括用可发射和检测具有可拆卸光导组件的辐射的手持装置。一种用于确定脑血肿病症的方法，其包括使用近红外光谱确定脑的各个区域的光密度。

64. 发明申请

US20110230738A1 Optical examination of biological tissue using non-contact irradiation and detection 审中-公开
公开(公告)号：US20110230738A1
公开(公告)日：2011-09-22
申请号：US12932625
申请日：2011-03-07
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B5/145
CPC分类号： A61B5/0059 , A61B5/0037 , A61B5/0068 , A61B5/0091 , A61B5/415 , A61B5/418 , A61B5/4312 , A61B5/6834 , A61B5/7285
摘要： An optical system for examination of biological tissue includes a light source, a light detector, optics and electronics. The light source generates a light beam, transmitted to the biological tissue, spaced apart from the source. The light detector is located away (i.e., in a non-contact position) from the examined biological tissue and is constructed to detect light that has migrated in the examined tissue. The electronics controls the light source and the light detector, and a system separates the reflected photons (e.g., directly reflected or scattered from the surface or superficial photons) from the photons that have migrated in the examined tissue. The system prevents detection of the “noise” photons by the light detector or, after detection, eliminates the “noise” photons in the detected optical data used for tissue examination.

65. 发明授权

US07943586B2 Antineoplastic agents targeted via glut transporters 有权
标题翻译：通过谷氨酸转运蛋白靶向的抗肿瘤剂
公开(公告)号：US07943586B2
公开(公告)日：2011-05-17
申请号：US10560075
申请日：2004-06-09
申请人： Gang Zheng , Jerry D. Glickson , Britton Chance
发明人： Gang Zheng , Jerry D. Glickson , Britton Chance
IPC分类号： C07G3/00 , C07G11/00 , C07H15/00 , C07H17/00 , C07H5/06 , A01N43/04 , A61K31/70
CPC分类号： A61K41/0071 , A61K41/0057 , A61K47/549 , A61K49/0036 , A61K49/0052 , C07H17/04
摘要： The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neo-plastic cells via the GLUT transportation system. More specifically, the invention relates to conjugates of 2-deoxyglucose, wherein a linker, which includes a covalent bond, is attached to 2-deoxyglucose at the 2 position, and the linker is attached to a therapeutic or diagnostic agent. The invention also relates to methods of treating tumor disease and methods of making the novel compounds of the present invention. The agents of the present invention are superior to previous agents as they are targeted via GLUT transporters.
摘要翻译：本发明涉及通过GLUT运输系统特异性靶向新塑料细胞的新型抗肿瘤剂和癌症诊断剂。更具体地，本发明涉及2-脱氧葡萄糖的缀合物，其中包含共价键的接头在2位连接于2-脱氧葡萄糖，并且接头连接到治疗剂或诊断剂。本发明还涉及治疗肿瘤疾病的方法和制备本发明新化合物的方法。本发明的药剂优于先前的药剂，因为它们通过GLUT转运蛋白靶向。

66. 发明授权

US07840257B2 Examination of biological tissue using non-contact optical probes 失效
标题翻译：使用非接触光学探针检查生物组织
公开(公告)号：US07840257B2
公开(公告)日：2010-11-23
申请号：US10752440
申请日：2004-01-05
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0035 , A61B5/0042 , A61B5/6834
摘要： An optical system for examination of biological tissue includes a light source, a light detector, optics and electronics. The light source generates a light beam to be transmitted to the biological tissue spaced apart from the source. The light detector is located away (i.e., in a non-contact position) from the examined biological tissue and is constructed to detect light that has migrated in the examined biological tissue. The electronics controls the light source and the light detector, and a system separates the reflected photons (e.g., directly reflected or scattered from the surface or superficial photons, i.e., “noise” photons) from the photons that have migrated in the examined biological tissue. This system prevents detection of the “noise” photons by the light detector or, after detection, eliminates the “noise” photons in the detected optical data used for tissue examination.
摘要翻译：用于生物组织检查的光学系统包括光源，光检测器，光学器件和电子器件。光源产生光束以被传送到与源极间隔开的生物组织。光检测器位于被检查的生物组织的远离（即处于非接触位置）处，并被构造成检测在被检查的生物组织中迁移的光。电子设备控制光源和光检测器，并且系统将被检测的生物组织中迁移的光子分离出反射的光子（例如，从表面或表面光子，即“噪声”光子）直接反射或散射。该系统防止光检测器检测“噪声”光子，或者在检测之后，消除用于组织检查的检测到的光学数据中的“噪声”光子。

67. 发明申请

US20100160752A1 Detection, imaging and characterization of breast tumors 审中-公开
标题翻译：乳腺肿瘤的检测，成像和表征
公开(公告)号：US20100160752A1
公开(公告)日：2010-06-24
申请号：US12592638
申请日：2009-11-30
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B5/1455 , A61B6/00
CPC分类号： A61B5/0091 , A61B5/0073 , A61B5/14552 , A61B5/4312 , A61B2562/0233 , A61B2562/0242 , A61B2562/046
摘要： An optical system for in vivo non-invasive examination of breast tissue of a subject includes an optical module, a controller and a processor. The optical module includes an array of optical input ports and optical detection ports located in a selected geometrical pattern to provide a multiplicity of source-detector paths of photon migration inside the breast tissue. Each optical input port is constructed to introduce into the tissue volume visible or infrared light emitted from a light source. Each optical detection port is constructed to provide light from the tissue to a light detector. The controller is constructed and arranged to activate one or several light sources and light detectors so that the light detector detects light that has migrated over at least one of the source-detector migration paths. The processor receives signals corresponding to the detected light and creates a defined spatial image of the examined tissue.
摘要翻译：用于体内非侵入性检查对象的乳腺组织的光学系统包括光学模块，控制器和处理器。光学模块包括位于选定的几何图案中的光学输入端口和光学检测端口的阵列，以提供乳腺组织内的光子迁移的多个源检测器路径。每个光学输入端口被构造成引入组织体积可见光或从光源发射的红外光。每个光学检测端口被构造成将来自组织的光提供给光检测器。控制器被构造和布置成激活一个或多个光源和光检测器，使得光检测器检测已经通过至少一个源检测器迁移路径迁移的光。处理器接收与检测到的光相对应的信号，并创建被检查组织的定义的空间图像。

68. 发明申请

US20090281402A1 Transabdominal examination, monitoring and imaging of tissue 审中-公开
标题翻译：腹部检查，组织监测和成像
公开(公告)号：US20090281402A1
公开(公告)日：2009-11-12
申请号：US12387467
申请日：2009-04-29
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B5/1455 , A61B5/02 , A61B8/00
CPC分类号： A61B5/1464 , A61B5/0042 , A61B5/0059 , A61B5/0073 , A61B5/0091 , A61B5/02411 , A61B5/14553 , A61B5/4312 , A61B5/4362 , A61B5/7285 , A61B8/0808 , A61B2562/0233 , A61B2562/0242 , A61B2562/046
摘要： An optical examination technique employs an optical system for in vivo, non-invasive examination of internal tissue of a subject. The optical system includes an optical module, a controller and a processor. The optical module is arranged for placement on the exterior of the abdomen or chest. The module includes an array of optical input ports and optical detection ports located in a selected geometrical pattern to provide a multiplicity of photon migration paths targeted to examine a selected tissue region, such as an internal organ or an in utero fetus. Each optical input port is constructed to introduce into the examined tissue visible or infrared light emitted from a light source. Each optical detection port is constructed to provide light from the tissue to a light detector. The controller is constructed and arranged to activate one or several light sources and light detectors so that the light detector detects light that has migrated over at least one of the photon migration paths. The processor receives signals corresponding to the detected light and forms at least one data set used for tissue examination.
摘要翻译：光学检查技术使用光学系统用于体内，非侵入性检查受试者的内部组织。光学系统包括光学模块，控制器和处理器。光学模块布置用于放置在腹部或胸部的外部。该模块包括位于所选择的几何图案中的光学输入端口和光学检测端口的阵列，以提供多个光子迁移路径，其目的是检查所选择的组织区域，例如内部器官或子宫内胎儿。每个光学输入端口构造成将被检查的组织引入可见光或从光源发射的红外光。每个光学检测端口被构造成将来自组织的光提供给光检测器。控制器被构造和布置成激活一个或多个光源和光检测器，使得光检测器检测已经通过至少一个光子迁移路径迁移的光。处理器接收对应于检测到的光的信号，并形成用于组织检查的至少一个数据集。

69. 发明申请

US20090221919A1 System and method for detection of hematoma 有权
标题翻译：用于血肿检测的系统和方法
公开(公告)号：US20090221919A1
公开(公告)日：2009-09-03
申请号：US11919851
申请日：2006-05-05
申请人： Baruch Ben Dor , Britton Chance
发明人： Baruch Ben Dor , Britton Chance
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/4076
摘要： A system and method for determining brain hematoma including a handheld device for emitting and detecting radiation with a removable light guide assembly. A method for determining a brain hematoma condition that includes determining optical density of various regions of the brain using near infrared spectroscopy.
摘要翻译：一种用于确定脑血肿的系统和方法，包括用可发射和检测具有可拆卸光导组件的辐射的手持装置。一种用于确定脑血肿病症的方法，其包括使用近红外光谱确定脑的各个区域的光密度。

70. 发明申请

US20090030327A1 Optical coupler for in vivo examination of biological tissue 审中-公开
标题翻译：用于体内检查生物组织的光耦合器
公开(公告)号：US20090030327A1
公开(公告)日：2009-01-29
申请号：US12082344
申请日：2008-02-29
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B6/00
CPC分类号： A61B5/6814 , A61B5/0035 , A61B5/0042 , A61B5/0077 , A61B5/0091 , A61B5/14532 , A61B5/1455 , A61B5/14551 , A61B5/14552 , A61B5/14553 , A61B5/1459 , A61B5/4312 , A61B5/6853 , A61B2562/0233 , A61B2562/046 , A61B2562/146
摘要： A spectrophotometric system for examination of biological tissue of interest includes a light source, a light coupling system, a light detector, and a processor. The light source is constructed and arranged to emit a light beam of visible or infra-red radiation. The light coupling system includes at least one mirror and is constructed and arranged to receive the emitted light beam and scan the light beam for introduction into the biological tissue of interest. The light detector is optically coupled to detect photons of radiation that have migrated over optical paths in the biological tissue of interest. The processor is operatively coupled to the light source and detector and is adapted to determine an optical property of the biological tissue of interest based on the changes between the introduced and detected radiation.
摘要翻译：用于检查感兴趣的生物组织的分光光度系统包括光源，光耦合系统，光检测器和处理器。光源被构造和布置成发射可见光或红外线辐射的光束。光耦合系统包括至少一个反射镜，并被构造和布置成接收发射的光束并扫描光束以引入感兴趣的生物组织。光检测器被光耦合以检测通过感兴趣的生物组织中的光路径迁移的辐射的光子。处理器可操作地耦合到光源和检测器，并且适于基于引入和检测到的辐射之间的变化来确定感兴趣的生物组织的光学性质。

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