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61. 发明申请

US20160130227A1 PRODRUGS OF ANTI-PLATELET AGENTS 审中-公开
标题翻译：抗药剂原料
公开(公告)号：US20160130227A1
公开(公告)日：2016-05-12
申请号：US14859377
申请日：2015-09-21
申请人： Cellix Bio Private Limited
发明人： Mahesh Kandula
IPC分类号： C07D211/54 , C07D513/04
CPC分类号： C07D211/54 , C07D211/72 , C07D495/04 , C07D513/04
摘要： The invention relates to the compounds of formula II, formula Ia, formula IIa or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula II, formula Ia, formula IIa and methods for treating or preventing atherothrombosis may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment or management of ischemia, stroke, cerebral thrombosis, arterial thrombosis, thrombotic cerebrovascular, cardiovascular diseases and blood clots.
摘要翻译：本发明涉及式II，式Ia，式IIa化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。包含有效量的式II，式Ia，式IIa的化合物和用于治疗或预防动脉粥样硬化血栓形成的方法的药物组合物可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。这样的组合物可用于治疗或治疗缺血，中风，脑血栓形成，动脉血栓形成，血栓性脑血管，心血管疾病和血块。

62. 发明授权

US09333187B1 Compositions and methods for the treatment of inflammatory bowel disease 有权
标题翻译：用于治疗炎症性肠病的组合物和方法
公开(公告)号：US09333187B1
公开(公告)日：2016-05-10
申请号：US14834411
申请日：2015-08-24
申请人： Cellix Bio Private Limited
发明人： Mahesh Kandula
IPC分类号： C07C69/76 , A61K31/245 , C07C235/74 , C07C243/22 , A61K31/655
CPC分类号： A61K31/245 , A61K31/202 , A61K31/235 , A61K31/606 , A61K31/655 , A61K45/06 , C07C233/54 , C07C233/55 , C07C235/74 , C07C243/22 , C07C251/86 , C07C2601/16 , A61K2300/00
摘要： The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing inflammatory bowel disease may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of gastrointestinal diseases and inflammation such as inflammatory bowel disease, ulcerative colitis, mild-to-moderate Crohn's disease, rheumatoid arthritis, inflammatory arthritis, psoriatic arthritis, liver cirrhosis and idiopathic urticaria.
摘要翻译：本发明涉及式I和式II化合物或其药学上可接受的盐，以及多晶型物，溶剂合物，对映体，立体异构体和水合物。药物组合物包含有效量的式I或式II化合物; 并且可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射的治疗或预防炎性肠病的方法。这样的组合物可用于治疗胃肠道疾病和炎症，例如炎性肠病，溃疡性结肠炎，轻度至中度克罗恩病，类风湿性关节炎，炎症性关节炎，牛皮癣关节炎，肝硬化和特发性荨麻疹。

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