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61. 发明申请

US20100322465A1 PANTOGRAPH DAMAGE AND WEAR MONITORING SYSTEM 失效
标题翻译： PANTOGRAPH损伤和磨损监测系统
公开(公告)号：US20100322465A1
公开(公告)日：2010-12-23
申请号：US12671871
申请日：2008-08-05
申请人： Darryl Wesche , Timothy John Watkins , Leonard George Chardborn Hamey
发明人： Darryl Wesche , Timothy John Watkins , Leonard George Chardborn Hamey
IPC分类号： G06K9/00 , H04N7/18
CPC分类号： B60L5/24 , B60L2200/26 , B60M1/28 , G06T7/0004
摘要： A system for evaluating the condition of a pantograph, the system comprising: a track-side pantograph monitoring station that captures one or more images of a pantograph, while a locomotive comprising the pantograph is in normal service; a station management system that analyses one or more images captured at the monitoring site and determines the condition of the pantograph; and a user interface that controls the system and presents the results of the analysis to the user. A user may control the track-side monitoring station and station management system remotely.
摘要翻译：一种用于评估受电弓的状况的系统，所述系统包括：轨道侧受电弓监视站，其捕获缩放仪的一个或多个图像，而包括所述受电弓的机车正常工作; 一个站点管理系统，分析在监控点捕获的一个或多个图像，并确定受电弓的状况; 以及控制系统并向用户呈现分析结果的用户界面。用户可以远程控制轨道侧监控站和站管理系统。

62. 发明申请

US20090324543A1 PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS 有权
标题翻译：吡咯烷酮（3,2-d）可用于治疗病毒感染的吡咯烷酮
公开(公告)号：US20090324543A1
公开(公告)日：2009-12-31
申请号：US12519496
申请日：2007-12-24
申请人： William John Watkins , Lee Shung Chong , Jennifer R. Zhang
发明人： William John Watkins , Lee Shung Chong , Jennifer R. Zhang
IPC分类号： A61K31/541 , C07D417/14 , A61K38/21 , A61K31/5377 , A61K31/519 , C07D413/14 , C07D471/04 , A61P31/14
CPC分类号： C07D471/04
摘要： 2-amino-pyrido(3,2-d)pyrimidine derivatives with a specific substitution pattern on positions 4 and 6 of the core structure are useful in the treatment or prevention of an infection due to a virus from the Flaviviridae family, especially HCV, when administered to a patient in a therapeutically effective amount.
摘要翻译：具有核心结构位置4和6上特定取代模式的2-氨基 - 吡啶并（3,2-d）嘧啶衍生物可用于治疗或预防由于来自黄病毒科的病毒感染，特别是HCV，当以治疗有效量施用于患者时。

63. 发明申请

US20090253696A1 SUBSTITUTED PYRIDO(3,2-D) PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS FOR TREATING VIRAL INFECTIONS 有权
标题翻译：替代吡蚜（3,2-D）吡嗪类和药物组合物治疗病毒感染
公开(公告)号：US20090253696A1
公开(公告)日：2009-10-08
申请号：US12374223
申请日：2007-06-20
申请人： Piet Andre' Maurits Maria Herdewijn , Steven Cesar Alfons De Jonghe , William John Watkins , Lee Shun Chong , Jennifer Zhang
发明人： Piet Andre' Maurits Maria Herdewijn , Steven Cesar Alfons De Jonghe , William John Watkins , Lee Shun Chong , Jennifer Zhang
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/519 , A61P31/12
CPC分类号： C07D471/04
摘要： This invention provides di-, tri- and tetra-substituted pyrido(3,2-d)pyrimidine derivatives with specific substituting patterns, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular being highly active antiviral agents. The invention also provides use of such derivatives in the treatment of viral infections and pathologic conditions associated therewith, including hepatitis C.
摘要翻译：本发明提供了具有特定取代模式的二，三和四取代的吡啶并（3,2-d）嘧啶衍生物，其药学上可接受的盐，N-氧化物，溶剂合物，前药和对映异构体，特别是高活性抗病毒剂。本发明还提供了这样的衍生物在治疗与其相关的病毒感染和病理状况（包括丙型肝炎）中的用途。

64. 发明申请

US20090191154A1 ASSEMBLY AND FOLDING OF FC-INTERFERON-BETA FUSION PROTEINS 失效
标题翻译： FC-INTERFERON-BETA融合蛋白的组装和折叠
公开(公告)号：US20090191154A1
公开(公告)日：2009-07-30
申请号：US12395165
申请日：2009-02-27
申请人： Stephen D. Gillies , Nigel John Watkins , Matthew Paul Baker , Kin-Ming Lo , Steven C. Degon
发明人： Stephen D. Gillies , Nigel John Watkins , Matthew Paul Baker , Kin-Ming Lo , Steven C. Degon
IPC分类号： A61K38/21 , C07K19/00
CPC分类号： C07K16/46 , A61K38/00 , A61K47/48423 , A61K47/6813 , C07K14/565 , C07K2319/30
摘要： Disclosed are Fc-interferon-beta (Fc-IFN-β) fusion proteins and nucleic acid molecules encoding them. The Fc-IFN-β fusion proteins include variants of the interferon-beta (IFN-β) protein that are altered to achieve enhanced biological activity, prolonged circulating half-life and greater solubility. Also disclosed are methods of producing the fusion proteins and methods of using the fusion proteins and/or nucleic acid molecules for treating diseases and conditions alleviated by the administration of interferon-beta.
摘要翻译：公开了Fc-干扰素-β（Fc-IFN-β）融合蛋白和编码它们的核酸分子。 Fc-IFN-β融合蛋白包括干扰素-β（IFN-β）蛋白的变体，其被改变以实现增强的生物活性，延长的循环半衰期和更大的溶解度。还公开了产生融合蛋白的方法和使用融合蛋白和/或核酸分子治疗通过施用干扰素-β缓解的疾病和病症的方法。

65. 发明申请

US20090043076A1 Modified interferon beta with reduced immunogenicity 失效
公开(公告)号：US20090043076A1
公开(公告)日：2009-02-12
申请号：US12077120
申请日：2008-03-17
申请人： Francis J. Carr , Graham Carter , Tim Jones , John Watkins , Matthew Baker
发明人： Francis J. Carr , Graham Carter , Tim Jones , John Watkins , Matthew Baker
IPC分类号： C07K14/565
CPC分类号： C07K14/565
摘要： The present invention relates a modified human interferon beta (INFβ) which is less immunogenic than human INFβ (SEQ ID NO: 1) when administered in vivo to a human. The modified human INFβ comprises an amino acid residue sequence that differs from SEQ ID NO: 1 by an amino acid residue substitution selected from the group consisting of L57A, L57C, L57D L57E, L57G, L57H, L57K, L57N, L57P, L57Q, L57R, L57S, and L57T and an additional substitution selected from the group consisting of the H140A, H140C, H140G, and H140P.

66. 发明申请

US20080150360A1 System and Method for Providing Power Management in a Sensor Network 有权
标题翻译：在传感器网络中提供电源管理的系统和方法
公开(公告)号：US20080150360A1
公开(公告)日：2008-06-26
申请号：US11613313
申请日：2006-12-20
申请人： Brian Vezza , Kent Felske , Alan Graves , John Watkins , Guy Duxbury , Tom Chmara , Jeff Fitchett
发明人： Brian Vezza , Kent Felske , Alan Graves , John Watkins , Guy Duxbury , Tom Chmara , Jeff Fitchett
IPC分类号： H02J4/00
CPC分类号： H02J1/00 , G01D21/00 , H04L67/125 , Y10T307/406
摘要： The present invention relates to a system and method for providing power management to sensing nodes in a sensor network. A system may include a plurality of sensing nodes, each sensing node connected through a power management device to an external power source, such as a powered node of another network, for managing power from the external power source to the sensing node. Beneficially, a plurality of power management devices allow for a sensor network of fixed or mobile wireless sensing nodes or sensor gateways to make use of power from an external source such as an another network e.g. an existing emergency lighting system or other similar powered building system. Thus for example, a sensor or group of sensing nodes and their associated power management devices may be integral with or co-located in proximity to powered nodes of these other networks. An intelligent power management device connected to at least one of the sensing nodes may provide for power policy management to sensing nodes based on monitoring power conditions such as available power, power level status, and information obtained from the sensing nodes indicative of network conditions, detecting a change therein, and regulating power to the sensing node depending on the change
摘要翻译：本发明涉及一种用于提供电力管理以感测传感器网络中的节点的系统和方法。系统可以包括多个感测节点，每个感测节点通过电力管理设备连接到外部电源，例如另一网络的供电节点，用于管理从外部电源到感测节点的电力。有利的是，多个电力管理装置允许固定或移动无线传感节点或传感器网关的传感器网络利用来自诸如另一个网络的外部源的功率。现有的应急照明系统或其他类似的动力建筑系统。因此，例如，传感器或一组感测节点及其相关联的电力管理设备可以与这些其他网络的动力节点接近或与其相邻。连接到所述感测节点中的至少一个的智能电力管理装置可以基于监视功率条件（例如可用功率，功率电平状态以及从指示网络状况的感测节点获得的信息）来检测节点来提供电力策略管理，检测其中的变化，并且根据变化调节对感测节点的功率

67. 发明申请

US20060160995A1 Thrombopoietin proteins with improved properties 失效
公开(公告)号：US20060160995A1
公开(公告)日：2006-07-20
申请号：US10561097
申请日：2004-06-25
申请人： Matthew Baker , John Watkins
发明人： Matthew Baker , John Watkins
IPC分类号： C07K16/44
CPC分类号： C07K14/524 , A61K38/00 , A61K39/00 , A61K2039/57 , C07K2319/30
摘要： The invention concerns human thrombopoietin and in particular modified forms of thrombopoietin (TPO) with improved properties. The improved proteins contain amino acid substitutions at specific positions within the TPO molecule. The invention provides modified TPO molecules, preferably fusion proteins comprising immunoglobulin constant regions and modified human TPO, with improved biological activity concomitant with reduced immunogenic potential in the protein. The improved proteins are intended for therapeutic use in the treatment of diseases in humans.

68. 发明申请

US20060017032A1 Scissor thrust valve actuator 失效
公开(公告)号：US20060017032A1
公开(公告)日：2006-01-26
申请号：US10896579
申请日：2004-07-21
申请人： Kevin DeWall , John Watkins , Michael Nitzel
发明人： Kevin DeWall , John Watkins , Michael Nitzel
IPC分类号： F16K31/02
CPC分类号： F16K31/53 , F16K31/046 , Y10T137/8242
摘要： Apparatus for actuating a valve includes a support frame and at least one valve driving linkage arm, one end of which is rotatably connected to a valve stem of the valve and the other end of which is rotatably connected to a screw block. A motor connected to the frame is operatively connected to a motor driven shaft which is in threaded screw driving relationship with the screw block. The motor rotates the motor driven shaft which drives translational movement of the screw block which drives rotatable movement of the valve driving linkage arm which drives translational movement of the valve stem. The valve actuator may further include a sensory control element disposed in operative relationship with the valve stem, the sensory control element being adapted to provide control over the position of the valve stem by at least sensing the travel and/or position of the valve stem.

69. 发明申请

US20050223222A1 Systems and methods for preserving confidentiality of sensitive information in a point-of-care communications environment 有权
标题翻译：在保护点通信环境中保护敏感信息的机密性的系统和方法
公开(公告)号：US20050223222A1
公开(公告)日：2005-10-06
申请号：US10813358
申请日：2004-03-31
申请人： Alan Graves , Jeffrey Fitchett , John Watkins
发明人： Alan Graves , Jeffrey Fitchett , John Watkins
IPC分类号： H04L9/08 , H04L9/32 , H04L29/06
CPC分类号： H04L63/0428 , H04L9/0894 , H04L63/08 , H04L2209/80 , H04L2209/88
摘要： A data processing apparatus comprises a memory store; a data bus connected to the memory store, the data bus being adapted for transporting data to and from the memory store; a processing entity operative to release read and write commands towards the memory store, the write command being accompanied by first data intended to be written to the memory store; and an encryption module communicatively coupled to the processing entity and to the data bus. Upon the processing entity releasing a write command accompanied by said first data, the encryption module encrypts, in accordance with an encryption key, said first data and send an encrypted version of said first data onto the data bus for writing into the memory store. The reverse operation is performed upon the processing entity releasing a read command.
摘要翻译：数据处理装置包括存储器存储器; 连接到存储器存储器的数据总线，数据总线适于将数据传送到存储器存储器和从存储器存储器传送数据; 处理实体，其用于释放对存储器存储器的读取和写入命令，所述写入命令伴随着要写入存储器存储器的第一数据; 以及通信地耦合到处理实体和数据总线的加密模块。在处理实体释放伴随有所述第一数据的写入命令时，加密模块根据加密密钥对所述第一数据进行加密，并将所述第一数据的加密版本发送到数据总线上以写入存储器存储器。在处理实体释放读取命令时执行相反的操作。

70. 发明授权

US06313127B1 Heterocyclic compounds useful as pharmaceutical agents 失效
标题翻译：用作药剂的杂环化合物
公开(公告)号：US06313127B1
公开(公告)日：2001-11-06
申请号：US09117523
申请日：1998-07-31
申请人： David Waterson , Elaine Sophie Elizabeth Stokes , George Robert Brown , John Graham Cumming , Nicholas John Newcombe , Robin Wood , William John Watkins
发明人： David Waterson , Elaine Sophie Elizabeth Stokes , George Robert Brown , John Graham Cumming , Nicholas John Newcombe , Robin Wood , William John Watkins
IPC分类号： A61K31496
CPC分类号： C07D239/42 , C07D213/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D513/04
摘要： Compounds of formula (I) in which all variables are defined in the description and their salts inhibit the enzyme oxido squalene cyclase and are useful in treating hypercholesterolemia and also as anti-fungal agents. Processes for their preparation are also described together with their use in medicine.
摘要翻译：其中所有变量在说明书中定义的式（I）化合物及其盐抑制酶氧化角鲨烯环化酶，并且可用于治疗高胆固醇血症，也可用作抗真菌剂。还描述了其制备方法及其在药物中的用途。

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