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    • 68. 发明授权
    • Polypeptides for treating and/or limiting influenza infection
    • 用于治疗和/或限制流感感染的多肽
    • US09388217B2
    • 2016-07-12
    • US14384901
    • 2013-03-12
    • University of Washington through its Center for Commercialization
    • David BakerTimothy A. WhiteheadSarel Fleishman
    • A61K38/00A61K38/16A61K38/10C07K14/00C07K7/08G01N33/53G01N33/569
    • C07K14/00A61K38/00C07K7/08G01N33/56983G01N2333/11
    • Polypeptides that recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection are disclosed. Isolated nucleic acids encoding the polypeptides of the invention, recombinant expression vectors comprising the nucleic acids encoding the polypeptides of the invention operatively linked to a suitable control sequence, and recombinant host cells comprising the recombinant expression vectors of the invention are disclosed. Antibodies that selectively bind to the polypeptides of the invention, and pharmaceutical compositions comprising one or more polypeptides according to the invention and a pharmaceutically acceptable carrier are disclosed. Additionally, methods for treating and/or limiting an influenza infection, methods for diagnosing an influenza infection, or monitoring progression of an influenza infection, methods for identifying candidate influenza vaccines, and methods for identifying candidate compounds for treating, limiting, and/or diagnosing influenza infection are disclosed.
    • 公开了识别并且是甲型流感血凝素的强粘合剂并且可用于例如治疗和/或限制流感感染发展的多肽。 公开了编码本发明多肽的分离的核酸,包含编码可操作地连接到合适的对照序列的本发明的多肽的核酸的重组表达载体和包含本发明的重组表达载体的重组宿主细胞。 公开了选择性结合本发明的多肽的抗体以及包含一种或多种本发明的多肽和药学上可接受的载体的药物组合物。 另外,用于治疗和/或限制流感感染的方法,用于诊断流感感染的方法或监测流感感染的进展,用于鉴定候选流感疫苗的方法以及用于鉴定用于治疗,限制和/或诊断的候选化合物的方法 流行性感冒被披露。