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61. 发明授权

US08828924B2 Methods of treating a diabetic embryopathy 有权
标题翻译：治疗糖尿病性胚胎病的方法
公开(公告)号：US08828924B2
公开(公告)日：2014-09-09
申请号：US12779935
申请日：2010-05-13
申请人： E. Albert Reece , Zhiyong Zhao , Peixin Yang
发明人： E. Albert Reece , Zhiyong Zhao , Peixin Yang
IPC分类号： A61K38/00 , A61K31/5377 , A61K31/415 , A61K31/4545 , A61K38/18 , A61K38/44 , A61K31/506 , A61K31/40 , A61K31/445 , A61K39/00
CPC分类号： A61K31/40 , A61K31/415 , A61K31/445 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K38/1808 , A61K38/1825 , A61K38/44 , A61K2039/505 , C12Y103/01024
摘要： Maternal diabetes can lead to a developmental malformation of an embryo. A developmental malformation caused by maternal diabetes is commonly referred to as a diabetic embryopathy. There is currently no effective treatment for reducing or inhibiting a diabetic embryopathy. To this end, the present invention is drawn to novel methods of treating a diabetic embryopathy.
摘要翻译：产妇糖尿病可导致胚胎发育畸形。由母亲糖尿病引起的发育畸形通常称为糖尿病性胚胎病。目前没有有效的治疗减少或抑制糖尿病性胚胎病。为此，本发明涉及治疗糖尿病性胚胎病的新方法。

62. 发明授权

US08770121B2 Seed distribution element for precision seed drills, seed drill including said element 有权
标题翻译：用于精密种子钻的种子分配元件，包括所述元件的种子钻
公开(公告)号：US08770121B2
公开(公告)日：2014-07-08
申请号：US13521896
申请日：2011-11-10
申请人： Enrico Bragatto
发明人： Enrico Bragatto
IPC分类号： A01C7/04
CPC分类号： A01C7/046
摘要： A seed distribution element (1) includes: —a sowing disc (16) rotated by a motor-driven transmission shaft (20) —a housing (10) with a fixed portion (11) in which the shaft (20) is supported and a portion (12) movable relative to the fixed portion and can be closed against it, with a seed collection chamber (15) in the fixed portion (11) and a pneumatic suction chamber (17) in the movable portion (12), —the sowing disc (16) being interposed between the portions (11, 12) and having opposed surfaces (16a, 16b) delimiting the chambers, and provided with a ring of selector holes (23) extending between the opposed surfaces structure for producing a pressure differential between the opposed surfaces in the region of a circumferential segment of the ring of holes, including the pneumatic suction chamber, and —a seal (24) on the movable portion (12) capable of sliding contact with the facing surface (16a) of the disc (16) when the portions are closed against one another,—a thrust-bearing element (26) of the sowing disc (16), supported rotatably in the movable portion (12), to withstand the axial load produced by the disc (16) on the seal (24).
摘要翻译：种子分配元件（1）包括： - 由马达驱动的传动轴（20）旋转的播种盘（16） - 具有支撑轴（20）的固定部分（11）的壳体（10），以及相对于固定部分可移动的部分（12）可以与固定部分（11）中的种子收集室（15）和可移动部分（12）中的气动抽吸室（17）相抵接，所述播种盘（16）插入在所述部分（11,12）之间并且具有限定所述室的相对表面（16a，16b），并且设置有在所述相对表面结构之间延伸的用于产生压力的选择器孔（23）在包括气动吸入室的孔环的周向区域的区域中的相对表面之间的差异以及能够与相对表面（16a）滑动接触的可移动部分（12）上的密封件（24）当这些部分彼此关闭时，盘（16） - 推力球播种盘（16）的环形元件（26）可旋转地支撑在可动部分（12）中，以承受由密封件（24）上的盘（16）产生的轴向载荷。

63. 发明授权

US08696895B2 Percolation filtering system 失效
标题翻译：渗滤过滤系统
公开(公告)号：US08696895B2
公开(公告)日：2014-04-15
申请号：US12671059
申请日：2007-07-31
申请人： Olga Alexandrou
发明人： Olga Alexandrou
IPC分类号： B01D35/143 , C02F1/00
CPC分类号： C02F1/003 , A47J31/605 , C02F1/008 , C02F2201/006 , C02F2307/04
摘要： A percolation filtering system comprises a flow path of the water to be filtered including a filter cartridge seat (4) for removably receiving a filter cartridge (5) so that said flow path extends through said filter cartridge when said filter cartridge is inserted into said seat, characterized in that it comprises recognition means and counter-means of the suitability of said cartridge, respectively on said cartridge and said seat, suitable for reciprocal interaction when the cartridge is inserted in the seat to enable operation of the filtering system following the cartridge's suitability recognition, or to disable it or signal the suitability/unsuitability respectively of the cartridge if the cartridge is recognized/ not recognized respectively by the recognition means.
摘要翻译：渗滤过滤系统包括待过滤的水的流路，包括用于可移除地接收过滤器滤芯（5）的过滤器滤芯座（4），使得当所述滤筒插入所述座中时所述流路延伸穿过所述滤筒其特征在于，其包括分别在所述盒和所述座上的所述盒的适合性的识别装置和相应装置，适用于当盒被插入座中时的往复相互作用，以使过滤系统能够按照盒的适用性进行操作识别，或者如果分别由识别装置识别/不识别盒式磁带，则分别禁止它或分别指示盒的适合性/不合适性。

64. 发明授权

US08568041B2 Support for video-photographic apparatus 有权
标题翻译：支持视频摄影器材
公开(公告)号：US08568041B2
公开(公告)日：2013-10-29
申请号：US13107156
申请日：2011-05-13
申请人： Enrico Cherubin
发明人： Enrico Cherubin
IPC分类号： G03B17/00 , H04N5/225
CPC分类号： F16M13/00 , F16M11/045 , F16M11/048 , F16M11/242 , F16M11/38 , F16M2200/044 , G03B17/561
摘要： A support (1; 100) for videophotographic equipment (2; 200), comprises a plate (3; 3′) fixable by suitable fixing means (5; 5′) to an item of video-photographic equipment (2; 200) to be supported, support elements (7; 7′) hinged on said plate (3; 3′) by means of respective hinge means (8; 8′) so as to be moved between a closed position (Y) in which said support elements (7; 7′) are folded onto said plate (3; 3′) and at least one open position (Z) in which said support elements (7; 7′) are opened out from said plate (3; 3′) to support the latter, said hinge means (8; 8′) comprise a resilient element (20; 20′) that is housed in a receiving seat (22; 22′) defined in said plate (3; 3′) and exerts on hinge portions (14, 15; 14′, 15′) of said support elements (7; 7′) a thrust force which thrusts said hinge portions (14, 15; 14′, 15′) against walls (23; 23′) of said seat (22; 22′) to brake the rotation of said support elements (7; 7′) in relation to said plate (3; 3′), the resilient element comprises at least one spring (20; 20′) interposed between said hinge portions (14, 15; 14′, 15′).
摘要翻译：用于视频摄影设备（2; 200）的支撑件（1; 100）包括可通过适当的固定装置（5; 5'）固定到视频摄影设备（2; 200）的物品的板（3; 3'），通过相应的铰链装置（8; 8'）支撑铰接在所述板（3; 3'）上的支撑元件（7; 7'），以便在关闭位置（Y）之间移动，在所述关闭位置（7; 7'）折叠到所述板（3; 3'）和至少一个打开位置（Z）上，其中所述支撑元件（7; 7'）从所述板（3; 3'）打开到所述铰链装置（8; 8'）包括弹性元件（20; 20'），所述弹性元件容纳在限定在所述板（3; 3'）中的接收座（22; 22'）中并施加在铰链所述支撑元件（7; 7'）的部分（14,15; 14'，15'）具有将所述铰链部分（14,15; 14'，15'）推压到所述铰链部分所述座椅（22; 22'）相对于所述板（3; 3'）制动所述支撑元件（7; 7'）的旋转，所述弹性元件c 至少有一个春天（20; 20'）插入在所述铰链部分（14,15; 14'，15'）之间。

65. 发明授权

US08367340B2 Prognostic tools to predict the efficacy of drug treatment targeting chromatin DNA or enzymes acting on DNA 有权
标题翻译：预测用于靶向染色质DNA或作用于DNA的酶的药物治疗功效的预后工具
公开(公告)号：US08367340B2
公开(公告)日：2013-02-05
申请号：US12630022
申请日：2009-12-03
申请人： France Carrier , Narasimharoa Nalabothula
发明人： France Carrier , Narasimharoa Nalabothula
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/686 , C12Q2545/114 , C12Q2545/101
摘要： Disclosed are methods of predicting cell response to drug-based therapy using both PCR-Stop assays and real time PCR assays. Methods herein may be used for assessment of drug effect, evaluation of regimen suitability for a given patient, and/or for determination of an optimal drug dose. Also provided are isolated oligonucleotide primers such as primers capable of annealing under PCR conditions to a segment of a c-myc locus, where the primers may be used in the disclosed methods. Further disclosed are kits and systems that may be used for predicting a cell response to drug-based therapy.
摘要翻译：公开了使用PCR-Stop测定和实时PCR测定法预测基于药物治疗的细胞应答的方法。本文中的方法可用于药物作用的评估，给定患者的方案适用性评估和/或用于确定最佳药物剂量的方法。还提供了分离的寡核苷酸引物，例如能够在PCR条件下退火到c-myc基因座的区段的引物，其中可以在所公开的方法中使用引物。还公开了可用于预测对药物治疗的细胞应答的试剂盒和系统。

66. 发明授权

US08342468B1 Drink container holding device 有权
标题翻译：饮用容器保持装置
公开(公告)号：US08342468B1
公开(公告)日：2013-01-01
申请号：US11533566
申请日：2006-09-20
申请人： Mark B. Strickland
发明人： Mark B. Strickland
IPC分类号： A47K1/08
CPC分类号： A47G23/0225
摘要： A drink container holding device for permitting articles and a beverage to be stored on a music stand includes a frame. At least one mounting assembly is coupled to the frame. The mounting assembly engages the stand to mount the frame to a stand. A sleeve is coupled to the frame. The sleeve has a beverage aperture extending therein through an upper end of the sleeve. The beverage aperture receives a drink container to allow the sleeve to support the drink container adjacent to the stand when the frame is mounted on the stand.
摘要翻译：用于容纳物品和饮料储存在音乐架上的饮料容器保持装置包括框架。至少一个安装组件联接到框架。安装组件与支架接合以将框架安装到支架上。套筒联接到框架。套筒具有通过套筒的上端在其中延伸的饮料孔。当框架安装在支架上时，饮料孔容纳饮料容器以允许套筒支撑靠近支架的饮料容器。

67. 发明授权

US08063011B2 Prediction and prophylactic treatment of type 1 diabetes 有权
标题翻译： 1型糖尿病的预测与预防治疗
公开(公告)号：US08063011B2
公开(公告)日：2011-11-22
申请号：US12375411
申请日：2007-07-30
申请人： Gian Franco Bottazzo , Mattia Locatelli
发明人： Gian Franco Bottazzo , Mattia Locatelli
IPC分类号： A61K38/00
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/156 , C12Q2600/172 , G01N33/564 , G01N33/56977 , G01N33/6806 , G01N2800/042 , Y10S514/866
摘要： An in vitro method for predicting the onset of type 1 diabetes (T1 D) in a subject, comprises the steps of: (a) measuring the concentration of at least one amino acid, amino acid derivative or amino acid metabolite in a biological sample taken from the subject; (b) determining the subject's HLA genotype; (c) assigning the subject's genetic risk of developing T1 D on the basis of the subject's HLA genotype; (d) combining the information obtained in step (a) with the information in step (c); and (e) predicting the likelihood of onset of T1 D based upon the combination of step (d). The diagnostic method can be used to select target subjects for T1 D prophylactic treatment, and as part of a T1 D preventative treatment regime for neonates having a likelihood of developing childhood T1 D.
摘要翻译：用于预测受试者中1型糖尿病（T1D）的发作的体外方法包括以下步骤：（a）测量所采集的生物样品中至少一种氨基酸，氨基酸衍生物或氨基酸代谢物的浓度从主题; （b）确定受试者的HLA基因型; （c）根据受试者的HLA基因型指定受试者发展T1D的遗传风险; （d）将步骤（a）中获得的信息与步骤（c）中的信息相结合; 和（e）基于步骤（d）的组合来预测T1D发生的可能性。该诊断方法可用于选择T1D预防性治疗的目标受试者，并且作为可能发展为儿童期T1的新生儿的T1D预防性治疗方案的一部分。

68. 发明授权

US08021060B2 Adjustable support head for optical or video/photographic equipment 有权
标题翻译：用于光学或视频/照相设备的可调支撑头
公开(公告)号：US08021060B2
公开(公告)日：2011-09-20
申请号：US12664057
申请日：2008-05-09
申请人： Hem Sudhana , Andrea Zen
发明人： Hem Sudhana , Andrea Zen
IPC分类号： F16M11/14
CPC分类号： F16M11/14 , F16C11/106 , F16M2200/022
摘要： An adjustable support head (1) for optical or video/photographic equipment, comprising a joint (5) including a first (3) and a second joint element (18), a body (3) defining the said first joint element, a connection plate (4) for the optical or video/photographic equipment, connected to the said second joint element, so as to enable the said connection plate to be freely adjustable in relation to the said body, locking means (25) mounted on the said body and including a clamping element (26) that can be selectively moved between a first non-operating position in which the clamping element is distanced from the second joint element and a second operating position in which the clamping element is in contact with the second joint element so as to lock the said second joint element in a desired position in relation to the first joint element. The head (1) also comprising adjustable friction means (35) mounted on the body and including at least one slide (36) placed in contact with the second joint element so as to adjust the sliding of the second joint element in relation to the first joint element. The friction means comprise resilient means (37) interposed between the clamping element and the slide to adjust the friction means by moving the clamping element between the first non-operating position and the second operating position.
摘要翻译：一种用于光学或视频/照相设备的可调节支撑头（1），包括包括第一和第二接头元件（18）的接头（5），限定所述第一接头元件的本体（3）连接到所述第二关节元件的用于光学或视频/照相设备的板（4），以使得所述连接板能够相对于所述主体自由调节，安装在所述主体上的锁定装置（25）并且包括夹紧元件（26），所述夹紧元件可选择性地在所述夹紧元件与所述第二接合元件间隔开的第一非操作位置和所述夹紧元件与所述第二接合元件接触的第二操作位置之间移动以便将所述第二关节元件相对于第一关节元件锁定在期望的位置。头部（1）还包括安装在主体上的可调节摩擦装置（35），并且包括与第二关节元件接触放置的至少一个滑动件（36），以便调节第二关节元件相对于第一关节元件关节元素。摩擦装置包括插入夹紧元件和滑块之间的弹性装置（37），以通过在第一非操作位置和第二操作位置之间移动夹紧元件来调节摩擦装置。

69. 外观设计

USD629828S1 Support head for video and/or photographic apparatuses 有权
标题翻译：用于视频和/或照相设备的支持头
公开(公告)号：USD629828S1
公开(公告)日：2010-12-28
申请号：US29358680
申请日：2010-03-30
申请人： Alberto Guidolin
设计人： Alberto Guidolin

70. 发明授权

US07637900B2 Methods of administering a material into a patient for dermal enhancement 有权
标题翻译：向患者施用材料用于皮肤增强的方法
公开(公告)号：US07637900B2
公开(公告)日：2009-12-29
申请号：US10793908
申请日：2004-03-08
申请人： Cheryl Burgess
发明人： Cheryl Burgess
IPC分类号： A61M31/00
CPC分类号： A61L27/52 , A61K38/05 , A61K38/07 , A61K38/08 , A61L27/18 , A61K2300/00 , C08L67/04
摘要： The present invention is directed to methods of administering a material to a patient for dermal enhancement and/or as soft tissue fillers. The invention also relates to double-gloved methods of molding such a material after administration to a patient to achieve a desired orientation of the material in the patient. The invention also relates to the use of certain materials, including polylactic acid, hyaluronic acid, hydrogel, and/or collagen or other suitable materials for the preparation of a pharmaceutical composition for dermal enhancement and/or as soft tissue filler. The invention further relates to kits or packages that include a material for dermal enhancement and/or soft tissue filler and instructions as to how dermal enhancement or the filling of soft tissue is achieved.
摘要翻译：本发明涉及向患者施用材料用于皮肤增强和/或作为软组织填充剂的方法。本发明还涉及在施用于患者之后模制这种材料以实现患者期望的材料取向的双手套的方法。本发明还涉及某些材料，包括聚乳酸，透明质酸，水凝胶和/或胶原或其它合适的材料用于制备用于皮肤增强的药物组合物和/或软组织填充剂。本发明进一步涉及包括用于皮肤增强和/或软组织填充物的材料的试剂盒或包装，以及如何实现软组织的皮肤增强或填充。

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