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51. 发明申请

US20090041774A1 Haemophilus influenzae type IV pili 有权
公开(公告)号：US20090041774A1
公开(公告)日：2009-02-12
申请号：US11970273
申请日：2008-01-07
申请人： Lauren O. Bakaletz , Robert S. Munson, JR.
发明人： Lauren O. Bakaletz , Robert S. Munson, JR.
IPC分类号： A61K39/395 , C07H21/00 , C12N15/63 , C07K14/00 , G01N33/53 , A61P37/04 , A61P31/04 , A61K31/7052 , C12Q1/68 , A61K38/16 , C07K16/00
CPC分类号： A61K39/102 , A61K39/00 , A61K2039/505 , C07K14/195 , C07K14/285 , C07K16/1242 , C07K2319/00 , C12Q1/689 , Y10S435/851
摘要： The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H. influenzae and methods of treating and preventing H. influenzae related pathological conditions.

52. 发明申请

US20080226637A1 Haemophilus influenzae BASB206 gene and protein 审中-公开
标题翻译：流感嗜血杆菌BASB206基因和蛋白质
公开(公告)号：US20080226637A1
公开(公告)日：2008-09-18
申请号：US11270269
申请日：2005-11-08
申请人： Joelle Thonnard
发明人： Joelle Thonnard
IPC分类号： A61K39/395 , A61K38/04 , A61K38/16 , C07K11/00 , C07K14/285 , A61K39/102 , C07H21/04 , C12N15/64 , C12N1/21 , C12N1/19 , C12N1/15 , C12N5/04 , C12N5/10 , C12P21/02 , C07K16/12 , G01N33/53 , A61P31/04 , A61P37/04
CPC分类号： C07K14/285 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K16/1242 , C07K2319/00
摘要： This invention relates to polynucleotides, (herein referred to as “BASB206 polynucleotide(s)”), polypeptides encoded by them (referred to herein as “BASB206” or “BASB206 polypeptide(s)”), recombinant materials and methods for their production. In another aspect, the invention relates to methods for using such polypeptides and polynucleotides, including vaccines against bacterial infections. In a further aspect, the invention relates to diagnostic assays for detecting infection of certain pathogens.
摘要翻译：本发明涉及多核苷酸（本文中称为“BASB206多核苷酸”），由它们编码的多肽（本文称为“BASB206”或“BASB206多肽”），重组材料及其生产方法。另一方面，本发明涉及使用这种多肽和多核苷酸的方法，包括针对细菌感染的疫苗。在另一方面，本发明涉及用于检测某些病原体的感染的诊断测定。

53. 发明授权

US06858209B2 Means for detecting bacteria of the taylorella equigenitalis species and their biological applications 失效
标题翻译：用于检测等叶小芽孢杆菌物种细菌的方法及其生物应用
公开(公告)号：US06858209B2
公开(公告)日：2005-02-22
申请号：US09155982
申请日：1997-04-11
申请人： Frédéric Klein , Dragos Gradinaru
发明人： Frédéric Klein , Dragos Gradinaru
IPC分类号： A61K38/00 , A61K39/00 , C07K16/12 , C07K16/42 , A01N57/00 , A61K31/665 , A61K39/395 , A61K48/00
CPC分类号： C07K16/4233 , A61K38/00 , A61K39/00 , C07K16/1242
摘要： Means for detection of bacteria of the genus Taylorella and biological applications thereof are described. In particular, the detection of T. equigenitalis and the treatment or prevention of infections caused by bacteria of this species are disclosed. Monoclonal antibodies which recognize an epitope of a bacterium of the species T. equigenitalis are disclosed. These monoclonal antibodies may be used to detect T. equigenitalis with certainty and by means of a single test.
摘要翻译：描述了用于检测泰乐菌属细菌的方法及其生物应用。特别地，公开了对等体细菌的检测以及由这种物种细菌引起的感染的治疗或预防。公开了识别等位基因的细菌表位的单克隆抗体。这些单克隆抗体可以用于确定地检测T. equigenitalis并通过单次测试。

54. 发明申请

US20040156837A1 Haemophilus influenzae sialyltransferase and methods of use thereof 失效
标题翻译：流感嗜血杆菌唾液酸转移酶及其使用方法
公开(公告)号：US20040156837A1
公开(公告)日：2004-08-12
申请号：US10366548
申请日：2003-02-12
发明人： Michael A. Apicella , Bradford W. Gibson , Nancy J. Phillips , Paul A. Jones
IPC分类号： A61K038/48 , C12Q001/68 , C07H021/04 , C08B037/00 , C12P019/30
CPC分类号： C07K16/1242 , C12N9/1081 , C12P19/18 , C12P19/26
摘要： The present invention is directed to sialytransferases, such as SiaA sialytransferases isolated from Haemophilus influenzae. Further provided herein are methods for producing sialylated lipooligosaccharides, vaccines, and host cells and systems for the production of sialylated lipooligosaccharides.
摘要翻译：本发明涉及唾液酸转移酶，例如从流感嗜血杆菌分离的SIAA唾液酸转移酶。本文还提供了用于生产唾液酸化低聚糖，疫苗和宿主细胞的方法以及用于生产唾液酸化低聚糖的体系。

55. 发明申请

US20040047875A1 Novel compounds 审中-公开
标题翻译：新型化合物
公开(公告)号：US20040047875A1
公开(公告)日：2004-03-11
申请号：US10399091
申请日：2003-08-28
发明人： Joelle Thonnard
IPC分类号： A61K039/00 , C07H021/04 , C07K014/47
CPC分类号： G01N33/56911 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/285 , C07K16/1242 , G01N2333/285
摘要： The invention provides BASB201 polypeptides and polynucleotides encoding BASB201 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
摘要翻译：本发明提供了BASB201多肽和编码BASB201多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供诊断，预防和治疗用途。

56. 发明申请

US20040014943A1 Antibodies for detecting microorganisms 审中-公开
标题翻译：用于检测微生物的抗体
公开(公告)号：US20040014943A1
公开(公告)日：2004-01-22
申请号：US10386050
申请日：2003-03-12
申请人： ASAHI KASEI KOGYO KABUSHIKI KAISHA
发明人： Kenji Matsuyama , Takashi Shirai , Takashi Etoh , Monzur Rahman
IPC分类号： C07K001/00 , C07K014/00 , C07K017/00
CPC分类号： C07K16/1217 , C07K16/1242 , C07K16/125 , C07K16/1253 , C07K16/1275 , G01N33/56911 , G01N33/56927 , G01N33/56933
摘要： An antibody for detection of microorganisms, a method of detection of microorganisms, and a reagent kit for detection of microorganisms, which is species specific for every species of microorganisms and with which all serototypes within the same species can be detected, are provided. Antibody to intracellular molecules with the same function in each type of microorganism, particular antibody to ribosomal protein, that is, ribosomal protein L7/Ll2, is made and antibody that reacts specifically with the microorganism in question is selected.
摘要翻译：提供了用于检测微生物的抗体，微生物检测方法和用于检测微生物的试剂盒，所述微生物是针对每种微生物而特异的物种，并且能够检测同一物种内的所有血清型。对每种类型的微生物具有相同功能的细胞内分子的抗体，特别是核糖体蛋白的抗体，即核糖体蛋白L7 / L12，并且选择与所述微生物特异性反应的抗体。

57. 发明授权

US06676948B2 Haemophilus adherence and penetration proteins 失效
公开(公告)号：US06676948B2
公开(公告)日：2004-01-13
申请号：US10080505
申请日：2002-02-22
申请人： Joseph W. St. Geme, III
发明人： Joseph W. St. Geme, III
IPC分类号： A61K39102
CPC分类号： C07K16/1242 , A61K38/00 , A61K39/00 , C07K14/285 , C12N9/52
摘要： Haemophilus adhesion and penetration proteins, nucleic acids, vaccines and monoclonal antibodies are provided.

58. 发明授权

US06660266B1 Reversal of proinflammatory response by ligating the macrophage Fc&ggr;RI receptor 失效
标题翻译：通过连接巨噬细胞FcgammaRI受体逆转促炎反应
公开(公告)号：US06660266B1
公开(公告)日：2003-12-09
申请号：US09692586
申请日：2000-10-19
申请人： David M. Mosser , Fayyaz Sutterwala
发明人： David M. Mosser , Fayyaz Sutterwala
IPC分类号： A61K39395
CPC分类号： C07K16/1203 , A61K38/00 , A61K2039/505 , C07K16/1242 , C07K16/28 , C07K16/2806 , C07K2317/52
摘要： Ligation of the Fc&ggr; receptor type I (Fc&ggr;RI) on IL-10-producing cells leads to a selective upregulation of IL-10 production, which in turn induces a marked suppression of IL-12 biosynthesis by IL-12-producing cells, particularly macrophages. The ligation of the Fc&ggr;RI receptor thus downmodulates IL-12 production via a mechanism that is dependent on macrophage-derived IL-10. Agents for ligating Fc&ggr;RI comprise, for example, multivalent antibodies which bind the Fc&ggr;RI receptor, immune complexes comprising antibodies which contain the Fc region of IgG, and IgG multimers, preferably IgG dimers and trimers. The ligating agent may be administered to therapeutically inhibit proinflammatory immune responses. In particular, the ligating agent may be administered to treat or prevent endotoxic shock associated with bacterial endotoxemia, and to treating autoimmune disorders.
摘要翻译：在产生IL-10的细胞上的Fcgamma受体I型（FcgammaRI）的连接导致IL-10产生的选择性上调，这又导致IL-12生产细胞，特别是巨噬细胞对IL-12生物合成的显着抑制。 Fcgamma受体的连接因此通过依赖于巨噬细胞衍生的IL-10的机制来下调IL-12的产生。用于连接FcγRRI的药剂包含例如结合FcγR受体的多价抗体，包含含有IgG的Fc区的抗体的免疫复合物和IgG多聚体，优选IgG二聚体和三聚体。可以施用连接剂以治疗性地抑制促炎免疫应答。特别地，可以施用连接剂以治疗或预防与细菌内毒素血症相关的内毒素性休克，以及治疗自身免疫性疾病。

59. 发明授权

US6020154A H. influenzae HxuB and HxuC genes, proteins and methods of use 失效
标题翻译：流感嗜血杆菌HxuB和HxuC基因，蛋白质和使用方法
公开(公告)号：US6020154A
公开(公告)日：2000-02-01
申请号：US425843
申请日：1995-04-20
申请人： Eric J. Hansen , Leslie D. Cope , Gregory P. Jarosik , Mark S. Hanson
发明人： Eric J. Hansen , Leslie D. Cope , Gregory P. Jarosik , Mark S. Hanson
IPC分类号： A61K38/00 , C07K14/285 , C07K16/12 , C12N15/31 , C12P21/06 , C07H21/04 , C12N1/20
CPC分类号： C07K16/1242 , C07K14/285 , A61K38/00
摘要： Disclosed are hxuB and hxuC genes and DNA segments from H. influenzae such as H. influenzae type b (Hib) and nontypeable H. influenzae (NTHI). The HxuB and HxuC proteins, being surface expressed, are contemplated for use in the preparation of vaccines against pathological H. influenzae infections, and in particular, vaccines for use in children and other individuals who respond poorly to capsular-based vaccines. DNA segments encoding these proteins and anti- HxuB and HxuC antibodies will also be of in various screening, diagnostic and therapeutic applications.
摘要翻译：公开了来自流感嗜血杆菌的hxuB和hxuC基因和DNA片段，例如流感嗜血杆菌b型（Hib）和不可流行的流感嗜血杆菌（NTHI）。表面表达的HxuB和HxuC蛋白被考虑用于制备针对病毒性流感嗜血杆菌感染的疫苗，特别是用于儿童和其他对荚膜基疫苗反应差的个体的疫苗。编码这些蛋白质和抗HxuB和HxuC抗体的DNA片段也将具有各种筛选，诊断和治疗应用。

60. 发明授权

US06013514A Haemophilus outer membrane protein 失效
标题翻译：嗜血杆菌外膜蛋白
公开(公告)号：US06013514A
公开(公告)日：2000-01-11
申请号：US433522
申请日：1995-09-12
申请人： Pele Chong , Wayne Thomas , Yan Ping Yang , Sheena Loosmore , Dwo Yuan Charles Sia , Michel Klein
发明人： Pele Chong , Wayne Thomas , Yan Ping Yang , Sheena Loosmore , Dwo Yuan Charles Sia , Michel Klein
IPC分类号： G01N33/569 , A61K39/00 , A61K39/102 , A61K39/12 , A61K39/395 , A61P31/04 , C07K14/11 , C07K14/195 , C07K14/285 , C07K16/12 , C12N15/09 , C12N15/31 , C12P21/02 , C12R1/19 , C07H21/04
CPC分类号： C07K14/285 , C07K16/1242 , A61K39/00 , C07K2317/34
摘要： Purified and isolated nucleic acid from specific strains of Haemophilus influenzae is provided which encodes at least a portion of the D15 outer membrane protein of Haemophilus. The nucleic acid is used to produce peptides, polypeptides and proteins free of contaminant associated with Haemophilus for purposes of diagnosis and medical treatment. Furthermore, the nucleic acid may be used in the diagnosis of Haemophilus infection. Antisera obtained following immunization with the nucleic acid D15 outer membrane protein or peptides also may be used for the purpose of diagnosis and medical treatment.
摘要翻译： PCT No.PCT / CA93 / 00501 Sec。 371 1995年9月12日第 102（e）日期1995年9月12日PCT 1993年11月23日PCT公布。公开号WO94 / 12641 日期1994年6月9日提供了来自嗜血杆菌流感嗜血杆菌的特异菌株的纯化和分离的核酸，其编码嗜血杆菌的D15外膜蛋白的至少一部分。为了诊断和治疗的目的，该核酸用于产生不含与嗜血杆菌相关的污染物的肽，多肽和蛋白质。此外，核酸可用于诊断嗜血杆菌感染。用核酸D15外膜蛋白或肽免疫后获得的抗血清也可用于诊断和治疗的目的。

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