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61. 发明授权

US08241621B2 Stem cell mediated treg activation/expansion for therapeutic immune modulation 有权
标题翻译：干细胞介导的treg活化/扩增用于治疗性免疫调节
公开(公告)号：US08241621B2
公开(公告)日：2012-08-14
申请号：US11959440
申请日：2007-12-18
申请人： Thomas E. Ichim
发明人： Thomas E. Ichim
IPC分类号： C12N5/071 , C12N5/077 , C12N5/0783
CPC分类号： C12N5/0667 , A61K2035/122 , C12N2501/22 , C12N2501/26
摘要： Disclosed are cells, methods of modulating cells, and therapeutic uses of the cells for the immune modulation of mammals in need thereof. Immune modulation including alteration of cytokine profile, cytotoxic activity, antibody production and inflammatory states is achieved through the administration of various cell types that have been unmanipulated or manipulated in order to endow specific biological activity. Cellular subsets and administration of the subsets in combination with various agents are also provided. One embodiment teaches the previously unknown finding that adipose tissue derived mononuclear cells contain T cells with immune regulatory properties that alone or synergistically with various stem cells induce immune modulation upon administration. Another embodiment is the finding that stimulation of stem cell activation results in stem cell secondary activation of immune modulatory cells, one type which is T regulatory cells (Tregs). One specific embodiment involves extraction of a heterogenous stem cell pool, which contains T regulatory cells, treatment in culture of the population with agents known to stimulate stem cell activation, then subsequent extraction and administration of the purified Tregs. Other embodiments include expansion of Tregs in the presence of antigen in order to generate anti-specific Tregs.
摘要翻译：公开了细胞，调节细胞的方法和细胞的治疗用途，用于有需要的哺乳动物的免疫调节。包括细胞因子分布的改变，细胞毒性活性，抗体产生和炎症状态的免疫调节是通过给予不被操纵或操纵以赋予特定生物学活性的各种细胞类型来实现的。还提供细胞子集和子集合与各种试剂的组合。一个实施方案教导了以前未知的发现，脂肪组织衍生的单核细胞含有具有免疫调节特性的T细胞，其与各种干细胞单独或协同地在给药时诱导免疫调节。另一个实施方案是发现干细胞活化的刺激导致免疫调节细胞的干细胞二次激活，一种是T调节细胞（Treg）。一个具体实施方案涉及提取含有T调节细胞的异源干细胞池，用已知刺激干细胞活化的试剂，然后随后提取和施用纯化的Treg进行群体培养的处理。其他实施方案包括在抗原存在下扩增Treg以产生抗特异性Treg。

62. 发明授权

US08109769B1 Micromachined flex interposers 有权
标题翻译：微加工柔性插入件
公开(公告)号：US08109769B1
公开(公告)日：2012-02-07
申请号：US12972300
申请日：2010-12-17
申请人： Salleh Ismail , Patrick Kayatta
发明人： Salleh Ismail , Patrick Kayatta
IPC分类号： H01R12/00
CPC分类号： H01R13/2435 , H01R12/73 , H01R13/03 , H05K3/325 , H05K3/4046 , H05K2201/10378 , H05K2201/2036
摘要： Micromachined flex interposers and methods of making the same are provided herein. More specifically the teachings herein are directed to interposer pins and strips having a rigid substrate supporting upper and lower cantilevered ends having a polyimide layer and a metal layer configured to flex towards the substrate layer during connection with upper and lower contact pads. Additional layers of polyimide and metal can be added to affect the flexibility and robustness of the pins and strips herein.
摘要翻译：微加工柔性插入件及其制造方法在此提供。更具体地，本文的教导涉及具有刚性基板的插入销和条带，所述刚性基板支撑具有聚酰亚胺层的上部和下部悬臂端，以及配置成在与上部和下部接触焊盘连接期间朝向基板层弯曲的金属层。可以加入附加的聚酰亚胺和金属层以影响这里的销和条的柔性和坚固性。

63. 发明授权

US07735615B2 Soft luggage having an internal barrier 失效
标题翻译：内部有障碍的软箱子
公开(公告)号：US07735615B2
公开(公告)日：2010-06-15
申请号：US11679165
申请日：2007-02-26
申请人： Mark Looram , Sean Looram
发明人： Mark Looram , Sean Looram
IPC分类号： A45C13/10 , A45C13/18 , A45C3/00
CPC分类号： A45C13/10 , A45C13/103 , A45C13/126 , Y10S190/903
摘要： Soft-sided luggage having means for preventing unauthorized access through the zipper is disclosed herein. Preferred means for preventing unauthorized access through the zipper include a rigid barrier attached internally to a first side of the luggage, positioned alongside and extending to the length of the zipper track, and extending past the plane of the zipper towards the second side of the luggage. Further security features can also be used with soft luggage provided herein, including padlocks, and flaps crossing the zipper plane, for example.
摘要翻译：本文公开了具有用于防止通过拉链的未经授权的访问的装置的软侧行李箱。用于防止通过拉链的未经授权的访问的优选方式包括在行李箱的第一面内部附着的刚性屏障，位于拉链轨道的长度方向并且延伸到拉链轨道的长度，并延伸穿过拉链的平面朝向行李的第二侧。另外的安全特征也可以用于这里提供的软包装，例如包括挂锁和穿过拉链平面的襟翼。

64. 发明授权

US11772014B2 Biological material collection and separation system and methods of use 有权
公开(公告)号：US11772014B2
公开(公告)日：2023-10-03
申请号：US17974370
申请日：2022-10-26
申请人： Hans-Werner Heinrich
发明人： Hans-Werner Heinrich
IPC分类号： B01D21/26 , B01L3/00 , B01L3/02
CPC分类号： B01D21/262 , B01L3/0293 , B01L3/5021 , B01L2300/042
摘要： A system for collecting and separating biological material includes a centrifuge tube, a separation tube having an open bottom, a cap, a plug for temporarily sealing the open bottom of the separation tube, and a separation medium disposable within the centrifuge tube. The centrifuge tube and the separation tube sealingly and releasably couple to the cap, such that, when coupled, the separation tube is positioned within the centrifuge tube. The cap is configured to facilitate and/or regulate the introduction of air, gas, or other matter into the separation tube. When fully sealed, the separation tube may be placed under a vacuum condition, whereby a needle apparatus is used to facilitate introduction of matter into the separation tube. When the separation tube is positioned within the centrifuge tube, the bottom portion of the separation tube is submersed in the separation medium.

65. 发明授权

US11649021B2 Marine surveillance and debris scow 有权
公开(公告)号：US11649021B2
公开(公告)日：2023-05-16
申请号：US17069661
申请日：2020-10-13
申请人： Shift Environmental Technologies Ltd.
发明人： James Spencer
IPC分类号： B63B79/10 , B63B3/48 , G05D1/00 , B63H11/00 , B63B35/32
CPC分类号： B63B79/10 , B63B3/48 , B63B35/32 , B63H11/00 , G05D1/0038
摘要： A marine monitoring and debris collection scow is provided, the scow comprising: a hull which includes an open stern, a bow opposite the open stern, a deck extending between the open stern and the bow and forming a bottom on an underside, the bottom extending between the open stern and the bow; a frame, the frame which is attached to the deck, the frame including a front, a back which is opposite the front and sides extending between the front and the back; at least one flotation chamber which extends around the sides and the front of the frame and forms a gunwale; a housing mounted on the deck; and a microcontroller unit housed in the housing, the microcontroller unit configured to receive a data set from at least one sensor, to store the data set, to process the data set into a processed data set and to send the processed data set to a radio.

66. 发明授权

US11617699B1 Posture enhancing device 有权
公开(公告)号：US11617699B1
公开(公告)日：2023-04-04
申请号：US16405039
申请日：2019-05-07
申请人： Parviz Jahangiri
发明人： Parviz Jahangiri
IPC分类号： A61H1/02
摘要： A device that allows the user to provide spinal traction and splay in a localized and fully controllable way that has the device auto-return to a neutral position in case the user inadvertently loses control of operating the device, that has the ability to induce corrective spinal curvature from the lordotic neck curvature to the sacral curvature, that has the ability to conform or adjust to the varying curvature of differing body builds, that has the ability to provide corrective curvatures to all sides of a human body (front, side, back, and any hybridized orientation), that is adjustable for ergonomics to stretch or to compress any sections of the spinal curvature in a localized manner, that allows the benefits of splaying forces to correct spinal curvature, and that allows axial adjustment to the spinuous process.

67. 发明授权

US11504410B2 Neuroprotection and neuroregeneration by pterostilbene and compositions thereof 有权
公开(公告)号：US11504410B2
公开(公告)日：2022-11-22
申请号：US17387158
申请日：2021-07-28
申请人： THERAPEUTIC SOLUTIONS INTERNATIONAL, INC.
发明人： Thomas E. Ichim , Timothy G. Dixon , James Veltmeyer
IPC分类号： A61K36/82 , A61K31/09 , A61K36/45 , A61K31/26 , A61K36/31 , A61K31/353 , A61K31/122 , A61K36/71
摘要： Disclosed are means, compositions of matter, and protocols useful for neuroprotection and neuroregeneration. In one embodiment the invention provides administration of pterostilbene alone or in combination with other ingredients to induce neuroprotection and/or neuroregeneration. The invention teaches protection/regeneration in conditions associated with neurological inflammation and/or other congenital or acquired neurodegenerative diseases.

68. 发明授权

US11448400B2 Firebox assembly for a gas fireplace and gas heating appliance 有权
公开(公告)号：US11448400B2
公开(公告)日：2022-09-20
申请号：US17613921
申请日：2020-05-22
申请人： FLEXCHANGER TECHNOLOGIES INC.
发明人： Walter Wardrop , Nicholas Barber
IPC分类号： F24C15/32 , F24C15/00 , F24C3/00 , F24H3/02
摘要： A firebox is provided for use in a gas fireplace, the firebox comprising: a back which includes at least one combustion fan aperture, an upper end and a lower end and a length therebetween, a pair of sides, each side including an upper end, a lower end, a first riser which has an inner section and an outer section, the inner section attached to the back, a first flange, which is parallel to the back and extends outward from the back, and a second riser, wherein the outer section of the first riser, the first flange and the second riser extend above the upper end of the back and below the lower end of the back; a top which is attached to the inner section of the first risers and to the back at the upper end; and a base which is attached to the inner section of the first risers and to the back above the combustion fan aperture, to define an opening. The fireplace is also provided.

69. 外观设计

USD952002S1 Plow shank assembly 有权
公开(公告)号：USD952002S1
公开(公告)日：2022-05-17
申请号：US29813072
申请日：2021-10-26
申请人： Seamless AG Works LLC
设计人： Stanley L. Adams

70. 发明授权

US11325824B2 Drainable fuel nozzle receptacle 有权
公开(公告)号：US11325824B2
公开(公告)日：2022-05-10
申请号：US17214867
申请日：2021-03-28
申请人： Justin Green
发明人： Justin Green
IPC分类号： B67D7/32 , B67D7/04 , B67D7/56 , B67D7/42
摘要： A fuel nozzle receptacle for use with auxiliary fuel tanks is disclosed. A fuel nozzle is received in a receptacle or boot in a nozzle-down orientation that defines a secure storage for the nozzle. The receptacle includes a drain port on the lower end of the receptacle and a drain tube is attached to the drain port. A valve is plumbed into the receptacle. When residual fuel has accumulated in the receptacle, the end of the drain tube is fed into an appropriate holding vessel and the valve is opened to allow the residual fuel to drain from the receptacle into the holding vessel.

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