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61. 发明授权

US06379345B1 Methods and devices for reducing the mineral content of vascular calcified lesions 有权
标题翻译：减少血管钙化病变矿物质含量的方法和装置
公开(公告)号：US06379345B1
公开(公告)日：2002-04-30
申请号：US09353127
申请日：1999-07-14
申请人： Brent R. Constantz
发明人： Brent R. Constantz
IPC分类号： A61M3100
CPC分类号： A61B17/22 , A61B2017/22067 , A61B2017/22082 , A61B2017/22084 , A61B2017/22098
摘要： Methods and devices are provided for at least reducing the mineral content of a vascular calcified lesion, i.e. a calcified lesion present on the vascular tissue of a host. In the subject methods, the local environment of the lesion is maintained at a subphysiologic pH for a period of time sufficient for the mineral content of the lesion to be reduced, e.g. by flushing the lesion with a fluid capable of locally increasing the proton concentration in the region of the lesion. Also provided are systems and kits for practicing the subject methods. The subject methods and devices find particular use in the treatment of vascular diseases associated with the presence of calcified lesions on vascular tissue.
摘要翻译：提供了至少减少血管钙化病变的矿物质含量的方法和装置，即存在于宿主血管组织上的钙化损伤。在本方法中，病变的局部环境在亚生物pH下保持足以使损伤的矿物质含量降低的时间，例如，通过用能够局部增加病变区域中的质子浓度的流体冲洗病变。还提供了用于实践主题方法的系统和工具包。本发明的方法和装置特别用于治疗与血管组织上的钙化损伤相关的血管疾病。

62. 发明授权

US6156350A Methods and kits for use in preventing restenosis 有权
标题翻译：用于预防再狭窄的方法和试剂盒
公开(公告)号：US6156350A
公开(公告)日：2000-12-05
申请号：US454235
申请日：1999-12-02
申请人： Brent R. Constantz
发明人： Brent R. Constantz
IPC分类号： A61K33/00 , A61K33/14 , A61K33/20 , A61K33/18
CPC分类号： A61K33/14 , A61K33/00 , A61K33/20
摘要： Methods and kits are provided for at least inhibiting the progression of, if not preventing, restenosis in a host. In the subject methods, a vascular site is contacted, usually flushed, with a solution having a pH that is less than about 4, e.g. a hydrochloric acid. The subject methods find use in applications where the prevention of restenosis is desirable, including angioplasty applications, and may be used in combination with other treatment modalities, e.g. stents, and the like.
摘要翻译：提供了方法和试剂盒，用于至少抑制宿主的进展，如果不防止再狭窄。在本发明的方法中，将血管部位通常用pH低于约4的溶液进行冲洗，通常冲洗。盐酸。本发明的方法可用于预防再狭窄的应用，包括血管成形术应用，并且可以与其它治疗方式组合使用。支架等。

63. 发明授权

US6053970A Storage stable calcium phosphate cements 有权
标题翻译：储存稳定的磷酸钙水泥
公开(公告)号：US6053970A
公开(公告)日：2000-04-25
申请号：US345984
申请日：1999-06-30
申请人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
发明人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
IPC分类号： A61F2/00 , A61L27/12 , C04B12/02 , C04B20/10 , C04B28/34 , C04B40/06
CPC分类号： C04B20/107 , A61L27/12 , C04B12/025 , C04B20/1077 , C04B28/34 , C04B28/344 , C04B40/06 , A61F2310/00293 , C04B2111/00836 , Y10S623/901 , Y10T428/2949 , Y10T428/2991 , Y10T428/2993
摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.
摘要翻译：提供了两种组分的储存稳定的磷灰石水泥组合物，以及它们的生产方法。受试者磷灰石水泥的干组分包括至少部分涂覆有部分中和的酸性磷酸钙的碱性钙源颗粒。通过将碱性钙源颗粒与溶解的酸性磷酸盐在至少部分水性介质中组合来制备主体组合物的干组分，由此碱性钙源颗粒部分地涂覆有部分中和的酸性磷酸钙。在酸性磷酸盐和碱性钙源之间的反应完成之后，通过从反应混合物中除去可用的水来终止反应。在第一模式中，主体水泥可以通过在水性溶剂的存在下将酸性磷酸盐源与碱性钙源颗粒机械混合并在完成之前停止酸和碱之间的反应来制备。或者，磷酸溶液可以与碱性磷酸钙颗粒浆料快速组合，使得部分中和的酸性磷酸钙在碱性磷酸钙颗粒的表面上沉淀。

64. 发明授权

US5782971A Calcium phosphate cements comprising amorophous calcium phosphate 失效
标题翻译：含磷酸钙的磷酸钙粘合剂
公开(公告)号：US5782971A
公开(公告)日：1998-07-21
申请号：US821021
申请日：1997-03-19
申请人： Brent R. Constantz , Bryan M. Barr
发明人： Brent R. Constantz , Bryan M. Barr
IPC分类号： A61F2/00 , A61L24/02 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C04B12/02 , C01B25/32
CPC分类号： C04B28/34 , A61K6/0038 , A61K6/033 , A61K6/0643 , A61K6/0668 , A61K6/0675 , A61L24/02 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , A61F2310/00293 , C04B2111/00836
摘要： Calcium phosphate cements are provided. The subject cements comprise amorphous calcium phosphate, at least one additional calcium source, usually an additional calcium phosphate, and a liquid component, such as a physiologically acceptable lubricant. Upon combination of the cement components, a flowable composition capable of setting in vivo into a solid calcium phosphate mineral product, such as hydroxyapatite, is produced. The subject cement compositions find use in a variety of applications, including the treatment of injured or compromised hard tissue.
摘要翻译：提供磷酸钙水泥。受试者水泥包括无定形磷酸钙，至少一种另外的钙源，通常是另外的磷酸钙，以及液体组分，例如生理上可接受的润滑剂。通过水泥组分的组合，可以制备能够体内固化成固体磷酸钙矿物产物如羟基磷灰石的可流动组合物。主题水泥组合物可用于各种应用，包括治疗受损或受损的硬组织。

65. 发明授权

US5455231A Mineralized collagen 失效
标题翻译：矿化胶原蛋白
公开(公告)号：US5455231A
公开(公告)日：1995-10-03
申请号：US980370
申请日：1992-11-23
申请人： Brent R. Constantz , Subramanian Gunasekaran
发明人： Brent R. Constantz , Subramanian Gunasekaran
IPC分类号： A61F2/00 , A61L27/24 , A61L27/36 , A61L27/42 , A61L27/46 , C07K14/78 , C08L89/06 , A61F2/28 , A61K38/39
CPC分类号： C08L89/06 , A61L27/46 , C07K14/78 , A61F2310/00365 , Y10S128/08 , Y10S514/801
摘要： Mineralized collagen is prepared by forming calcium phosphate mineral under mild agitation in situ in the presence of dispersed collagen fibrils. A stable composition is obtained with desirable physical characteristics mimicking the characteristics of bone.
摘要翻译：在分散的胶原纤维存在下，通过在温和搅拌下原位形成磷酸钙矿物来制备矿化胶原蛋白。获得具有模拟骨特征的理想物理特性的稳定组合物。

66. 发明授权

US5129905A Methods for in situ prepared calcium phosphate minerals 失效
标题翻译：原位制备磷酸钙矿物的方法
公开(公告)号：US5129905A
公开(公告)日：1992-07-14
申请号：US393579
申请日：1989-08-14
申请人： Brent R. Constantz
发明人： Brent R. Constantz
IPC分类号： A61L27/00 , A61F2/00 , A61K6/033 , A61L24/02 , A61L27/12 , A61L27/46 , C01B25/32 , C01B25/455 , C04B35/447
CPC分类号： A61K6/033 , A61K6/0023 , A61K6/0038 , A61L24/02 , A61L27/12 , A61L27/46 , C01B25/32 , C01B25/322 , C01B25/327 , C01B25/455 , A61F2310/00293
摘要： Calcium phosphate minerals are formed by using phosphoric acid source substantially free of uncombined water in conjunction with a calcium source, normally as any combination of carbonate, phosphate and hydroxide, and, as required, any additional base to neutralize the phosphoric acid. Protein may be optionally added. The resulting product is readily formed and then sets to a hard, stable, workable shaped object.
摘要翻译：磷酸钙矿物是通过使用基本上不含未结合水的磷酸源与钙源形成的，钙源通常以碳酸盐，磷酸盐和氢氧化物的任何组合以及根据需要的任何额外的碱来中和磷酸。蛋白质可以任选加入。所得到的产品容易地形成，然后设置成硬的，稳定的可加工的成形物体。

67. 发明授权

US4880610A In situ calcium phosphate minerals--method and composition 失效
标题翻译：原位磷酸钙矿物的方法和组成
公开(公告)号：US4880610A
公开(公告)日：1989-11-14
申请号：US183770
申请日：1988-04-20
申请人： Brent R. Constantz
发明人： Brent R. Constantz
IPC分类号： A61K47/02 , A61F2/00 , A61F2/02 , A61F2/28 , A61K6/033 , A61L24/02 , A61L27/00 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/455
CPC分类号： A61K6/033 , A61K6/0023 , A61K6/0038 , A61K6/0085 , A61K6/0643 , A61K6/0668 , A61K6/0675 , A61L24/02 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/322 , C01B25/327 , C01B25/455 , A61F2002/2817 , A61F2002/30062 , A61F2210/0004 , A61F2310/00293 , Y10S623/901
摘要： Calcium phosphate minerals are formed by using highly concentrated phosphoric acid in conjunction with a calcium source, normaly as carbonate or a combination of carbonate and hydroxide, optimally in conjunction with calcium phosphate crystals and additional base to neutralize the phosphoric acid. Protein may be optionally added. The resulting product is readily formed and then sets to a hard, stable, workable shaped object.

68. 发明授权

US08728026B2 Devices and methods for treating aortic valve stenosis 有权
标题翻译：用于治疗主动脉瓣狭窄的装置和方法
公开(公告)号：US08728026B2
公开(公告)日：2014-05-20
申请号：US11295677
申请日：2005-12-05
申请人： Brent R. Constantz , Peter K. Johansson
发明人： Brent R. Constantz , Peter K. Johansson
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61B17/22 , A61B17/320708 , A61B2017/22082 , A61B2017/22097 , A61M25/1011 , A61M2025/1013 , A61M2025/1015 , A61M2025/1052
摘要： Devices and methods for their use in increasing the aortic valve flow of a stenotic aortic valve are provided. The subject devices include an aortic valve isolation element and an aortic valve flushing element. The aortic valve isolation element is made up of a ventricular side aortic valve occlusion element, coronary ostia occlusion elements and an ascending aorta occlusion element. The aortic valve flushing element is made up of a dissolution fluid introducing element and a fluid removal element. In practicing the subject methods, a stenotic aortic valve is first isolated. Next, the isolated valve is flushed with a dissolution fluid, e.g., an acidic dissolution fluid, for a period of time sufficient for the aortic valve flow of the treated valve to be increased. In certain embodiments, the valve is also contacted with a dissolution fluid attenuating fluid, e.g., a buffer, during the flushing step in order to limit the contact of non-valve tissue with the dissolution fluid. Also provided are systems and kits that include the subject devices and can be employed in practicing the subject methods. The subject devices, methods, systems and kits find use in treating conditions associated with the presence of stenotic aortic valves.
摘要翻译：提供了用于增加狭窄主动脉瓣主动脉瓣流量的装置和方法。主体装置包括主动脉瓣隔离元件和主动脉瓣冲洗元件。主动脉瓣隔离元件由心室侧主动脉瓣闭塞元件，冠状动脉闭塞元件和升主动脉闭塞元件组成。主动脉瓣冲洗元件由溶解流体引入元件和流体去除元件组成。在实践主题方法中，首先分离狭窄的主动脉瓣。接下来，将隔离的阀用溶解流体例如酸性溶解流体冲洗一段足以使被处理的阀的主动脉瓣流动增加的时间。在某些实施方案中，在冲洗步骤期间，阀还与溶解流体衰减流体例如缓冲液接触，以限制非阀组织与溶解流体的接触。还提供了包括主题装置并且可以用于实践主题方法的系统和工具包。主题装置，方法，系统和试剂盒可用于治疗与狭窄主动脉瓣的存在相关的病症。

69. 发明授权

US08496620B2 Fluid delivery systems for delivering fluids to multi-lumen catheters 有权
标题翻译：用于将流体输送到多腔导管的流体输送系统
公开(公告)号：US08496620B2
公开(公告)日：2013-07-30
申请号：US11267944
申请日：2005-11-04
申请人： Brent R. Constantz , Peter K. Johansson
发明人： Brent R. Constantz , Peter K. Johansson
IPC分类号： A61M29/00 , A61M1/00
CPC分类号： A61M5/142 , A61M5/16827 , A61M5/19 , A61M25/0026 , A61M25/104 , A61M2025/1052
摘要： Fluid delivery systems capable of introducing first and second fluids into first and second lumens of a multi-lumen catheter are provided. The first and second fluids are generally a dissolution fluid and a dissolution fluid attenuating fluid. Also provided are fluid delivery devices and kits that include the subject systems. The subject fluid delivery systems find use in a variety of different applications, and are particularly suited for use in the chemical ablation of internal vascular lesions.
摘要翻译：提供能够将第一和第二流体引入多腔导管的第一和第二腔的流体输送系统。第一和第二流体通常是溶解流体和溶解流体衰减流体。还提供了包括主题系统的流体输送装置和试剂盒。本发明的流体输送系统可用于各种不同的应用，并且特别适用于内部血管损伤的化学消融。

70. 发明授权

US08419803B2 Calcium phosphate cements and methods for using the same 有权
标题翻译：磷酸钙水泥及其使用方法
公开(公告)号：US08419803B2
公开(公告)日：2013-04-16
申请号：US11189555
申请日：2005-07-25
申请人： Brent R. Constantz , David Delaney , Duran Yetkinler
发明人： Brent R. Constantz , David Delaney , Duran Yetkinler
IPC分类号： A61K9/14 , A61K33/42 , A61K33/06 , A61F2/28 , C04B12/02 , C04B7/00
CPC分类号： A61L27/12 , Y10S514/951 , Y10S514/955
摘要： Methods and compositions for producing flowable compositions, e.g. pastes, that set into calcium phosphate products are provided. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid to produce the flowable composition. A feature of the subject methods is that the dry reactants include a particulate calcium and/or phosphate reactant having a mean particle size of less than about 8 μm and narrow size distribution. Also provided are the compositions themselves as well as kits for use in practicing the subject methods. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.
摘要翻译：用于生产可流动组合物的方法和组合物，例如提供了设置成磷酸钙产品的糊剂。在本发明方法中，包括钙源和磷酸盐源的干燥反应物与固化流体组合以产生可流动组合物。本发明方法的特征在于干燥的反应物包括平均粒径小于约8μm并且尺寸分布窄的粒状钙和/或磷酸盐反应物。还提供了组合物本身以及用于实践本发明方法的试剂盒。由此产生的主题方法和组合物可用于各种应用，包括修复硬组织缺陷，例如骨缺损。

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