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61. 发明授权

US10243329B2 External resonator laser 有权
公开(公告)号：US10243329B2
公开(公告)日：2019-03-26
申请号：US14430054
申请日：2013-09-19
申请人： NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
发明人： Kiyofumi Muro , Yuji Wakabayashi , Tomohisa Endo , Ken Kitahara
IPC分类号： H01S5/14 , H01S5/065 , H01S3/105 , H01S5/022 , H01S5/10
摘要： A tunable external resonator laser is mode-hop-free for broadband and has a laser chip which emits light; a lens which collimates the light emitted from the laser chip, a diffraction grating which diffracts the light collimated by the lens, a support body to which the diffraction grating is fixed, and a movable mirror which reflects the light diffracted by the diffraction grating, wherein the diffraction grating is arranged a prescribed distance apart from a Littman-type tunable external resonator laser arrangement in which the movable mirror rotates on a pivot which is the intersection point of the surface of said movable mirror and the surface of the diffraction grating.

62. 发明授权

US10006005B2 Culture medium and method for inducing differentiation of pluripotent stem cells to hepatoblasts 有权
公开(公告)号：US10006005B2
公开(公告)日：2018-06-26
申请号：US14749715
申请日：2015-06-25
申请人： National University Corporation Chiba University
发明人： Minoru Tomizawa
IPC分类号： C12N5/00 , C12N5/071
摘要： Provided are a method of inducing differentiation of pluripotent stem cells, such as induced pluripotent stem cells (hereinafter abbreviated as iPS cells), to hepatocytes in a short period of time, and a substance to be used in the method. Specifically, provided are a method of producing a cell culture formed substantially of hepatoblasts, the method including culturing pluripotent stem cells, such as iPS cells, in a culture medium having a composition shown in Table 1 below, and a culture medium for inducing differentiation of pluripotent stem cells into hepatoblasts, which has a composition shown in Table 1 below.

63. 发明授权

US09957262B2 Opioid analgesic 有权
公开(公告)号：US09957262B2
公开(公告)日：2018-05-01
申请号：US15032070
申请日：2014-10-28
申请人： NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
发明人： Hiromitsu Takayama
IPC分类号： C07D491/22 , A61K31/4375 , C07D455/00
CPC分类号： C07D455/00 , A61K31/4375 , C07D491/22
摘要： Provided are a compound represented by formula (I) or (II), a salt thereof, or solvates of the compound and salt, having an analgesic effect and high metabolic stability. Further provided are the following: an analgesic obtained from the compound, a salt thereof, or solvates of the compound and salt; a pharmaceutical composition containing the compound, a salt thereof, or solvates of the compound and salt; an analgesic treatment method using the compound, a salt thereof, or solvates of the compound and salt; and a use of the compound, a salt thereof, or solvates of the compound and salt, in the production of an analgesic composition.

64. 发明申请

US20180100012A1 RGMa BINDING PROTEIN AND USE THEREOF 审中-公开
公开(公告)号：US20180100012A1
公开(公告)日：2018-04-12
申请号：US15569382
申请日：2016-04-27
申请人： MITSUBISHI TANABE PHARMA CORPORATION , OSAKA UNIVERSITY , NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
发明人： Motonori HASHIMOTO , Toshihide YAMASHITA
IPC分类号： C07K16/22 , A61P25/00 , A61P37/00 , A61P25/28 , A61P25/16 , A61P25/14 , A61P25/02 , A61P25/18 , A61P27/06 , A61P11/06 , A61P19/02 , A61P1/00 , A61P17/00 , A61P17/06 , A61P7/04 , A61P27/02
CPC分类号： C07K16/22 , A61K39/395 , A61K2039/505 , A61P1/00 , A61P7/04 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P27/06 , A61P37/00 , C07K16/28 , C07K16/46 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N5/10 , C12N15/09
摘要： The present invention aims to obtain an anti-repulsive guidance molecule a (RGMa) antibody having a high binding activity arid few side effects which can be used as a medicine for preventing, treating, or preventing the relapse of neurological or immunological diseases. The problem is solved by providing an isolated RGMa binding protein which does not inhibit binding between RGMa and neogenin but neutralizes the neurite outgrowth inhibiting activity of RGMa, preferably by providing an anti-RGMa antibody which has complementarity determining regions having amino acid sequences of SEQ ID NOS: 30-35 or SEQ ID NOS: 36-40 in Sequence Listing, and SFG.

65. 发明授权

US09900570B2 Projector system and calibration board 有权
公开(公告)号：US09900570B2
公开(公告)日：2018-02-20
申请号：US15126976
申请日：2014-12-10
申请人： ADVANCED HEALTHCARE CO., LTD. , NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
发明人： Toshiya Nakaguchi
IPC分类号： H04N9/31 , H04N1/00
CPC分类号： H04N9/3194 , G03B21/14 , G03B43/00 , G06F3/1415 , G09G2320/0693 , H04N1/00015 , H04N1/00045 , H04N1/00087 , H04N9/3185 , H04N2201/0089
摘要： This invention provides a simple projector system that can be operated by a user who is not an expert of image processing technology. The projector system comprises a projector (1), a personal computer (2), a mouse (3), and a calibration board (4). A checker flag pattern is added to the calibration board (4), and an intersection point serves as a marker. A cursor, which is projected from the projector (1) onto the calibration board (4), is used as an intuitive input interface. An operator, while seeing the cursor, operates the mouse (3), thereby placing the cursor onto the calibration marker. In this state, the operator clicks the mouse (3), thereby selecting the calibration marker. The operator then acquires the corresponding projection image coordinates on the basis of the selection instruction.

66. 发明授权

US09848831B2 Apparatus for determining respiratory condition 有权
公开(公告)号：US09848831B2
公开(公告)日：2017-12-26
申请号：US13901135
申请日：2013-05-23
申请人： NIHON KOHDEN CORPORATION , National University Corporation Chiba University
发明人： Yukio Nonaka , Shiroh Isono , Tsuyoshi Shimizu
IPC分类号： A61B5/087 , A61B5/00 , A61B5/08 , A61M16/00 , A61M16/06
CPC分类号： A61B5/742 , A61B5/0826 , A61B5/087 , A61B5/4818 , A61B5/7239 , A61M16/0051 , A61M16/021 , A61M16/0672 , A61M2016/0027 , A61M2205/502
摘要： An apparatus for determining a respiratory condition, the apparatus includes: a signal acquirer which is configured to acquire a signal waveform corresponding to a respiratory flow of a subject; a differential calculator which is configured to acquire a differential waveform which is obtained by performing differentiation of the signal waveform; and a first determiner which is configured to determine that inspiratory flow limitation occurs in the subject, when the differential waveform satisfies a predetermined condition in a portion of the signal waveform, which corresponds to inspiration of the subject.

67. 发明授权

US09795636B2 Stable bicarbonate ion-containing drug solution 有权
公开(公告)号：US09795636B2
公开(公告)日：2017-10-24
申请号：US14272026
申请日：2014-05-07
申请人： NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY , FUSO PHARMACEUTICAL INDUSTRIES, LTD.
发明人： Shigeto Oda , Tomohito Sadahiro , Masataka Nakamura , Syuichi Tanaka , Shogo Tokuoka , Hiroya Otani
IPC分类号： A61K33/42 , A61K31/7004 , A61K33/06 , A61K33/14 , A61K45/06 , A61K47/02 , A61K47/26 , A61K9/00 , A61K9/08 , A61K33/10 , A61M1/16 , B65D81/32
CPC分类号： A61K33/42 , A61K9/0019 , A61K9/08 , A61K31/7004 , A61K33/06 , A61K33/10 , A61K33/14 , A61K45/06 , A61K47/02 , A61K47/26 , A61M1/1654 , B65D81/3261 , A61K2300/00
摘要： The invention relates to a stable bicarbonate ion-containing drug solution, particularly a bicarbonate-containing drug solution for dialysis in which the stability has been improved by the presence of a phosphate ion. Further, the invention relates to a drug solution for acute blood purification, particularly a dialysate and a substitution liquid for acute blood purification to be mixed before use containing the drug solution. Still further, the invention relates to a dialysate and a substitution liquid for acute blood purification to be mixed before use in which the formation of insoluble fine particles or precipitates is prevented for a long time after mixing and with which hypokalemeia and hypophosphatemia are not caused.

68. 发明申请

US20170299580A1 POLYMER MICROPARTICLE FOR CARRYING PHYSIOLOGICALLY ACTIVE SUBSTANCE AND METHOD FOR PREPARING SAME 审中-公开
公开(公告)号：US20170299580A1
公开(公告)日：2017-10-19
申请号：US15507858
申请日：2015-09-02
申请人： LSI Medience Corporation , National University Corporation Chiba University
发明人： Atsushi KADOWAKI , Tatsuo TANIGUCHI , Yusuke SASAKI , Naho KONISHI
IPC分类号： G01N33/545 , C08F293/00
CPC分类号： G01N33/545 , C08F2/24 , C08F2/38 , C08F293/005 , C08F297/00
摘要： Provided are novel polymer particles for carrying a physiologically active substance and a method of preparing the same. The polymer particles for carrying a physiologically active substance can provide an analytical reagent, which has high analytical precision and sensitivity and can be stably prepared; can easily and precisely control the amount of functional groups carrying the physiologically active substance; can introduce, onto the surface of latex particles, a hydrophilic compound for inhibiting a nonspecific reaction; and can be prepared to have a narrow and uniform particle size distribution. The polymer particles for carrying a physiologically active substance are obtained by polymerizing a monomer, a radical polymerization initiator, and an emulsifier, and the emulsifier is an amphiphilic block polymer of the general formula (1):

69. 发明申请

US20170046819A1 IMAGE PROCESSING APPARATUS AND IMAGE ACQUISITION APPARATUS 有权
标题翻译：图像处理装置和图像采集装置
公开(公告)号：US20170046819A1
公开(公告)日：2017-02-16
申请号：US15338046
申请日：2016-10-28
申请人： OLYMPUS CORPORATION , NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
发明人： Masao SAMBONGI , Norimichi TSUMURA , Mayu YOKOYA
IPC分类号： G06T5/00 , G06T5/50
CPC分类号： G06T5/005 , G06T5/50 , G06T7/514 , G06T7/593 , G06T2207/10004 , G06T2207/10052 , G06T2207/20221 , H04N5/2254 , H04N5/232
摘要： Provided is an image processing apparatus including a transformation unit that is configured to deform images so that corresponding points in a plurality of images obtained from several viewpoints with respect to the same subject are matched; a separating unit that is configured to separate specular-reflection components from the plurality of images transformed by the transformation unit and create an image from which the specular-reflection component is removed; and an image reconstructing unit that is configured to combine at least one of the specular-reflection components of the plurality of images, separated by the separating unit, and the image from which the specular-reflection component is removed.
摘要翻译：提供了一种图像处理装置，包括：变换单元，被配置为使图像变形，使得从相同对象的多个视点获得的多个图像中的对应点相匹配; 分离单元，被配置为从由所述变换单元变换的所述多个图像中分离镜面反射分量，并创建去除所述镜面反射分量的图像; 以及图像重建单元，被配置为组合由分离单元分离的多个图像的镜面反射分量中的至少一个与去除了镜面反射分量的图像。

70. 发明授权

US09460637B2 Stethoscopy training system and simulated stethoscope 有权
标题翻译：听诊器训练系统和模拟听诊器
公开(公告)号：US09460637B2
公开(公告)日：2016-10-04
申请号：US14235018
申请日：2012-05-11
申请人： Toshiya Nakaguchi , Masahiro Tanabe
发明人： Toshiya Nakaguchi , Masahiro Tanabe
IPC分类号： G09B23/28
CPC分类号： G09B23/28 , A61B7/00 , G09B23/285
摘要： Provided is a stethoscopy training system which is inexpensive and has a simple configuration, without using a device which measures a respiratory operation of a simulated patient. The stethoscopy training system for this objective is formed from: a simulated stethoscope (1) having a sound acquisition unit further comprising a location display means (1d), a tube, and ear pipes; a location sensing means (2) for sensing the location of the sound acquisition unit; biological sound database (3); a biological sound reproducing means (4); and a timing display means (5) for displaying a timing of a repetition of a reproduced respiratory sound. The database retains as information biological sounds which are prerecorded from actual patients in correspondence with chest locations. The biological sound reproducing means further comprises a voice reproducing apparatus (4a), extracts prescribed biological sound information from the database according to the sound acquisition unit location which the location sensing means has sensed, and emits a reproduced biological sound from the voice reproducing apparatus, which a trainee hears via the ear pipes. The simulated patient views the timing display means and matches his or her respiratory operation to a reproduced respiratory sound.
摘要翻译：提供一种便宜且具有简单结构的听诊器训练系统，而不使用测量模拟患者的呼吸操作的装置。用于该目的的听诊器训练系统由以下部分形成：具有声音获取单元的模拟听诊器（1），还包括位置显示装置（1d），管和耳道; 位置检测装置（2），用于感测声音获取单元的位置; 生物声音数据库（3）; 生物声音再现装置（4）; 以及用于显示再现的呼吸音的重复定时的定时显示装置（5）。数据库保留作为信息生物声音，它们是从实际患者预先记录的胸部位置。生物声音再现装置还包括语音再现装置，根据位置感测装置感测到的声音获取单元位置从数据库中提取规定的生物声音信息，并从语音再现装置发出再现的生物声音，受训者通过耳道听到。模拟患者查看定时显示装置并将其呼吸操作与再现的呼吸音相匹配。

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