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61. 发明授权

US08128673B2 System for inner eyelid heat and pressure treatment for treating meibomian gland dysfunction 有权
标题翻译：用于治疗睑板腺功能障碍的内眼睑热压治疗系统
公开(公告)号：US08128673B2
公开(公告)日：2012-03-06
申请号：US12015675
申请日：2008-01-17
申请人： Donald R. Korb , Stephen M. Grenon
发明人： Donald R. Korb , Stephen M. Grenon
IPC分类号： A61F7/00
CPC分类号： A61F7/12 , A61B18/12 , A61B2017/00084 , A61B2018/046 , A61B2018/048 , A61F7/007 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N7/00
摘要： A system for treating meibomian gland dysfunction. A controller controls heat applied to the inside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. Temperatures at the meibomian glands reach desired levels more quickly and efficiently when heating the inside of the eyelid. Reaching such higher temperature levels may be instrumental in removing obstructions in the meibomian glands. Less time may also be required to reach desired temperature levels when applying heat to the inside of the eyelid. A force may also be applied to the inside of the patient's eyelid to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions.
摘要翻译：治疗睑板腺功能障碍的系统。控制器控制施加到眼睑内部的热量，以向睑板腺提供导电热传递。热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。在加热眼睑内部时，睑板腺的温度可以更快速有效地达到所需水平。达到更高的温度水平可能有助于消除睑板腺中的障碍物。当向眼睑内部施加热量时，也可能需要较少的时间达到所需的温度水平。也可以将力施加到患者眼睑的内侧，以改善导电传热并减少眼睑中引起对流热损失的血液流动。因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物的时间。

62. 发明申请

US20090043365A1 METHODS, APPARATUSES, AND SYSTEMS FOR REDUCING INTRAOCULAR PRESSURE AS A MEANS OF PREVENTING OR TREATING OPEN-ANGLE GLAUCOMA 审中-公开
标题翻译：用于减少眼压的方法，装置和系统作为预防或治疗开放性角膜炎的手段
公开(公告)号：US20090043365A1
公开(公告)日：2009-02-12
申请号：US12246071
申请日：2008-10-06
申请人： Beth Friedland , Donald R. Korb , Steve Grenon , John Jans , Keith Gausmann , Timothy R. Willis
发明人： Beth Friedland , Donald R. Korb , Steve Grenon , John Jans , Keith Gausmann , Timothy R. Willis
IPC分类号： A61F7/00
CPC分类号： A61B18/04 , A61B18/10 , A61B2018/00642 , A61B2018/00791 , A61B2018/046 , A61B2018/048 , A61F9/00781 , A61F2007/0004 , A61F2007/0059 , A61F2007/0071 , A61H1/008 , A61N7/00
摘要： Embodiments include methods, apparatuses, and systems for reducing elevated intraocular pressure (IOP) in a patient to either prevent or treat open-angle glaucoma. Heat is applied to the trabecular meshwork in the patient's eye without damaging proteins in the trabecular meshwork. The application of heat to the trabecular meshwork has the effect of relaxing or loosening protein clogs or other inhibitors in the trabecular meshwork, which are either reducing or obstructing of the outflow of aqueous humor, thereby increasing the patient's IOP and causing ocular hypertension (OHT). By loosening or relaxing clogs or other inhibitors in the trabecular meshwork, the outflow path for aqueous humor is increased or restored, which can lower IOP and either prevent or treat glaucoma. Force may also be applied to the patient's eye to apply pressure to the trabecular meshwork to further assist in the loosening or relaxing of clogs or other inhibitors in the trabecular meshwork.
摘要翻译：实施方案包括用于降低患者眼内压升高（IOP）以预防或治疗开角型青光眼的方法，装置和系统。热量被施加到患者眼睛中的小梁网，而不损伤小梁网中的蛋白质。对小梁网应用热量具有放松或松动小梁网中的蛋白质堵塞物或其他抑制剂的作用，其减少或阻碍房水流出，从而增加患者的眼压并引起眼高压（OHT）。通过在小梁网中松动或松弛堵塞物或其他抑制剂，房水的流出路径增加或恢复，这可以降低IOP并预防或治疗青光眼。力也可以应用于患者的眼睛，以向小梁网施加压力，以进一步协助松动或松弛小梁网中的堵塞物或其它抑制剂。

63. 发明授权

US5294607A Dry eye treatment process and solution 失效
标题翻译：干眼治疗过程和解决方案
公开(公告)号：US5294607A
公开(公告)日：1994-03-15
申请号：US898375
申请日：1992-06-09
申请人： Thomas Glonek , Jack V. Greiner , Donald R. Korb
发明人： Thomas Glonek , Jack V. Greiner , Donald R. Korb
IPC分类号： A61K9/107 , A61F9/00 , A61K9/00 , A61K31/685 , A61K47/24 , A61P27/02 , A61P27/04 , A61K31/20 , A61K31/66
CPC分类号： A61K9/0048 , Y10S514/912
摘要： A method and composition for reducing evaporation of an aqueous layer from the surface of the eye. The method comprises applying an admixture of a charged phospholipid and a non-polar oil over the eye, preferably in the form of a meta-stable oil in water emulsion in a dosage not exceeding 100 microliters.
摘要翻译：一种用于减少水层从眼表的蒸发的方法和组合物。该方法包括在眼睛上施用带电荷的磷脂和非极性油的混合物，优选以不超过100微升的剂量的元稳定的水包油乳液的形式。

64. 发明授权

US4543371A Polymeric compositions and hydrogels formed therefrom 失效
标题翻译：由此形成的聚合物组合物和水凝胶
公开(公告)号：US4543371A
公开(公告)日：1985-09-24
申请号：US466274
申请日：1983-02-14
申请人： Paul M. Gallop , Donald R. Korb
发明人： Paul M. Gallop , Donald R. Korb
IPC分类号： A01N25/10 , A61K6/08 , A61K9/20 , B29D11/02 , C08F220/28 , C08F220/20
CPC分类号： C08F220/28 , A01N25/10 , A61K6/08 , A61K9/2027 , B01D71/40 , B29D11/02 , B01D2323/30 , B01D61/025 , B01D61/145 , B01D61/246
摘要： The invention provides new hydrogel forming materials comprising synthetic, hydrophilic, aqueous-insoluble polymer networks formed by copolymerization of a hydrophilic dihydroxyalkyl acrylate or methacrylate, a substantially water insoluble alkyl acrylate or methacrylate, one or more additional hydrophilic comonomers selected from the group of vinylic monomers, acrylates, and methacrylates, and a cross-linking agent. The hydrogels are preferably used for the formation of contact lenses, but may also be used for drug and pesticides delivery devices; dialysis, ultrafiltration and reverse osmosis membranes; implants in surgery and dentistry; and the like.
摘要翻译：本发明提供了新的水凝胶形成材料，其包括由亲水性丙烯酸酯或甲基丙烯酸二羟烷基酯，基本上不溶于水的丙烯酸烷基酯或甲基丙烯酸烷基酯，一种或多种另外的亲水共聚单体共聚形成的合成的，亲水的，不溶于水的聚合物网络，所述共聚单体选自乙烯基单体，丙烯酸酯和甲基丙烯酸酯，以及交联剂。水凝胶优选用于形成隐形眼镜，但也可用于药物和农药递送装置; 透析，超滤和反渗透膜; 手术和牙科植入物; 等等。

65. 发明授权

US4338419A Process for treatment of hydrogel lens with thiols 失效
标题翻译：用硫醇处理水凝胶透镜的方法
公开(公告)号：US4338419A
公开(公告)日：1982-07-06
申请号：US184596
申请日：1980-09-05
申请人： Donald R. Korb , Paul M. Gallop
发明人： Donald R. Korb , Paul M. Gallop
IPC分类号： B29D11/00 , C08F8/34 , G02B1/04 , G02C7/04
CPC分类号： G02B1/043 , B29D11/00 , B29D11/00038
摘要： The invention provides a method of treating hydrogels formed from the polymerization of monomers having reactive olefinic double bonds by contacting them with reactive thiol compounds. In a preferred embodiment where the hydrogel structure includes a cis-glycol containing unit, a suitable thiol is used in conjunction with a borate buffer. The present invention also provides materials that are treated with the above thiol compounds.
摘要翻译：本发明提供了一种处理由具有反应性烯属双键的单体的聚合形成的水凝胶的方法，通过使它们与反应性硫醇化合物接触。在其中水凝胶结构包含含顺式二醇单元的优选实施方案中，合适的硫醇与硼酸盐缓冲液结合使用。本发明还提供用上述硫醇化合物处理的材料。

66. 发明授权

US4267295A Polymeric compositions and hydrogels formed therefrom 失效
标题翻译：由此形成的聚合物组合物和水凝胶
公开(公告)号：US4267295A
公开(公告)日：1981-05-12
申请号：US10992
申请日：1979-02-09
申请人： Paul M. Gallop , Donald R. Korb
发明人： Paul M. Gallop , Donald R. Korb
IPC分类号： A01N25/10 , A61K6/083 , A61K9/20 , A61L27/16 , A61L33/06 , B01D71/40 , B29D11/02 , C08F220/28 , C08F220/20
CPC分类号： C08F220/28 , A01N25/10 , A61K6/083 , A61K9/2027 , A61L27/16 , A61L33/064 , B01D71/40 , B29D11/02 , Y10S528/92
摘要： The invention provides new hydrogel forming materials comprising synthetic, hydrophilic, aqueous-insoluble polymer networks formed by copolymerization of a hydrophilic dihydroxyalkyl acrylate or methacrylate, a substantially water insoluble alkyl acrylate or methacrylate, one or more additional hydrophilic comonomers selected from the group of vinylic monomers, acrylates, and methacrylates, and a cross-linking agent. The hydrogels are preferably used for the formation of contact lenses, but may also be used for drug and pesticides delivery devices; dialysis, ultrafiltration and reverse osmosis membranes; implants in surgery and dentistry; and the like.
摘要翻译：本发明提供了新的水凝胶形成材料，其包括由亲水性丙烯酸酯或甲基丙烯酸二羟烷基酯，基本上不溶于水的丙烯酸烷基酯或甲基丙烯酸烷基酯，一种或多种另外的亲水共聚单体共聚形成的合成的，亲水的，不溶于水的聚合物网络，所述共聚单体选自乙烯基单体，丙烯酸酯和甲基丙烯酸酯，以及交联剂。水凝胶优选用于形成隐形眼镜，但也可用于药物和农药递送装置; 透析，超滤和反渗透膜; 手术和牙科植入物; 等等。

67. 发明授权

US08956311B2 Methods for diagnosing meibomian gland dysfunction 有权
标题翻译：睑板腺功能障碍诊断方法
公开(公告)号：US08956311B2
公开(公告)日：2015-02-17
申请号：US13271768
申请日：2011-10-12
申请人： Donald R. Korb , Caroline Blackie , Christy Stevens
发明人： Donald R. Korb , Caroline Blackie , Christy Stevens
IPC分类号： A61B5/103 , A61B5/00 , A61B3/10
CPC分类号： A61B5/4261 , A61B3/10
摘要： Methods of diagnosing meibomian gland dysfunction are disclosed. The methods may be standardized and provide an accurate diagnosis of whether meibomian gland dysfunction exists. In one embodiment, a method is provided that utilizes an evaluation tool to apply a force for a preselected period of time to at least one of a plurality of meibomian glands in two or more regions of a plurality of regions of an eyelid. A grade is assigned to the at least one meibomian gland of the plurality of meibomian glands in each of the two or more regions based on any secretion that is expressed from each meibomian gland. In this manner, a plurality of meibomian gland secretion grades is obtained. The plurality of meibomian gland secretion grades is indicative of the presence of meibomian gland dysfunction.
摘要翻译：公开了睑板腺功能障碍诊断方法。方法可以被标准化，并提供是否存在睑板腺功能障碍的准确诊断。在一个实施例中，提供了一种利用评估工具将预定时间段的力施加到眼睑多个区域的两个或更多个区域中的多个睑板腺中的至少一个的方法。基于从每个睑板腺表达的任何分泌，将等级分配给两个或更多个区域中的每一个中的多个睑板腺中的至少一个睑板腺。以这种方式，获得多个睑板腺分泌等级。多个睑板腺分泌级别表示睑板腺功能障碍的存在。

68. 发明授权

US5851543A Skin care preparation and method 失效
公开(公告)号：US5851543A
公开(公告)日：1998-12-22
申请号：US978538
申请日：1997-11-26
申请人： Donald R. Korb , Thomas Glonek , Jack V. Greiner
发明人： Donald R. Korb , Thomas Glonek , Jack V. Greiner
IPC分类号： A61K9/06 , A61K8/37 , A61K8/55 , A61K9/08 , A61K9/107 , A61K9/12 , A61K31/23 , A61K31/661 , A61K47/44 , A61Q19/00 , A61K7/48
CPC分类号： A61Q19/00 , A61K8/375 , A61K8/553 , A61Q19/007 , Y10S514/844 , Y10S514/861 , Y10S514/863 , Y10S514/864 , Y10S514/937
摘要： A composition and method for treatment of skin. The composition comprises a pharmaceutically acceptable carrier containing a bilayer component having one or more polar terminus groups and one or more non-polar terminus groups separated from said polar terminus groups capable of penetrating the outer surface of the skin to form an aligned bilayer within the stratum corneum. The bilayer assists in the formation of bilayer lamellae that is believed to replicate the bilayer lamellae present in healthy skin. The composition is topically applied to the skin as often as is required.

69. 发明授权

US4914088A Dry eye treatment solution and method 失效
标题翻译：干眼治疗溶液及方法
公开(公告)号：US4914088A
公开(公告)日：1990-04-03
申请号：US111874
申请日：1987-10-23
申请人： Thomas Glonek , Jack V. Greiner , Donald R. Korb
发明人： Thomas Glonek , Jack V. Greiner , Donald R. Korb
IPC分类号： A61K31/685 , A61K9/00 , A61K31/683 , A61K38/00 , A61P27/02
CPC分类号： A61K31/685 , A61K9/0048
摘要： A method and composition for treating dry eye. The method comprises addition of a positively or negatively charged, complex phospholipid to the ocular surface of the eye. The phospholipid is desirably added in a treatment composition, preferably in the form of an aqueous emulsion. It is believed that the phospholipid component of the treatment composition permits replication of a tear film.
摘要翻译：一种治疗干眼症的方法和组合物。该方法包括向眼睛的眼表面添加带正电荷或带负电荷的复合磷脂。优选将磷脂加入到处理组合物中，优选以水乳液的形式加入。认为处理组合物的磷脂成分允许复制泪液膜。

70. 发明授权

US4056496A Hydrogels and articles made therefrom 失效
标题翻译： HYDROGELS AND ARTICLES THEEFROM
公开(公告)号：US4056496A
公开(公告)日：1977-11-01
申请号：US685996
申请日：1976-05-13
申请人： William L. Mancini , Donald R. Korb , Miguel F. Refojo
发明人： William L. Mancini , Donald R. Korb , Miguel F. Refojo
IPC分类号： A61K6/083 , A61K9/20 , B01D71/40 , C08F220/28 , G02B1/04 , C08F220/14 , G02C7/04
CPC分类号： C08F220/28 , A61K6/083 , A61K9/2027 , B01D71/40 , G02B1/043 , Y10S521/905 , Y10S524/916 , Y10S528/92
摘要： This invention relates to polymers and hydrogels of polymers formed from a hydrophilic monomer of the group of dihydroxyalkyl acrylates and methacrylates, a substantially water insoluble monomer from the group of alkyl acrylates and methacrylates and preferably a minor amount of a water insoluble epoxidized alkyl acrylate or methacrylate. The hydrogels are preferably used for the formation of contact lenses, but may also be used for drug and pesticides delivery devices: dialysis, ultrafiltration and reverse osmosis membranes; implants in surgery and dentistry, and the like.

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