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61. 发明申请

US20100064385A1 CROP GRAIN FILLING GENE GIF1 AND THE APPLICATIONS THEREOF 有权
标题翻译：作物颗粒填充基因GIF1及其应用
公开(公告)号：US20100064385A1
公开(公告)日：2010-03-11
申请号：US12312235
申请日：2007-10-30
申请人： Zuhua He , Ertao Wang , Qun Li
发明人： Zuhua He , Ertao Wang , Qun Li
IPC分类号： A01H5/00 , C12N15/82 , C07K14/415 , C12N15/29 , C12N5/10
CPC分类号： C07K14/415 , C12N15/8245 , C12N15/8246 , C12N15/8261 , Y02A40/146
摘要： A novel crop grain filling gene (GIF1) and the applications thereof are presented in the invention. The GIF1 gene can be applied to control grain filling, enhance crop yield or quality, or improve disease resistance or storage stability of crop grains. A method for improving crops is also presented in the invention. The GIF1 gene shows valuable potentials in controlling crop yield, quality, storage, and resistance to diseases.
摘要翻译：本发明提出了一种新型作物种子灌浆基因（GIF1）及其应用。 GIF1基因可用于控制谷物灌浆，提高作物产量或品质，提高作物品种的抗病性或贮藏稳定性。本发明还提供了改良作物的方法。 GIF1基因在控制作物产量，质量，储存和抗病性方面具有宝贵的潜力。

62. 发明申请

US20090298756A1 FUNCTIONS AND USES OF GPR39 GENE IN MAMMALIAN CENTRAL NERVOUS SYSTEM 审中-公开
标题翻译： GPR39基因在MAMMALIAN中央神经系统中的功能和用途
公开(公告)号：US20090298756A1
公开(公告)日：2009-12-03
申请号：US11912247
申请日：2006-04-24
申请人： Meilei Jin , Yun Peng , Hong Zou , Guoping Zhao , Xuedong Zhou , Anne O. Chua , Robert A. Goodnow , Ulrich A. Gubler , Holly Hilton , David Fu-Chi Mark , Mitchell Lee Martin , James Andrew Rosinski
发明人： Meilei Jin , Yun Peng , Hong Zou , Guoping Zhao , Xuedong Zhou , Anne O. Chua , Robert A. Goodnow , Ulrich A. Gubler , Holly Hilton , David Fu-Chi Mark , Mitchell Lee Martin , James Andrew Rosinski
IPC分类号： A61K38/17 , C07K14/71 , C12Q1/68
CPC分类号： A61K38/1796 , G01N33/5023 , G01N2333/726 , G01N2500/00
摘要： The present invention provides mammalian GPR39 gene, its coded products, and the uses in regulating appetite and pain sensitivity. A pharmaceutical composition and a health product comprising GPR39 protein are also provided. The health product and the pharmaceutical composition for suppressing appetite or decreasing pain sensitivity comprise a safe and efficient amount of antagonists of mammalian GPR39 protein (for example, 0.01-99%) and a bromatologically or pharmaceutically acceptable carrier in a suitable amount (for example 1-99.99 wt %).
摘要翻译：本发明提供哺乳动物GPR39基因及其编码产物，以及调节食欲和疼痛敏感性的用途。还提供了包含GPR39蛋白质的药物组合物和健康产品。用于抑制食欲或降低疼痛敏感性的健康产品和药物组合物包含安全有效量的哺乳动物GPR39蛋白（例如，0.01-99％）的拮抗剂和适当量的溴酸盐或药学上可接受的载体（例如1 -99.99重量％）。

63. 发明申请

US20030234979A1 X-Y stage for two-photon microscope 审中-公开
标题翻译： X-Y舞台为双光子显微镜
公开(公告)号：US20030234979A1
公开(公告)日：2003-12-25
申请号：US10463429
申请日：2003-06-18
申请人： Shanghai Institutes for Biological Sciences
发明人： Muming Poo , Zhuan Zhou , Shumin Duan , Xinqiao He , Qian Hu
IPC分类号： G02B021/00
CPC分类号： G02B21/26
摘要： The invention is related to a mechanical x-y-axis adjustable stage, which is designed for microscopic electro-physiological studies. The stage adopted a three-layer flat-slab structure. The up-most layer was a bearing layer on which other equipment could be mounted. The middle layer and bottom layer were guide layers, and rails for x-axis or y-axis guiding were installed. In order to move the top layer smoothly along two-dimension relative to the bottom layer, the three layers were jointed using grooved rails. By moving the top layer accordingly along the x-axis and y-axis, biological sample (animal/cells) as well as other instruments such as electrophysiological probes and manipulators could be moved smoothly and flexibly, and specific visual fields could be defined without moving the complex microscope system as well as other optical components. Therefore, the present invention has broad application values, for example two-electrodes electrophysiological recordings.
摘要翻译：本发明涉及一种用于微观电生理研究的机械x-y轴可调节段。舞台采用三层平板结构。最上层是可以安装其他设备的轴承层。中间层和底层为导向层，安装x轴或y轴导轨。为了使顶层相对于底层沿着二维平滑地移动，三层使用开槽轨道连接。通过沿x轴和y轴相应地移动顶层，生物样本（动物/细胞）以及其他仪器如电生理探针和操纵器可以平稳而灵活地移动，可以定义特定的视野而不移动复合显微镜系统以及其他光学元件。因此，本发明具有广泛的应用价值，例如两电极电生理记录。

64. 发明授权

US11603537B2 Method for improving rice yield by jointly knocking out ABA receptor PYL family genes and use thereof 有权
公开(公告)号：US11603537B2
公开(公告)日：2023-03-14
申请号：US16652391
申请日：2018-09-30
申请人： Shanghai Institutes For Biological Sciences, Chinese Academy Of Sciences
发明人： Jiankang Zhu , Chunbo Miao
IPC分类号： C12N15/82 , A01H1/04 , A01H4/00 , C12N9/22
摘要： Provided are a method for improving rice yield by jointly knocking out ABA receptor PYL family genes and a use thereof.

65. 发明授权

US11571400B2 ACAT1 inhibitors for treating cancer 有权
公开(公告)号：US11571400B2
公开(公告)日：2023-02-07
申请号：US16069135
申请日：2017-01-11
申请人： Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
发明人： Chenqi Xu , Boliang Li , Wei Yang , Yibing Bai , Ying Xiong
IPC分类号： A61K31/145 , A61K31/655 , A61P35/00 , A61K39/395 , A61K31/255 , A61K45/00 , A61K45/06 , A61K31/496 , A61K31/4188 , A61K31/495 , C07K16/28 , A61K39/00
摘要： The present disclosure relates to methods and compositions for the treatment of cancer using an ACAT1 inhibitor. The cancer may be any of melanoma, lymphoma, esophageal cancer, liver cancer, head and neck cancer, bladder cancer, endometrial cancer, kidney cancer and thyroid cancer. In some embodiments, the cancer itself it not responsive directly to the ACAT1 inhibitor but is rather treated through the immune system activated by the ACAT1 inhibitor. Combination therapies are also provided, for instance in combination with an alkylating antineoplastic agent.

66. 发明申请

US20210261977A9 METHOD FOR IMPROVING RICE YIELD BY JOINTLY KNOCKING OUT ABA RECEPTOR PYL FAMILY GENES AND USE THEREOF 有权
公开(公告)号：US20210261977A9
公开(公告)日：2021-08-26
申请号：US16652391
申请日：2018-09-30
申请人： Shanghai Institutes For Biological Sciences, Chinese Academy Of Sciences
发明人： Jiankang Zhu , Chunbo Miao
IPC分类号： C12N15/82 , A01H1/04 , A01H4/00 , C12N9/22
摘要： Provided are a method for improving rice yield by jointly knocking out ABA receptor PYL family genes and a use thereof.

67. 发明申请

US20210163901A1 GROUP OF UDP-GLYCOSYLTRANSFERASE FOR CATALYZING CARBOHYDRATE CHAIN ELONGATION AND APPLICATION THEROF 有权
公开(公告)号：US20210163901A1
公开(公告)日：2021-06-03
申请号：US16614944
申请日：2018-05-21
申请人： SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES
发明人： Zhihua ZHOU , Wei WEI , Xing YAN , Chengshuai YANG , Chaojing LI , Yongjun WEI , Pingping WANG
IPC分类号： C12N9/10 , C12P19/18 , C12P19/56 , C12N15/82
摘要： The present invention relates to a group of glycosyltransferase, and an application thereof. Specifically, provided is using glycosyltransferase GT29-32, GT29-33, GT29-34, GT29-4, GT29-5, GT29-7, GT29-9, GT29-11, GT29-13, GT29-17, GT29-18, GT29-19, GT29-20, GT29-21, GT29-22, GT29-23, GT29-24, GT29-25, GT29-36, GT29-37, GT29-42, GT29-43, GT29-45, GT29-46, PNUGT29-1, PNUGT29-2, PNUGT29-3, PNUGT29-4, PNUGT29-5, PNUGT29-6, PNUGT29-7, PNUGT29-8, PNUGT29-9, PNUGT29-14, and PNUGT29-15, as well as derived polypeptides thereof to catalyze the first glycosyl at position C-20, the first glycosyl at position C-6, and the first glycosyl at position C-3 of a tetracyclic triterpene compound substrate to elongate a carbohydrate chain, thereby obtaining a catalytic reaction of ginsenoside products such as ginsenoside Rg3, ginsenoside Rd, ginsenoside Rb1, ginsenoside Rb3, saponin DMGG, saponin DMGX, gypenoside LXXV, gypenoside XVII, gypenoside XIII, gypenoside IX, notoginsenoside U, and notoginsenoside R1, notoginsenoside R2, notoginsenoside R3, 3-O-β-(D-xylopyranosyl)-β-(D-glucopyranosyl)-PPD, 3-O-β-(D-xylopyranosyl)-β-(D-glucopyranosyl)-CK, 20-O-Glucosylginsenoside Rf, and Ginsenoside F3. Glycosyltransferase in the present invention can further be applied to construction of artificially synthesized ginsenoside, novel ginsenoside, and derivatives thereof.

68. 发明授权

US10920229B2 Method for improving heterologous synthesis of Escherichia coli into polyketides and use of same 有权
公开(公告)号：US10920229B2
公开(公告)日：2021-02-16
申请号：US15523829
申请日：2015-05-18
申请人： Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
发明人： Yong Wang , Zhiqiang Xiong , Shujie Song , Qiaoxia Liu , Jianfeng Wang
IPC分类号： C12N15/70 , C12N15/113 , C12N9/12 , C12P19/62 , C12P17/08 , C07H17/08 , C12N15/09 , C12Q1/18 , C12R1/465
摘要： The present invention relates to a method for improving the heterologous synthesis of a polyketide by E. coli and use thereof. The yield of the polyketide heterologously synthesized by E. coli is significantly increased by attenuating the expression of seventy-two genes, such as sucC and talB, in a host strain, wherein the highest yield increase rate can reach 60% or more. Currently, erythromycin is the most clear model compound in the study on the biosynthesis of polyketids. The production strain of the present invention enables massive accumulation of 6-deoxyerythronolide (6-dEB), an erythromycin precursor, in the fermentation process, laying the foundation for the industrial production of the heterologous synthesis of erythromycin by E. coli.

69. 发明申请

US20200283785A1 METHOD FOR IMPROVING RICE YIELD BY JOINTLY KNOCKING OUT ABA RECEPTOR PYL FAMILY GENES AND USE THEREOF 审中-公开
公开(公告)号：US20200283785A1
公开(公告)日：2020-09-10
申请号：US16652391
申请日：2018-09-30
申请人： Shanghai Institutes For Biological Sciences, Chinese Academy Of Sciences
发明人： Jiankang Zhu , Chunbo Miao
IPC分类号： C12N15/82 , A01H1/04 , A01H4/00 , C12N9/22
摘要： Provided are a method for improving rice yield by jointly knocking out ABA receptor PYL family genes and a use thereof.

70. 发明授权

US10647990B2 Rice high temperature resistance gene and use in crop breeding resistance to high temperature thereof 有权
公开(公告)号：US10647990B2
公开(公告)日：2020-05-12
申请号：US15515630
申请日：2015-05-28
申请人： SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES
发明人： Hongxuan Lin , Xinmin Li , Jiping Gao , Junxiang Shan , Min Shi
IPC分类号： C12N15/82 , C07K14/415 , A01H1/04 , A01H5/10 , C12Q1/6895
摘要： The present invention provides a new plant gene-rice high temperature resistance 1 gene (Rice High Temperature Resistance 1, HTR1) and encoded protein thereof. Also disclosed is the use of the high temperature resistance gene, especially for the enhancement of high-temperature resistance of plants in plant variety improvement and cross breeding.

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