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61. 发明授权

US06947844B2 Modulators of ribosomal function and identification thereof 有权
标题翻译：核糖体功能调节剂及其鉴定
公开(公告)号：US06947844B2
公开(公告)日：2005-09-20
申请号：US09922251
申请日：2001-08-03
申请人： Thomas A. Steitz , Peter B. Moore , Nenad Ban , Poul Nissen , Jeffrey Hansen
发明人： Thomas A. Steitz , Peter B. Moore , Nenad Ban , Poul Nissen , Jeffrey Hansen
IPC分类号： G01N33/50 , A61K31/165 , A61K31/40 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K45/06 , C07K1/14 , C07K14/195 , C07K14/215 , G01N33/15 , G01N33/48 , G06F17/00 , G06F31/00
CPC分类号： A61K31/40 , A61K31/165 , A61K31/506 , A61K31/513 , A61K31/5355 , A61K31/7048 , A61K45/06 , C07K14/215 , C07K2299/00
摘要： The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
摘要翻译：本发明提供了生产核糖体和核糖体亚基的高分辨率晶体以及通过这些方法产生的晶体的方法。本发明还单独或与蛋白质合成抑制剂组合提供核糖体亚基的高分辨率结构。本发明提供了用于鉴定核糖体相关配体的方法和用于设计具有特定核糖体结合特性的配体的方法以及可用作蛋白质合成抑制剂的配体。因此，本发明的方法和组合物可用于产生设计用于特异性杀死或抑制任何靶生物体生长的配体。

62. 发明授权

US06940089B2 Semiconductor device structure 失效
标题翻译：半导体器件结构
公开(公告)号：US06940089B2
公开(公告)日：2005-09-06
申请号：US10116559
申请日：2002-04-04
申请人： Zhiyuan Cheng , Eugene A. Fitzgerald , Dimitri A. Antoniadis
发明人： Zhiyuan Cheng , Eugene A. Fitzgerald , Dimitri A. Antoniadis
IPC分类号： H01L21/20 , H01L21/306 , H01L21/762 , H01L29/06 , H01L29/04 , H01L31/0328 , H01L31/0336 , H01L31/072
CPC分类号： H01L21/76256 , H01L21/02381 , H01L21/0245 , H01L21/0251 , H01L21/02532 , H01L21/02664 , H01L21/30608
摘要： A method of fabricating a semiconductor structure. According to one aspect of the invention, on a first semiconductor substrate, a first compositionally graded Si1-xGex buffer is deposited where the Ge composition x is increasing from about zero to a value less than about 20%. Then a first etch-stop Si1-yGey layer is deposited where the Ge composition y is larger than about 20% so that the layer is an effective etch-stop. A second etch-stop layer of strained Si is then grown. The deposited layer is bonded to a second substrate. After that the first substrate is removed to release said first etch-stop Si1-yGey layer. The remaining structure is then removed in another step to release the second etch-stop layer. According to another aspect of the invention, a semiconductor structure is provided. The structure has a layer in which semiconductor devices are to be formed. The semiconductor structure includes a substrate, an insulating layer, a relaxed SiGe layer where the Ge composition is larger than approximately 15%, and a device layer selected from a group consisting of, but not limited to, strained-Si, relaxed Si1-yGey layer, strained S1-zGez layer, Ge, GaAs, III-V materials, and II-VI materials, where Ge compositions y and z are values between 0 and 1.
摘要翻译：一种制造半导体结构的方法。根据本发明的一个方面，在第一半导体衬底上沉积第一组分梯度的Si 1-x N Ge x N x缓冲层，其中Ge组合物x从约零到小于约20％的值。然后沉积第一蚀刻停止Si 1-y Ge层，其中Ge组分y大于约20％，使得该层是有效的蚀刻停止。然后生长第二蚀刻停止层的应变Si。沉积层结合到第二衬底。之后，去除第一衬底以释放所述第一蚀刻停止Si 1-y Ge层。然后在另一步骤中除去剩余的结构以释放第二蚀刻停止层。根据本发明的另一方面，提供一种半导体结构。该结构具有要形成半导体器件的层。半导体结构包括基底，绝缘层，Ge组分大于约15％的弛豫SiGe层，以及选自但不限于应变Si的弛豫Si

63. 发明授权

US06939848B2 Crystals of the large ribosomal subunit 有权
标题翻译：大核糖体亚基的晶体
公开(公告)号：US06939848B2
公开(公告)日：2005-09-06
申请号：US10391491
申请日：2003-03-17
申请人： Thomas A. Steitz , Peter B. Moore , Nenad Ban , Poul Nissen , Jeffrey Hansen
发明人： Thomas A. Steitz , Peter B. Moore , Nenad Ban , Poul Nissen , Jeffrey Hansen
IPC分类号： C07K14/215 , A61K38/00 , G01N33/48 , G06F17/00 , G06F19/00
CPC分类号： C07K14/215 , C07K2299/00
摘要： The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of the crystals provided by the present invention are of sufficiently high resolution for determining the three-dimensional structure of ribosomes and ribosomal subunits, for identifying ligand binding sites on ribosomes and ribosomal subunits, and for molecular modeling of ligands which interact with ribosomes and ribosomal subunits. The present invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties. Thus, the methods of the present invention may be used to produce ligands which are designed to kill or inhibit any specific target organism(s).
摘要翻译：本发明提供了生产核糖体和核糖体亚基的高分辨率晶体的方法以及通过这些方法制备的晶体。由本发明提供的晶体的x射线衍射图具有足够高的分辨率，用于确定核糖体和核糖体亚基的三维结构，用于鉴定核糖体和核糖体亚基上的配体结合位点，以及用于配体的分子模拟与核糖体和核糖体亚基相互作用。本发明提供鉴定核糖体相关配体的方法和用于设计具有特定核糖体结合特性的配体的方法。因此，本发明的方法可用于产生设计用于杀死或抑制任何特定靶生物的配体。

64. 发明授权

US06896957B1 Magnetizable device 失效
标题翻译：可磁化装置
公开(公告)号：US06896957B1
公开(公告)日：2005-05-24
申请号：US09308166
申请日：1997-11-17
申请人： Eric Leigh Mayes , Malvin Nicolas Tyler
发明人： Eric Leigh Mayes , Malvin Nicolas Tyler
IPC分类号： B82B1/00 , C07K14/47 , G11B5/62 , G11B5/712 , G11B5/855 , H01F1/00 , H01F10/08 , G11B5/64
CPC分类号： B82Y25/00 , C07K14/47 , G11B5/712 , G11B5/714 , G11B5/855 , H01F1/0054 , H01F1/0063 , Y10T428/25 , Y10T428/256 , Y10T428/26 , Y10T428/2991
摘要： Theres is disclosed a magnetic recording medium which includes a magnetizable layer thereon, wherein said magnetizable layer comprises a plurality of ferri- or ferromagnetic particles each having a largest dimension no greater than 100 nm, and each of which particles represents a separate ferromagnetic domain.
摘要翻译：公开了一种在其上包括可磁化层的磁记录介质，其中所述可磁化层包括每个具有不大于100nm的最大尺寸的多个铁磁性或铁磁性颗粒，并且其中每个颗粒代表单独的铁磁畴。

65. 发明授权

US06890563B2 Tissue regenerative composition, method of making, and method of use thereof 有权
公开(公告)号：US06890563B2
公开(公告)日：2005-05-10
申请号：US10281372
申请日：2002-10-25
申请人： Alan R. Spievack
发明人： Alan R. Spievack
IPC分类号： A61L27/36 , A61K35/38
CPC分类号： A61L27/3687 , A61L27/3604 , A61L27/362 , A61L27/3629 , A61L27/3633 , A61L27/3679 , A61L27/3683 , A61L27/3691 , A61L27/54 , A61L2400/06 , A61L2430/20 , A61L2430/22 , A61L2430/40
摘要： A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.

66. 发明授权

US06887495B2 Tissue regenerative composition, method of making, and method of use thereof 有权
公开(公告)号：US06887495B2
公开(公告)日：2005-05-03
申请号：US10280818
申请日：2002-10-25
申请人： Alan R. Spievack
发明人： Alan R. Spievack
IPC分类号： A61L27/36 , A61K35/38
CPC分类号： A61L27/3687 , A61L27/3604 , A61L27/362 , A61L27/3629 , A61L27/3633 , A61L27/3679 , A61L27/3683 , A61L27/3691 , A61L27/54 , A61L2400/06 , A61L2430/20 , A61L2430/22 , A61L2430/40
摘要： A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.

67. 发明授权

US06882875B1 Visible display for an interventional device 失效
标题翻译：介入装置的可见显示
公开(公告)号：US06882875B1
公开(公告)日：2005-04-19
申请号：US09691550
申请日：2000-10-18
申请人： Robert J. Crowley
发明人： Robert J. Crowley
IPC分类号： A61B1/00 , A61B5/00 , A61B10/00 , A61B19/00 , A61B5/05
CPC分类号： A61B5/00
摘要： A display is located on an interventional device insertible into a body. More specifically, the display is located on a distal end of the device and is coupled to a sensing system. The sensing system senses a bodily condition. The display receives the sensed bodily condition and displays a signal indicative of the bodily condition within a pre-existing field of view.
摘要翻译：显示器位于可插入体内的介入装置上。更具体地，显示器位于设备的远端并耦合到感测系统。感测系统感测身体状况。显示器接收感测到的身体状况，并且在预先存在的视野内显示表示身体状况的信号。

68. 发明授权

US06881632B2 Method of fabricating CMOS inverter and integrated circuits utilizing strained surface channel MOSFETS 有权
标题翻译：使用应变表面沟道MOSFET制造CMOS反相器和集成电路的方法
公开(公告)号：US06881632B2
公开(公告)日：2005-04-19
申请号：US10611739
申请日：2003-07-01
申请人： Eugene A. Fitzgerald , Nicole Gerrish
发明人： Eugene A. Fitzgerald , Nicole Gerrish
IPC分类号： H01L21/8238 , H01L27/092 , H01L29/10 , H01L21/336
CPC分类号： H01L27/0922 , H01L21/823807 , H01L27/092 , H01L29/1054
摘要： A method of fabricating a CMOS inverter including providing a heterostructure having a Si substrate, a relaxed Si1-xGex layer on the Si substrate, and a strained surface layer on said relaxed Si1-xGex layer; and integrating a pMOSFET and an nMOSFET in said heterostructure, wherein the channel of said pMOSFET and the channel of the nMOSFET are formed in the strained surface layer. Another embodiment provides a method of fabricating an integrated circuit including providing a heterostructure having a Si substrate, a relaxed Si1-xGex layer on the Si substrate, and a strained layer on the relaxed Si1-xGex layer; and forming a p transistor and an n transistor in the heterostructure, wherein the strained layer comprises the channel of the n transistor and the p transistor, and the n transistor and the p transistor are interconnected in a CMOS circuit.
摘要翻译：一种制造CMOS反相器的方法，包括提供在Si衬底上具有Si衬底，弛豫的Si 1-x Ge 2 x层的异质结构，以及在Si衬底上的应变表面层所述松弛的Si 1-x Ge x层; 以及将pMOSFET和nMOSFET集成在所述异质结构中，其中所述pMOSFET的沟道和nMOSFET的沟道形成在应变表面层中。另一个实施例提供一种制造集成电路的方法，该集成电路包括提供在Si衬底上具有Si衬底，弛豫的Si 1-x N x Ge x Si层的异质结构和应变层在松弛的Si 1-x Ge层上; 以及在所述异质结构中形成p晶体管和n晶体管，其中所述应变层包括所述n晶体管和所述p晶体管的沟道，并且所述n晶体管和所述p晶体管在CMOS电路中互连。

69. 发明授权

US06872297B2 Analytical instruments, biosensors and methods thereof 有权
公开(公告)号：US06872297B2
公开(公告)日：2005-03-29
申请号：US09871885
申请日：2001-05-31
申请人： Sohrab Mansouri , Vasile Cosofret , Clarke Xu
发明人： Sohrab Mansouri , Vasile Cosofret , Clarke Xu
IPC分类号： G01N27/327 , G01N27/38 , G01N27/40
CPC分类号： C12Q1/002 , G01N27/38 , G01N33/492
摘要： An electrochemical sensor system and membrane and method thereof for increased accuracy and effective life of electrochemical and enzyme sensors.

70. 发明授权

US06869619B2 Tissue regenerative composition, method of making, and method of use thereof 有权
标题翻译：组织再生组合物，制备方法及其使用方法
公开(公告)号：US06869619B2
公开(公告)日：2005-03-22
申请号：US10280582
申请日：2002-10-25
申请人： Alan R. Spievack
发明人： Alan R. Spievack
IPC分类号： A61L27/36 , A61K35/38
CPC分类号： A61L27/3687 , A61L27/3604 , A61L27/362 , A61L27/3629 , A61L27/3633 , A61L27/3679 , A61L27/3683 , A61L27/3691 , A61L27/54 , A61L2400/06 , A61L2430/20 , A61L2430/22 , A61L2430/40
摘要： A matrix, including epithelial basement membrane, for inducing repair of cmammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.
摘要翻译：一种包括上皮基底膜的基质，用于诱导来自温血脊椎动物上皮组织的血管生成组织缺陷和体外细胞增殖。

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