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    • 53. 发明授权
    • Method of preparing single nanoparticle containing organic-inorganic composite material
    • 制备含有机 - 无机复合材料的单一纳米颗粒的方法
    • US07601391B2
    • 2009-10-13
    • US11642772
    • 2006-12-19
    • Kyoungja WooDong Hyun Koo
    • Kyoungja WooDong Hyun Koo
    • B05D7/00B06B1/00B32B5/16
    • B82Y30/00A61K49/0052A61K49/0054A61K49/0067B82Y5/00Y10S977/827Y10S977/83Y10T428/2998
    • There is provided an organic-inorganic composite material containing a single nanoparticle therein, which is prepared by individually dispersing hydrophilic inorganic nanoparticles having a uniform particle size and conjugating biodegradable polymers to the surface of the nanoparticle, and a method of preparing the same. More particularly, the preparation method of the present invention comprises the following steps: 1) preparing hydrophilic nanoparticles by conjugating organic substances having a thiol group and a hydrophilic amine group to the surface of a core or a core/shell inorganic nanoparticle protected with a surfactant through a metal-thiolate (M-S) bond between them; 2) adjusting the concentration of the hydrophilic nanoparticles prepared in step 1) to 2×10−6 M or less and treating them in a sonication bath to prepare individually dispersed nanoparticles in the form of a single particle; and 3) conjugating biopolymers to the nanoparticle individually dispersed in step 2) through the formation of an amide bond between them under treatment in a sonication bath. The organic-inorganic composite material of the present invention exhibits high efficient photoluminescence and photostability as well as excellent chemical stability, dispersibility in water, biocompatibility and targetibility. Thus, it can be effectively used as a raw material for bioimaging or film coating.
    • 提供一种其中含有单一纳米颗粒的有机 - 无机复合材料,其通过将具有均匀粒度的亲水性无机纳米颗粒和将可生物降解的聚合物共轭分散在纳米颗粒的表面上而制备,及其制备方法。 更具体地说,本发明的制备方法包括以下步骤:1)通过将具有硫醇基和亲水性胺基的有机物质缀合到核表面或用表面活性剂保护的核/壳无机纳米颗粒的表面制备亲水性纳米颗粒 通过它们之间的金属硫醇盐(MS)键; 2)将步骤1)中制备的亲水性纳米颗粒的浓度调节至2×10 -6 M或更小,并在超声处理浴中处理以制备单个颗粒形式的单独分散的纳米颗粒; 和3)将生物聚合物与步骤2)中分散分散的纳米颗粒共轭,通过在超声处理浴中处理之间通过它们之间形成酰胺键。 本发明的有机 - 无机复合材料显示出高效的光致发光和光稳定性以及优异的化学稳定性,在水中的分散性,生物相容性和可目标性。 因此,其可以有效地用作生物成像或薄膜包衣的原料。
    • 60. 发明申请
    • Slot via filled dual damascene structure without middle stop layer and method for making the same
    • 通过填充的双镶嵌结构而无中间层的槽和制造相同的方法
    • US20020106889A1
    • 2002-08-08
    • US10105509
    • 2002-03-26
    • ADVANCED MICRO DEVICES, INC.
    • Fei WangLynne A. OkadaRamkumar SubramanianCalvin T. Gabriel
    • H01L021/4763
    • H01L21/76835H01L21/76808H01L2221/1031Y10S977/827
    • An interconnect structure and method of forming the same in which a bottom anti-reflective coating/etch stop layer is deposited over a conductive layer. An inorganic low k dielectric material is deposited over the BARC/etch stop layer to form a first dielectric layer. The first dielectric layer is etched to form a slot via in the first dielectric layer. An organic low k dielectric material is deposited within the slot via and over the first dielectric layer to form a second dielectric layer over the slot via and the first dielectric layer. The re-filled via is simultaneously etched with the second dielectric layer in which a trench is formed. The trench extends in a direction that is normal to the length of the slot via. The entire width of the trench is directly over the via. The re-opened via and the trench are filled with a conductive material.
    • 一种互连结构及其形成方法,其中底部抗反射涂层/蚀刻停止层沉积在导电层上。 无机低k介电材料沉积在BARC /蚀刻停止层上以形成第一介电层。 蚀刻第一介电层以在第一介电层中形成槽通孔。 有机低k电介质材料通过第一电介质层和第一介电层上方沉积在槽内,以在槽通孔和第一介电层上形成第二电介质层。 再次填充的通孔与其中形成沟槽的第二电介质层同时蚀刻。 沟槽沿与槽通孔的长度垂直的方向延伸。 沟槽的整个宽度直接在通孔上方。 重新打开的通孔和沟槽填充有导电材料。