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51. 发明申请

US20110207149A1 METHODS AND COMPOSITIONS FOR RISK STRATIFICATION 有权
公开(公告)号：US20110207149A1
公开(公告)日：2011-08-25
申请号：US13098912
申请日：2011-05-02
申请人： Omar D. Perez , Garry P. Nolan , Jonathan M. Irish
发明人： Omar D. Perez , Garry P. Nolan , Jonathan M. Irish
IPC分类号： G01N33/53 , G01N33/573 , C12Q1/02
CPC分类号： G01N33/5094 , C12Q1/485 , G01N15/1456 , G01N33/5041 , G01N33/5047 , G01N33/5091 , G01N33/537 , G01N33/54313 , G01N33/56966 , Y10S435/973 , Y10T436/101666 , Y10T436/107497 , Y10T436/13 , Y10T436/25
摘要： The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.

52. 发明申请

US20110120368A1 METHOD AND DEVICE FOR DISPERSING DRY POWDERS 有权
标题翻译：用于分散干粉的方法和装置
公开(公告)号：US20110120368A1
公开(公告)日：2011-05-26
申请号：US12975113
申请日：2010-12-21
申请人： Vincent Chapeau , Christian Godino
发明人： Vincent Chapeau , Christian Godino
IPC分类号： B05B13/00 , B05B15/12
CPC分类号： G01N1/2813 , G01N1/286 , Y10T436/13 , Y10T436/25
摘要： A device for dispersing a sample of dry powder onto a surface in a dispersion chamber. The device includes a dispersion chamber situated in an environment, and a pressure source that provides a pressure difference between the environment and an inside of the dispersion chamber. The surface is positioned in the dispersion chamber. The sample of dry powder is introduced into the dispersion chamber through a membrane that is interposed between the environment and the inside of the dispersion chamber and on which the sample is disposed. The membrane is rupturable so as to open into the dispersion chamber when a predetermined pressure difference across the membrane is exceeded. This permits entry of a fluid in the environment through the ruptured membrane, and movement of the dry powder sample in an evenly dispersed manner without producing an ordered movement of powder grains in the dispersion chamber.
摘要翻译：用于将干粉样品分散到分散室中的表面上的装置。该装置包括位于环境中的分散室，以及在环境和分散室的内部之间提供压力差的压力源。表面位于分散室中。将干粉样品通过介于环境和分散室内部的隔膜引入到分散室中，并将样品置于其上。当膜超过预定的压力差时，膜是可破裂的，以便进入分散室。这允许流体在环境中通过破裂的膜进入，并且以均匀分散的方式移动干粉样品，而不会在分散室中产生粉末颗粒的有序移动。

53. 发明授权

US07932091B2 Colorant tracer for cooling water treatment formulations 有权
标题翻译：着色剂示踪剂用于冷却水处理配方
公开(公告)号：US07932091B2
公开(公告)日：2011-04-26
申请号：US11700643
申请日：2007-01-31
申请人： Timothy Keister
发明人： Timothy Keister
IPC分类号： G01N35/08 , G01N21/00
CPC分类号： G01N21/31 , C02F1/50 , C02F5/08 , C02F5/125 , C02F5/145 , C02F2103/023 , C02F2303/08 , G01N21/85 , Y10T436/12 , Y10T436/13
摘要： Water-based colorant traced formulations (products) containing one or more water treatment agents, such as phosphonates, polyacrylic acids and/or polymers, co-polymers, terpolymers thereof, azoles, molybdate, polysilicates, phosphates, zinc, polyphosphates, etc., are provided wherein the water-soluble colorant is detectable in the visible light range of about 580-640 nm and is chemically inert relative to the water treatment agent(s). Measurement of an optical property of the colorant in the treated coolant water permits the concentration of the product therein to be ascertained, and the level of the product containing can be adjusted for controlling scale, corrosion, deposition, and/or microbial activity in commercial and/or industrial cooling water systems. These products may be reliably monitored and dosed to maintain a product level in treated water of 5 to 500 mg/L.
摘要翻译：含有一种或多种水处理剂的水性着色剂追踪配方（产品），例如膦酸盐，聚丙烯酸和/或聚合物，共聚物，其三元共聚物，唑类，钼酸盐，聚硅酸盐，磷酸盐，锌，聚磷酸盐等，其中所述水溶性着色剂在约580-640nm的可见光范围内是可检测的并且相对于水处理剂是化学惰性的。在处理过的冷却水中测量着色剂的光学性能可以确定其中产品的浓度，并且可以调节含有产品的含量以控制商业和商业中的污垢，腐蚀，沉积和/或微生物活性 /或工业冷却水系统。这些产品可以可靠地监测和剂量以维持处理水中的产品水平为5至500mg / L。

54. 发明授权

US07927808B2 Polynucleotides for use as tags and tag complements, manufacture and use thereof 有权
公开(公告)号：US07927808B2
公开(公告)日：2011-04-19
申请号：US12912834
申请日：2010-10-27
申请人： Petr Pancoska , Vit Janota , Albert S. Benight , Richard S. Bullock , Peter V. Riccelli , Daniel Kobler , Daniel Fieldhouse
发明人： Petr Pancoska , Vit Janota , Albert S. Benight , Richard S. Bullock , Peter V. Riccelli , Daniel Kobler , Daniel Fieldhouse
IPC分类号： C12Q1/68 , C07H21/04 , C12N15/11
CPC分类号： C12Q1/6876 , C12Q1/6855 , Y10T436/13 , Y10T436/143333
摘要： A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.

55. 发明申请

US20110076711A1 PHOTON REDUCING AGENTS FOR FLUORESCENCE ASSAYS 有权
标题翻译：用于荧光测定的光子还原剂
公开(公告)号：US20110076711A1
公开(公告)日：2011-03-31
申请号：US12861791
申请日：2010-08-23
申请人： Tom KNAPP , Gregor Zlokarnik , Paul Negulescu , Roger Y. Tsien , Timothy James Rink
发明人： Tom KNAPP , Gregor Zlokarnik , Paul Negulescu , Roger Y. Tsien , Timothy James Rink
IPC分类号： C12Q1/02
CPC分类号： G01N33/582 , C12Q1/682 , G01N33/5005 , G01N33/542 , Y10S436/80 , Y10S436/809 , Y10T436/13 , C12Q2563/107 , C12Q2527/125
摘要： The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon reducing agents). The present invention further provides a method for reducing undesirable light emission from a sample (e.g., a biochemical or cellular sample) with at least one photon producing agent and at least one collisional quencher. The present invention also provides a method for reducing undesirable light emission from a sample (e.g., a biochemical or cellular sample) with at least one photon producing agent and at least one quencher, such as an electronic quencher. The present invention also provides a system and method of screening test chemicals in fluorescent assays using photon reducing agents. The present invention also provides compositions, pharmaceutical compositions, and kits for practicing these methods.
摘要翻译：本发明提供一种使用至少一种光子产生剂和至少一种光子还原剂（例如基于染料的光子还原剂）来减少来自样品的不希望的光发射的方法。本发明进一步提供了用至少一种光子产生剂和至少一种碰撞猝灭剂减少来自样品（例如生物化学或细胞样品）的不希望的光发射的方法。本发明还提供了用至少一种光子产生剂和至少一种猝灭剂（例如电子猝灭剂）减少来自样品（例如，生物化学或细胞样品）的不希望的光发射的方法。本发明还提供了使用光子还原剂在荧光测定中筛选测试化学品的系统和方法。本发明还提供了用于实施这些方法的组合物，药物组合物和试剂盒。

56. 发明授权

US07910371B2 Method of monitoring treating agent residuals in water treatment processes 有权
标题翻译：在水处理过程中监测处理剂残留物的方法
公开(公告)号：US07910371B2
公开(公告)日：2011-03-22
申请号：US11038718
申请日：2005-01-20
申请人： Brian S. Johnson
发明人： Brian S. Johnson
IPC分类号： G01N33/52
CPC分类号： C02F1/5209 , C02F1/44 , C02F1/441 , C02F1/56 , C02F2209/003 , G01N21/643 , Y10T436/12 , Y10T436/13
摘要： A method of monitoring residual treating agent in treated water wherein fluorescent tracers are used to determine the concentration of treating agent in the water at two different treating agent dosages and the difference in the measured concentrations of the fluorescent tracer at the respective doses are correlated with the residual concentration of the treating agent. The fluorescence response at the different treating agent dosages is used to determine whether the system is overdosed or underdosed on a continuous basis and to control treating agent dose accordingly.
摘要翻译：一种在处理水中监测残留处理剂的方法，其中荧光示踪剂用于以两种不同的处理剂剂量测定水中处理剂的浓度，并且在各剂量下测量的荧光示踪剂浓度的差异与处理剂的残留浓度。使用不同处理剂剂量下的荧光响应来确定系统是否连续过量或过量给药并相应地控制治疗剂剂量。

57. 发明授权

US07908937B2 Method to detect and characterize contaminants in pipes and ducts with interactive tracers 有权
标题翻译：用交互式示踪剂检测和表征管道和管道中污染物的方法
公开(公告)号：US07908937B2
公开(公告)日：2011-03-22
申请号：US12145458
申请日：2008-06-24
申请人： Wesley L. Bratton , Joseph W. Maresca, Jr.
发明人： Wesley L. Bratton , Joseph W. Maresca, Jr.
IPC分类号： G01M19/00 , G01N37/00
CPC分类号： F17D5/00 , Y10T137/8359 , Y10T436/117497 , Y10T436/13
摘要： A method and an apparatus for detecting, locating, and quantifying contamination in a fluid flow system like a pipe or duct. This characterization technique uses a conservative and one or more interactive tracers that are injected into the fluid flow system and then monitored at another location in the system. Detection, location, and quantification are accomplished by analysis of the characteristic features of measured curves of tracer concentration.
摘要翻译：用于检测，定位和定量流体流动系统（如管道或管道）中的污染物的方法和装置。该表征技术使用保守和一个或多个交互式示踪剂，其被注入到流体流动系统中，然后在系统中的另一个位置进行监测。通过分析示踪剂浓度的测量曲线的特征来实现检测，定位和定量。

58. 发明授权

US07893220B2 Busulfan immunoassay 有权
标题翻译：白念兰免疫测定
公开(公告)号：US07893220B2
公开(公告)日：2011-02-22
申请号：US12170355
申请日：2008-07-09
申请人： Salvatore J. Salamone , Jodi Blake Courtney , Shu He
发明人： Salvatore J. Salamone , Jodi Blake Courtney , Shu He
IPC分类号： C07K16/00 , C07K1/10 , C07K1/04 , G01N33/532
CPC分类号： G01N33/5308 , C07C311/06 , C07D207/46 , C07K16/44 , G01N33/94 , Y10S435/81 , Y10S435/961 , Y10S436/815 , Y10S530/807 , Y10T436/13
摘要： Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological fluids.
摘要翻译：来自白消安的α-取代衍生物的白消安和新的白消安免疫原的新型缀合物和由这些白消安结合的免疫原产生的抗体在免疫测定中是有用的，用于定量和监测生物流体中的白消安。

59. 发明申请

US20110039728A1 Polynucleotides for Use as Tags and Tag Complements, Manufacture and Use Thereof 有权
标题翻译：用作标签和标签的多核苷酸，其制造和使用
公开(公告)号：US20110039728A1
公开(公告)日：2011-02-17
申请号：US12912834
申请日：2010-10-27
申请人： PETR PANCOSKA , VIT JANOTA , ALBERT S. BENIGHT , RICHARD S. BULLOCK , PETER V. RICCELLI , DANIEL KOBLER , DANIEL FIELDHOUSE
发明人： PETR PANCOSKA , VIT JANOTA , ALBERT S. BENIGHT , RICHARD S. BULLOCK , PETER V. RICCELLI , DANIEL KOBLER , DANIEL FIELDHOUSE
IPC分类号： C40B30/04 , C07H21/04 , C40B40/06 , G01N33/50
CPC分类号： C12Q1/6876 , C12Q1/6855 , Y10T436/13 , Y10T436/143333
摘要： A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
摘要翻译：最小交叉杂交核苷酸序列家族，使用方法等。描述了一个特定的210-24个家族。

60. 发明授权

US07858399B2 Synthesis and application of procainamide analogs for use in an immunoassay 失效
标题翻译：普鲁卡因酰胺类似物的合成和应用用于免疫测定
公开(公告)号：US07858399B2
公开(公告)日：2010-12-28
申请号：US11846327
申请日：2007-08-28
申请人： Victor P. Chu , Zhu Teng , Steve P. A. Goss , Ronald A. Edwards , Kelle M. Garvey , Timothy J. Gorzynski , William D. Bedzyk
发明人： Victor P. Chu , Zhu Teng , Steve P. A. Goss , Ronald A. Edwards , Kelle M. Garvey , Timothy J. Gorzynski , William D. Bedzyk
IPC分类号： G01N33/546 , G01N33/543 , C07C237/28
CPC分类号： C07C237/34 , C07B2200/11 , C07C231/02 , Y10S436/815 , Y10T436/13
摘要： The present invention relates to immobilized procainamide analogs, as well as to a method of making immobilized procainamide analogs. These immobilized analogs are prepared by activating the carboxyl group on a substituted p-benzoic acid derivative toward nucleophilic attack; reacting the activated benzoic acid derivative with a polyamine to produce the benzoic acid derivative of Formula 3: and binding the benzoic acid derivative of Formula 3 to a latex polymer having functional groups that react with aliphatic amino groups. A method of conducting an immunoassay using the immobilized procainamide analog Formula 3 is described, comprising the steps of preparing a solution comprising said immobilized procainamide analog; adding a sample suspected of containing procainamide to said solution; adding an anti-procainamide antibody to said solution and observing the rate of increase in solution turbidity following antibody addition.
摘要翻译：本发明涉及固定化的普鲁卡因酰胺类似物，以及制备固定的普鲁卡酰胺类似物的方法。这些固定化的类似物通过将取代的对苯甲酸衍生物上的羧基活化成亲核攻击来制备; 使活化的苯甲酸衍生物与多胺反应以制备式3的苯甲酸衍生物：将式3的苯甲酸衍生物与具有与脂族氨基反应的官能团的胶乳聚合物结合。描述了使用固定的普鲁卡酰胺类似物式3进行免疫测定的方法，包括以下步骤：制备包含所述固定的普鲁卡因酰胺类似物的溶液; 在所述溶液中加入怀疑含有普鲁卡因酰胺的样品; 向所述溶液中加入抗普鲁卡因酰胺抗体，并观察抗体加入后溶液浊度的增加速率。

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