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51. 发明授权

US5283241A Benzo-fused lactams promote release of growth hormone 失效
标题翻译：苯并稠合内酰胺促进生长激素的释放
公开(公告)号：US5283241A
公开(公告)日：1994-02-01
申请号：US936975
申请日：1992-08-28
申请人： Richard J. Bochis , Matthew J. Wyvratt , William R. Schoen
发明人： Richard J. Bochis , Matthew J. Wyvratt , William R. Schoen
IPC分类号： A23K1/16 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/535 , A61K31/54 , A61K31/5415 , A61K31/55 , A61K31/554 , A61K31/66 , A61K38/00 , A61K38/04 , A61K38/25 , A61K38/27 , A61K38/28 , A61K38/29 , A61K38/30 , A61P3/00 , A61P3/04 , A61P5/00 , A61P43/00 , C07D209/40 , C07D223/16 , C07D225/06 , C07D265/36 , C07D267/14 , C07D267/22 , C07D279/16 , C07D281/10 , C07D285/38 , C07D401/12 , C07D403/12 , C07D453/02 , C07K5/06 , C07K5/065 , C07K5/078 , C07D209/34 , C07D215/227
CPC分类号： C07D223/16 , A23K20/132 , A23K20/137 , A61K38/25 , A61K38/28 , A61K38/29 , A61K38/30 , C07D281/10 , C07K5/06026 , C07K5/06034 , C07K5/0606 , C07K5/06069 , C07K5/06078 , C07K5/06147 , C07K5/06156
摘要： There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. The compounds are prepared by substitution of an amino-lactam with a substituted amide function. Growth promoting compositions containing such benzo-fused lactams as the active ingredient thereof are also disclosed. ##STR1## Where L is ##STR2##
摘要翻译：公开了确定为促进人和动物中生长激素释放的苯并稠合内酰胺的某些新化合物。该物质可用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人体中，增加受缺乏正常分泌天然生长激素影响的人的身高。通过用取代的酰胺官能团取代氨基 - 内酰胺来制备化合物。还公开了含有这样的苯并稠合内酰胺作为其活性成分的生长促进组合物。（*化学结构*）其中L为（*化学结构*）

52. 发明授权

US5242912A Cyclic anthranilic acid derivatives and process of preparing the same 失效
标题翻译：环丙磺酸衍生物及其制备方法
公开(公告)号：US5242912A
公开(公告)日：1993-09-07
申请号：US674343
申请日：1991-04-25
申请人： Mitsutomo Miyashita , Yasushi Kohno , Eisuke Kojima , Koji Saito
发明人： Mitsutomo Miyashita , Yasushi Kohno , Eisuke Kojima , Koji Saito
IPC分类号： A61K31/395 , A61K31/47 , A61K31/55 , A61K31/554 , A61P3/00 , A61P29/00 , A61P37/00 , A61P43/00 , C07D209/08 , C07D215/48 , C07D223/16 , C07D225/06 , C07D267/14 , C07D267/22 , C07D279/16 , C07D281/10 , C07D281/18 , C07D498/06 , C07D513/06
CPC分类号： C07D223/16 , C07D209/08 , C07D279/16 , C07D281/10
摘要： The following cyclic anthranilic acid derivative, their acid addition salts or alkali salts thereof represented by a general formula [I] are useful for antirheumatic drug, autoimmune disease curing drug and metabolic bone disease curing drug. ##STR1## wherein R.sup.1 to R.sup.6 and X are as defined in claim 1.

53. 发明授权

US3914421A Pyridopyrrolobenzheterocycles for combatting depression 失效
标题翻译：吡啶并吡唑并杂环用于对抗抑郁症
公开(公告)号：US3914421A
公开(公告)日：1975-10-21
申请号：US35752873
申请日：1973-05-07
申请人： ENDO LAB
发明人： RAJAGOPALAN PARTHASARATHI
IPC分类号： C07D265/36 , C07D267/14 , C07D267/22 , C07D281/10 , C07D281/18 , C07D498/16 , C07D513/16 , A61K31/535
CPC分类号： C07D267/14 , C07D265/36 , C07D267/22 , C07D281/10 , C07D281/18
摘要： where X is O, S. S -> O, or SO2; n is 0 or 1; m is 0 or 1; the R''s are the same or different and are H or CH3, and one of them can be C2-C9 alkyl, phenyl, C7-C10 phenylalkyl, furyl, thienyl, pyridyl or substituted phenyl or phenylalkyl; when X is S, and m is 0, one R in the group -RCR- can be OCH3; when X is S and m is 1, the R in the group (CHR)mcan be OCH3; and R1is H, C1-C4 alkyl, C3-C5 alkenyl, C3-C5 alkynyl, C3-C6 cycloalkyl, C2-C4 alkoxycarbonyl, trifluoroacetyl, or substituted C1-C4 alkyl where the substituent is C3-C6 cycloalkyl, phenyl or substituted phenyl; and their pharmaceutically suitable salts. The compounds are useful as sedatives; some of them also exhibit antidepressant, antihypertensive and antibacterial activity. The compounds are prepared by cyclizing compounds of formula II

wherein R2 is R1 or acyl. The latter compounds are prepared by reacting 4-piperidones with compounds of formula III in the presence of a reducing agent

OR WITH COMPOUNDS OF FORMULA VI
摘要翻译：其中X是O，S.S-> O或SO2; n为0或1; m为0或1; 苯基，C7-C10苯基烷基，呋喃基，噻吩基，吡啶基或取代的苯基或苯基烷基;其中一个可以是C 2 -C 9烷基，苯基，当X为S且m为0时，基团-RCR-中的一个R可为OCH 3; 当X为S且m为1时，基团（CHR）中的R可以是OCH 3; 和R 1为H，C 1 -C 4烷基，C 3 -C 5烯基，C 3 -C 5炔基，C 3 -C 6环烷基，C 2 -C 4烷氧基羰基，三氟乙酰基或取代的C 1 -C 4烷基，其中取代基为C 3 -C 6环烷基，苯基或取代苯基 ; 及其药学上合适的盐。这些化合物可用作镇静剂; 其中一些还表现出抗抑郁，抗高血压和抗菌活性。

54. 发明授权

US3549621A 12-substituted-6h-dibenz(b,f)(1,4)oxazocin-11(12h) ones 失效
标题翻译： 12-取代-6H-二苯并（B，F）（1,4）氧化十一烷（12H）
公开(公告)号：US3549621A
公开(公告)日：1970-12-22
申请号：US3549621D
申请日：1968-04-29
申请人： HARRY LOUIS YALE , ERVIN RICHARD SPITZMILLER
发明人： YALE HARRY LOUIS , SPITZMILLER ERVIN RICHARD
IPC分类号： C07D267/22 , C07D87/54
CPC分类号： C07D267/22

55. 发明授权

US3441564A Novel benzoxazines,benzoxazepines and benzoxazocines 失效
标题翻译：新型苯并噻嗪，苯并吖辛因和苯甲酸
公开(公告)号：US3441564A
公开(公告)日：1969-04-29
申请号：US3441564D
申请日：1968-01-29
申请人： SQUIBB & SONS INC
发明人： KRAPCHO JOHN
IPC分类号： C07D265/36 , C07D267/14 , C07D267/22 , C07D281/10 , C07D87/54 , A61K27/00 , C07D87/38
CPC分类号： C07D267/22 , C07D265/36 , C07D267/14 , C07D281/10

56. 发明授权

US3150129A Phenthiazine derivatives and processes for their preparation 失效
标题翻译：苯噻嗪衍生物及其制备方法
公开(公告)号：US3150129A
公开(公告)日：1964-09-22
申请号：US18519562
申请日：1962-04-05
申请人： RHONE POULENC SA
发明人： MICHEL JACOB ROBERT , GEORGES ROBERT JACQUES
IPC分类号： C07D241/44 , C07D267/00 , C07D267/22 , C07D417/06
CPC分类号： C07D417/06 , C07D241/44 , C07D267/00 , C07D267/22

57. 发明授权

US3075976A Phenthiazine derivatives 失效
公开(公告)号：US3075976A
公开(公告)日：1963-01-29
申请号：US76779758
申请日：1958-10-17
申请人： RHONE POULENC SA
发明人： MICHEL JACOB ROBERT , GEORGES ROBERT JACQUES
IPC分类号： C07D241/44 , C07D267/00 , C07D267/22 , C07D417/06
CPC分类号： C07D417/06 , C07D241/44 , C07D267/00 , C07D267/22

58. 发明公开

US20230364108A1 NEFOPAM DOSAGE FORMS AND METHODS OF TREATMENT 审中-公开
公开(公告)号：US20230364108A1
公开(公告)日：2023-11-16
申请号：US18223581
申请日：2023-07-19
申请人： Shahin Fatholahi
发明人： Shahin Fatholahi
IPC分类号： A61K31/395 , C07D267/22 , A61K31/194 , A61K47/32 , A61K47/26
CPC分类号： A61K31/5545 , C07D267/22 , A61K31/194 , A61K47/32 , A61K47/26
摘要： Dosage forms containing nefopam, nefopam metabolite, nefopam prodrug, isomers thereof or combinations of the foregoing, optionally an acid, and optionally an opioid analgesic and/or NSAID, and associated methods for treating various types of pain in patients.

59. 发明授权

US10407418B2 Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors 有权
公开(公告)号：US10407418B2
公开(公告)日：2019-09-10
申请号：US16199489
申请日：2018-11-26
申请人： FORMA Therapeutics, Inc.
发明人： Xiaozhang Zheng , Pui Yee Ng , Aleksandra Rudnitskaya , David R. Lancia, Jr.
IPC分类号： C07D245/06 , C07D471/04 , C07D487/04 , C07D413/06 , C07D267/22
摘要： The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formulae I or Formula II: where R, L, X1, X2, X3, X4, X5, Y1, Y2, Y3, and Y4 are described herein.

60. 发明申请

US20190092762A1 BICYCLIC [4,6,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS 审中-公开
公开(公告)号：US20190092762A1
公开(公告)日：2019-03-28
申请号：US16199489
申请日：2018-11-26
申请人： FORMA Therapeutics, Inc.
发明人： Xiaozhang Zheng , Pui Yee Ng , Aleksandra Rudnitskaya , David R. Lancia, JR.
IPC分类号： C07D413/06 , C07D267/22
CPC分类号： C07D413/06 , C07D267/22
摘要： The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formulae I or Formula II: where R, L, X1, X2, X3, X4, X5, Y1, Y2, Y3, and Y4 are described herein.

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