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61. 发明授权

US06555580B2 Amino- and amido-diphenyl ethers 失效
标题翻译：氨基和酰氨基二苯基醚
公开(公告)号：US06555580B2
公开(公告)日：2003-04-29
申请号：US09918741
申请日：2001-07-31
申请人： Helmut Haning , Josef Pernerstorfer , Gunter Schmidt , Michael Woltering , Hilmar Bischoff , Verena Vöhringer , Axel Kretschmer , Christiane Faeste
发明人： Helmut Haning , Josef Pernerstorfer , Gunter Schmidt , Michael Woltering , Hilmar Bischoff , Verena Vöhringer , Axel Kretschmer , Christiane Faeste
IPC分类号： C07C23301
CPC分类号： C07D295/215 , C07C233/25 , C07C233/26 , C07C233/29 , C07C233/56 , C07C233/60 , C07C233/73 , C07C233/75 , C07C235/16 , C07C235/24 , C07C235/60 , C07C235/62 , C07C237/30 , C07C271/28 , C07C275/36 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D213/38 , C07D223/10 , C07D307/14 , C07D307/52 , C07D311/24 , C07D333/38
摘要： The invention relates to novel amino- and amido-diphenyl ethers, processes for their preparation and their use in pharmaceuticals, in particular for the indications of arteriosclerosis and hypercholesterolaemia.
摘要翻译：本发明涉及新的氨基和酰氨基二苯基醚，其制备方法及其在药物中的用途，特别是用于动脉硬化和高胆固醇血症的适应症。

62. 发明申请

US20060189624A1 Novel combination for treating sexual dysfunction 审中-公开
标题翻译：治疗性功能障碍的新型组合
公开(公告)号：US20060189624A1
公开(公告)日：2006-08-24
申请号：US11347741
申请日：2006-02-03
申请人： Erwin Bischoff , Hilmar Bischoff , Francois Giuliano
发明人： Erwin Bischoff , Hilmar Bischoff , Francois Giuliano
IPC分类号： A61K31/519 , A61K31/455 , A61K31/401 , A61K31/366 , A61K31/22
CPC分类号： A61K45/06
摘要： Disclosed is a combination preparation for the treatment of sexual dysfunction in men or women containing at least one active ingredient A and one active ingredient B as pharmaceutically active ingredients, whereby the active ingredient A is a PDE inhibitor, preferably a cGMP PDE inhibitor and the active ingredient B a lipid-reducing agent. Both the active ingredients A and B can be administered simultaneously or at alternate intervals, that is, as a functional unit or separated from each other.
摘要翻译：公开了用于治疗男性或女性的性功能障碍的组合制剂，其含有至少一种活性成分A和一种活性成分B作为药物活性成分，由此活性成分A是PDE抑制剂，优选cGMP PDE抑制剂，活性成分成分B是减脂剂。活性成分A和B都可以同时或以交替间隔施用，即作为功能单元或彼此分离。

63. 发明申请

US20050272732A1 5-ethyl-imidazo (5,1-F) (1,2,4,) triazin-4 (3h)-ones as phosphodiesterase inhibitors 审中-公开
标题翻译：作为磷酸二酯酶抑制剂的5-乙基咪唑并（5,1-F）（1,2,4）三嗪-4（3h） - 酮
公开(公告)号：US20050272732A1
公开(公告)日：2005-12-08
申请号：US10513115
申请日：2003-04-22
申请人： Cristina Alonso-Alija , Heike Gielen-Haertwig , Martin Michels , Dagmar Karthaus , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton , Ulrich Niewohner , Maria Niewohner
发明人： Cristina Alonso-Alija , Heike Gielen-Haertwig , Martin Michels , Dagmar Karthaus , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton , Ulrich Niewohner , Maria Niewohner
IPC分类号： C07D253/06 , A61K31/53 , A61P11/00 , A61P11/06 , A61P29/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to novel 5-ethyl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.
摘要翻译：本发明涉及新的5-乙基 - 咪唑并三嗪酮，其制备方法及其在药物中的用途，用于治疗和/或预防炎症过程和/或免疫疾病。

64. 发明申请

US20050234096A1 Tetrahydroisoquinoline derivatives 审中-公开
标题翻译：四氢异喹啉衍生物
公开(公告)号：US20050234096A1
公开(公告)日：2005-10-20
申请号：US10514906
申请日：2003-05-05
申请人： Hilmar Bischoff , Elke Dittrich-Wengenroth , Verena Vohringer , Heike Heckroth , Andrea Vaupel , Michael Woltering , Michael Otteneder
发明人： Hilmar Bischoff , Elke Dittrich-Wengenroth , Verena Vohringer , Heike Heckroth , Andrea Vaupel , Michael Woltering , Michael Otteneder
IPC分类号： A61P9/00 , C07D217/08 , C07D221/20 , C07D217/22 , A61K31/47
CPC分类号： C07D221/20 , C07D217/08
摘要： The invention relates to novel substituted tetrahydroisoquinoline derivatives, methods for the production thereof and the use thereof in medicaments, especially as potent PPAR-delta activating compounds for the prophylaxis and/or treatment of cardiovascular diseases, especially dislipidaemia, coronary heart disease and arteriosclerosis.
摘要翻译：本发明涉及新型取代的四氢异喹啉衍生物，其生产方法及其在药物中的用途，特别是用于预防和/或治疗心血管疾病，特别是血脂异常，冠心病和动脉硬化的有效PPAR-δ活化化合物。

65. 发明授权

US06479503B2 Cycloalkano-indole and -azaindole derivatives 有权
标题翻译：环烷基 - 吲哚和-azaindole衍生物
公开(公告)号：US06479503B2
公开(公告)日：2002-11-12
申请号：US09814263
申请日：2001-03-21
申请人： Ulrich Müller , Richard Connell , Siegfried Goldmann , Rudi Grützmann , Martin Beuck , Hilmar Bischoff , Dirk Denzer , Anke Domdey-Bette , Stefan Wohlfeil
发明人： Ulrich Müller , Richard Connell , Siegfried Goldmann , Rudi Grützmann , Martin Beuck , Hilmar Bischoff , Dirk Denzer , Anke Domdey-Bette , Stefan Wohlfeil
IPC分类号： A61K31437
CPC分类号： C07D471/04 , C07D219/02
摘要： Cycloalcanoindole and -azaindole derivatives are prepared by reaction of appropriately substituted carboxylic acids with anmines. The cycloahloanindole and -azaindole derivatives are suitable as active compounds for medicaments, preferably antiatherosclerotic medicaments.
摘要翻译：环烷基吲哚和卤素衍生物通过适当取代的羧酸与烟矿的反应来制备。环亚氨基吲哚和卤素衍生物适合作为药物的活性化合物，优选抗动脉粥样硬化药物。

66. 发明授权

US06245775B1 Cycloalkano-indole and -azaindole derivatives 失效
标题翻译：环烷基 - 吲哚和-azaindole衍生物
公开(公告)号：US06245775B1
公开(公告)日：2001-06-12
申请号：US08887781
申请日：1997-07-03
申请人： Ulrich Müller , Richard Connell , Siegfried Goldmann , Rudi Grützmann , Martin Beuck , Hilmar Bischoff , Dirk Denzer , Anke Domdey-Bette , Stefan Wohlfeil
发明人： Ulrich Müller , Richard Connell , Siegfried Goldmann , Rudi Grützmann , Martin Beuck , Hilmar Bischoff , Dirk Denzer , Anke Domdey-Bette , Stefan Wohlfeil
IPC分类号： A61K31437
CPC分类号： C07D471/04 , C07D219/02
摘要： Cycloakano-indole and -azaindole derivatives are prepared by reaction of appropriately substituted carbonylic acids with amines. The cycloalkano-indole and -azaindole derivatives are suitable as active compounds for medicaments, preferably antiatherosclerotic medicaments.
摘要翻译：通过适当取代的羰基酸与胺的反应制备环烷基 - 吲哚和吖啶衍生物。环烷基 - 吲哚和吖啶衍生物适合用作药物，优选抗动脉粥样硬化药物的活性化合物。

67. 发明授权

US6034115A Indolyl-substituted phenylacetic acid derivatives 失效
公开(公告)号：US6034115A
公开(公告)日：2000-03-07
申请号：US761922
申请日：1996-12-09
申请人： Richard Connell , Siegfried Goldmann , Ulrich Muller , Stefan Lohmer , Hilmar Bischoff , Dirk Denzer , Rudi Grutzmann , Stefan Wohlfeil
发明人： Richard Connell , Siegfried Goldmann , Ulrich Muller , Stefan Lohmer , Hilmar Bischoff , Dirk Denzer , Rudi Grutzmann , Stefan Wohlfeil
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/435 , A61P3/06 , A61P9/00 , A61P9/10 , C07D209/08 , C07D209/42 , C07D235/16 , C07D471/04 , C07D235/08 , C07D235/10 , C07D235/18
CPC分类号： C07D471/04 , C07D209/08 , C07D209/42 , C07D235/16
摘要： The indolyl-substituted phenylacetic acid derivatives are prepared by reacting the corresponding phenylacetic acids with the required amines. The indolyl-substituted phenylacetic acid derivatives are suitable as active compounds in medicaments, in particular in antiarteriosclerotic medicaments.

68. 发明授权

US5747505A Heterocyclic aryl-, alkyl- and cycloalkylacetamides 失效
标题翻译：杂环芳基，烷基和环烷基乙酰胺
公开(公告)号：US5747505A
公开(公告)日：1998-05-05
申请号：US717027
申请日：1996-09-20
申请人： Richard Connell , Siegfried Goldmann , Ulrich Muller , Martin Beuck , Hilmar Bischoff , Dirk Denzer , Rudi Grutzmann , Stefan Wohlfeil
发明人： Richard Connell , Siegfried Goldmann , Ulrich Muller , Martin Beuck , Hilmar Bischoff , Dirk Denzer , Rudi Grutzmann , Stefan Wohlfeil
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/47 , A61P3/06 , A61P9/08 , A61P9/10 , C07C69/732 , C07C69/734 , C07D213/65 , C07D215/14 , C07D401/12 , C07D409/12 , C07D215/12 , C07D217/12
CPC分类号： C07D401/12 , C07C69/732 , C07C69/734 , C07D213/65 , C07D215/14 , C07D409/12
摘要： The heterocyclic aryl-, alkyl- and cycloalklacetamides are prepared by reacting the appropriately substituted acetic acids with amines, if appropriate in complexed form. The heterocyclic aryl-, alkyl- and cycloalkylacetamides can be used as active compounds in medicaments, in particular in antiatherosclerotic medicaments.
摘要翻译：杂环芳基 - ，烷基 - 和环烷基乙酰胺通过使适当取代的乙酸与胺反应制备，如果合适的话，可以配合形式。杂环芳基 - ，烷基 - 和环烷基乙酰胺可用作药物中的活性化合物，特别是抗动脉粥样硬化药物。

69. 发明授权

US5334610A .alpha.-aryl-.alpha.-hydroxy-.beta.-imidazolinyl-propionamides 失效
标题翻译： α-芳基-α-羟基-β-咪唑啉基 - 丙酰胺
公开(公告)号：US5334610A
公开(公告)日：1994-08-02
申请号：US4341
申请日：1993-01-14
申请人： Wilfried Draber , Hilmar Bischoff
发明人： Wilfried Draber , Hilmar Bischoff
IPC分类号： A61K31/415 , A61K31/4184 , A61P3/08 , C07D233/06 , C07D233/10 , C07D233/26 , C07D235/02
CPC分类号： C07D235/02 , C07D233/06
摘要： The present invention relates to novel .alpha.-aryl-.alpha.-hydroxy-.beta.-imidazolinyl-propionamides of the general formula (I) ##STR1## in which n, R.sup.1 to R.sup.4 and X have the meaning indicated in the description, to a process for their preparation and to their use in medicaments.
摘要翻译：本发明涉及通式（I）的化合物，其中n，R 1至R 4和X具有说明书所示的含义，它们的制备过程及其在药物中的用途。

70. 发明授权

US4786641A Dihydropyridine compounds and their use in reducing blood sugar 失效
标题翻译：二氢吡啶化合物及其在降血糖中的应用
公开(公告)号：US4786641A
公开(公告)日：1988-11-22
申请号：US87491
申请日：1987-08-20
申请人： Siegfried Goldmann , Hans-Jurgen Ahr , Walter Puls , Hilmar Bischoff , Dieter Petzinna , Klaus Schlossmann , Joachim Bender
发明人： Siegfried Goldmann , Hans-Jurgen Ahr , Walter Puls , Hilmar Bischoff , Dieter Petzinna , Klaus Schlossmann , Joachim Bender
IPC分类号： A61K31/465 , A61K31/445 , A61K31/451 , A61P3/08 , C07D211/90 , C07D491/04 , C07D491/044 , C07D491/048 , A61K31/44
CPC分类号： C07D491/04 , C07D211/90
摘要： Blood-sugar-lowering dihydropyridines of the formula ##STR1## in which R.sup.1 represents phenyl, naphthyl, thienyl, pyridyl, chromenyl or thiochromenyl, it being possible for the radicals mentioned each to carry up to 2 identical or different substituents from the series comprising halogen, alkyl, alkoxy and alkylthio with in each case up to 6 carbon atoms, fluoroalkyl and fluoroalkoxy with in each case up to 3 carbon atoms and 3 fluorine atoms, nitro and cyano,R.sup.2 represents straight-chain, branched or cyclic alkyl which has up to 8 carbon atoms, can be interrupted in the alkyl chain by an oxygen or a sulphur atom and can be substituted by halogen, phenyl, cyano, hydroxyl, amino, alkylamino or dialkylamino with in each case up to 3 carbon atoms per alkyl group or by N-benzylmethylamino,R.sup.3 represents straight-chain, branched or cyclic alkyl which has up to 6 carbon atoms, can be interrupted in the alkyl chain by an oxygen atom and can be substituted by halogen, hydroxyl, amino, phenyl, morpholino, carboxy or alkoxycarbonyl with up to 4 carbon atoms andR.sup.4 and R.sup.5 each represent hydroxyl, orR.sup.4 and R.sup.5 together represent --O--,or a physiologically acceptable salt thereof.
摘要翻译：其中R1代表苯基，萘基，噻吩基，吡啶基，色烯基或硫代色烯基的式“IMAGE”的降血糖二氢吡啶类，各自所提及的基团有可能从包含卤素的系列中携带多达2个相同或不同的取代基，烷基，烷氧基和烷硫基，在每种情况下最多6个碳原子，氟代烷基和氟代烷氧基，在每种情况下最多3个碳原子和3个氟原子，硝基和氰基，R2表示直链，支链或环状的烷基，至8个碳原子，可以通过氧或硫原子在烷基链中被中断，并且可以被卤素，苯基，氰基，羟基，氨基，烷基氨基或二烷基氨基取代，在每种情况下，每个烷基最多为3个碳原子，或通过N-苄基甲基氨基，R3表示具有多至6个碳原子的直链，支链或环状烷基，可以在烷基链中被氧原子中断，并可被卤素，羟基，氨基，苯基，具有至多4个碳原子的直链，羧基或烷氧基羰基，且R 4和R 5各自表示羟基，或者R 4和R 5一起表示-O-或其生理上可接受的盐。

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