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51. 发明申请

US20140296531A1 Novel semi-synthetic small molecules for the treatment parasitic disease 有权
标题翻译：新型半合成小分子治疗寄生虫病
公开(公告)号：US20140296531A1
公开(公告)日：2014-10-02
申请号：US14236030
申请日：2012-07-28
申请人： Khanitha Pudhom , Gabriel Navarro , James McKerrow , Roger Linington
发明人： Khanitha Pudhom , Gabriel Navarro , James McKerrow , Roger Linington
IPC分类号： C07D319/02 , C07D405/12 , C07D409/12 , C07D413/12 , C07D407/12 , C07D417/12
CPC分类号： C07D319/02 , C07D311/02 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Small molecule therapeutics for the treatment of parasitic diseases, in particular, semi-synthetic derivatives of the fugally-derived natural product merulin A for the treatment of African Sleeping Sickness.
摘要翻译：用于治疗寄生虫病的小分子治疗剂，特别是用于治疗非洲睡眠疾病的假性天然产物Merulin A的半合成衍生物。

52. 发明申请

US20140186875A1 NOVEL OPTICAL LABELING MOLECULES FOR PROTEOMICS AND OTHER BIOLOGICAL ANALYSIS 审中-公开
标题翻译：用于保护和其他生物分析的新型光学标签分子
公开(公告)号：US20140186875A1
公开(公告)日：2014-07-03
申请号：US14143608
申请日：2013-12-30
申请人： Montana State University
发明人： Edward Dratz , Paul Grieco
IPC分类号： G01N33/68
CPC分类号： G01N33/6803 , C07D209/12 , C07D209/14 , C07D213/75 , C07D213/81 , C07D311/02 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/08 , C07D471/04 , C07F5/022 , G01N33/582 , Y02A50/52
摘要： The invention relates to compositions and methods useful in the labeling and identification of changes in protein levels, changes in enzyme activity, and changes in protein modification. The invention provides for highly soluble optical labeling molecules which are optionally cleavable after separation of mixtures of labeled proteins into components. These optical labeling molecules find utility in a variety of applications, including use in the field of proteomics.
摘要翻译：本发明涉及用于标记和鉴定蛋白质水平变化，酶活性变化和蛋白质修饰变化的组合物和方法。本发明提供了高度可溶的光学标记分子，其在将标记的蛋白质的混合物分离成组分后任选地可切割。这些光学标记分子可用于各种应用，包括在蛋白质组学领域的应用。

53. 发明申请

US20100151379A1 COMPOUND AND CHEMICALLY AMPLIFIED RESIST COMPOSITION CONTAINING THE SAME 失效
标题翻译：化合物和化学抑制剂组合物
公开(公告)号：US20100151379A1
公开(公告)日：2010-06-17
申请号：US12631061
申请日：2009-12-04
申请人： Ichiki Takemoto , Nobuo Ando
发明人： Ichiki Takemoto , Nobuo Ando
IPC分类号： G03F7/004 , C07D311/96 , C07D311/02
CPC分类号： C07D311/02 , C07D311/96 , G03F7/0045 , G03F7/0046 , G03F7/0392 , Y10S430/122 , Y10S430/126
摘要： The present invention provides a compound represented by the formula (I): wherein P1, P2, P3, P4 and P5 each independently represents a hydrogen atom etc., and at least one selected from the group consisting of R1, R2, R3, R4, R5, R6, R7, R8 and R9 is the group represented by the formula (II): wherein X1 and X2 each independently represent a hydrogen atom etc., n represents an integer of 1 to 4, Z1 represents a C1-C6 alkyl group etc., and ring Y represents an alicyclic hydrocarbon group, and the others each independently represent a hydrogen atom, a C1-C6 alkyl group or a hydroxyl group, and a chemically amplified resist composition containing the same.
摘要翻译：本发明提供由式（I）表示的化合物：其中P1，P2，P3，P4和P5各自独立地表示氢原子等，以及选自由R1，R2，R3，R4 ，R 5，R 6，R 7，R 8和R 9为由式（II）表示的基团：其中X 1和X 2各自独立地表示氢原子等，n表示1至4的整数，Z 1表示C 1 -C 6烷基基团等，环Y表示脂环烃基，其余各自独立地表示氢原子，C1-C6烷基或羟基，以及含有该烷氧基的化学放大抗蚀剂组合物。

54. 发明授权

US07704667B2 Dyes and use thereof in imaging members and methods 有权
标题翻译：染料及其在成像部件和方法中的应用
公开(公告)号：US07704667B2
公开(公告)日：2010-04-27
申请号：US12022969
申请日：2008-01-30
申请人： Kap-Soo Cheon , Stephen J. Telfer , Michael P. Filosa , John L. Marshall , Fariza B. Hasan , David A. Skyler , John M. Hardin
发明人： Kap-Soo Cheon , Stephen J. Telfer , Michael P. Filosa , John L. Marshall , Fariza B. Hasan , David A. Skyler , John M. Hardin
IPC分类号： G03F7/00 , G03C1/00 , G03C1/72 , C07D493/10
CPC分类号： B41M5/284 , B41M5/385 , C07D311/02 , C07D491/20 , C07D493/10
摘要： There are described novel rhodamine dye compounds and imaging members and imaging methods, including thermal imaging members and imaging methods, utilizing the compounds. The dye compounds exhibit a first color when in the crystalline form and a second color, different from the first color, when in the liquid, amorphous form.
摘要翻译：描述了利用该化合物的新型罗丹明染料化合物和成像构件和成像方法，包括热成像构件和成像方法。当处于液体，无定形形式时，染料化合物呈现为结晶形式的第一颜色和与第一颜色不同的第二颜色。

55. 发明申请

US20100016154A1 IMAGING SYSTEM 审中-公开
标题翻译：成像系统
公开(公告)号：US20100016154A1
公开(公告)日：2010-01-21
申请号：US12369600
申请日：2009-02-11
申请人： Peter K. CHU , Chien LIU , Stephen J. TELFER
发明人： Peter K. CHU , Chien LIU , Stephen J. TELFER
IPC分类号： B41M5/28
CPC分类号： B41M5/385 , B41M5/1455 , B41M5/284 , B41M5/3275 , B41M5/34 , C07D311/02 , C07D493/10 , C09B11/24 , C09B67/006 , Y10S430/145 , Y10S430/146
摘要： There are disclosed imaging members wherein a chemical compound in a crystalline form is converted, at least partially, and preferably substantially completely or completely, to a liquid in the amorphous form, the liquid having intrinsically a different color from the crystalline form. Also described are imaging methods utilizing the imaging members. The conversion of the compound from the crystalline form to the liquid form can be effected by the application of thermal energy or by other imaging techniques.
摘要翻译：公开了成像构件，其中结晶形式的化合物至少部分地，优选地基本上完全或完全地转化为无定形形式的液体，该液体本质上与结晶形式不同。还描述了利用成像构件的成像方法。化合物从结晶形式转化为液体形式可以通过施加热能或通过其它成像技术来实现。

56. 发明申请

US20080045586A1 OXYDECAHYDRONAPHTHALENE MODULATORS OF HM74 审中-公开
标题翻译： HM74的氧化亚硝酸盐调节剂
公开(公告)号：US20080045586A1
公开(公告)日：2008-02-21
申请号：US11847370
申请日：2007-08-30
申请人： Anne MINNICH , Theresa KUNTZWEILER , Haifeng EISHINGDRELO , Michael ANGELASTRO , Stephan HENKE
发明人： Anne MINNICH , Theresa KUNTZWEILER , Haifeng EISHINGDRELO , Michael ANGELASTRO , Stephan HENKE
IPC分类号： A61K31/35 , A61P29/00
CPC分类号： A61K31/352 , C07D311/02
摘要： Host cells expressing HM74 were used to obtain oxydecalin-like molecules with agonist activity having the following structure:
摘要翻译：使用表达HM74的宿主细胞获得具有以下结构的激动剂活性的氧六心肌样分子：

57. 发明授权

US07282317B2 Dye complexes and use thereof in imaging members and methods 失效
标题翻译：染料复合物及其在成像构件和方法中的应用
公开(公告)号：US07282317B2
公开(公告)日：2007-10-16
申请号：US10789600
申请日：2004-02-27
申请人： Richard M. Allen , Michael P. Filosa , Stephen J. Telfer
发明人： Richard M. Allen , Michael P. Filosa , Stephen J. Telfer
IPC分类号： G03F7/00 , G03F7/004
CPC分类号： B41M5/385 , B41M5/1455 , B41M5/284 , B41M5/3275 , B41M5/34 , C07D311/02 , C07D493/10 , C09B11/24 , C09B67/006 , Y10S430/145 , Y10S430/146
摘要： There are described novel complexes formed between hydrogen bond acceptors and phenolic dye compounds and imaging members and imaging methods, including thermal imaging members and methods utilizing the complexes.
摘要翻译：描述了在氢键受体和酚类染料化合物和成像构件之间形成的新型复合物和成像方法，包括热成像构件和利用复合物的方法。

58. 发明申请

US20060116421A1 Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity 失效
标题翻译：趋化因子受体活性的四氢吡喃基环戊基苄基酰胺调节剂
公开(公告)号：US20060116421A1
公开(公告)日：2006-06-01
申请号：US10533326
申请日：2003-10-24
申请人： Gabor Butora , Sander Mills , Alexander Pasternak , Kothandaraman Shankaran , Lihu Yang , Changyou Zhou , Stephen Goble
发明人： Gabor Butora , Sander Mills , Alexander Pasternak , Kothandaraman Shankaran , Lihu Yang , Changyou Zhou , Stephen Goble
IPC分类号： A61K31/35 , A61K31/16 , C07D309/04
CPC分类号： C07D311/00 , C07C237/24 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07D211/58 , C07D211/96 , C07D305/08 , C07D307/22 , C07D309/14 , C07D311/02 , C07D311/68 , C07D311/74 , C07D313/04 , C07D319/06 , C07D333/36 , C07D335/02 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/12 , C07D491/04 , C07D491/107 , C07D493/08
摘要： The present invention is directed to compounds of the formula (I) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R27, R28, R29, R30, R31, X, m, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
摘要翻译：本发明涉及式（I）化合物（其中R 1，R 2，R 3，R 3，R 4， R 5，R 6，R 7，R 8，R 9，R 9， R 10，R 11，R 27，R 28，R 29， R 30，R 30，R 31，X，m，n，虚线在本文中定义），其可用作趋化因子受体活性的调节剂。特别地，这些化合物可用作趋化因子受体CCR-2的调节剂。

59. 发明申请

US20040176617A1 Novel dyes 有权
标题翻译：新型染料
公开(公告)号：US20040176617A1
公开(公告)日：2004-09-09
申请号：US10789276
申请日：2004-02-27
发明人： Kap-Soo Cheon , Michael P. Filosa , Stephen J. Telfer
IPC分类号： C07D321/00
CPC分类号： B41M5/385 , B41M5/1455 , B41M5/284 , B41M5/3275 , B41M5/34 , C07D311/02 , C07D493/10 , C09B11/24 , C09B67/006 , Y10S430/145 , Y10S430/146
摘要： There are described novel rhodol dye compounds The dye compounds exhibit a first color when in the crystalline form and a second color, different from the first color, when in the liquid, amorphous form.
摘要翻译：描述了新颖的罗丹明染料化合物当处于液体，无定形形式时，染料化合物呈现为结晶形式的第一种颜色和与第一种颜色不同的第二种颜色。

60. 发明授权

US06608010B2 Bicyclic lactones, perfumery uses thereof, processes for preparing same and intermediates therefor 有权
标题翻译：双环内酯，其香料用途，其制备方法及其中间体
公开(公告)号：US06608010B2
公开(公告)日：2003-08-19
申请号：US10210386
申请日：2002-08-01
申请人： Richard A. Weiss , Mark A. Sprecker , Marie R. Hanna , Charles E. J. Beck , Harold W. Jackson
发明人： Richard A. Weiss , Mark A. Sprecker , Marie R. Hanna , Charles E. J. Beck , Harold W. Jackson
IPC分类号： C11D350
CPC分类号： A61K8/498 , A61L9/01 , A61L9/012 , A61Q13/00 , C07D311/02 , C07D311/74 , C11B9/008 , C11D3/2096 , C11D3/50
摘要： Described are bicyclic lactones, both fused ring lactones defined according to the generic structure: and spiro lactones defined according to the generic structure: uses thereof in augmenting, enhancing or imparting aromas in or to perfume compositions, perfumed articles, colognes and perfumed polymers; processes for preparing such bicyclic lactones and intermediates therefor. In the structure: Z is one of the moieties: one of R1 or R3 is methyl and the other is hydrogen; and R4, R5, R6, R7, R8 and R9 are hydrogen or nonadjacent C1-C3 alkyl. In the structure: Y represents C2-C12 substituted or unsubstituted alkylidenyl, alkenylidenyl or alkadienylidenyl having the structure: and completes a C5-C15 cycloalkyl, cycloalkadienyl or cycloalkenyl ring moiety; and wherein R12, R13, R14, R16, R17, R28, R29, R30 and R31 represent hydrogen or C1-C3 nonadjacent alkyl; wherein s is an integer of from 0 up to 10; t is an integer of from 0 up to 10; and v is an integer of 1 or 2; with the proviso that the sum of s and t is between 0 and 10 according to the inequalities: 0≦s+t≦10; 0≦s≦10; and 0≦t≦10.
摘要翻译：描述的是双环内酯，根据通用结构定义的稠环内酯和根据通用结构定义的螺内酯：用于增强，增强或赋予香料组合物，香料制品，古龙水和加香聚合物中的香气; 制备这种双环内酯的方法及其中间体。在结构中：Z是部分之一：R 1或R 3中的一个是甲基，另一个是氢; 且R 4，R 5，R 6，R 7，R 8和R 9为氢或不相邻的C 1 -C 3烷基。在结构中：Y表示具有以下结构的C 2 -C 12取代或未取代的亚烷基，亚烯基或链二烯基;并且完成C 5 -C 15环烷基，环链二烯基或环烯基环部分; 并且其中R12，R13，R14，R16，R17，R28，R29，R30和R31表示氢或C1-C3不相邻的烷基; 其中s为0至10的整数; t是0到10的整数; v为1或2的整数; 条件是根据不等式，s和t之和在0和10之间：0 <= s + t <= 10; 0 <= s <= 10; 0 <= t <= 10。

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