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51. 发明申请

US20140162300A1 SPHINGOMYELIN MEASUREMENT METHOD AND MEASUREMENT KIT 有权
标题翻译： SPHINGOMYELIN测量方法和测量套件
公开(公告)号：US20140162300A1
公开(公告)日：2014-06-12
申请号：US14232427
申请日：2012-07-25
申请人： Takehide Kimura , Kazuhito Miyauchi , Hideyuki Kuwata
发明人： Takehide Kimura , Kazuhito Miyauchi , Hideyuki Kuwata
IPC分类号： C12Q1/61
CPC分类号： C12Q1/61 , C12Q1/28 , C12Q1/44 , C12Y101/03017 , C12Y301/01005 , C12Y301/04004 , G01N33/92 , G01N2333/92 , G01N2405/08
摘要： Provided is a method for simply and accurately measuring sphingomyelin in a sample, and a kit therefor. The method is a method for measuring sphingomyelin in a sample, comprising reacting the sample with a phospholipase D which does not react with sphingomyelin and lysophosphatidylcholine but reacts with phosphatidylcholine, a lysophospholipase or a monoglyceride lipase, and a choline oxidase, eliminating the formed hydrogen peroxide, reacting the resultant with a phospholipase D which does not react with glycerol-3-phosphorylcholine and free fatty acid but reacts with sphingomyelin, and a choline oxidase, and measuring the formed hydrogen peroxide.
摘要翻译：本发明提供了简单且准确地测定样品中鞘磷脂的方法及其用途。该方法是测量样品中鞘磷脂的方法，包括使样品与磷脂酶D反应，磷脂酶D不与鞘磷脂和溶血磷脂酰胆碱反应，但与磷脂酰胆碱，溶血磷脂酶或单甘油脂肪酶和胆碱氧化酶反应，消除形成的过氧化氢使所得物与不与甘油-3-磷酸胆碱和游离脂肪酸反应但与鞘磷脂反应的磷脂酶D和胆碱氧化酶，并测量形成的过氧化氢。

52. 发明申请

US20130017557A1 COMBINATION OF sPLA2 TYPE IIA MASS AND OXPL/APOB CARDIOVASCULAR RISK FACTORS FOR THE DIAGNOSIS/PROGNOSIS OF A CARDIOVASCULAR DISEASE/EVENT 失效
标题翻译： sPLA2型IIA质量和OXPL / APOB心血管危险因素的联合用于诊断/预防心血管疾病/事件
公开(公告)号：US20130017557A1
公开(公告)日：2013-01-17
申请号：US13498208
申请日：2009-12-08
申请人： Ziad Mallat , Alain Tedgui , Sotirios Tsimikas , Joseph Witztum
发明人： Ziad Mallat , Alain Tedgui , Sotirios Tsimikas , Joseph Witztum
IPC分类号： G01N33/573 , C12Q1/44 , G01N27/62 , G01N33/566
CPC分类号： G01N33/6893 , C12Q1/44 , G01N33/92 , G01N2333/775 , G01N2333/918 , G01N2333/92 , G01N2800/32 , G01N2800/52
摘要： The present invention related to a method of identifying a subject having or at risk of having or developing a cardiovascular disease and/or a cardiovascular event, comprising: —measuring, in a sample obtained from said subject, at least two cardiovascular risk factors: a) sPLA2 type HA mass and b) oxidized phospholipids on apolipoprotein B-IOO particles (OxPL/apoB), —combining said measurements, the combined value of sPLA2 type HA mass and OxPL/apoB being indicative of having or a risk of having or developing a cardiovascular disease and/or cardiovascular event.
摘要翻译：本发明涉及鉴定患有或有风险的患有心血管疾病和/或心血管事件的患者的方法，其包括： - 在从所述受试者获得的样品中测定至少两种心血管危险因素：a ）sPLA2型HA质量和b）载脂蛋白B-100颗粒（OxPL /载脂蛋白）上的氧化磷脂，组合所述测量，sPLA2型HA质量和OxPL / apoB的组合值表示具有或具有或发展的风险心血管疾病和/或心血管事件。

53. 发明授权

US08216799B2 Dry analytical element for lipase measurement 有权
标题翻译：用于脂肪酶测量的干燥分析元件
公开(公告)号：US08216799B2
公开(公告)日：2012-07-10
申请号：US12155890
申请日：2008-06-11
申请人： Shigeki Kageyama , Hideaki Tanaka
发明人： Shigeki Kageyama , Hideaki Tanaka
IPC分类号： C12Q1/44 , C12Q1/34
CPC分类号： G01N33/526 , C12Q1/44 , G01N2333/92
摘要： It is an object of the present invention to provide a dry analytical element for pancreatic lipase analysis having high selectivity with respect to pancreatic lipase, whose multianalyte correlation has been improved. The present invention provides a dry analytical element for measurement of pancreatic lipase contained in a body fluid, which comprises at least one development layer and/or reagent layer containing diglyceride or triglyceride of long-chain alkyl fatty acid having 12 to 22 carbon atoms, monoglyceride lipase, and a glycerine measurement reagent, wherein the development layer and/or the reagent layer comprise two or more types of anionic surfactants and at least one type of the anionic surfactant is alkylarylsulfonate.
摘要翻译：本发明的一个目的是提供一种用于胰脂肪酶分析的干燥分析元件，该分析元件具有相对于胰腺脂肪酶具有高选择性，其胰多糖分子相关性得到改善。本发明提供了一种用于测量包含在体液中的胰脂肪酶的干燥分析元件，其包含至少一个含有12-22个碳原子的长链烷基脂肪酸的甘油二酯或甘油三酸酯的显影层和/或试剂层，单酸甘油酯脂肪酶和甘油测量试剂，其中显影层和/或试剂层包含两种或更多种类型的阴离子表面活性剂，并且至少一种类型的阴离子表面活性剂是烷基芳基磺酸盐。

54. 发明申请

US20110312006A1 Enzymatic Assay for the Quantitative Determination of Phospholipase A1 or A2 Activity in a Sample 审中-公开
标题翻译：用于定量测定样品中磷脂酶A1或A2活性的酶法测定
公开(公告)号：US20110312006A1
公开(公告)日：2011-12-22
申请号：US13148905
申请日：2010-02-10
申请人： Emmanuel Valentin , Carla Sibella
发明人： Emmanuel Valentin , Carla Sibella
IPC分类号： C12Q1/34
CPC分类号： C12Q1/44 , G01N33/58 , G01N2333/92
摘要： The invention relates to a new method for measuring a calcium-dependent phospholipase A1 or A2 enzymatic activity in a sample, comprising the following steps: a) contacting said sample with a solid phase coated with a fluorochrome-labelled phospholipase A1 or A2 substrate, wherein the molecular coverage is in the range 8 to 30 fluorochrome-labelled phospholipase A1 or A2 substrate molecules/nm2 in conditions where calcium-dependent phospholipase A1 or A2 enzymatic activity is blocked. b) reading the fluorescence emission overtime c) adding a solution to initiate calcium-dependent phospholipase A1 or A2 enzymatic activity d) reading the fluorescence emission overtime, and kits for carrying out said method.
摘要翻译：本发明涉及一种用于测量样品中钙依赖性磷脂酶A1或A2酶活性的新方法，包括以下步骤：a）使所述样品与涂有荧光染料标记的磷脂酶A1或A2底物的固相接触，其中在钙依赖性磷脂酶A1或A2酶活性被阻断的条件下，分子量覆盖范围为8〜30个荧光染料标记的磷脂酶A1或A2底物分子/ nm2。 b）超时读取荧光发射c）添加溶液以引发钙依赖性磷脂酶A1或A2酶活性d）读取荧光发射超时，以及用于实施所述方法的试剂盒。

55. 发明申请

US20110166138A1 Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase for Modulation of Cannabinoid Receptors 有权
标题翻译：脂肪酸酰胺水解酶和单酰甘油脂肪酶抑制剂用于调节大麻素受体
公开(公告)号：US20110166138A1
公开(公告)日：2011-07-07
申请号：US12933322
申请日：2009-03-17
申请人： Alexandros Makriyannis , Lakshmipathi Pandarinathan , Nikolai Zvonok , Teija Parkkari , Lauren Chapman
发明人： Alexandros Makriyannis , Lakshmipathi Pandarinathan , Nikolai Zvonok , Teija Parkkari , Lauren Chapman
IPC分类号： A61K31/5377 , A61K31/41 , C07D257/04 , A61K31/4439 , C07D401/06 , C07D413/06 , A61K31/454 , A61K31/438 , C07D491/113 , A61K31/496 , C07D403/06 , A61K31/522 , C07D473/28 , A61K31/4192 , C07D249/18 , A61K31/437 , C07D471/04 , A61K31/4164 , C07D233/90 , A61P29/00 , A61P25/00 , A61P3/00 , A61P35/00 , C12Q1/34 , C12Q1/44 , G01N33/573
CPC分类号： G01N33/9406 , A61K31/41 , A61K31/415 , C07D231/12 , C07D233/56 , C07D235/08 , C07D249/08 , C07D249/18 , C07D263/22 , C07D401/12 , C07D471/04 , C07D473/00 , C07D473/28 , G01N21/6428 , G01N2333/70571 , G01N2333/92 , G01N2333/98 , G01N2500/02 , G01N2500/20
摘要： Disclosed are compounds and compositions that inhibit the action of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL), methods of inhibiting FAAH and MGL, methods of modulating cannabinoid receptors, and methods of treating various disorders related to modulation of cannabinoid receptors.
摘要翻译：公开了抑制脂肪酰胺水解酶（FAAH）和单酰基甘油脂肪酶（MGL）的作用的化合物和组合物，抑制FAAH和MGL的方法，调节大麻素受体的方法，以及治疗与大麻素受体调节有关的各种疾病的方法。

56. 发明申请

US20090317819A1 PHOSPHOLIPID OXIDATION AND Lp-PLA2 AS PREDICTORS OF CORONARY ARTERY DISEASE 有权
标题翻译：磷酸化氧化和Lp-PLA2作为冠状动脉疾病的预防因素
公开(公告)号：US20090317819A1
公开(公告)日：2009-12-24
申请号：US12465930
申请日：2009-05-14
申请人： Sotirios Tsimikas , Joseph Witztum
发明人： Sotirios Tsimikas , Joseph Witztum
IPC分类号： C12Q1/68 , C12Q1/02
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , G01N33/92 , G01N2333/92 , G01N2800/324 , Y10S514/824
摘要： Provided herein are compositions and methods for identifying individuals at risk for developing coronary artery disease (CAD).
摘要翻译：本文提供了用于鉴定发生冠状动脉疾病（CAD）风险的个体的组合物和方法。

57. 发明申请

US20090246812A1 DRY ANALYTICAL ELEMENT FOR LIPASE MEASUREMENT 有权
标题翻译：用于脂肪测量的干燥分析元素
公开(公告)号：US20090246812A1
公开(公告)日：2009-10-01
申请号：US12410046
申请日：2009-03-24
申请人： Kentaro Nakamura , Shigeki Kageyama
发明人： Kentaro Nakamura , Shigeki Kageyama
IPC分类号： C12Q1/44
CPC分类号： C12Q1/44 , G01N2333/92
摘要： It is an object of the present invention to provide: a dry analytical element for analyzing pancreatic lipase wherein the triglyceride is not transcribed on the support to contaminate a transportation slip or other analytical elements and wherein an additive solution of the triglyceride neither reaggregates nor precipitate, so that the dry analytical element is stable and is compatible with production. The present invention provides a dry analytical element for measuring pancreatic lipase contained in body fluid, which comprises triglyceride of long chain alkyl fatty acid having 12 to 22 carbon atoms, monoglyceride lipase, and a glycerin measurement reagent, and which comprises a water-impermeable support and at least one spreading or reagent layer, wherein a hydrophilic polymer at a weight ratio of 1.8:1 or greater with respect to the triglyceride is contained.
摘要翻译：本发明的目的是提供：用于分析胰脂肪酶的干燥分析元件，其中甘油三酯不在载体上转录以污染运输滑移或其它分析元件，并且其中甘油三酯的添加剂溶液既不再聚集也不沉淀，使干燥分析元件稳定，与生产兼容。本发明提供一种用于测量体液中包含的胰脂肪酶的干燥分析元件，其包含具有12-22个碳原子的长链烷基脂肪酸甘油三酯，甘油单酯脂肪酶和甘油测量试剂，并且其包含不透水的载体和至少一个铺展剂或试剂层，其中含有相对于甘油三酯的1.8:1或更大重量比的亲水性聚合物。

58. 发明申请

US20090246811A1 DRY ANALYTICAL ELEMENT FOR LIPASE MEASUREMENT 有权
标题翻译：用于脂肪测量的干燥分析元素
公开(公告)号：US20090246811A1
公开(公告)日：2009-10-01
申请号：US12410035
申请日：2009-03-24
申请人： Jun Arakawa , Nobuhito Masuda , Kentaro Nakamura , Shigeki Kageyama
发明人： Jun Arakawa , Nobuhito Masuda , Kentaro Nakamura , Shigeki Kageyama
IPC分类号： C12Q1/44
CPC分类号： C12Q1/44 , G01N2333/92
摘要： The present invention provides a method for producing a dry analytical element for measurement of pancreatic lipase contained in a body fluid which contains triglyceride of long chain alkyl fatty acid having 12 to 22 carbon atoms, monoglyceride lipase, and a glycerine measurement reagent, and comprises a water-impermeable support and at least one spreading or reagent layer, said method comprising the step of coating an emulsion/dispersion solution of triglyceride with an average particle size of 1 μm or less.
摘要翻译：本发明提供了含有含有碳原子数12〜22的长链烷基脂肪酸甘油三酯，单甘油酯脂肪酶，甘油测定试剂的体液中所含的胰脂肪酶的测定用干燥分析元件的制造方法，水不渗透性载体和至少一种扩散剂或试剂层，所述方法包括涂覆平均粒度为1μm以下的甘油三酯的乳液/分散液的步骤。

59. 发明申请

US20180238866A1 SUPPRESSION OF SPLA2-INTEGRIN BINDING FOR TREATING AN INFLAMMATORY CONDITION OR SUPPRESSING CELL PROLIFERATION 审中-公开
公开(公告)号：US20180238866A1
公开(公告)日：2018-08-23
申请号：US15526573
申请日：2015-11-12
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Yoshikazu TAKADA , Yoko TAKADA , Masaaki FUJITA
IPC分类号： G01N33/543 , A61K38/17 , C07K14/705 , G01N33/533 , G01N33/52 , G01N33/58 , G01N33/53 , G01N33/566
CPC分类号： G01N33/54306 , A61K38/00 , A61K38/177 , C07K14/70546 , G01N33/52 , G01N33/5306 , G01N33/533 , G01N33/566 , G01N33/582 , G01N2333/70546 , G01N2333/92 , G01N2500/02
摘要： The present invention relates to the discovery that a secretory phospholipase A2 (sPLA2-IIA) plays an active role in mediating cellular signaling leading to an inflammatory response or cell proliferation by way of its specific binding with integrin β at site 2 of integrin β. More specifically, the invention provides a method for identifying inhibitors of inflammatory or proliferative signaling by screening for compounds that interrupt the specific binding of sPLA2 and integrin β at site 2. The invention also provides the novel use of a substance that suppresses the specific binding between sPLA2 and site 2 of integrinβ for the purpose of treating or preventing a condition involving an undesired inflammatory response or cell proliferation.

60. 发明申请

US20180161298A1 TREATMENT OF AUTOPHAGY-RELATED DISORDERS 审中-公开
公开(公告)号：US20180161298A1
公开(公告)日：2018-06-14
申请号：US15813438
申请日：2017-11-15
申请人： STC.UNM
发明人： Vojo P. Deretic , Michael Mandell
IPC分类号： A61K31/201 , C12N9/00 , A61K38/53 , C12Q1/44 , C12Q1/61 , A61K45/06
CPC分类号： A61K31/201 , A61K38/53 , A61K45/06 , C12N9/93 , C12Q1/44 , C12Q1/61 , C12Y603/02 , G01N2333/92 , G01N2405/00 , G01N2405/02 , G01N2500/20 , G01N2800/7028
摘要： The present invention relates to the use of neutral lipids, including triglycerides, diglycerides and monoglycerides which may be used to increase neutral lipids (lipid stores and/or lipid droplets) and neutral lipid stores in order to regulate (in particular, induce) autophagy and treat and/or prevent autophagy related disease states and/or conditions. In one embodiment, the invention relates to the use of neutral lipids and/or TRIM proteins which may be used to regulate (in particular, induce) autophagy, target autophagic substrates and treat and/or prevent autophagic disease states and/or conditions.

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