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51. 发明申请

US20130216569A1 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：US20130216569A1
公开(公告)日：2013-08-22
申请号：US13813410
申请日：2011-08-02
申请人： Damer Blake , Adrian Smith , Martin Shirley
发明人： Damer Blake , Adrian Smith , Martin Shirley
IPC分类号： A61K39/012
CPC分类号： A61K39/012 , C07K14/455
摘要： The present invention provides a polypeptide comprising the amino acid sequence as shown as SEQ ID No. 1 or a homologue or fragment thereof, a nucleic acid capable of encoding such a polypeptide and a vaccine comprising such a polypeptide/nucleic acid. The vaccine may be used for the treatment and/or prevention of a disease associated with an apicomplexan parasite.
摘要翻译：本发明提供了包含如SEQ ID No.1所示的氨基酸序列或其同源物或片段，能够编码这种多肽的核酸和包含该多肽/核酸的疫苗的多肽。疫苗可用于治疗和/或预防与复合体寄生虫相关的疾病。

52. 发明授权

US08257714B2 Compositions and methods for immunotherapy of cancer and infectious diseases 有权
标题翻译：癌症和传染病免疫治疗的组成和方法
公开(公告)号：US08257714B2
公开(公告)日：2012-09-04
申请号：US12102292
申请日：2008-04-14
申请人： Charles Aylsworth , Siu-Cheong Ho , David Juckett , John W. Judge , Barnett Rosenberg , Igor V. Zlatkin , Tatiana Zlatkin
发明人： Charles Aylsworth , Siu-Cheong Ho , David Juckett , John W. Judge , Barnett Rosenberg , Igor V. Zlatkin , Tatiana Zlatkin
IPC分类号： A61K39/00 , A61K39/002 , A61K35/68 , A61P31/16
CPC分类号： A61K39/39 , A61K38/16 , A61K39/012 , A61K2039/55516 , C07K14/455
摘要： The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.
摘要翻译：本发明提供用于预防和治疗原发性和转移性肿瘤疾病和感染性疾病，用于刺激受试者的免疫应答并用作白细胞介素-12（IL-12）治疗的替代物的组合物和方法。特别地，本发明提供了具有免疫刺激活性的Apicocplexa相关蛋白（ARP），因此具有用于治疗和预防癌症和感染性疾病以及免疫调节的用途。提供了包含ARP的组合。还提供了用于预防和/或治疗癌症和/或感染性疾病（用作白细胞介素-12（IL-12）治疗的替代物）和用于在受试者中引发免疫应答的方法。

53. 发明申请

US20110053148A1 COCCIDIOSIS VACCINES 审中-公开
标题翻译： COCCIDOOSIS VACCINES
公开(公告)号：US20110053148A1
公开(公告)日：2011-03-03
申请号：US12633426
申请日：2009-12-08
申请人： Theodorus Cornelis Schaap , Catharina Maria Kuiper , Arnoldus Nicolaas Vermeulen
发明人： Theodorus Cornelis Schaap , Catharina Maria Kuiper , Arnoldus Nicolaas Vermeulen
IPC分类号： C12Q1/68 , C07H21/04 , C12N1/00
CPC分类号： C07K14/455 , A61K39/00
摘要： The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host cells comprising such DNA-fragments, recombinant DNA molecules or live recombinant carriers. Furthermore, the invention relates to antibodies against the polypeptides and to coccidiosis vaccines based upon said polypeptides. The invention also relates to methods for the preparation of such antibodies and vaccines, and to methods for the detection of Eimeria parasites and antibodies against Eimeria parasites.
摘要翻译：本发明涉及亲水艾美球虫多肽，编码那些肽的DNA片段，包含此类DNA片段的重组DNA分子，包含该DNA片段或重组DNA分子的活重组载体和包含该DNA片段的宿主细胞，重组DNA分子或活重组载体。此外，本发明涉及基于所述多肽的针对多肽的抗体和针对球虫病的疫苗。本发明还涉及制备这种抗体和疫苗的方法，以及用于检测艾美虫寄生虫和针对艾美虫寄生虫的抗体的方法。

54. 发明授权

US07423137B2 Nucleic acids encoding recombinant 56 and 82 kDa antigens from gametocytes of Eimeria maxima and their uses 失效
标题翻译：编码重组56和82 kDa抗原的核酸从艾美球虫的配子体及其用途
公开(公告)号：US07423137B2
公开(公告)日：2008-09-09
申请号：US10483159
申请日：2002-07-03
申请人： Sabina I. Belli , Nicholas C. Smith , Michael Wallach
发明人： Sabina I. Belli , Nicholas C. Smith , Michael Wallach
IPC分类号： C07H21/04 , C07K14/00 , C12P21/04 , C12N1/10 , A61K39/012 , A61K39/00
CPC分类号： C07K14/455 , A61K39/00
摘要： The present invention provides the recombinant cloning and sequencing of two of the major Eimeria maxima gametocyte antigens having molecular weights of 56 and 82 kDa and the expression of these recombinant antigens in an E. coli expression system using the plasmid pTrcHis. The subject invention also provides a vaccine against coccidiosis comprising the recombinant 56 kDa or 82 kDa antigen. The subject invention also provides two 30 kDa proteins and three 14 kDa proteins from Eimeria maxima gametocytes having at the N-terminal end the amino acid sequence described herein. The subject invention also provides a vaccine against coccidiosis comprising the recombinant 56 kDa or 82 kDa antigen and any of the aforementioned proteins. Additionally, the subject invention also provides a method of immunizing a subject against infection by Eimeria tenella, Eimeria maxima, Eimeria acervulina, Eimeria necatrix, Eimeria praecox, Eimeria mitis or Eimeria brunetti, or a microorganism expressing an immunologically cross-reactive antigen, comprising the step of administering to the subject any of the aforementioned vaccines.
摘要翻译：本发明提供了分子量为56和82kDa的两种主要的艾美球虫最大配子型抗原的重组克隆和测序，以及这些重组抗原在使用质粒pTrcHis的大肠杆菌表达系统中的表达。本发明还提供了包含重组56kDa或82kDa抗原的针对球虫病的疫苗。本发明还提供了在最终端具有本文所述氨基酸序列的来自艾美球虫最大配子配子的两个30kDa蛋白质和三个14kDa蛋白质。本发明还提供了包含重组56kDa或82kDa抗原和任何上述蛋白质的抗球虫病疫苗。此外，本发明还提供了免疫受试者免受艾美球虫艾美球虫，艾美球虫艾美球虫，艾美球虫，艾美球虫，艾美球虫或艾美球虫艾美球虫或表达免疫交叉反应性抗原的微生物的感染的方法，向受试者施用任何上述疫苗的步骤。

55. 发明授权

US07150873B2 Coccidiosis vaccines 失效
标题翻译：球虫病疫苗
公开(公告)号：US07150873B2
公开(公告)日：2006-12-19
申请号：US10723123
申请日：2003-11-26
申请人： Theodorus Cornelis Schaap , Catharina Maria Kuiper , Arnoldus Nicolaas Vermeulen
发明人： Theodorus Cornelis Schaap , Catharina Maria Kuiper , Arnoldus Nicolaas Vermeulen
IPC分类号： A61K39/00 , A61K39/012 , C07H21/04 , C12P21/06
CPC分类号： C07K14/455 , A61K39/00
摘要： The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host cells comprising such DNA-fragments, recombinant DNA molecules or live recombinant carriers. Furthermore, the invention relates to antibodies against the polypeptides and to coccidiosis vaccines based upon said polypeptides. The invention also relates to methods for the preparation of such antibodies and vaccines, and to methods for the detection of Eimeria parasites and antibodies against Eimeria parasites.
摘要翻译：本发明涉及亲水艾美球虫多肽，编码那些肽的DNA片段，包含此类DNA片段的重组DNA分子，包含该DNA片段或重组DNA分子的活重组载体和包含该DNA片段的宿主细胞，重组DNA分子或活重组载体。此外，本发明涉及基于所述多肽的针对多肽的抗体和针对球虫病的疫苗。本发明还涉及制备这种抗体和疫苗的方法，以及用于检测艾美虫寄生虫和针对艾美虫寄生虫的抗体的方法。

56. 发明申请

US20050169935A1 Compositions and methods for immunotherapy of cancer and infectious diseases 有权
标题翻译：癌症和传染病免疫治疗的组成和方法
公开(公告)号：US20050169935A1
公开(公告)日：2005-08-04
申请号：US10892659
申请日：2004-07-15
申请人： Charles Aylsworth , Siu-Cheong Ho , David Juckett , John Judge , Barnett Rosenberg , Igor Zlatkin , Tatiana Zlatkin
发明人： Charles Aylsworth , Siu-Cheong Ho , David Juckett , John Judge , Barnett Rosenberg , Igor Zlatkin , Tatiana Zlatkin
IPC分类号： A61K38/16 , A61K39/00 , A61K39/012 , A61K39/39 , C07K14/455 , A61K38/17
CPC分类号： A61K39/39 , A61K38/16 , A61K39/012 , A61K2039/55516 , C07K14/455
摘要： The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomlexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.
摘要翻译：本发明提供用于预防和治疗原发性和转移性肿瘤疾病和感染性疾病，用于刺激受试者的免疫应答并用作白细胞介素-12（IL-12）治疗的替代物的组合物和方法。特别地，本发明提供具有免疫刺激活性的Apicomlexa相关蛋白（ARP），因此具有用于治疗和预防癌症和感染性疾病以及免疫调节的用途。提供了包含ARP的组合。还提供了用于预防和/或治疗癌症和/或感染性疾病（用作白细胞介素-12（IL-12）治疗的替代物）和用于在受试者中引发免疫应答的方法。

57. 发明申请

US20050008659A1 Vaccination modalities 有权
标题翻译：疫苗接种方式
公开(公告)号：US20050008659A1
公开(公告)日：2005-01-13
申请号：US10841476
申请日：2004-05-10
申请人： David Richards , Wayne Jorgensen , Norman Stewart
发明人： David Richards , Wayne Jorgensen , Norman Stewart
IPC分类号： C12N1/10 , A61K39/00 , A61K39/012 , A61P33/02 , C07K14/455
CPC分类号： C12R1/01 , A61K39/00 , A61K39/012 , C07K14/455
摘要： Vaccines for the prevention and/or treatment of Eimeria infection including one or more strains of E. maxima ARI-73/97, E. acervulina ARI-77/97, E. tenella ARI-11/98, E. necatrix MCK01 and/or E. necatrix ARI-MEDNEC3+8 are described. Eimeria selected from E. maxima ARI-73/97, E. acervuina ARI-77/97, E. tenella ARI-11/98, E. necatrix MCK01 and/or E. mecatrix ARI-MEDNEC3+8 are also described.
摘要翻译：用于预防和/或治疗艾美球虫感染的疫苗，包括一种或多种大肠杆菌ARI-73/97，，ina ina ina I I---------ella ella ella AR AR AR AR--rix rix rix rix rix / / 或大肠杆菌ARI-MEDNEC3 + 8。还描述了选自大肠杆菌ARI-73/97，大肠埃希氏菌属ARI-77/97，埃氏弧菌ARI-11/98，大肠杆菌MCK01和/或胚芽抗性ARI-MEDNEC3 + 8的艾美球虫。

58. 发明授权

US06680061B1 Coccidiosis vaccines 失效
标题翻译：球虫病疫苗
公开(公告)号：US06680061B1
公开(公告)日：2004-01-20
申请号：US09749233
申请日：2000-12-27
申请人： Theodorus Cornelis Schaap , Catharina Maria Kuiper , Arnoldus Nicolaas Vermeulen
发明人： Theodorus Cornelis Schaap , Catharina Maria Kuiper , Arnoldus Nicolaas Vermeulen
IPC分类号： A61K39012
CPC分类号： C07K14/455 , A61K39/00
摘要： The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host cells comprising such DNA-fragments, recombinant DNA molecules or live recombinant carriers. Furthermore, the invention relates to antibodies against the polypeptides and to coccidiosis vaccines based upon said polypeptides. The invention also relates to methods for the preparation of such antibodies and vaccines, and to methods for the detection of Eimeria parasites and antibodies against Eimeria parasites.
摘要翻译：本发明涉及亲水艾美球虫多肽，编码那些肽的DNA片段，包含此类DNA片段的重组DNA分子，包含该DNA片段或重组DNA分子的活重组载体和包含该DNA片段的宿主细胞，重组DNA分子或活重组载体。此外，本发明涉及基于所述多肽的针对多肽的抗体和针对球虫病的疫苗。本发明还涉及制备这种抗体和疫苗的方法，以及用于检测艾美虫寄生虫和针对艾美虫寄生虫的抗体的方法。

59. 发明授权

US5824656A Recombinant and native group B eimeria tenella immunogens useful as coccidiosis vaccines 失效
标题翻译：可用作球虫病疫苗的重组和天然B组艾美球虫免疫原
公开(公告)号：US5824656A
公开(公告)日：1998-10-20
申请号：US458590
申请日：1995-06-02
申请人： Helen Profous-Juchelka , Mervyn J. Turner , Paul A. Liberator
发明人： Helen Profous-Juchelka , Mervyn J. Turner , Paul A. Liberator
IPC分类号： A61K39/00 , C07K14/455 , C07K16/20 , A61K48/00 , C07H21/04
CPC分类号： C07K16/20 , C07K14/455 , A61K39/00
摘要： Genes coding for novel Group B Eimeria tenella protein immunogens have been isolated and inserted into a novel expression vector which in turn has been used to transform appropriate hosts. The transformed host cells produce recombinant Group B E. tenella proteins which are capable of inducing immunity in chickens to coccidiosis.
摘要翻译：已经分离了编码新型组B的艾美球虫（Eimeria tenella）蛋白免疫原的基因，并将其插入到新的表达载体中，其又被用于转化合适的宿主。转化的宿主细胞产生能够在鸡中诱导球虫病免疫的重组B组E.eella蛋白。

60. 发明授权

US5789233A DNA encoding an Eimekia 50 KD antigen 失效
标题翻译：编码Eimekia 50 KD抗原的DNA
公开(公告)号：US5789233A
公开(公告)日：1998-08-04
申请号：US310357
申请日：1994-09-21
申请人： Arnoldus Nicolaas Vermeulen , Paul van den Boogaart , Jacobus Johannus Kok
发明人： Arnoldus Nicolaas Vermeulen , Paul van den Boogaart , Jacobus Johannus Kok
IPC分类号： C12N15/09 , A61K20060101 , A61K39/00 , A61K39/002 , A61K39/012 , A61K39/395 , A61P33/02 , C07D20060101 , C07K20060101 , C07K14/455 , C07K16/20 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/30 , C12N15/63 , C12N15/83 , C12P20060101 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/19
CPC分类号： C07K14/455 , C07K16/20 , A61K39/00
摘要： The invention is concerned with novel Eimeria proteins with immunogenic properties as well as with DNA sequences encoding these proteins. These proteins can be administered to chickens thereby protecting the chickens against coccidiosis. In addition the DNA encoding these proteins can be used for the preparation of a vector vaccine against coccidiosis.
摘要翻译：本发明涉及具有免疫原性的新颖艾美球虫蛋白以及编码这些蛋白质的DNA序列。这些蛋白质可以施用于鸡，从而保护鸡免于球虫病。此外，编码这些蛋白质的DNA可用于制备针对球虫病的载体疫苗。

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