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51. 发明授权

US09833411B2 Solid oral dosage forms 有权
公开(公告)号：US09833411B2
公开(公告)日：2017-12-05
申请号：US14993294
申请日：2016-01-12
申请人： Enteris Biopharma, Inc.
发明人： John Vrettos , Thomas Daggs , Paul Shields , Raymundo Claudio
IPC分类号： A61K9/20 , A61K38/09 , A61K31/00 , A61K47/69
CPC分类号： A61K9/2054 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2846 , A61K31/00 , A61K31/216 , A61K31/65 , A61K31/7012 , A61K31/7036 , A61K38/09 , A61K47/6903
摘要： The present invention provides pharmaceutical compositions suitable for oral delivery of active agent, such as peptides and small molecules, and methods for treating subjects in need thereof. The pharmaceutical compositions of the present invention enhance the bioavailability of therapeutic active agents.

52. 发明授权

US09724397B2 Sustained release formulations comprising very low molecular weight polymers 有权
公开(公告)号：US09724397B2
公开(公告)日：2017-08-08
申请号：US12447431
申请日：2007-10-26
申请人： Roland Cherif-Cheikh , Anne-Paula De Sousa Delgado , Frédéric Lacombe , Laurence Lachamp , Didier Bourissou
发明人： Roland Cherif-Cheikh , Anne-Paula De Sousa Delgado , Frédéric Lacombe , Laurence Lachamp , Didier Bourissou
IPC分类号： A61F13/00 , A61K38/09 , A61K38/30 , A61K9/00 , A61K38/25 , A61K38/26 , A61K38/27 , A61K47/34 , A61K47/36
CPC分类号： A61K38/30 , A61K9/0024 , A61K38/09 , A61K38/25 , A61K38/26 , A61K38/27 , A61K47/34 , A61K47/36
摘要： The present invention relates to a parenteral, sustained and controlled release, semisolid formulation comprising an end-capped oligomer and at least one active substance without any supplementary viscosity reducing agent or excipient.

53. 发明申请

US20170196981A1 CARDIOVASCULAR DISEASE TREATMENT AND PREVENTION 有权
公开(公告)号：US20170196981A1
公开(公告)日：2017-07-13
申请号：US15409857
申请日：2017-01-19
申请人： Transdermal Biotechnology, Inc.
发明人： Nicholas V. Perricone
IPC分类号： A61K47/24 , A61K9/06 , A61K33/00 , A61K9/00 , A61K38/09
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/06 , A61K9/107 , A61K31/519 , A61K33/00 , A61K38/066 , A61K38/08 , A61K38/09 , A61K38/10 , A61K38/12 , A61K38/22 , A61K38/43 , A61K38/55 , A61K45/06 , A61K47/14 , A61K2300/00
摘要： The present invention generally relates to compositions and methods for treatment of subjects having or at risk of arteriosclerosis, hypertension, sickle-cell anemia, or other conditions. In some cases, the composition may include nitric oxide, peptides, or both. The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other structures containing nitric oxide and/or peptides such as thyrotropin-releasing hormone (TRH) and/or GnRH (gonadotropin-releasing hormone). The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.

54. 发明授权

US09700626B2 Wound healing using topical systems and methods 有权
公开(公告)号：US09700626B2
公开(公告)日：2017-07-11
申请号：US15182708
申请日：2016-06-15
申请人： Transdermal Biotechnology, Inc.
发明人： Nicholas V. Perricone
IPC分类号： A61K47/24 , A61K38/06 , A61K38/09 , A61K9/06 , A61K9/107 , A61K45/06 , A61K33/00 , A61K9/00 , A61K38/22
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/06 , A61K9/107 , A61K33/00 , A61K38/066 , A61K38/09 , A61K38/22 , A61K45/06 , A61K2300/00
摘要： The present invention generally relates to compositions and methods for topical or transdermal delivery and treatment of wounds and/or promoting wound healing. In some cases, the composition may include nitric oxide and/or peptides such as thyrotropin-releasing hormone (TRH) and/or GnRH (gonadotropin-releasing hormone). The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other structures containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., wounded skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.

55. 发明授权

US09651561B2 Diagnosis and treatment of endometriosis and related conditions 有权
公开(公告)号：US09651561B2
公开(公告)日：2017-05-16
申请号：US14443804
申请日：2013-11-13
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： Joseph V. Bonventre , Venkata Sabbisetti
IPC分类号： G01N33/68 , A61B1/313 , A61K31/522 , A61K31/567 , A61K31/57 , A61K31/58 , A61K38/09 , A61K38/00
CPC分类号： G01N33/689 , A61B1/3132 , A61K31/522 , A61K31/567 , A61K31/57 , A61K31/58 , A61K38/00 , A61K38/09 , G01N2800/364 , G01N2800/52
摘要： The technology described herein relates to KIM-1 and the diagnosis, prognosis, and treatment of endometrial diseases and disorders.

56. 发明授权

US09616212B2 Implant cannula having an implant and a method for securing implants in an injection cannula 有权
公开(公告)号：US09616212B2
公开(公告)日：2017-04-11
申请号：US13637672
申请日：2011-02-17
申请人： Heiko Spilgies
发明人： Heiko Spilgies
IPC分类号： A61M37/00 , A61K38/09 , A61L29/06 , A61L29/16 , A61B17/34
CPC分类号： A61M37/0069 , A61B17/3468 , A61K38/09 , A61L29/06 , A61L29/16 , A61L2300/40 , C08L67/04
摘要： The application provides an injection cannula having an implant which is detachably secured in the cannula. The application also provides a method for detachably securing an implant in an injection cannula.

57. 发明授权

US09585829B2 Treatment of skin, including aging skin, to improve appearance 有权
标题翻译：治疗皮肤，包括皮肤老化，改善外观
公开(公告)号：US09585829B2
公开(公告)日：2017-03-07
申请号：US14705099
申请日：2015-05-06
申请人： Transdermal Biotechnology, Inc.
发明人： Nicholas V. Perricone
IPC分类号： A61K9/127 , A61K8/64 , A61K38/09 , A61Q19/00 , A61Q19/08 , A61K33/00 , A61K8/19 , A61K8/55 , A61K9/107
CPC分类号： A61K8/64 , A61K8/06 , A61K8/19 , A61K8/37 , A61K8/553 , A61K9/1075 , A61K33/00 , A61K38/09 , A61K38/22 , A61Q19/00 , A61Q19/004 , A61Q19/08
摘要： The present invention generally relates to compositions and methods for topical or transdermal delivery, treatment of skin, and improving the appearance of skin, e.g., medically or cosmetically. In some cases, the composition may include nitric oxide and/or peptides such as thyrotropin-releasing hormone (TRH) and/or GnRH (gonadotropin-releasing hormone). The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other structures containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
摘要翻译：本发明一般涉及用于局部或透皮递送，皮肤治疗以及改善皮肤外观的组合物和方法，例如在医学上或美容上。在一些情况下，组合物可以包括一氧化氮和/或肽，例如促甲状腺激素释放激素（TRH）和/或GnRH（促性腺激素释放激素）。一氧化氮和/或肽可以存在于包含卵磷脂（例如磷脂酰胆碱）的第一相内。在某些实施方案中，卵磷脂存在于含有一氧化氮，肽或两者的脂质体，胶束或其它结构中。组合物可以采用可以被摩擦或喷到皮肤上的凝胶，乳膏，洗剂，软膏，溶液，固体“棒”等的形式。本发明的其它方面一般涉及制备或使用这种组合物的方法，促进这种组合物的方法，包括这种组合物的试剂盒等。

58. 发明申请

US20160220548A1 ANDROGEN RECEPTOR MODULATOR AND USES THEREOF 审中-公开
标题翻译：雄激素受体调节剂及其用途
公开(公告)号：US20160220548A1
公开(公告)日：2016-08-04
申请号：US15094113
申请日：2016-04-08
申请人： ARAGON PHARMACEUTICALS, INC.
发明人： ISAN CHEN , JEFFREY H. HAGER , EDNA CHOW MANEVAL , MARK R. HERBERT , NICHOLAS D. SMITH
IPC分类号： A61K31/4439 , A61K9/00 , A61K31/337 , A61K47/00 , A61K51/10 , A61K31/436 , A61K31/58 , A61K39/395 , C07K16/28 , A61K51/00 , A61K31/47 , C07K16/40 , A61K47/48 , A61N5/10 , A61K38/09
摘要： Described herein is the androgen receptor modulator of formula (I) in the treatment of prostate cancer in combination with other therapeutic options and in the treatment of diseases or conditions that are amenable to treatment with the androgen receptor modulator, as well as pharmaceutical compositions and medicaments that include such compound.
摘要翻译：本文描述了式（I）的雄激素受体调节剂在治疗前列腺癌中与其它治疗方案的组合以及治疗适于用雄激素受体调节剂治疗的疾病或病症以及药物组合物和药物包括这种化合物。

59. 发明申请

US20160184386A1 AQUEOUS SUSTAINED RELEASE COMPOSITIONS OF LHRH ANALOGUES 审中-公开
标题翻译： LHRH类似物的水质持续释放组合物
公开(公告)号：US20160184386A1
公开(公告)日：2016-06-30
申请号：US14908953
申请日：2014-07-21
申请人： IPSEN PHARMA S.A.S.
发明人： Joel RICHARD , Anne PETIT , Jeremiah HARNETT , Marie-Madeleine BARONNET , Franck ARTZNER , Mercedes CARDUS MALESPINA , Roland CHERIF-CHEIKH , Martin MONTES , Marie-Therese PATERNOSTRE , Celine VALERY
IPC分类号： A61K38/09 , A61K47/02 , A61K9/08
CPC分类号： A61K38/09 , A61K9/0019 , A61K9/08 , A61K47/02
摘要： An aqueous pharmaceutical composition for the sustained release of an LHRH analogue, in particular for a sustained release compatible with therapeutic treatments for at least 2 weeks. The pharmaceutical compositions are particularly useful for the treatment of diseases an LHRH analogue is indicated for.
摘要翻译：用于持续释放LHRH类似物的水性药物组合物，特别是用于与治疗治疗相容至少2周的持续释放。药物组合物特别可用于治疗LHRH类似物的疾病。

60. 发明授权

US09364524B2 Pharmaceutical composition using gonadotropin-releasing hormone (GNRH) combined variants as immunogen 有权
标题翻译：使用促性腺激素释放激素（GNRH）联合变种作为免疫原的药物组合物
公开(公告)号：US09364524B2
公开(公告)日：2016-06-14
申请号：US14662482
申请日：2015-03-19
申请人： Centro de Ingenieria Genetica Y Biotecnologia
发明人： Jesus Arturo Junco Barranco , Osvaldo Reyes Acosta , Eddy Emilio Bover Fuentes , Franklin Fuentes Aguilar , Eulogio Pimentel Vazquez , Roberto Basulto Baker , Gerardo Enrique Guillen Nieto , Yovisleidys Lopez Saez , Hilda Elisa Garay Perez , Lesvia Calzada Aguilera , Maria Castro Santana , Niurka Oneysi Arteaga More , Luis Alberto Aguero Barrocal
IPC分类号： A61K39/00 , A61K38/09 , A61K47/48
CPC分类号： A61K39/0011 , A61K38/09 , A61K39/0006 , A61K47/48261 , A61K47/4833 , A61K47/6415 , A61K47/646 , A61K2039/585 , A61K2039/6037 , A61K2300/00
摘要： A pharmaceutical composition using natural gonadotropin—releasing hormone (GnRH), and/or some of its mimetic peptides, indistinctly bound by its amino or carboxyl extremes to a carrier molecule; in one case by its carboxyl extreme and in the other case by the amino terminal extreme, thus eliciting a faster and more potent immunological response against the endogenous GnRH hormone. This finally leads to the ablation of the GnRH and consequently of the rest of the involved hormones in the stream GnRH/LH-FSH/Testosterone-(estrogens). An advantage of this formulation consists on facilitating the exposition to the immune system of a greater number of epitopes of the GnRH or its mimetics, minimizing thus the steric hindrance produced by the carriers. This invention has a direct application in the castration of pets and animals of economic interest, in the control of human fertility as well as in the treatment of hormone-sensitive tumors, such as that of the prostate, the breast, ovary, the endometry, testicles, hypophysis, salivary glands and other kinds of human tumors.
摘要翻译：使用天然促性腺激素释放激素（GnRH）和/或其一些模拟肽的药物组合物，其不明显地被其氨基或羧基末端与载体分子结合; 在一种情况下其羧基末端，另一种情况下由氨基末端极端，从而引发对内源GnRH激素的更快更有效的免疫应答。这最终导致消化GnRH，从而导致流GnRH / LH-FSH /睾酮（雌激素）中涉及的其他激素的消融。该制剂的优点在于促进免疫系统暴露于更多数量的GnRH或其模拟物的表位，从而最小化载体产生的空间位阻。本发明直接应用于经济兴趣的宠物和动物的阉割，控制人的生育能力以及治疗激素敏感性肿瘤，如前列腺，乳腺，卵巢，睾丸，垂体，唾液腺等多种人体肿瘤。

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