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51. 发明授权

US06025484A Protein D--an IgD-binding protein ofhaemophilus influenzae 失效
标题翻译：蛋白D型流感嗜血杆菌的IgD结合蛋白
公开(公告)号：US06025484A
公开(公告)日：2000-02-15
申请号：US969761
申请日：1997-11-13
申请人： Arne Forsgren
发明人： Arne Forsgren
IPC分类号： A61K39/00 , A61K38/00 , A61K39/102 , A61P31/04 , C07K14/005 , C07K14/195 , C07K14/285 , C07K14/41 , C07K14/705 , C07K16/00 , C07K16/12 , C07K19/00 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/31 , C12P21/00 , C12P21/08 , C12R1/19 , C12R1/21 , C12R1/91 , G01N33/53 , G01N33/569 , G01N33/577 , C07H21/04
CPC分类号： A61K39/102 , C07K14/285 , C07K16/1242 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/705 , Y10T436/116664
摘要： A novel surface exposed protein of Haemophilus influenzae or related Haemophilus species is described. The protein named protein D is an Ig receptor for human IgD and has an apparent molecular weight of 42,000. Protein D can be detected in all of 116 encapsulated and non-encapsulated isolates of H. influenzae studied. The protein from all strains shows in addition to the same apparent molecular weight immunogenic similarities since protein D from all strains interacts with three different mouse monoclonal antibodies and monoclonal human IgD. A method for purification of protein D is described. Cloning of the protein D gene from H. influenzae in E. coli is described as well as the nucleotide sequence and the deduced amino acid sequence.
摘要翻译：描述了流感嗜血杆菌或相关嗜血杆菌物种的新型表面暴露蛋白。称为蛋白D的蛋白质是人IgD的Ig受体，其表观分子量为42,000。蛋白D可以在所研究的流感嗜血杆菌的所有116个包封和非包囊的分离物中检测到。来自所有菌株的蛋白质除了具有相同的表观分子量的免疫原性相似性之外还显示出，因为来自所有菌株的蛋白质D与三种不同的小鼠单克隆抗体和单克隆人IgD相互作用。描述了蛋白D的纯化方法。描述大肠杆菌中流感嗜血杆菌蛋白D基因的克隆以及核苷酸序列和推导的氨基酸序列。

52. 发明授权

US5989828A Protein D-an IgD binding protein of Haemophilus influenzae 失效
标题翻译：流感嗜血杆菌蛋白D-IgD结合蛋白
公开(公告)号：US5989828A
公开(公告)日：1999-11-23
申请号：US747381
申请日：1996-11-12
申请人： Arne Forsgren
发明人： Arne Forsgren
IPC分类号： A61K39/00 , A61K38/00 , A61K39/102 , A61P31/04 , C07K14/005 , C07K14/195 , C07K14/285 , C07K14/41 , C07K14/705 , C07K16/00 , C07K16/12 , C07K19/00 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/31 , C12P21/00 , C12P21/08 , C12R1/19 , C12R1/21 , C12R1/91 , G01N33/53 , G01N33/569 , G01N33/577 , C07K1/00 , C12Q1/70 , H01R31/08
CPC分类号： A61K39/102 , C07K14/285 , C07K16/1242 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/705 , Y10T436/116664
摘要： A novel surface exposed protein of Haemophilus influenzae or related Haemophilus species is described. The protein named protein D is an Ig receptor for human IgD and has an apparent molecular weight of 42,000. Protein D can be detected in all of 116 encapsulated and non-encapsulated isolates of H. influenzae studied. The protein from all strains shows in addition to the same apparent molecular weight immunogenic similarities since protein D from all strains interacts with three different mouse monoclonal antibodies and monoclonal human IgD. A method for purification of protein D is described. Cloning of the protein D gene from H. influenzae in E. coli is described as well as the nucleotide sequence and the deduced amino acid sequence.
摘要翻译：描述了流感嗜血杆菌或相关嗜血杆菌物种的新型表面暴露蛋白。称为蛋白D的蛋白质是人IgD的Ig受体，其表观分子量为42,000。蛋白D可以在所研究的流感嗜血杆菌的所有116个包封和非包囊的分离物中检测到。来自所有菌株的蛋白质除了具有相同的表观分子量的免疫原性相似性之外还显示出，因为来自所有菌株的蛋白质D与三种不同的小鼠单克隆抗体和单克隆人IgD相互作用。描述了蛋白D的纯化方法。描述大肠杆菌中流感嗜血杆菌蛋白D基因的克隆以及核苷酸序列和推导的氨基酸序列。

53. 发明授权

US5955580A Vaccines for nontypable haemophilus influenzae 失效
标题翻译：用于不可流行的流感嗜血杆菌疫苗
公开(公告)号：US5955580A
公开(公告)日：1999-09-21
申请号：US449406
申请日：1995-05-23
申请人： Bruce A. Green , Gary W. Zlotnick
发明人： Bruce A. Green , Gary W. Zlotnick
IPC分类号： C12N15/09 , A61K20060101 , A61K31/00 , A61K39/00 , A61K39/102 , A61K39/395 , A61P31/00 , A61P31/04 , C07K1/20 , C07K1/22 , C07K14/285 , C07K16/00 , C07K16/12 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/31 , C12N15/62 , C12P21/02 , C12R1/19 , C07K1/00
CPC分类号： C07K16/1242 , C07K14/285 , C07K19/00 , A61K39/00 , C07K2319/00 , C07K2319/40
摘要： Protein "e" of H. influenzae, a lipoprotein of approximately 28,000 daltons, has been purified and sequenced. Protein "e" and peptides or proteins having a shared epitope, can be used to vaccinate against nontypable (and typable) H. influenzae and to prevent otitis media caused by H. influenzae. For this purpose, protein "e" or derivatives thereof can be produced in native, synthetic or recombinant forms and can be administered alone or in conjunction with other antigens of H. influenzae. Protein "e" can also be used in multivalent vaccines designed for H. influenzae and one or more other infectious organisms.
摘要翻译：流感嗜血杆菌蛋白质“e”，一种约28,000道尔顿的脂蛋白已被纯化和测序。具有共享表位的蛋白质“e”和肽或蛋白质可用于针对非型（和类型的）流感嗜血杆菌接种疫苗并预防流感嗜血杆菌引起的中耳炎。为此，蛋白质“e”或其衍生物可以天然的，合成的或重组形式产生，并且可以单独施用或与流感嗜血杆菌的其他抗原结合施用。蛋白质“e”也可用于针对流感嗜血杆菌和一种或多种其他感染性生物体设计的多价疫苗。

54. 发明授权

US5110908A Haemophilus influenzae peptides and proteins 失效
标题翻译：流感嗜血杆菌肽和蛋白质
公开(公告)号：US5110908A
公开(公告)日：1992-05-05
申请号：US436092
申请日：1989-11-09
申请人： Robert A. Deich , Gary Zlotnick , Bruce Green
发明人： Robert A. Deich , Gary Zlotnick , Bruce Green
IPC分类号： A61K38/00 , A61K39/00 , C07K14/285 , C07K16/12 , C12N15/62 , C12N15/70 , C12Q1/68 , G01N33/569
CPC分类号： G01N33/56911 , C07K14/285 , C07K16/1242 , C12N15/625 , C12N15/70 , C12Q1/689 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/035 , C07K2319/40 , Y10S435/82 , Y10S435/851 , Y10S530/806 , Y10S530/808 , Y10S530/825
摘要： Peptides and proteins related to an epitope comprising an outer membrane protein of Haemophilus influenzae are described. The peptides and proteins can be prepared by methods including novel and improved methods of puiification from H. influenzae cultures, and by recombinant DNA and chemical synthetic techniques. Additionally, recombinant vectors containing nucleotide sequences encoding PBOMP-1 and PBOMP-2 related peptides and proteins are also described. Recombinant vectors include plasmid DNA and viral DNA such as human viruses, animal viruses, insect viruses and bacteriophages that direct the expression of the PBOMP-1 and PBOMP-2 related peptides and proteins in appropriate host cells. The peptides, proteins and viruses both "live" and "inactivated" are used as immunogens in vaccine formulations to protect against H. influenzae infections. The peptides and proteins are also used as reagents in immunoassays as well as to prepare immunoglobulins for passive immunization. Use of the nucleotide sequences encoding the PBOMP related peptides and proteins in hybridization assays is also described.
摘要翻译：描述了与包含流感嗜血杆菌的外膜蛋白的表位相关的肽和蛋白质。肽和蛋白质可以通过包括来自流感嗜血杆菌培养物的新颖改良方法和重组DNA和化学合成技术的方法制备。此外，还描述了含有编码PBOMP-1和PBOMP-2相关肽和蛋白质的核苷酸序列的重组载体。重组载体包括质粒DNA和病毒DNA，例如人类病毒，动物病毒，昆虫病毒和噬菌体，其将PBOMP-1和PBOMP-2相关肽和蛋白质的表达指导在合适的宿主细胞中。 “活”和“灭活”的肽，蛋白质和病毒用作疫苗制剂中的免疫原，以防止流感嗜血杆菌感染。肽和蛋白质也用作免疫测定中的试剂以及制备用于被动免疫的免疫球蛋白。还描述了在杂交测定中使用编码PBOMP相关肽和蛋白质的核苷酸序列。

55. 发明授权

US5108744A Vaccines for Haemophilus influenzae 失效
标题翻译：流感嗜血杆菌疫苗
公开(公告)号：US5108744A
公开(公告)日：1992-04-28
申请号：US434625
申请日：1989-11-09
申请人： Robert A. Deich , Gary W. Zlotnick , Bruce A. Green
发明人： Robert A. Deich , Gary W. Zlotnick , Bruce A. Green
IPC分类号： A61K38/00 , A61K39/00 , C07K14/285 , C07K16/12 , C12N15/62 , C12N15/70 , C12Q1/68 , G01N33/569
CPC分类号： C07K16/1242 , C07K14/285 , C12N15/625 , C12N15/70 , C12Q1/689 , G01N33/56911 , A61K38/00 , A61K39/00 , C07K2319/02 , C07K2319/035 , C07K2319/40
摘要： Peptides and proteins related to an epitope comprising an outer membrane protein of Haemophilus influenzae are described. The peptides and proteins can be prepared by methods includng novel and improved methods of purification from H. influenzae cultures, and by recombinant DNA and chemical synthetic techniques. Additionally, recombinant vectors containing nucleotide sequence encoding PBOMP-1 and PBOMP-2 related peptides and proteins are also described. Recombinant vectors include plasmid DNA and viral DNA such as human viruses, animal viruses, insect viruses and bacteriophages that direct the expression of the PBOMP-1 and PBOMP-2 related peptides and proteins in appropriate host cells. The peptides, proteins and viruses both "live" and "inactivated" are used as immunogens in vaccine formulations to protect against H. influenzae infections. The peptides and proteins are also used as reagents in immunoassays as well as to prepare immunoglobulins for passive immunization. Use of the nucleotide sequences encoding the PBOMP related peptides and proteins in hybridization assays is also described.
摘要翻译：描述了与包含流感嗜血杆菌的外膜蛋白的表位相关的肽和蛋白质。肽和蛋白质可以通过包括来自流感嗜血杆菌培养物的新颖和改进的纯化方法以及重组DNA和化学合成技术的方法制备。此外，还描述了含有编码PBOMP-1和PBOMP-2相关肽和蛋白质的核苷酸序列的重组载体。重组载体包括质粒DNA和病毒DNA，例如人类病毒，动物病毒，昆虫病毒和噬菌体，其将PBOMP-1和PBOMP-2相关肽和蛋白质的表达指导在合适的宿主细胞中。 “活”和“灭活”的肽，蛋白质和病毒在疫苗制剂中用作免疫原，以防止流感嗜血杆菌感染。肽和蛋白质也用作免疫测定中的试剂以及制备用于被动免疫的免疫球蛋白。还描述了在杂交测定中使用编码PBOMP相关肽和蛋白质的核苷酸序列。

56. 发明授权

US09714283B2 Compositions and methods for the treatment of immunodeficiency 有权
公开(公告)号：US09714283B2
公开(公告)日：2017-07-25
申请号：US14790872
申请日：2015-07-02
申请人： ADMA Biologics, Inc.
发明人： Adam S. Grossman , Jerrold B. Grossman , James Mond , Dov A. Goldstein
IPC分类号： A61K39/395 , C07K16/06 , A61K39/42 , C07K16/08 , C07K16/10 , A61K45/06 , G01N33/68 , C07K16/12 , A61K39/155 , A61K39/00
CPC分类号： C07K16/06 , A61K39/155 , A61K39/39516 , A61K39/42 , A61K45/06 , A61K2039/507 , C07K16/08 , C07K16/10 , C07K16/1009 , C07K16/1027 , C07K16/1203 , C07K16/1232 , C07K16/1242 , C07K16/1271 , C07K16/1275 , C07K16/1282 , C07K16/1285 , C07K16/1289 , C07K2317/10 , C07K2317/21 , C07K2317/31 , C07K2317/76 , G01N33/6854 , Y02A50/466 , Y02A50/469
摘要： The present invention relates to compositions and methods for the treatment of immunodeficiency (e.g., primary immunodeficiency disease). In particular, the invention provides human plasma immunoglobulin compositions containing select antibody titers specific for a plurality of respiratory pathogens, methods of identifying human donors and donor samples for use in the compositions, methods of manufacturing the compositions, and methods of utilizing the compositions (e.g., for prophylactic administration and/or therapeutic treatment (e.g., passive immunization (e.g., immune-prophylaxis))).

57. 发明授权

US09655962B2 Methods and compositions for reducing microorganisms in the oropharynx, nasopharynx and oral cavities 有权
公开(公告)号：US09655962B2
公开(公告)日：2017-05-23
申请号：US14211947
申请日：2014-03-14
申请人： Camas Incorporated
发明人： Bradley M. Mitteness , Connie Phillips
IPC分类号： A61K39/395 , A61K39/40 , A61K9/00 , C07K16/12 , C07K16/14 , A61K39/00
CPC分类号： A61K39/395 , A61K9/0012 , A61K9/0063 , A61K39/39575 , A61K39/40 , A61K2039/505 , C07K16/1203 , C07K16/1207 , C07K16/1242 , C07K16/1275 , C07K16/14 , C07K2317/11 , C07K2317/23
摘要： The present disclosure relates to methods and compositions administered to the lymphatic tissue of an animal to prevent or reduce the incidence of disease or disease symptoms caused by one or more disease causing entities. Tonsillar compositions can be administered to the lymphatic tissue in the oral/nasal region of the animal and can include avian antibodies from eggs of hens inoculated with one or more target disease causing entities. Treating the lymphatic tissue in the oral/nasal region with the compositions described herein can reduce or prevent the disease causing entities from adhering to the lymphatic tissue resulting in reduced infection rates. The present disclosure also relates to oral compositions that can be used to reduce or eliminate oral pathogens in animals.

58. 发明申请

US20160289278A1 GENES OF AN OTITIS MEDIA ISOLATE OF NONTYPEABLE HEAMOPHILUS INFLUENZAE 审中-公开
公开(公告)号：US20160289278A1
公开(公告)日：2016-10-06
申请号：US15177584
申请日：2016-06-09
申请人： RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL , THE BOARD OF REGENTS OF UNIVERSITY OF OKLAHOMA
发明人： Lauren O. Bakaletz , Robert S. Munson, JR. , David W. Dyer
IPC分类号： C07K14/285 , C07K16/12 , A61K9/00 , G01N33/569 , C12N15/113 , A61K39/102 , C12Q1/68
CPC分类号： C07K14/285 , A61K9/0046 , A61K39/00 , A61K39/102 , C07K16/1242 , C07K2317/76 , C12N15/113 , C12N2310/11 , C12N2320/30 , C12Q1/689 , C12Q2600/158 , G01N33/56911 , G01N2333/285 , G01N2469/10
摘要： The invention relates to the polynucleotide sequence of a nontypeable strain of Haemophilus influenza (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.

59. 发明授权

US09034642B2 Genes of an otitis media isolate of nontypeable Haemophilus influenzae 有权
标题翻译：不可流行的流感嗜血杆菌中耳炎分离株的基因
公开(公告)号：US09034642B2
公开(公告)日：2015-05-19
申请号：US14151227
申请日：2014-01-09
申请人： Nationwide Children's Hospital, Inc.
发明人： Lauren O. Bakaletz , Robert S. Munson, Jr. , David W. Dyer
IPC分类号： C12N15/00 , C07K16/12 , C07K14/285 , A61K39/102 , A61K39/00
CPC分类号： C07K14/285 , A61K9/0046 , A61K39/00 , A61K39/102 , C07K16/1242 , C07K2317/76 , C12N15/113 , C12N2310/11 , C12N2320/30 , C12Q1/689 , C12Q2600/158 , G01N33/56911 , G01N2333/285 , G01N2469/10
摘要： The invention relates to the polynucleotide sequence of a nontypeable strain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.
摘要翻译：本发明涉及流感嗜血杆菌（NTHi）不可分型菌株的多核苷酸序列和由多核苷酸编码的多肽及其用途。本发明还涉及在中耳和/或鼻咽的NTHi感染期间或其响应中上调的NTHi基因。

60. 发明申请

US20150086561A1 BINDING MOIETIES FOR BIOFILM REMEDIATION 审中-公开
标题翻译：生物技术补救的绑定机制
公开(公告)号：US20150086561A1
公开(公告)日：2015-03-26
申请号：US14497147
申请日：2014-09-25
申请人： TRELLIS BIOSCIENCE, LLC
发明人： Lawrence M. KAUVAR , Stefan RYSER , Angeles ESTELLES , Robert STEPHENSON , Reyna J. SIMON , Omar NOURZAIE
IPC分类号： C07K16/12 , C07K14/285 , G01N33/569 , A61K39/104 , A61K39/108 , A61K39/102 , C07K7/08 , A61K39/085
CPC分类号： C07K16/1271 , C07K7/08 , C07K16/1214 , C07K16/1228 , C07K16/1242 , C07K16/1275 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/92 , C12Q1/18 , G01N33/566 , G01N33/56911 , G01N2333/21 , G01N2333/245 , G01N2333/26 , G01N2333/285 , G01N2500/04
摘要： Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
摘要翻译：描述了能够破坏不同来源的细菌生物膜的结合剂，包括由人B淋巴细胞分泌的单克隆抗体。还描述了防止用这些结合剂形成或溶解生物膜的方法。还描述了用于引发抗体破坏生物膜的免疫原。

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