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51. 发明授权

US5646302A Heterotrifunctional compounds for photoaffinity labelling 失效
标题翻译：用于光亲和标记的异双官能化合物
公开(公告)号：US5646302A
公开(公告)日：1997-07-08
申请号：US085719
申请日：1993-06-30
申请人： Richard Barner , Walter Huber , Josef Hubscher , Jurg Hurst , Daniel Schlatter
发明人： Richard Barner , Walter Huber , Josef Hubscher , Jurg Hurst , Daniel Schlatter
IPC分类号： C07C247/16 , C07C247/18 , C07D207/40 , C07D207/416 , C07D213/18 , C07K1/113 , C07K14/00 , C07K16/00 , C07K19/00 , G01N33/532 , C07D207/452
CPC分类号： C07D207/416 , C07C247/18 , G01N33/532
摘要： The invention is concerned with novel heterotrifunctional compounds which contain a chemically reactive group R, a photochemically reactive group Ar--N.sup.3 and a reductively cleavable S--S(X.sub.2)-group. The chemically reactive group and the photochemically reactive group are separated by a spacer group which contains a disulfide group. The water-solubilizing groups are carboxylic acids and sulfonic acids or derivatives thereof which are attached either to the aromatic ring or to the spacer group between the aromatic ring and the cleavable SS group. The compounds facilitate a novel photoaffinity method for the labelling of biomolecules, whereby the labelled biomolecule preserves its water solubility and the labelling molecule preferably projects free into the solution after anchorage to the surface of the biomolecule.
摘要翻译：本发明涉及含有化学反应性基团R，光化学反应性基团Ar-N 3和还原性可切割的S-S（X 2） - 基团的新型异三官能化合物。化学反应性基团和光化学反应性基团被含有二硫基的间隔基隔开。水溶性基团是羧酸和磺酸或其衍生物，其连接到芳香环或芳族环和可切割SS基团之间的间隔基。该化合物促进用于标记生物分子的新型光亲和方法，由此标记的生物分子保持其水溶性，并且标记分子优选在锚定到生物分子的表面之后自由地投入溶液中。

52. 发明授权

US5502206A Liquid-crystalline organosiloxanes containing chiral tartarimides 失效
标题翻译：含有手性葡萄糖苷的液晶有机硅氧烷
公开(公告)号：US5502206A
公开(公告)日：1996-03-26
申请号：US239780
申请日：1994-05-09
申请人： Ingo P. Zahn , Franz-Heinrich Kreuzer , Hans-Peter Weitzel
发明人： Ingo P. Zahn , Franz-Heinrich Kreuzer , Hans-Peter Weitzel
IPC分类号： C07D207/40 , C07D207/416 , C07F7/08 , C07F7/21 , C08G77/388 , C09K19/40 , G02F1/13
CPC分类号： C07D207/416 , C07F7/0847 , C07F7/21 , C08G77/388 , C09K19/406 , C09K19/408
摘要： The liquid-crystalline organosiloxanes containing, per molecule, at least one Si--C-bonded chiral tartarimide radical of the formula ##STR1## in which M, A.sup.5 and k are as defined in claim 1, can be employed as chiral filter materials, for decorative purposes and in optical elements.
摘要翻译：每分子含有式（1）的至少一个Si-C键合的手性酒石酸酰亚胺基团，其中M，A5和k如权利要求1中所定义的液晶有机硅氧烷可用作手性过滤器材料，装饰用途和光学元件。

53. 发明授权

US5489693A Cyclic imino derivatives, pharmaceutical compositions containing these compounds and processes preparing them 失效
标题翻译：环状亚氨基衍生物，含有这些化合物的药物组合物和制备它们的方法
公开(公告)号：US5489693A
公开(公告)日：1996-02-06
申请号：US52877
申请日：1993-04-26
申请人： Guenter Linz , Volkhard Austel , Frank Himmelsbach , Johannes Weisenberger , Thomas Mueller , Helmut Pieper , Elke Seewaldt-Becker
发明人： Guenter Linz , Volkhard Austel , Frank Himmelsbach , Johannes Weisenberger , Thomas Mueller , Helmut Pieper , Elke Seewaldt-Becker
IPC分类号： A61K31/40 , A61K31/4015 , A61K31/44 , A61K31/4427 , A61K31/495 , A61K31/505 , A61K31/535 , A61P7/02 , C07D207/24 , C07D207/26 , C07D207/36 , C07D207/38 , C07D207/40 , C07D207/416 , C07D401/04 , C07D403/04
CPC分类号： C07D207/26 , C07D207/38
摘要： Cyclic imino derivatives of the formula ##STR1## wherein X and R.sub.a to R.sub.g are as defined herein, useful for their inhibitory effects on aggregation, pharmaceutical compositions containing the compounds and processes for preparing them.
摘要翻译：其中X和R a至R g如本文所定义的式（I）的环亚胺衍生物可用于其对聚集的抑制作用，含有该化合物的药物组合物及其制备方法。

54. 发明授权

US5128120A Use of 9-anthrylalkyl compounds as derivatization reagents for separation and detection purposes 失效
标题翻译：使用9-蒽基烷基化合物作为分离和检测目的的衍生化试剂
公开(公告)号：US5128120A
公开(公告)日：1992-07-07
申请号：US650868
申请日：1991-02-05
申请人： Hans-Dieter Becker , Stefan Einarsson , Andrzej Grzegorczyk , Bjorn Josefsson , Stig S. Lagerkvist , Per L. Moller , Domingo Sanchez , Johan H. Sorensen
发明人： Hans-Dieter Becker , Stefan Einarsson , Andrzej Grzegorczyk , Bjorn Josefsson , Stig S. Lagerkvist , Per L. Moller , Domingo Sanchez , Johan H. Sorensen
IPC分类号： C07D207/16 , A61K49/00 , C07B57/00 , C07B63/02 , C07C33/18 , C07C67/00 , C07C69/96 , C07C201/00 , C07C205/43 , C07C227/40 , C07C229/36 , C07C241/00 , C07C247/20 , C07C247/22 , C07C281/02 , C07D207/404 , C07D207/416 , C07D255/02
CPC分类号： C07C69/96 , C07C227/34 , C07C33/18 , C07C2103/24 , Y10S435/968 , Y10T436/142222 , Y10T436/143333 , Y10T436/173845 , Y10T436/203332 , Y10T436/204998
摘要： New 9-anthrylalkyl compounds having the general formula ##STR1## wherein R is hydrogen or an alkyl group, whereby, however, not more than one of the groups R is an alkyl group; R.sub.1 is hydrogen, lower alkyl, halogen or nitro; n is an integer of from 1 to 7, whereby, however, the total number of carbon atoms in the group --CHR--(CHR).sub.n -- does not exceed 8; and X is halogen, an azide group or a succinimidyl group.The new compounds are prepared from 9-anthrylalcohols which are reacted with a compound X--CO--X wherein X is a halogen, and then optionally with compounds giving azide or succinimidyl group. The compounds are used as derivatization reagents for separation and detection purposes.Intermediates for preparation of the above defined 9-anthrylalkyl compounds wherein one R is an alkyl group are 9-anthrylalcohols with the group --CHR--(CHR).sub.n --OH, wherein one R is an alkyl group.
摘要翻译：具有通式“IMAGE”的新的9-蒽基烷基化合物，其中R是氢或烷基，其中R不多于一个是烷基; R1是氢，低级烷基，卤素或硝基; n为1〜7的整数，但-CHR-（CHR）n-基团中的碳原子总数不超过8; X为卤素，叠氮基或琥珀酰亚胺基。新化合物由与蒽化合物X-CO-X反应的9-蒽醇制备，其中X为卤素，然后任选与化合物反应，得到叠氮化物或琥珀酰亚胺基。该化合物用作分离和检测目的的衍生试剂。制备其中一个R为烷基的上述定义的9-蒽基烷基化合物的中间体是具有基团-CHR-（CHR）n -OH的9-蒽基，其中一个R为烷基。

55. 发明授权

US4970323A Preparation process of N-substituted monochlorosuccinimides 失效
标题翻译： N-取代的一氯代琥珀酰亚胺的制备方法
公开(公告)号：US4970323A
公开(公告)日：1990-11-13
申请号：US370211
申请日：1989-06-22
申请人： Mihaya Matsukawa , Masaru Wada , Hiroshi Suizu , Masayuki Furuya , Teruyuki Nagata
发明人： Mihaya Matsukawa , Masaru Wada , Hiroshi Suizu , Masayuki Furuya , Teruyuki Nagata
IPC分类号： C07D207/10 , C07D207/40 , C07D207/416
CPC分类号： C07D207/416
摘要： N-substituted monochlorosuccinimides e.g., N-phenylmonochlorosuccinimide, can be prepared in a high yield by reacting a maleamic acid, e.g., N-phenylmaleamic acid, with phosgene in the presence of a catalyst, e.g., dimethylformamide.

56. 发明授权

US4873344A Cyano containing indene derivatives 失效
标题翻译：含氰基的茚衍生物
公开(公告)号：US4873344A
公开(公告)日：1989-10-10
申请号：US124820
申请日：1987-11-24
申请人： Klaus P. Bogeso , Michael B. Sommer
发明人： Klaus P. Bogeso , Michael B. Sommer
IPC分类号： C07C255/47 , C07C45/65 , C07C45/67 , C07C49/617 , C07C49/67 , C07C49/693 , C07C49/697 , C07C49/755 , C07C62/38 , C07C67/00 , C07C253/00 , C07C253/30 , C07C255/45 , C07C255/58 , C07C311/37 , C07C315/04 , C07C317/14 , C07C317/48 , C07C319/20 , C07C323/38 , C07C323/63 , C07D207/32 , C07D207/337 , C07D207/416 , C07D213/57 , C07D317/06 , C07D317/60 , C07D333/24
CPC分类号： C07D207/337 , C07C255/00 , C07C45/676 , C07C49/697 , C07C62/38 , C07D213/57 , C07D317/60 , C07D333/24
摘要： The present invention relates to novel indene derivatives with the general formula I: ##STR1## wherein R.sup.1 is (a) a phenyl group optionally substituted with one or two groups selected from halogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfonyl, dilower alkylamino, acylamino such as acetylamino, cyano, trifluoromethyl, trifluoromethoxy, pyrrole and dilower alkylpyrrole,(b) a polycyclic aromatic or heteroaromatic group, such as naphthalene or quinoline,(c) a heteroaromatic group such as thiophene, pyridine, and pyrrole, optionally substituted with one or more groups selected from halogen, lower alkyl, lower alkoxy, lower alkylthio, trifluoromethyl or trifluoromethoxy,R.sub.2 is selected from H, halogen, lower alkyl, benzyl, lower alkylthio, methoxy, lower alkylsulfonyl, dilower alkylsulfamoyl, acylamino such as acetylamino, benzylamino, dilower alkylamino, cyano, pyrrole, dilower alkylpyrrole, trifluoromethyl and trifluoromethoxy,R.sup.3 is CN, COOR.sup.4, --CON(R.sup.4).sub.2 or COR.sup.4, where R.sup.4 is a lower alkyl group, and "n" is an integer of from 1-3 inclusive.The indene derivatives of formula I are, when R.sup.1 is as defined under (a) above, valuable intermediates which are useful in the preparation of pharmacologically effective indane and indene derivatives known from e.g. U.S. Pat. Nos. 4,443,448 and 4,525,360.Moreover, the invention relates to a method for the preparation of the compounds of formula I and to a method for the preparation of compounds of the following formula IV: ##STR2## wherein R.sup.1, R.sup.2 and "n" are as defined above.
摘要翻译：本发明涉及具有通式I的新颖的茚衍生物：其中R 1是（a）任选被一个或两个选自卤素，低级烷基，低级烷氧基，低级烷硫基，低级烷基磺酰基，二氯烷基氨基，酰氨基如乙酰氨基，氰基，三氟甲基，三氟甲氧基，吡咯和二烯烷基吡咯，（b）多环芳族或杂芳族基团如萘或喹啉，（c）杂芳基如噻吩，吡啶和吡咯，任选被一个或多个选自卤素，低级烷基，低级烷氧基，低级烷硫基，三氟甲基或三氟甲氧基的基团取代，R 2选自H，卤素，低级烷基，苄基，低级烷硫基，甲氧基，低级烷基磺酰基，二低级烷基氨磺酰基，作为乙酰氨基，苄氨基，二元烷基氨基，氰基，吡咯，二元烷基吡咯，三氟甲基和三氟甲氧基，R3是CN，COOR4，-CON（R4）2或COR4，其中 R4是低级烷基，“n”是1-3的整数。当R1如上述（a）中所定义时，式I的茚衍生物是有用的中间体，它们可用于制备药物学有效的二氢化茚和茚衍生物，其从例如，美国专利第4,443,448号和第4,525,360号。此外，本发明涉及制备式I化合物的方法和制备下式IV化合物的方法：其中R 1，R 2和“n”如上所定义。

57. 发明授权

US4822886A Cyclic N-hydroxyimides 失效
标题翻译：环状N-羟基酰亚胺
公开(公告)号：US4822886A
公开(公告)日：1989-04-18
申请号：US84239
申请日：1987-08-12
申请人： Stephen F. Donovan
发明人： Stephen F. Donovan
IPC分类号： C07D207/46 , C07D211/94 , C11D3/28 , C07D207/416
CPC分类号： C11D3/28 , C07D207/46 , C07D211/94
摘要： Cyclic N-hydroxyimide compounds are disclosed which show strong metal ion chelating properties and are useful as detergent additives. Detergent compositions containing the N-hydroxyimides improve the stain removing effectiveness of detergents and are biodegradable.
摘要翻译：公开了环状N-羟基酰亚胺化合物，其显示出强的金属离子螯合性质并且可用作洗涤剂添加剂。含有N-羟基酰亚胺的洗涤剂组合物可提高洗涤剂的去污效果，并且是可生物降解的。

58. 发明授权

US4668795A Process for the production of optically active 1-benzyl-3,4-bis-(diphenylphosphino)-pyrrolidine 失效
标题翻译：制备光学活性1-苄基-3,4-二 - （二苯基膦基） - 吡咯烷的方法
公开(公告)号：US4668795A
公开(公告)日：1987-05-26
申请号：US804470
申请日：1985-12-04
申请人： Juan G. Andrade , G/u/ nter Prescher , Ulrich Nagel
发明人： Juan G. Andrade , G/u/ nter Prescher , Ulrich Nagel
IPC分类号： B01J31/18 , C07D207/12 , C07D207/40 , C07D207/416 , C07F9/572 , C07F9/65
CPC分类号： C07F9/5726 , B01J31/181 , C07D207/12 , C07D207/416 , B01J2231/641 , B01J2531/822
摘要： Optically active 1-benzyl-3,4-bis-(diphenylphosphino)-pyrrolidine is produced in a three-step process from optically active 1-benzyl-2,5-dioxo-3,4-dihydroxy-pyrrolidine. The product is useful as a chiral ligand in rhodium complexes which serve as catalysts for the homogeneous asymmetric hydrogenation of prochiral substrates.
摘要翻译：光学活性1-苄基-3,4-双 - （二苯基膦基） - 吡咯烷是由光学活性的1-苄基-2,5-二氧代-3,4-二羟基 - 吡咯烷的三步法生产的。该产物可用作铑配合物中的手性配体，其用作前置手性底物的均相不对称氢化的催化剂。

59. 发明授权

US4424345A 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process 失效
标题翻译： 4-O-取代-2-脱氧神经氨酸糖苷的1-N-酰化和1-N-烷基化衍生物和方法
公开(公告)号：US4424345A
公开(公告)日：1984-01-03
申请号：US304291
申请日：1981-09-21
申请人： Herbert A. Kirst , Brenda A. Truedell
发明人： Herbert A. Kirst , Brenda A. Truedell
IPC分类号： C07D207/40 , C07D207/416 , C07H15/22 , C07H15/224
CPC分类号： C07D207/416 , C07H15/22 , C07H15/224
摘要： Zinc salts are used to effect the regio-selective acylation and alkylation of the 1-amino group of 4-O-substituted-2-deoxystreptamine-containing aminoglycosides. The 1-N-substituted derivatives of apramycin, 3'-hydroxyapramycin, certain .alpha. or .beta.-(lower alkyl)aprosaminides and certain .alpha. or .beta.-(substituted lower alkyl)-aprosaminides are new. The 1-N-substituted-4-O-substituted-2-deoxystreptamine aminoglycosides produced by the process of this invention are antibacterial agents.
摘要翻译：锌盐用于实现4-O-取代-2-脱氧神经丝氨酸糖苷的1-氨基的区域选择性酰化和烷基化。阿普霉素，3'-羟基普拉霉素，某些α或β-（低级烷基）异氰脲酸酯和某些α或β-（取代的低级烷基） - 二酰胺的1-N-取代衍生物是新的。通过本发明方法制备的1-N-取代-4-O-取代-2-脱氧链霉胺氨基糖苷类是抗菌剂。

60. 发明授权

US4422856A N-Substituted succinimides, their preparation and use as motor fuel additives 失效
标题翻译： N-取代的琥珀酰亚胺，其制备和用作汽油添加剂
公开(公告)号：US4422856A
公开(公告)日：1983-12-27
申请号：US234134
申请日：1981-02-13
申请人： Paul Maldonado , Choua Cohen , Bernard Sillion
发明人： Paul Maldonado , Choua Cohen , Bernard Sillion
IPC分类号： C07D207/40 , C07D207/416 , C08G65/32 , C08G65/332 , C08G65/333 , C10L1/22 , C10L1/224
CPC分类号： C07D207/416 , C08G65/3324 , C08G65/33306 , C10L1/224
摘要： N-substituted succinimides are obtained by reacting in a first stage, maleic anhydride with an oxyalkylated or polyoxyalkylated monoalcohol of formulaR.sup.1 --O--A.sub.n OHwherein R.sup.1 is an aliphatic radical having from 12 to 25 carbon atoms, A is an alkylene radical having 2 to 4 carbon atoms and n is an integer from 1 to 50, and by further reacting the reaction product of the first stage either with a monoprimary amine of formulaR.sup.2 --X--Z.sub.m NH.sub.2or a bi-primary amine of the formulaH.sub.2 N--Z--NH.sub.p H,wherein R.sup.2 is an aliphatic radical having from 8 to 25 carbon atoms, Z is an alkylene radical having from 2 to 4 carbon atoms, X is --NH-- or --O--, m is an integer from 0 to 4 and p an integer from 2 to 6.The resultant succinimides are useful as anti-rust and detergent additives for motor fuels.
摘要翻译： N-取代的琥珀酰亚胺通过在第一阶段中与马来酸酐与式R 1 -O-OH的烷氧基化或聚氧化烷基化的一元醇反应来获得，其中R1是具有12-25个碳原子的脂族基团，A是具有2个至4个碳原子，n是1至50的整数，并且通过使第一阶段的反应产物与式R2-X-Zm NH2的单原子胺或式H2N-Z的双伯胺进一步反应 -NHp H，其中R2是具有8至25个碳原子的脂族基团，Z是具有2至4个碳原子的亚烷基，X是-NH-或-O-，m是0-4的整数，以及 p为2至6的整数。所得琥珀酰亚胺可用作汽车燃料的防锈和洗涤剂添加剂。

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