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61. 发明申请

US20110270157A1 Sensing and interactive drug delivery 审中-公开
标题翻译：感应和互动药物递送
公开(公告)号：US20110270157A1
公开(公告)日：2011-11-03
申请号：US13135473
申请日：2011-07-05
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61M5/168
CPC分类号： A61N1/0428 , A61B5/0022 , A61B5/0059 , A61M37/00 , A61N1/08 , A61N1/30 , A61N1/327
摘要： An interactive drug delivery system includes a drug delivery module, an optical probe, a local controller, and an optional central controller. The drug delivery module is constructed and arranged to deliver selected amounts of a drug into a subject. The optical probe is constructed and arranged to detect in a selected tissue region of the subject a manifestation caused by the delivered drug. The local controller is constructed and arranged to receive data from or transmit data to the optical probe and the drug delivery module. The local controller is arranged to correlate optical data, received from the optical probe, to selected data and provide signals to the drug delivery module for adjusting the amounts of the drug to be delivered into the subject.
摘要翻译：交互式药物递送系统包括药物递送模块，光学探针，本地控制器和可选的中央控制器。药物递送模块被构造和布置成将选定量的药物递送到受试者中。光学探针被构造和布置成在对象的选定组织区域中检测由递送的药物引起的表现。本地控制器被构造和布置成从光学探针和药物传递模块接收数据或传输数据。本地控制器被布置成将从光学探针接收的光学数据与所选择的数据相关联，并向药物递送模块提供信号，以调整要递送到受试者的药物的量。

62. 发明申请

US20080161697A1 Examination of subjects using photon migration with high directionality techniques 审中-公开
标题翻译：使用高度方向性技术的光子迁移检查受试者
公开(公告)号：US20080161697A1
公开(公告)日：2008-07-03
申请号：US11369221
申请日：2006-03-06
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B6/00
CPC分类号： G01N21/6456 , A61B5/0073 , A61B5/0091 , A61B5/1455 , A61B5/14551 , A61B5/14553 , A61B5/4312 , A61B5/7239 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N21/3151 , G01N21/47 , G01N21/4795 , G01N21/49 , G01N21/6486 , G01N2021/1789 , G01N2021/3181 , G01N2021/6421 , G01N2021/6484 , G01N2201/0696
摘要： A spectroscopic method and system for examination of biological tissue includes multiple input ports optically connected to at least one light source, multiple detection ports optically connected to at least one detector, a radiation pattern controller coupled to the light source and detector, and a processor. The multiple input ports are arranged to introduce light at input locations into biological tissue and the multiple detection ports are arranged to collect light from detection locations of the biological tissue. The radiation pattern controller is constructed to control patterns of light introduced from the multiple input ports and constructed to control detection of light migrating to the multiple detection ports. The processor is operatively connected to the radiation pattern controller and connected to receive detector signals from the detector, and is constructed to examine a tissue region based on the introduced and detected light patterns.
摘要翻译：用于检查生物组织的光谱方法和系统包括与至少一个光源光学连接的多个输入端口，与至少一个检测器光学连接的多个检测端口，耦合到光源和检测器的辐射图案控制器以及处理器。多个输入端口被布置成将输入位置处的光引入生物组织，并且多个检测端口被布置成从生物组织的检测位置收集光。辐射图形控制器被构造为控制从多个输入端口引入的光的图案，并被构造成控制对多个检测端口迁移的光的检测。处理器可操作地连接到辐射图案控制器并被连接以接收来自检测器的检测器信号，并且被构造成基于引入和检测到的光图案来检查组织区域。

63. 发明申请

US20050228291A1 Imaging and characterization of brain tissue 失效
标题翻译：脑组织成像和表征
公开(公告)号：US20050228291A1
公开(公告)日：2005-10-13
申请号：US10982542
申请日：2004-11-05
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： G01N21/17 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B10/00 , A61B6/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/0073 , A61B5/4064 , A61B2562/0233 , A61B2562/0242 , A61B2562/046
摘要： An optical examination technique employs an optical system for in vivo non-invasive transcranial examination of brain tissue of a subject. The optical system includes an optical module arranged for placement on the exterior of the head, a controller and a processor. The optical module includes an array of optical input ports and optical detection ports located in a selected geometrical pattern to provide a multiplicity of photon migration paths inside the biological tissue. Each optical input port is constructed to introduce into the examined tissue visible or infrared light emitted from a light source. Each optical detection port is constructed to provide light from the tissue to a light detector. The controller is constructed and arranged to activate one or several light sources and light detectors so that the light detector detects light that has migrated over at least one of the photon migration paths. The processor receives signals corresponding to the detected light and forms at least two data sets, a first of said data sets representing blood volume in the examined tissue region and a second of said data sets representing blood oxygenation of the examined tissue. The processor is arranged to correlate the first and second data sets to detect abnormal tissue in the examined tissue.
摘要翻译：光学检查技术采用光学系统用于受试者脑组织的体内非侵入性经颅检查。光学系统包括布置成放置在头部外部的光学模块，控制器和处理器。光学模块包括位于选定几何图案中的光学输入端口和光学检测端口的阵列，以在生物组织内部提供多个光子迁移路径。每个光学输入端口构造成将被检查的组织引入可见光或从光源发射的红外光。每个光学检测端口被构造成将来自组织的光提供给光检测器。控制器被构造和布置成激活一个或多个光源和光检测器，使得光检测器检测已经通过至少一个光子迁移路径迁移的光。所述处理器接收对应于检测到的光的信号并形成至少两个数据集，所述数据集中的第一个表示所检查的组织区域中的血液体积，所述数据集中的第二个表示所检查的组织的血氧。处理器被布置成使第一和第二数据集相关联，以检测检查的组织中的异常组织。

64. 发明授权

US06618614B1 Optical examination device, system and method 有权
标题翻译：光学检测装置，系统及方法
公开(公告)号：US06618614B1
公开(公告)日：2003-09-09
申请号：US09077835
申请日：1998-09-08
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B600
CPC分类号： A61B5/6814 , A61B5/0035 , A61B5/0042 , A61B5/0077 , A61B5/0091 , A61B5/14532 , A61B5/1455 , A61B5/14551 , A61B5/14552 , A61B5/14553 , A61B5/1459 , A61B5/4312 , A61B5/6853 , A61B2562/0233 , A61B2562/046 , A61B2562/146
摘要： As part of an examination device, an input or output optical coupler device for transmitting photons between an optical source or detector and an examined body part includes an array of optical fibers with end portions freely protruding as cantilevers from a support. The optical fibers have the end portions fabricated, sized and distributed to penetrate freely extending hair when the support is placed on the head or other surface of a subject to make optical contact directly over an array of points with the surface of the scalp or skin below the free hair.
摘要翻译：作为检查装置的一部分，用于在光源或检测器和被检体的部分之间传输光子的输入或输出光耦合器装置包括光纤阵列，其端部从支撑件自由地突出为悬臂。光纤具有制造，尺寸和分布的端部，以便当将支撑物放置在受试者的头部或其他表面上时穿透自由延伸的头发，以使光学接触直接在与头皮或皮肤的表面下方的点阵列上免费的头发。

65. 发明授权

US06549795B1 Spectrophotometer for tissue examination 失效
标题翻译：分光光度计用于组织检查
公开(公告)号：US06549795B1
公开(公告)日：2003-04-15
申请号：US09115329
申请日：1998-07-14
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B500
CPC分类号： A61B5/14552 , A61B5/6824 , A61B5/7257 , A61B2562/0242
摘要： A method and apparatus for transcranial examination of brain activity. Electromagnetic radiation of a selected wavelength is introduced into the brain from an input port located on an exterior of the subject's head. Radiation that has migrated through the subject's head is detected at a detection port to generate detected signals. While introducing and detecting the electromagnetic radiation, stimulation of brain activity is induced. The detected radiation signals are processed, and the processed signals are analyzed to determine a characteristic of the brain activity by correlating the processed signals with the stimulation.
摘要翻译：脑活动经颅检查的方法和装置。所选波长的电磁辐射从位于对象头部外部的输入端口引入脑中。在检测端口处检测到通过被检者的头部迁移的辐射，以产生检测到的信号。在引入和检测电磁辐射的同时，诱导大脑活动的刺激。对所检测的辐射信号进行处理，并且通过将经处理的信号与刺激相关联来分析处理的信号以确定大脑活动的特征。

66. 发明授权

US06397099B1 Non-invasive imaging of biological tissue 失效
标题翻译：生物组织的非侵入性成像
公开(公告)号：US06397099B1
公开(公告)日：2002-05-28
申请号：US09266982
申请日：1999-03-12
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B500
CPC分类号： A61B5/0073 , A61B5/0042 , A61B5/0059 , A61B5/1455 , A61B5/14553 , A61B5/4064 , A61B5/445 , A61B5/6824 , A61B2562/02 , A61B2562/0233 , A61B2562/0242 , A61B2562/046
摘要： An optical system for in vivo, non-invasive imaging of tissue change includes an optical module with an array of input ports and detection ports located in a selected geometrical pattern to provide a multiplicity of arrayed single source, single detector pairs engaged directly with the subject; a spectrophotometer including a light source constructed to introduce electromagnetic radiation of visible or infra-red wavelength into the examined tissue successively at the input ports, the wavelength being sensitive to a constituent of the imaged tissue; a detector constructed to detect, at the detection ports, radiation of the selected wavelength that has migrated in the tissue from respective input ports; and a processor receiving signals of the detected radiation from the detector, and constructed and arranged to create a defined spatial image of the tissue by effectively producing from signals from the multiplicity of arrayed single source, single detector pairs, a succession of data sets representing, from a selected view, a succession of spatial images of the tissue, and an image data set related to differences between data of the successive data sets. Imaging instruments and a method are also described.
摘要翻译：用于组织变化的体内非侵入性成像的光学系统包括具有位于选定几何图案中的输入端口和检测端口阵列的光学模块，以提供多个直接与受检者接合的排列单个源单个检测器对 ; 分光光度计，其包括被构造成在输入端口连续地将可见或红外波长的电磁辐射引入检查的组织中的光源，所述波长对成像组织的成分敏感; 检测器，被构造成在检测端口处检测已经从相应输入端口在组织中迁移的所选波长的辐射; 以及处理器，其接收来自检测器的检测到的辐射的信号，并被构造和布置成通过从多个排列的单个源，单个检测器对的信号有效地产生组织的定义的空间图像，一系列数据集，从选定的视图，组织的一系列空间图像，以及与连续数据集的数据之间的差异相关的图像数据集。还描述了成像仪器和方法。

67. 发明授权

US6134460A Spectrophotometers with catheters for measuring internal tissue 失效
标题翻译：分光光度计与导管测量内部组织
公开(公告)号：US6134460A
公开(公告)日：2000-10-17
申请号：US731443
申请日：1996-10-15
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , A61B5/1495 , A61B10/00 , G01N21/27 , G01N21/31 , G01N21/47 , G01N21/49 , G01N21/64
CPC分类号： A61B5/14551 , A61B5/14552 , A61B5/14553 , A61B5/1459 , A61B5/6828 , G01N21/3151 , G01N21/4795 , G01N21/49 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , G01N2021/1789 , G01N2021/3181 , G01N21/47 , G01N2201/0696
摘要： The present invention provides in various embodiments novel, wearable systems for determining the metabolic condition of an aerobically stressed portion of tissue such as the muscle tissue of an exercising person. Generally, the systems comprise lightweight rugged detectors, worn adjacent the tissue being monitored. The system of the present invention thus minimizes any performance impairment. In preferred systems a wearable power pack and a wearable display means are provided for displaying information indicative of the aerobic metabolic condition of the region being monitored. In a preferred embodiment intended for use while running or engaged in similar athletic activities, the display is worn on the wrist and displays information from a leg-mounted detector. In another embodiment, intended to provide information to coaches, a telemetry system is employed to transmit a signal carrying the data from the detector to a remote location, for processing and display. Various other embodiments and applications are also included.
摘要翻译：本发明在各种实施方案中提供了用于确定诸如锻炼者的肌肉组织的组织有氧应激部分的代谢状况的新型可穿戴系统。通常，系统包括邻近被监测的组织的轻质坚固检测器。因此，本发明的系统使任何性能损害最小化。在优选的系统中，提供了一种可戴式电源组件和一种穿戴式显示装置，用于显示指示所监视区域的有氧代谢状态的信息。在旨在用于运行或参与类似运动活动的优选实施例中，显示器佩戴在手腕上并且显示来自腿部安装的检测器的信息。在另一个实施例中，为了向教练提供信息，采用遥测系统将携带数据的信号从检测器传送到远程位置，以进行处理和显示。还包括各种其他实施例和应用。

68. 发明授权

US06058324A Examination and imaging of biological tissue 有权
标题翻译：生物组织的检查和成像
公开(公告)号：US06058324A
公开(公告)日：2000-05-02
申请号：US170833
申请日：1998-10-13
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B5/00 , G01N21/47
CPC分类号： A61B5/14553 , A61B5/0073 , A61B5/0091 , A61B5/1455 , A61B5/4312 , A61B5/6814 , G01N21/3151 , G01N21/4795 , G01N21/49 , G01N21/6456 , A61B2562/0233 , A61B2562/0242 , A61B2562/043 , A61B2562/146 , A61B5/14551 , G01N2021/1789 , G01N2021/3181 , G01N2021/6421 , G01N2021/6484 , G01N21/47 , G01N2201/0696
摘要： Optical methods and systems for in vivo, non-invasive examination of biological tissue include at least one light source constructed to emit light of a visible or infra-red wavelength for introduction into an examined tissue volume from at least one input port, and at least one detector constructed to detect light of the visible or infra-red wavelength that has migrated in the examined tissue volume from at least one input port to at least one detection port. The optical systems also include an optical array, a radiation controller, and a processor. The optical array includes the input and detection ports located in a selected geometrical pattern providing several average photon migration pathlengths in the examined tissue volume. Each arrangement of least one input port and at least one detection port provides one of the average pathlengths, wherein the average pathlength is characteristic of the tissue between one input port and one detection port. The radiation controller is constructed to sequentially control light emitted from the at least one input port and constructed to control detection of light of the introduced wavelength to define a null plane in the tissue volume for two of the arrangements of the input and detection ports. The processor is operatively connected to the radiation controller and is constructed to examine the biological tissue based on data corresponding to the introduced and detected light for at least two of the average pathlengths and the defined location of the null plane.
摘要翻译：用于生物组织的体内非侵入性检查的光学方法和系统包括构造成发射可见光或红外波长的光的至少一个光源，用于从至少一个输入端口引入检查的组织体积，并且至少一个检测器，其被构造成检测已经在检查的组织体积中从至少一个输入端口迁移到至少一个检测端口的可见或红外波长的光。光学系统还包括光学阵列，辐射控制器和处理器。光学阵列包括位于所选择的几何图案中的输入和检测端口，提供检查的组织体积中的几个平均光子迁移路径长度。至少一个输入端口和至少一个检测端口的每个布置提供平均路径长度之一，其中平均路径长度是一个输入端口和一个检测端口之间的组织的特征。辐射控制器被构造成顺序地控制从至少一个输入端口发射的光，并被构造成控制引入波长的光的检测，以在输入和检测端口的两个布置中的组织体积中定义零平面。处理器可操作地连接到辐射控制器，并被构造成基于对于平均路径长度和零平面的限定位置中的至少两个的引入和检测到的光的数据来检查生物组织。

69. 发明授权

US5954053A Detection of brain hematoma 失效
标题翻译：脑血肿检测
公开(公告)号：US5954053A
公开(公告)日：1999-09-21
申请号：US466392
申请日：1995-06-06
申请人： Britton Chance , Claudia Robertson
发明人： Britton Chance , Claudia Robertson
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/0059 , A61B5/445 , A61B2562/0242 , A61B5/4519 , A61B5/7257
摘要： Systems are shown that utilize differential measurement of radiation that has migrated through migration paths between two source-detector pairs placed on the head in a manner that each path is localized in a portion of one hemisphere of the brain. Various spectrophotometer systems are also shown for in vivo examination of tissue of a human by measuring changes in electromagnetic radiation scattered and absorbed in a migration path in the tissue. Generally, the spectrophotometer systems comprise a light source for introducing the radiation into the tissue, a detector for detecting radiation that has migrated in the tissue, a processor for processing signals of the detected radiation to create processed data, and a system for determining physiological or pathophysiological changes in the tissue of interest such as bleeding or tumor.
摘要翻译：示出了利用差分测量的辐射，该辐射已经以放置在头部上的两个源 - 检测器对之间的迁移路径迁移，每个路径被定位在脑的一个半球的一部分中。还示出了各种分光光度计系统，用于通过测量在组织中迁移路径中散射和吸收的电磁辐射的变化来体内检查人体组织。通常，分光光度计系统包括用于将辐射引入组织的光源，用于检测已经在组织中迁移的辐射的检测器，用于处理检测到的辐射的信号以产生经处理的数据的处理器，以及用于确定生理或感兴趣组织如出血或肿瘤的病理生理变化。

70. 发明授权

US5779631A Spectrophotometer for measuring the metabolic condition of a subject 失效
标题翻译：分光光度计，用于测量受试者的代谢状况
公开(公告)号：US5779631A
公开(公告)日：1998-07-14
申请号：US485346
申请日：1995-06-07
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B5/00 , G01N21/49
CPC分类号： A61B5/14546 , A61B5/14532 , A61B5/1455 , A61B5/14551 , A61B5/14552 , A61B5/14553 , A61B5/1459 , A61B5/6828 , A61B5/6853 , G01N21/49 , A61B2503/06 , A61B2562/0242 , A61B5/6824 , A61B5/7257
摘要： One preferred embodiment utilizes differential measurement of radiation that migrated in two migration paths between two source (100) detector (110) pairs placed on the head in a manner that each path is localized in a portion of one hemisphere. The present invention also provides in various embodiments of spectrophotometer systems for in vivo examination of a tissue of a human by measuring changes in electromagnetic radiation scattered and absorbed in a migration path in the tissue. Generally, the spectrophotometer systems comprise a light source for introducing the radiation into the tissue, a detector for detecting radiation that has migrated in the tissue, processing means for processing signals of the detected radiation to create processed data, and evaluation means for determining physiological or pathophysiological changes in the tissue of interest. The present invention also provides for determining the metabolic condition of an aerobically stressed portion of tissue such as the muscle tissue of an exercising person.
摘要翻译：一个优选实施例利用在每个路径被定位在一个半球的一部分中的两个源（100）检测器（110）对之间的两个迁移路径中迁移的辐射的差分测量。本发明还通过测量在组织中迁移路径中散射和吸收的电磁辐射的变化来提供分光光度计系统的各种实施方式，用于体内检查人体组织。通常，分光光度计系统包括用于将辐射引入组织的光源，用于检测在组织中迁移的辐射的检测器，用于处理检测到的辐射的信号以产生处理数据的处理装置，以及用于确定生理或感兴趣组织的病理生理变化。本发明还提供了确定锻炼者肌肉组织的有氧应激部分的代谢状况。

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