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51. 发明授权

US4209511A Aminoglycoside antibiotics and process for production thereof 失效
标题翻译：氨基糖苷类抗生素及其生产方法
公开(公告)号：US4209511A
公开(公告)日：1980-06-24
申请号：US793
申请日：1979-01-03
申请人： Yoshihiko Oka , Hitoshi Ishida , Moto Morioka , Yoso Numasaki , Tsutomu Yamafuji , Takashi Osono , Hamao Umezawa
发明人： Yoshihiko Oka , Hitoshi Ishida , Moto Morioka , Yoso Numasaki , Tsutomu Yamafuji , Takashi Osono , Hamao Umezawa
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236 , C12P19/48 , C12P19/50 , C12R1/29 , A61K31/71 , C07H15/22
CPC分类号： C07H15/236 , C12P19/485 , Y10S435/867
摘要： Aminoglycoside antibiotics biochemically transformed from Kanamycin A or Kanamycin B, which are represented by the formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group and R.sub.2 represents an amino group or a hydroxyl group.
摘要翻译：由卡那霉素A或卡那霉素B生物化学转化的氨基糖苷类抗生素，其由式表示，其中R1表示氢原子或甲基，R2表示氨基或羟基。

52. 发明授权

US4189569A Seldomycin factor 5 derivatives 失效
标题翻译：西妥昔单抗5型衍生物
公开(公告)号：US4189569A
公开(公告)日：1980-02-19
申请号：US922134
申请日：1978-07-05
申请人： Ronald E. Carney , James B. McAlpine
发明人： Ronald E. Carney , James B. McAlpine
IPC分类号： C07H15/236 , C12P19/48 , A61K31/71 , C07H15/22
CPC分类号： C07H15/234 , C12P19/485
摘要： Described are novel derivatives of seldomycin factor 5 (XK-88-5) and particularly 3'-Epi-seldomycin factor 5, which exhibit improved activity against gram-positive and gram-negative bacteria resistant to aminoglycoside antibiotics, and a method of preparing them.
摘要翻译：描述了对青霉素因子5（XK-88-5）特别是3-Epi-seldomycin因子5的新型衍生物，其对抗氨基糖苷类抗生素的革兰氏阳性和革兰氏阴性菌具有改善的活性，以及制备它们的方法。

53. 发明授权

USB554291I5 失效
公开(公告)号：USB554291I5
公开(公告)日：1976-03-09
申请号：US55429175
申请日：1975-02-28
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236 , C12P1/06 , C12P19/48 , C12R1/29
CPC分类号： C07H15/236 , Y10S435/863

54. 发明公开

US20240301461A1 Recombinant Escherichia Coli for Expressing Synthesis Pathway of Asiaticoside and Application Thereof 审中-公开
公开(公告)号：US20240301461A1
公开(公告)日：2024-09-12
申请号：US18414523
申请日：2024-01-17
申请人： Jiangnan University
发明人： Jingwen Zhou , Weizhu Zeng , Xingying Zhao , Sha Xu , Jian Chen
IPC分类号： C12P19/48 , C12N1/20 , C12N9/10 , C12R1/19
CPC分类号： C12P19/485 , C12N1/205 , C12N9/1051 , C12N2527/00 , C12R2001/19
摘要： The present disclosure discloses recombinant Escherichia coli for expressing a synthesis pathway of asiaticoside and application thereof, and belongs to the field of bioengineering. Rhamnosyltransferase with an amino acid sequence shown in any one of SEQ ID NO: 25 to SEQ ID NO: 29, glucosyltransferase with an amino acid sequence shown in any one of SEQ ID NO: 10 to SEQ ID NO: 17 and UGT73AH1 reported in a document are transferred into E. coli BL21 (DE3)Δpgi to realize co-expression. Fermentation results show that all 5 rhamnosyltransferases screened in the present disclosure can achieve effects, and a unique new peak appears at 0.596 min, which is consistent with a characteristic ion flow of an asiaticoside standard product. According to the present disclosure, barriers of the prior art are broken through, a new biosynthesis method for asiaticoside is provided, and industrialization of biosynthesis of asiaticoside becomes possible.

55. 发明授权

US10337044B2 Kanamycin compound, kanamycin-producing Streptomyces species bacterium, and method of producing kanamycin 有权
公开(公告)号：US10337044B2
公开(公告)日：2019-07-02
申请号：US14831519
申请日：2015-08-20
申请人： iNtRON Biotechnology, Inc.
发明人： Yeo Joon Yoon , Sung Ryeol Park , Je Won Park , Jae Kyung Sohng
IPC分类号： C12N15/52 , C12N15/74 , C12N1/20 , C12P19/48 , A61K31/351 , A61K31/7036 , C07H15/22 , C07H15/234 , C12N15/76 , C12R1/61
摘要： Vectors expressing kanA-kanB-kanK and other kanamycin production-related genes, Streptomyces species recombinant bacteria transformed with the vectors, a method of producing kanamycin antibiotics by the bacteria, and a new kanamycin compound produced by the bacterium are provided. With the use of the recombinant bacteria of the present invention, the direct fermentative biosynthesis of amikacin and tobramycin as semi-synthetic kanamycins is possible, and the yield of kanamycin B as a precursor of the semi-synthetic kanamycin is improved.

56. 发明申请

US20160331708A1 MEANS AND METHODS FOR INCREASING ANTIBIOTIC ACTIVITY 审中-公开
标题翻译：增加抗生素活性的手段和方法
公开(公告)号：US20160331708A1
公开(公告)日：2016-11-17
申请号：US15110936
申请日：2015-01-09
申请人： UNIVERSITEIT LEIDEN
发明人： Hye Kyong Kim , Anne van der Meij , Robert Verpoorte , Young Hae Choi , Gilles Philippus van Wezel
IPC分类号： A61K31/196 , A61K31/7036 , A61K31/165 , A61K31/7056 , A61K31/43 , A61K31/545 , A61K38/14 , A61K38/08 , A61K31/496 , C12P19/54 , C12P19/52 , C12P19/48 , C12P13/02 , C12P37/00 , A61K35/74
CPC分类号： A61K31/196 , A61K31/00 , A61K31/165 , A61K31/43 , A61K31/496 , A61K31/545 , A61K31/7036 , A61K31/7056 , A61K35/74 , A61K38/08 , A61K38/14 , C12P13/02 , C12P19/485 , C12P19/52 , C12P19/54 , C12P37/00 , A61K2300/00
摘要： The disclosure provides means and methods for increasing the activity of antibiotics. This enables the use of lower antibiotic dosages and the treatment of multidrug-resistant bacteria.
摘要翻译：本公开提供了增加抗生素活性的方法和方法。这使得能够使用较低的抗生素剂量和多药耐药性细菌的治疗。

57. 发明申请

US20130096078A1 NEW KANAMYCIN COMPOUND, KANAMYCIN-PRODUCING STREPTOMYCES SPECIES BACTERIUM, AND METHOD OF PRODUCING KANAMYCIN 有权
标题翻译：新的卡那霉素化合物，卡那霉素生产型菌体细菌和生产卡那霉素的方法
公开(公告)号：US20130096078A1
公开(公告)日：2013-04-18
申请号：US13642842
申请日：2010-10-14
申请人： Yeo Joon Yoon , Sung Ryeol Park , Je Won Park , Jae Kyung Sohng
发明人： Yeo Joon Yoon , Sung Ryeol Park , Je Won Park , Jae Kyung Sohng
IPC分类号： C12P19/48
CPC分类号： C12P19/485 , A61K31/351 , A61K31/7036 , C07H15/22 , C07H15/234 , C12N15/52 , C12N15/76 , C12R1/61 , Y02A50/473
摘要： Vectors expressing kanA-kanB-kanK and other kanamycin production-related genes, Streptomyces species recombinant bacteria transformed with the vectors, a method of producing kanamycin antibiotics by the bacteria, and a new kanamycin compound produced by the bacterium are provided. With the use of the recombinant bacteria of the present invention, the direct fermentative biosynthesis of amikacin and tobramycin as semi-synthetic kanamycins is possible, and the yield of kanamycin B as a precursor of the semi-synthetic kanamycin is improved.
摘要翻译：提供了表达kanA-kanB-kanK和其他卡那霉素生产相关基因的载体，用载体转化的链霉菌属重组细菌，细菌产生卡那霉素抗生素的方法和由细菌产生的新的卡那霉素化合物。通过使用本发明的重组细菌，可以直接发酵生物合成作为半合成的卡那霉素的阿米卡星和妥布霉素作为半合成卡那霉素的前体的卡那霉素B的产率。

58. 发明授权

US5814488A Semisynthetic 1-N-ethylgentamicin C.sub.1a and method for its preparation 失效
标题翻译：半合成1-N-乙基酪氨酸C1a及其制备方法
公开(公告)号：US5814488A
公开(公告)日：1998-09-29
申请号：US537784
申请日：1996-01-05
申请人： Min Zhao , Jin Fan , Jun Liu , Xiaoling Hu , Minqi Fan
发明人： Min Zhao , Jin Fan , Jun Liu , Xiaoling Hu , Minqi Fan
IPC分类号： C12P19/26 , A61K31/7036 , C07H15/22 , C07H17/04 , C12N1/20 , C12P19/28 , C12P19/48 , C12R1/29
CPC分类号： C12P19/28
摘要： This invention relates to the fields of microbiology and antibiotics. Particularly, it relates to a new mutant strain, a method of its mutation breeding, to a monocomponent Gentamicin C.sub.1a produced by this strain which is used as mother nucleus of semisynthetic antibiotic 1-N-ethylgentamicin C.sub.1a, and to compositions composed of semisynthetic 1-N-ethylgentamicin derivatives as active component and pharmaceutically acceptable accitives and their manufacturing methods.
摘要翻译： PCT No.PCT / CN94 / 00029 Sec。 371日期1996年1月5日 102（e）日期1996年1月5日PCT 1994年4月23日PCT公布。出版物WO94 / 25566 日期1994年11月10日本发明涉及微生物学和抗生素领域。特别涉及一种新突变菌株，其突变育种方法，由该菌株产生的单组分庆大霉素C1a，其用作半合成抗生素1-N-乙基链霉胺C1a的母核，以及由半合成1- 作为活性成分的N-乙基链霉素衍生物和药学上可接受的指控及其制造方法。

59. 发明授权

US4515942A Antibiotics KA-6606 XII, XIII, XV, XVI and XVII 失效
标题翻译：抗生素KA-6606 XII，XIII，XV，XVI和XVII
公开(公告)号：US4515942A
公开(公告)日：1985-05-07
申请号：US541291
申请日：1983-10-11
申请人： Akio Iwasaki , Takeo Deushi , Isamu Watanabe , Toshihito Mori
发明人： Akio Iwasaki , Takeo Deushi , Isamu Watanabe , Toshihito Mori
IPC分类号： C07H15/224 , C12P19/48 , C07H15/22
CPC分类号： C07H15/224 , C12P19/48 , C12R1/01 , Y10S435/822
摘要： A process for producing an antibiotic, which comprises cultivating an antibiotic KA-6606-producing strain of the genus Saccharopolyspora in a nutrient culture medium, isolating an antibiotic KA-6606-containing substance from the culture broth, and separating from the resulting antibiotic KA-6606-containing substance at least one antibiotic selected from the group consisting of antibiotic KA-6606 VII, KA-6606 VIII, KA-6606 IX, KA-6606 X, KA-6606 XI, KA-6606 XII, KA-6606 XIII, KA-6606 XIV, KA-6606 XV, KA-6606 XVI and KA-6606 XVII; and novel antibiotics KA-6606 XII, XIII and XV to XVII.

60. 发明授权

US4489693A Air-fuel ratio control system 失效
标题翻译：空燃比控制系统
公开(公告)号：US4489693A
公开(公告)日：1984-12-25
申请号：US550078
申请日：1983-11-09
申请人： Takeshi Matsuzaki
发明人： Takeshi Matsuzaki
IPC分类号： C12P19/48 , F02D41/14 , F02M3/09 , F02M7/24 , F02M11/02 , F02M7/00
CPC分类号： F02M3/09 , C12P19/48 , F02D41/1489 , F02M11/02 , F02M7/24 , F02D41/1456
摘要： A system for controlling the air-fuel ratio of an air-fuel mixture for an internal combustion engine having a two-barrel carburetor. The system is provided with an O.sub.2 sensor for detecting the concentration of oxygen in the exhaust gases, an on-off electromagnetic valve for correcting the air-fuel ratio of the air-fuel mixture supplied by the carburetor and an electronic control circuit. The electronic control circuit operates to compare output signals of the detector with a stoichiometric value, and to produce driving pulses for driving the on-off electromagnetic valve and for controlling the air-fuel ratio to a value approximately equal to the stoichiometric air-fuel ratio. A fixed signal generating circuit is selectively connected to the electronic control circuit. The two-barrel carburetor has an actuator actuated by the vacuum at the venturi of the carburetor for opening a throttle valve of the secondary side of the carburetor. A first vacuum switch is provided to be operated in response to the vacuum in the intake passage and a second vacuum switch is provided to be operated by the vacuum in the secondary side of the carburetor. When one of vacuum switches is operated, the fixed signal generating circuit is connected to the electronic control circuit for providing a fixed duty ratio for the valve and renders the electronic control circuit non-responsive to the output of the O.sub.2 sensor.
摘要翻译：一种用于控制具有双桶化油器的内燃机的空气燃料混合物的空燃比的系统。该系统设置有用于检测排气中的氧浓度的O2传感器，用于校正由化油器供应的空气燃料混合物的空燃比的开关电磁阀和电子控制电路。电子控制电路用于将检测器的输出信号与化学计量值进行比较，并产生用于驱动开关电磁阀的驱动脉冲，并将空燃比控制为大致等于理论空燃比。固定信号发生电路选择性地连接到电子控制电路。双桶化油器具有由化油器的文丘里管处的真空致动的致动器，用于打开化油器次级侧的节流阀。提供第一真空开关以响应于进气通道中的真空而操作，并且第二真空开关设置成由化油器二次侧的真空操作。当操作真空开关之一时，固定信号发生电路连接到电子控制电路，为阀提供固定占空比，并使电子控制电路对O2传感器的输出无响应。

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