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61. 发明授权

US08114070B2 Methods and systems for treating BPH using electroporation 有权
标题翻译：使用电穿孔治疗BPH的方法和系统
公开(公告)号：US08114070B2
公开(公告)日：2012-02-14
申请号：US11166974
申请日：2005-06-24
申请人： Boris Rubinsky , Gary Onik , Paul Mikus
发明人： Boris Rubinsky , Gary Onik , Paul Mikus
IPC分类号： A61B18/18
CPC分类号： A61N1/327 , A61N1/0412 , A61N1/0476
摘要： A system for treating benign prostate hyperplasia (BPH) of a prostate. At least first and second mono-polar electrodes are configured to be introduced at or near a BPH tissue site of the prostate gland of the patient. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply sufficient electrical pulses between the first and second mono-polar electrodes to induce electroporation of cells in the BPH tissue site, to create necrosis of cells of the BPH tissue site, but insufficient to create a thermal damaging effect to a majority of the BPH tissue site.
摘要翻译：一种用于治疗前列腺良性前列腺增生（BPH）的系统。至少第一和第二单极电极被配置为在患者的前列腺的BPH组织部位处或附近引入。电压脉冲发生器耦合到第一和第二单极电极。电压脉冲发生器被配置为在第一和第二单极电极之间施加足够的电脉冲以诱导BPH组织部位中的细胞的电穿孔，以产生BPH组织部位的细胞坏死，但不足以产生热损伤作用到大多数BPH组织部位。

62. 发明授权

US07638341B2 Volumetric induction phase shift detection system for determining tissue water content properties 有权
标题翻译：用于确定组织含水量特性的体积感应相移检测系统
公开(公告)号：US07638341B2
公开(公告)日：2009-12-29
申请号：US11664755
申请日：2006-05-12
申请人： Boris Rubinsky , Cesar A. Gonzalez
发明人： Boris Rubinsky , Cesar A. Gonzalez
IPC分类号： G01N27/00 , G01N33/48 , G01R27/08 , G01R25/00
CPC分类号： A61B5/0537 , A61B5/02042 , A61B5/0205 , A61B5/05 , A61B5/053 , A61B5/4064 , A61B5/413 , A61B5/4244 , A61B5/443 , A61B5/4519 , A61B5/4869 , A61B5/4878 , A61B5/7225 , A61B5/7228 , A61B5/725 , A61B2562/143 , G01N27/026 , G01R33/34 , G01R33/36 , G01R33/4828 , G01R33/483
摘要： A method of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample. An apparatus for determining the condition of a bulk tissue sample, having: a first induction coil (or antenna); a second induction coil (or antenna); an alternating current power supply connected to the first induction coil (or antenna), the alternating current power supply configured to generate a spectrum of currents (or voltage) in the first induction coil (or antenna); and a measurement system connected to the second induction coil (or antenna), wherein the measurement system is configured to measure a phase shift difference in the spectrum of currents (or voltages) between the first and second induction coils (or antennae) when the first and second induction coils (or antennae) are positioned on opposite sides of a tissue sample.
摘要翻译：通过以下步骤确定体组织样本的状况的方法：将体组织样本定位在一对感应线圈（或天线）之间; 通过感应线圈（或天线）中的第一个通过交流（或电压）的频谱; 测量第二个感应线圈（或天线）中产生的交流（或电压）的频谱; 以及比较第一和第二感应线圈（或天线）中的交流电流（或电压）的频谱之间的相移，由此确定本体组织样本的状况。一种用于确定体组织样本的状况的装置，具有：第一感应线圈（或天线）; 第二感应线圈（或天线）; 连接到所述第一感应线圈（或天线）的交流电源，所述交流电源被配置为在所述第一感应线圈（或天线）中产生电流（或电压）的频谱; 以及连接到所述第二感应线圈（或天线）的测量系统，其中所述测量系统被配置为当所述第一感应线圈（或天线））测量所述第一和第二感应线圈（或天线）之间的电流（或电压）的频谱中的相移差和第二感应线圈（或天线）位于组织样本的相对侧上。

63. 发明申请

US20080224688A1 Volumetric Induction Phase Shift Detection System for Determining Tissue Water Content Properties 有权
标题翻译：用于确定组织水含量特性的体积感应相移检测系统
公开(公告)号：US20080224688A1
公开(公告)日：2008-09-18
申请号：US11664755
申请日：2006-05-12
申请人： Boris Rubinsky , Cesar A. Gonzalez
发明人： Boris Rubinsky , Cesar A. Gonzalez
IPC分类号： G01N33/48
CPC分类号： A61B5/0537 , A61B5/02042 , A61B5/0205 , A61B5/05 , A61B5/053 , A61B5/4064 , A61B5/413 , A61B5/4244 , A61B5/443 , A61B5/4519 , A61B5/4869 , A61B5/4878 , A61B5/7225 , A61B5/7228 , A61B5/725 , A61B2562/143 , G01N27/026 , G01R33/34 , G01R33/36 , G01R33/4828 , G01R33/483
摘要： A method of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample. An apparatus for determining the condition of a bulk tissue sample, having: a first induction coil (or antenna); a second induction coil (or antenna); an alternating current power supply connected to the first induction coil (or antenna), the alternating current power supply configured to generate a spectrum of currents (or voltage) in the first induction coil (or antenna); and a measurement system connected to the second induction coil (or antenna), wherein the measurement system is configured to measure a phase shift difference in the spectrum of currents (or voltages) between the first and second induction coils (or antennae) when the first and second induction coils (or antennae) are positioned on opposite sides of a tissue sample.
摘要翻译：通过以下步骤确定体组织样本的状况的方法：将体组织样本定位在一对感应线圈（或天线）之间; 通过感应线圈（或天线）中的第一个通过交流（或电压）的频谱; 测量第二个感应线圈（或天线）中产生的交流（或电压）的频谱; 以及比较第一和第二感应线圈（或天线）中的交流电流（或电压）的频谱之间的相移，由此确定本体组织样本的状况。一种用于确定体组织样本的状况的装置，具有：第一感应线圈（或天线）; 第二感应线圈（或天线）; 连接到所述第一感应线圈（或天线）的交流电源，所述交流电源被配置为在所述第一感应线圈（或天线）中产生电流（或电压）的频谱; 以及连接到所述第二感应线圈（或天线）的测量系统，其中所述测量系统被配置为当所述第一感应线圈（或天线））测量所述第一和第二感应线圈（或天线）之间的电流（或电压）的频谱中的相移差和第二感应线圈（或天线）位于组织样本的相对侧上。

64. 发明申请

US20080021371A1 Methods and systems for treating restenosis using electroporation 有权
标题翻译：使用电穿孔治疗再狭窄的方法和系统
公开(公告)号：US20080021371A1
公开(公告)日：2008-01-24
申请号：US11864320
申请日：2007-09-28
申请人： Boris Rubinsky , Gary Onik , Paul Mikus
发明人： Boris Rubinsky , Gary Onik , Paul Mikus
IPC分类号： A61N1/30
CPC分类号： A61B18/1492 , A61B2017/22002 , A61B2018/00214 , A61B2018/0022 , A61B2018/00422
摘要： A system is provided for reducing restenosis. A catheter apparatus is provided with at least first and second mono-polar electrodes positioned at an inflatable balloon. The balloon is sized to be positioned and expanded at a restenosis site. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply an electric field, in a controlled manner, to the restenosis site in an amount sufficient to produce electroporation of the restenosis site, and below an amount that causes thermal damage to the restenosis site.
摘要翻译：提供减少再狭窄的系统。导管装置设置有位于可充气气囊的至少第一和第二单极电极。气囊的大小可在再狭窄部位定位和扩张。电压脉冲发生器耦合到第一和第二单极电极。电压脉冲发生器被配置为以足以产生再狭窄部位的电穿孔并且低于对再狭窄部位造成热损伤的量以受控的方式将电场施加到再狭窄部位。

65. 发明申请

US20080015571A1 Methods and systems for treating tumors using electroporation 审中-公开
标题翻译：使用电穿孔治疗肿瘤的方法和系统
公开(公告)号：US20080015571A1
公开(公告)日：2008-01-17
申请号：US11864217
申请日：2007-09-28
申请人： Boris Rubinsky , Gary Onik , Paul Mikus
发明人： Boris Rubinsky , Gary Onik , Paul Mikus
IPC分类号： A61B18/00
CPC分类号： A61B18/1477 , A61B2018/0016 , A61B2018/00577 , A61B2018/00613 , A61B2018/00797 , A61B2018/143
摘要： A system is provided for treating tumor tissue sites of a patient. At least first and second mono-polar electrodes are configured to be introduced at or near the tumor tissue site of the patient. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply sufficient electrical pulses between the first and second mono-polar electrodes to induce electroporation of cells in the tumor tissue site, to create necrosis of cells of the tumor tissue site, but insufficient to create a thermal damaging effect to a majority of the tumor tissue site.
摘要翻译：提供了一种用于治疗患者的肿瘤组织部位的系统。至少第一和第二单极电极被配置为在患者的肿瘤组织部位处或附近引入。电压脉冲发生器耦合到第一和第二单极电极。电压脉冲发生器被配置为在第一和第二单极电极之间施加足够的电脉冲以诱导肿瘤组织部位的细胞的电穿孔，以产生肿瘤组织部位的细胞坏死，但不足以产生热损伤作用到大多数肿瘤组织部位。

66. 发明申请

US20070156135A1 System and methods for treating atrial fibrillation using electroporation 审中-公开
标题翻译：使用电穿孔治疗房颤的系统和方法
公开(公告)号：US20070156135A1
公开(公告)日：2007-07-05
申请号：US11325256
申请日：2006-01-03
申请人： Boris Rubinsky , Paul Mikus
发明人： Boris Rubinsky , Paul Mikus
IPC分类号： A61B18/14
CPC分类号： A61B18/1482 , A61B18/1477 , A61B2018/00351 , A61B2018/00613 , A61B2018/1425 , A61B2018/143
摘要： The present invention provides an improved system and method for treating atrial fibrillation using electroporation. The system creates transmural lesions in tissue. At least first and second tissue penetrating, mono-polar electrodes are provided that are configured to be introduced at or near an epicardial tissue site of the heart of the patient. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator applies sufficient electrical pulses between the first and second mono-polar electrodes to induce electroporation of cells in the epicardial tissue site to create a trausmural lesion, but insufficient to create a thermal damaging effect to a majority of the epicardial tissue site.
摘要翻译：本发明提供了一种改进的使用电穿孔治疗心房颤动的系统和方法。系统在组织中产生透壁病变。提供至少第一和第二组织穿透的单极电极，其被配置为被引导到患者心脏的心外膜组织部位处或附近。电压脉冲发生器耦合到第一和第二单极电极。电压脉冲发生器在第一和第二单极电极之间施加足够的电脉冲以诱导心外膜组织部位中的细胞的电穿孔以产生外伤性损伤，但不足以对大多数心外膜组织部位产生热损伤作用。

67. 发明申请

US20070043345A1 Tissue ablation with irreversible electroporation 有权
标题翻译：组织消融与不可逆电穿孔
公开(公告)号：US20070043345A1
公开(公告)日：2007-02-22
申请号：US10571162
申请日：2004-12-21
申请人： Rafael Davalos , Boris Rubinsky
发明人： Rafael Davalos , Boris Rubinsky
IPC分类号： A61B18/14
CPC分类号： A61B18/12 , A61B18/1233 , A61B18/1477 , A61B2018/00577 , A61B2018/00613 , A61B2018/1425 , A61N1/0412 , A61N1/0472 , A61N1/05 , A61N1/327
摘要： A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable.
摘要翻译：公开了一种用于消除不想要的组织的新方法，例如癌性或非癌性肿瘤的细胞。它涉及通过施加电脉冲将电极放置在不期望的组织附近或附近，从而在不期望的组织的整个区域内引起细胞的不可逆电穿孔。电脉冲不可逆地渗透细胞膜，从而引起细胞死亡。不可逆透化的细胞留在原位，并通过身体免疫系统去除。通过使用不可逆电穿孔而不引起热损伤可实现的组织消融量是相当大的。

68. 发明申请

US20060293730A1 Methods and systems for treating restenosis sites using electroporation 审中-公开
标题翻译：使用电穿孔治疗再狭窄部位的方法和系统
公开(公告)号：US20060293730A1
公开(公告)日：2006-12-28
申请号：US11165881
申请日：2005-06-24
申请人： Boris Rubinsky , Gary Onik , Paul Mikus
发明人： Boris Rubinsky , Gary Onik , Paul Mikus
IPC分类号： A61F7/00
CPC分类号： A61B18/1492 , A61B2017/22002 , A61B2018/00214 , A61B2018/0022 , A61B2018/00422 , A61B2018/00613
摘要： A system is provided for reducing restenosis. A catheter apparatus is provided with at least first and second mono-polar electrodes positioned at an inflatable balloon. The balloon is sized to be positioned and expanded at a restenosis site. A voltage pulse generator is coupled to the first and second mono-polar electrodes. The voltage pulse generator is configured to apply an electric field, in a controlled manner, to the restenosis site in an amount sufficient to produce electroporation of the restenosis site, and below an amount that causes thermal damage to the restenosis site.
摘要翻译：提供减少再狭窄的系统。导管装置设置有位于可充气气囊的至少第一和第二单极电极。气囊的大小可在再狭窄部位定位和扩张。电压脉冲发生器耦合到第一和第二单极电极。电压脉冲发生器被配置为以足以产生再狭窄部位的电穿孔并且低于对再狭窄部位造成热损伤的量以受控的方式将电场施加到再狭窄部位。

69. 发明申请

US20050171574A1 Electroporation to interrupt blood flow 审中-公开
标题翻译：电穿孔打扰血流
公开(公告)号：US20050171574A1
公开(公告)日：2005-08-04
申请号：US11022310
申请日：2004-12-21
申请人： Boris Rubinsky , Jon Edd , Liana Horowitz
发明人： Boris Rubinsky , Jon Edd , Liana Horowitz
IPC分类号： A61B18/04 , A61B18/12 , A61B18/18 , A61N1/00 , A61N1/04 , A61N1/05 , A61N1/32
CPC分类号： A61B18/12 , A61B18/1233 , A61B18/1477 , A61B2018/00577 , A61B2018/00613 , A61B2018/1425 , A61N1/0412 , A61N1/0472 , A61N1/05 , A61N1/327
摘要： A method for disrupting blood flow to undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of vessels supplying blood to the undesirable tissue and through the application of electrical pulses causing blood flow disruption. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The process may further comprise monitoring blood flow and/or infusion of a material such as a chemotherapeutic agent or marker into the blood.
摘要翻译：公开了一种破坏血液流向不良组织如癌性或非癌性肿瘤细胞的方法。它涉及将电极放置在向不需要的组织供应血液的血管附近，以及通过施加引起血流破裂的电脉冲。电脉冲不可逆地渗透细胞膜，从而引起细胞死亡。不可逆透化的细胞留在原位，并通过身体免疫系统去除。该方法还可以包括监测血液流动和/或将诸如化学治疗剂或标记物的材料输注到血液中。

70. 发明授权

US06482619B1 Cell/tissue analysis via controlled electroporation 有权
标题翻译：通过受控电穿孔进行细胞/组织分析
公开(公告)号：US06482619B1
公开(公告)日：2002-11-19
申请号：US09618951
申请日：2000-07-19
申请人： Boris Rubinsky , Yong Huang
发明人： Boris Rubinsky , Yong Huang
IPC分类号： C12N1300
CPC分类号： G01N33/48728 , C12M35/02 , C12N15/87
摘要： An electrical current is created across an electrically conductive medium comprising a cell which may be part of a tissue of a living organism. A first electrical parameter which may be current, voltage, or electrical impedance is measured. A second electrical parameter which may be current, voltage or a combination of both is then adjusted and/or analyzed. Adjustments are carried out to facilitate analysis and/or obtain a desired degree of electroporation. Analysis is carried out to determine characteristics of the cell membrane and/or tissue.
摘要翻译：跨导电介质产生电流，该导电介质包括可以是生物体的组织的一部分的细胞。测量可以是电流，电压或电阻抗的第一电参数。然后调整和/或分析可以是电流，电压或两者的组合的第二电参数。进行调整以便于分析和/或获得期望的电穿孔程度。进行分析以确定细胞膜和/或组织的特征。

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