专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明申请

US20030068301A1 Method and reagent for inhibiting hepatitis B virus replication 审中-公开
标题翻译：用于抑制乙型肝炎病毒复制的方法和试剂
公开(公告)号：US20030068301A1
公开(公告)日：2003-04-10
申请号：US09877478
申请日：2001-06-08
发明人： Kenneth Draper , Lawrence Blatt , James A. McSwiggen , David Morrissey
IPC分类号： A61K038/21 , C07H021/02 , A61K048/00
CPC分类号： C12N15/1131 , A61K38/21 , C07H19/10 , C07H19/20 , C07H21/00 , C07K14/005 , C12N15/1137 , C12N15/1138 , C12N15/85 , C12N15/86 , C12N2310/11 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/13 , C12N2310/16 , C12N2310/18 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/319 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/346 , C12N2310/3519 , C12N2310/3521 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2320/31 , C12N2320/51 , C12N2730/10122 , C12P19/30 , C12P19/305 , C12Q1/706 , C12Y207/07049 , C12Y301/03048 , A61K2300/00 , C12Q2521/337 , C12N2310/3523
摘要： Nucleic acid molecules, including antisense and enzymatic nucleic acid molecules, such as hammerhead ribozymes, DNAzymes, Inozymes, Zinzymes, Amberzymes, and G-cleaver ribozymes, which modulate the synthesis, expression and/or stability of an RNA encoding one or more protein components of Hepatitis B virus (HBV), and methods for their use alone or in combination with other therapies, such as 3TCnull (Lamivudine) and Interferons are disclosed.
摘要翻译：核酸分子，包括反义和酶核酸分子，例如锤头核酶，DNA酶，酶，酶，琥珀酶和G切割酶核酶，其调节编码一种或多种蛋白质组分的RNA的合成，表达和/或稳定性乙型肝炎病毒（HBV），以及单独使用或与其他疗法（如3TC（拉米夫定）和干扰素）组合使用的方法。

52. 发明申请

US20030044941A1 Human RNase III and compositions and uses thereof 审中-公开
公开(公告)号：US20030044941A1
公开(公告)日：2003-03-06
申请号：US10079185
申请日：2002-02-20
发明人： Stanley T. Crooke
IPC分类号： C12P019/34 , C12N015/87
CPC分类号： C07H21/00 , A61K38/00 , C12N9/22 , C12N15/113 , C12N15/1135 , C12N2310/311 , C12N2310/312 , C12N2310/314 , C12N2310/315 , C12N2310/316 , C12N2310/318 , C12N2310/3181 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/335 , C12N2310/341 , C12N2310/346 , C12Y301/26003 , Y02A50/473 , C12N2310/3525 , C12N2310/3527 , C12N2310/3521
摘要： The present invention provides polynucleotides encoding human RNase III and polypeptides encoded thereby. Methods of using said polynucleotides and polypeptides are also provided.

53. 发明申请

US20030022848A1 Antisense oligonucleotide modulation of tumor necrosis factor-alpha (TNF-alpha) expression 审中-公开
标题翻译：肿瘤坏死因子-α（TNF-α）表达的反义寡核苷酸调控
公开(公告)号：US20030022848A1
公开(公告)日：2003-01-30
申请号：US09824322
申请日：2001-04-02
发明人： Brenda F. Baker , C. Frank Bennett , Madeline M. Butler , William R. Shanahan JR.
IPC分类号： A61K048/00 , C07H021/04
CPC分类号： C12N15/1136 , A61K38/00 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compositions and methods are provided for inhibiting the expression of human tumor necrosis factor-null (TNF-null). Antisense oligonucleotides targeted to nucleic acids encoding TNF-null_ are preferred. Methods of using these oligonucleotides for inhibition of TNF-null expression and for treatment of diseases, particularly inflammatory and autoimmune diseases, associated with overexpression of TNF-null are provided.
摘要翻译：提供了抑制人肿瘤坏死因子-α（TNF-α）表达的组合物和方法。靶向编码TNF-α的核酸的反义寡核苷酸是优选的。提供了使用这些寡核苷酸抑制TNF-α表达和治疗与TNF-α过度表达相关的疾病，特别是炎性和自身免疫性疾病的方法。

54. 发明申请

US20020165189A1 Oligoribonucleotides and ribonucleases for cleaving RNA 失效
标题翻译：用于切割RNA的寡核糖核苷酸和核糖核酸酶
公开(公告)号：US20020165189A1
公开(公告)日：2002-11-07
申请号：US10078949
申请日：2002-02-20
发明人： Stanley T. Crooke
IPC分类号： A61K048/00 , C07H021/02 , C12N015/87
CPC分类号： C12N15/113 , A61K38/00 , C07H21/00 , C12N9/22 , C12N15/1135 , C12N2310/311 , C12N2310/312 , C12N2310/314 , C12N2310/315 , C12N2310/316 , C12N2310/318 , C12N2310/3181 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/335 , C12N2310/341 , C12N2310/346 , Y02A50/395 , Y02P20/582 , C12N2310/3527 , C12N2310/3525 , C12N2310/3521
摘要： Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2null-pentoribofuranosyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementary nucleic acid strand as well as substituent groups for increasing nuclease resistance. The oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to oligonucleotide therapeutics. Also included in the invention are mammalian ribonucleases, i.e., enzymes that degrade RNA, and substrates for such ribonucleases. Such a ribonuclease is referred to herein as a dsRNase, wherein nulldsnull indicates the RNase's specificity for certain double-stranded RNA substrates. The artificial substrates for the dsRNases described herein are useful in preparing affinity matrices for purifying mammalian ribonuclease as well as non-degradative RNA-binding proteins.
摘要翻译：提供了包含寡核糖核苷酸和寡核糖核苷的寡聚化合物，其具有激活dsRNase的2'-戊二呋呋糖基核苷的亚序列。寡核糖核苷酸和寡核糖核苷可以包括用于增加对互补核酸链的结合亲和力的取代基以及用于增加核酸酶抗性的取代基。寡聚化合物可用于诊断和其他研究目的，用于调节生物体中的蛋白质的表达，以及用于诊断，检测和治疗对寡核苷酸治疗剂敏感的其它病症。本发明还包括哺乳动物核糖核酸酶，即降解RNA的酶和这种核糖核酸酶的底物。这样的核糖核酸酶在本文中称为dsRNase，其中“ds”表示RNase对某些双链RNA底物的特异性。本文所述的dsR酶的人造底物可用于制备用于纯化哺乳动物核糖核酸酶以及非降解性RNA结合蛋白的亲和基质。

55. 发明申请

US20020160969A1 Nucleosides and oligonucleotides containing boron clusters 失效
标题翻译：含有硼簇的核苷和寡核苷酸
公开(公告)号：US20020160969A1
公开(公告)日：2002-10-31
申请号：US09774223
申请日：2001-01-30
发明人： Raymond F. Schinazi , Geraldine Fulcrand-El Kattan , Zbigniew Jan Lesnikowski
IPC分类号： A61K031/70 , A01N043/04
CPC分类号： C07H19/20 , A61K41/0095 , A61K49/085 , A61K49/10 , C07H19/10 , C07H21/00 , C07H23/00 , C12N9/1276 , C12N15/10 , C12N15/113 , C12N2310/318 , C12N2310/33 , C12N2310/3527 , C12Q1/6816 , C12Q1/6827 , C12Q1/6886
摘要： Carboranyl-containing nucleosides and oligonucleotides are provided for use in boron neutron capture therapy (BNCT) and for other therapeutic and diagnostic purposes.
摘要翻译：提供含硼烷基的核苷和寡核苷酸用于硼中子俘获治疗（BNCT）和其他治疗和诊断目的。

56. 发明申请

US20020102694A1 Nucleozymes with endonuclease activity 审中-公开
标题翻译：具有核酸内切酶活性的核酶
公开(公告)号：US20020102694A1
公开(公告)日：2002-08-01
申请号：US09781902
申请日：2001-02-08
发明人： Ronald Breaker , Gail Emilsson
IPC分类号： C12N009/22 , C12Q001/68 , C07H021/04
CPC分类号： A61K31/7115 , A61K31/7105 , A61K31/711 , A61K31/712 , A61K31/7125 , A61K38/00 , A61K48/00 , C12N15/113 , C12N2310/111 , C12N2310/12 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332
摘要： The present invention relates to nucleozymes (DNA catalysts, DNA enzymes), methods of synyhesis, and uses thereof.
摘要翻译：本发明涉及核酶（DNA催化剂，DNA酶），合成方法及其应用。

57. 发明授权

US06420549B1 Oligonucleotide analogs having modified dimers 失效
标题翻译：具有改性二聚体的寡核苷酸类似物
公开(公告)号：US06420549B1
公开(公告)日：2002-07-16
申请号：US09131102
申请日：1998-08-07
申请人： Phillip Dan Cook , Muthiah Manoharan , Balkrishen Bhat
发明人： Phillip Dan Cook , Muthiah Manoharan , Balkrishen Bhat
IPC分类号： C07H1900
CPC分类号： C12N15/1135 , C07H21/00 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Q1/6876 , Y02P20/582 , C12N2310/3525
摘要： Modified dimers having a ribose sugar moiety in the 5′ nucleoside and a 2′ modified sugar in the 3′ nucleoside are provided. The modified dimers are useful in the preparation of oligonucleotide analogs having enhanced properties compared to native oligonucleotides, including increased nuclease resistance, enhanced binding affinity and improved protein binding.
摘要翻译：提供了在5'核苷中具有核糖部分和3'核苷中的2'修饰的糖的修饰二聚体。修饰的二聚体可用于制备与天然寡核苷酸相比具有增强的性质的寡核苷酸类似物，包括增加的核酸酶抗性，增强的结合亲和力和改善的蛋白质结合。

58. 发明授权

US06180766B2 Nucleosides and oligonucleotides containing boron clusters 失效
标题翻译：含有硼簇的核苷和寡核苷酸
公开(公告)号：US06180766B2
公开(公告)日：2001-01-30
申请号：US08161674
申请日：1993-12-02
申请人： Raymond F. Schinazi , Geraldin{acute over (e)} Fulcrand-El Kattan , Zbigniew Jan Lesnikowski
发明人： Raymond F. Schinazi , Geraldin{acute over (e)} Fulcrand-El Kattan , Zbigniew Jan Lesnikowski
IPC分类号： C07H1900
CPC分类号： C07H19/20 , A61K41/0095 , A61K49/085 , A61K49/10 , C07H19/10 , C07H21/00 , C07H23/00 , C12N9/1276 , C12N15/10 , C12N15/113 , C12N2310/318 , C12N2310/33 , C12N2310/3527 , C12Q1/6816 , C12Q1/6827 , C12Q1/6886
摘要： Carboranyl-containing nucleosides and oligonucleotides are provided for use in boron neutron capture therapy (BNCT) and for other therapeutic and diagnostic purposes.
摘要翻译：提供含硼烷基的核苷和寡核苷酸用于硼中子俘获治疗（BNCT）和其他治疗和诊断目的。

59. 发明授权

US06048974A Oligonucleotide clamps having diagnostic and therapeutic applications 失效
标题翻译：具有诊断和治疗应用的寡核苷酸夹具
公开(公告)号：US06048974A
公开(公告)日：2000-04-11
申请号：US70477
申请日：1998-04-30
申请人： Sergei M. Gryaznov , David H. Lloyd
发明人： Sergei M. Gryaznov , David H. Lloyd
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C07H21/00 , C12Q1/6813 , C12N2310/152 , C12N2310/315 , C12N2310/318 , C12N2310/3341 , C12N2310/351 , C12N2310/3515
摘要： Compounds referred to herein as oligonucleotide clamps are provided that stably bind to target polynucleotides in a sequence-specific manner. The oligonucleotide clamps comprise one or more oligonucleotide moieties capable of specifically binding to a target polynucleotide and one or more pairs of binding moieties covalently linked to the oligonudeotide moieties. In accordance with the invention, upon annealing of the oligonucleotide moieties to the target polynucleotide, the binding moieties of a pair are brought into juxtaposition so that they form a stable covalent or non-covalent inkage or complex. The interaction of the binding moieties of the one or more pairs effectively clamps the specifically annealed oligonucleotide moieties to the target polynucleotide.
摘要翻译：提供本文中称为寡核苷酸钳位的化合物，其以序列特异性方式稳定地结合靶多核苷酸。寡核苷酸夹具包含能够特异性结合靶多核苷酸的一个或多个寡核苷酸部分和与寡核苷酸部分共价连接的一对或多对结合部分。根据本发明，当将寡核苷酸部分退火至靶多核苷酸时，一对的结合部分并列，使其形成稳定的共价或非共价的墨水或复合物。一个或多个对的结合部分的相互作用有效地将特异性退火的寡核苷酸部分夹持到靶多核苷酸。

60. 发明授权

US5981732A Antisense modulation of G-alpha-13 expression 有权
标题翻译： G-α-13表达的反义调制
公开(公告)号：US5981732A
公开(公告)日：1999-11-09
申请号：US205860
申请日：1998-12-04
申请人： Lex M. Cowsert
发明人： Lex M. Cowsert
IPC分类号： A61K38/00 , C12N15/113 , C07H21/04 , C12Q1/68
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/318 , C12N2310/3181 , C12N2310/321 , C12N2310/341 , C12N2310/346 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of G-alpha-13. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding G-alpha-13. Methods of using these compounds for modulation of G-alpha-13 expression and for treatment of diseases associated with expression of G-alpha-13 are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节G-α-13的表达。组合物包含靶向编码G-α-13的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节G-α-13表达和治疗与G-α-13表达有关的疾病的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式