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51. 发明申请

US20180193643A1 METHOD AND DEVICE FOR SACRAL NERVE STIMULATION 审中-公开
公开(公告)号：US20180193643A1
公开(公告)日：2018-07-12
申请号：US15579488
申请日：2016-06-03
申请人： The Johns Hopkins University
发明人： Jiande Chen , Jieyun Yin , Pankaj J. Pasricha
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61N1/36132 , A61N1/36135 , A61N1/36146 , A61N1/36157 , A61N1/36189
摘要： The present invention provides a method and device for sacral nerve stimulation (SNS) for treatment of disease, such as inflammatory disease. The SNS therapy is automatically adjusted in response to detection of physiological data from the patient.

52. 发明申请

US20180104488A1 NEUROMODULATION USING STOCHASTICALLY-MODULATED STIMULATION PARAMETERS 审中-公开
公开(公告)号：US20180104488A1
公开(公告)日：2018-04-19
申请号：US15818186
申请日：2017-11-20
申请人： Boston Scientific Neuromodulation Corporation
发明人： Changfang Zhu
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/36071 , A61N1/36189 , A61N1/37247
摘要： An example of a system may include an electrode arrangement and a neuromodulation device configured to use electrodes in the electrode arrangement to generate a neuromodulation field. The neuromodulation device may include a neuromodulation generator, a neuromodulation control circuit and a storage. The storage may include a stochastically-modulated neuromodulation parameter set and the stochastically-modulated neuromodulation parameter set may include at least one stochastically-modulated parameter. The controller may be configured to control the neuromodulation generator using the stochastically-modulation parameter set to generate the neuromodulation field.

53. 发明授权

US09770595B2 Tibial nerve stimulation therapy device calibration 有权
公开(公告)号：US09770595B2
公开(公告)日：2017-09-26
申请号：US14750258
申请日：2015-06-25
申请人： AMS Research Corporation
发明人： David J. Yonce
IPC分类号： A61N1/00 , A61N1/36 , A61N1/04
CPC分类号： A61N1/36139 , A61N1/0484 , A61N1/3606 , A61N1/36071 , A61N1/36185 , A61N1/36189
摘要： A tibial nerve stimulation therapy device configured to provide an electrical stimulation therapy to branches of the tibial nerve includes a plurality of stimulation electrodes, a support member, a stimulation circuit, and a sensing circuit. The support member is configured to support the plurality of electrodes on a top surface of an ankle area of the patient. The stimulation circuit is configured to generate electrical stimulation pulses. The sensing circuit is configured to generate an output signal indicative of an electromyogram (EMG) signal generated by the patient.

54. 发明申请

US20170246456A1 PATTERNED STIMULATION INTENSITY FOR NEURAL STIMULATION 审中-公开
公开(公告)号：US20170246456A1
公开(公告)日：2017-08-31
申请号：US15104589
申请日：2014-12-16
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： Dustin Tyler , Daniel Tan , Matthew Schiefer
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/0551 , A61N1/36003 , A61N1/36014 , A61N1/36067 , A61N1/361 , A61N1/36103 , A61N1/36139 , A61N1/36146 , A61N1/3615 , A61N1/36178 , A61N1/36189
摘要： One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

55. 发明申请

US20170036030A1 MULTI-CHANNEL NEUROMODULATION SYSTEM HAVING FREQUENCY MODULATION STIMULATION 审中-公开
标题翻译：具有频率调制刺激的多通道神经网络系统
公开(公告)号：US20170036030A1
公开(公告)日：2017-02-09
申请号：US15331473
申请日：2016-10-21
申请人： Boston Scientific Neuromodulation Corporation
发明人： Que T. Doan , Changfang Zhu
IPC分类号： A61N1/36
CPC分类号： A61N1/36189 , A61N1/36071 , A61N1/36146 , A61N1/36167 , A61N1/36171 , A61N1/36178
摘要： A neuromodulation system comprises a plurality of electrical terminals configured for being respectively coupled to electrodes, modulation output circuitry configured for respectively outputting a plurality of individual electrical pulse trains in a plurality of timing channels to the electrical terminals, wherein each of the timing channels prevents the respective pulse train from having a specific characteristic, and control circuitry configured for controlling the modulation output circuitry in a manner that outputs the pulse trains to a common set of the electrical terminals, thereby creating a combined electrical pulse train at the common set of electrical terminals that has the specific characteristic. A method of providing therapy to a patient comprises delivering a plurality of electrical pulse trains respectively in a plurality of timing channels to a common set of electrodes implanted within the patient, thereby creating a combined electrical pulse train at the common set of electrical terminals.
摘要翻译：神经调节系统包括被配置为分别耦合到电极的多个电端子，调制输出电路，被配置为分别在多个定时通道中向电端子输出多个单独的电脉冲串，其中每个定时通道阻止具有特定特性的相应的脉冲串，以及被配置为以将脉冲序列输出到公共电端子的方式来控制调制输出电路的控制电路，从而在公共电气端子组产生组合电脉冲串具有特定的特点。向患者提供治疗的方法包括将多个定时通道中的多个电脉冲序列传送到植入患者体内的一组共同的电极，由此在共同的电端子组上形成组合的电脉冲串。

56. 发明申请

US20170001010A1 SYSTEM AND METHOD FOR SHAPED PHASED CURRENT DELIVERY 审中-公开
标题翻译：用于形成相位电流输送的系统和方法
公开(公告)号：US20170001010A1
公开(公告)日：2017-01-05
申请号：US15269591
申请日：2016-09-19
申请人： Boston Scientific Neuromodulation Corporation
发明人： Kerry Bradley , Rafael Carbunaru
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/36071 , A61N1/36171 , A61N1/36189 , A61N1/36192 , A61N1/37223 , A61N1/37241
摘要： A method of treating an ailment suffered by a patient using one or more electrodes adjacent spinal column tissue of the patient, comprises delivering electrical modulation energy from the one or more electrodes to the spinal column tissue in accordance with a continuous bi-phasic waveform having a positive phase and a negative phase, thereby modulating the spinal column tissue to treat the ailment. An implantable electrical modulation system, comprises one or more electrical terminals configured for being coupled to one or more modulation leads, output modulation circuitry capable of outputting electrical modulation energy to the electrical terminal(s) in accordance with a continuous bi-phasic waveform, and control circuitry configured for modifying a shape of the continuous bi-phasic waveform, thereby changing the characteristics of the electrical modulation energy outputted to the electrode(s).
摘要翻译：治疗患者使用邻近患者脊柱组织的一个或多个电极所遭受的疾病的方法包括根据连续的两相波形将电调制能量从所述一个或多个电极传递到脊柱组织，所述连续的两相波形具有正相和负相，从而调节脊柱组织以治疗疾病。一种可植入电调制系统，包括被配置为耦合到一个或多个调制引线的一个或多个电端子，输出调制电路，其能够根据连续的双相波形向电端子输出电调制能量;以及控制电路被配置为修改连续两相波形的形状，从而改变输出到电极的电调制能量的特性。

57. 发明授权

US09526906B2 External resonance matching between an implanted device and an external device 有权
标题翻译：植入器件与外部器件之间的外部谐振匹配
公开(公告)号：US09526906B2
公开(公告)日：2016-12-27
申请号：US13952063
申请日：2013-07-26
申请人： Adi Mashiach
发明人： Adi Mashiach
IPC分类号： A61N1/372 , A61N1/378 , A61N1/05 , A61B17/04 , A61N1/36 , H04B5/00 , H02J7/02 , A61N1/375
CPC分类号： A61B17/0482 , A61N1/0526 , A61N1/0548 , A61N1/0558 , A61N1/36003 , A61N1/3601 , A61N1/3605 , A61N1/3606 , A61N1/36071 , A61N1/36075 , A61N1/3611 , A61N1/36117 , A61N1/36125 , A61N1/36132 , A61N1/36189 , A61N1/37229 , A61N1/375 , A61N1/3787 , H02J7/025 , H02J50/05 , H02J50/12 , H04B5/0031 , H04B5/0037 , H04B5/0081 , H04B5/0093 , Y10T29/49018
摘要： Some embodiments of the disclosure may include a device for wirelessly powering an implant unit in a body of a subject from a location outside of the body of the subject, wherein the implant unit includes a secondary antenna for wirelessly receiving energy. The device may include a primary antenna configured to be located external to the body of the subject, a circuit electrically connected to the primary antenna, and at least one processor electrically connected to the primary antenna and the circuit. The at least one processor may determine a resonant frequency mismatch between a first resonant frequency associated with the primary antenna and a second resonant frequency associated with the secondary antenna associated with the implant unit; and apply an adjustment to at least one component of the circuit to cause a change in the first resonant frequency associated with the primary antenna and a reduction in the resonant frequency mismatch.
摘要翻译：本公开的一些实施例可以包括用于从被摄体的身体外部的位置向被摄体的植入单元无线供电的装置，其中所述植入单元包括用于无线地接收能量的次级天线。该设备可以包括被配置为位于对象的主体外部的主天线，电连接到主天线的电路，以及电连接到主天线和电路的至少一个处理器。所述至少一个处理器可以确定与所述主天线相关联的第一谐振频率与与所述植入单元相关联的次天线相关联的第二谐振频率之间的谐振频率失配; 并且对所述电路的至少一个分量施加调整以引起与所述主天线相关联的所述第一谐振频率的变化以及所述谐振频率失配的减小。

58. 发明申请

US20160271413A1 METHOD AND APPARATUS FOR MULTIMODAL ELECTRICAL MODULATION OF PAIN 审中-公开
标题翻译：多用途电气调制方法与装置
公开(公告)号：US20160271413A1
公开(公告)日：2016-09-22
申请号：US15075582
申请日：2016-03-21
申请人： Ricardo Vallejo , David Leonardo Cedeno , Ramsin M. Benyamin
发明人： Ricardo Vallejo , David Leonardo Cedeno , Ramsin M. Benyamin
IPC分类号： A61N2/00
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36062 , A61N1/36189 , A61N1/36192 , A61N1/36196 , A61N2/002 , A61N2/008
摘要： Apparatus and methods for managing pain uses separate varying electromagnetic fields, with a variety of temporal and amplitude characteristics, which are applied to a particular neural structure to modulate glial and neuronal interactions as a mechanism for relieving chronic pain. In another embodiment, a single composite modulation/stimulation signal which has rhythmically varying characteristics is used to achieve the same results as separate varying electromagnetic fields. Also, disclosed is an apparatus and method for modulating the expression of genes involved in diverse pathways including inflammatory/immune system mediators, ion channels and neurotransmitters, in both the Spinal Cord (SC) and Dorsal Root Ganglion (DRG) where such expression modulation is caused by spinal cord stimulation or peripheral nerve stimulation using the disclosed apparatus and techniques. In one embodiment of multimodal modulation therapy, the prime signal may be monophasic, or biphasic, in which the polarity of the first phase of the biphasic prime signal may be either cathodic or anodic while the tonic signal may be either monophasic, or biphasic, with the polarity of the first phase of the biphasic tonic signal being either cathodic or anodic.
摘要翻译：用于治疗疼痛的装置和方法使用单独的变化的电磁场，具有各种时间和幅度特征，其被应用于特定神经结构以调节胶质和神经元相互作用，作为缓解慢性疼痛的机制。在另一个实施例中，使用具有节奏变化特性的单个复合调制/刺激信号来获得与单独变化的电磁场相同的结果。此外，公开了一种用于调节在脊髓（SC）和背根神经节（DRG）中的各种途径（包括炎症/免疫系统介质，离子通道和神经递质）的基因表达的装置和方法，其中这种表达调节是使用所公开的装置和技术由脊髓刺激或周围神经刺激引起。在多模调制治疗的一个实施例中，主信号可以是单相或双相，其中双相主信号的第一相的极性可以是阴极或阳极，而补音信号可以是单相的或双相的，双相滋补信号的第一相极性为阴极或阳极。

59. 发明申请

US20160235985A1 UTILIZATION OF DIFFERENT LOUDNESS ENCODING SCHEMES IN COCHLEAR IMPLANT SYSTEMS 有权
标题翻译： COCHLEAR植物系统中不同程度的编码方案的应用
公开(公告)号：US20160235985A1
公开(公告)日：2016-08-18
申请号：US15024024
申请日：2013-10-30
申请人： Lakshmi N. MISHRA , ADVANCED BIONICS AG
发明人： Lakshmi N. Mishra
IPC分类号： A61N1/36
CPC分类号： A61N1/36032 , A61N1/36036 , A61N1/36189
摘要： An exemplary sound processor included in a cochlear implant system associated with a patient may 1) identify a loudness level of an audio signal presented to the patient, 2) determine that a stimulation pulse amplitude corresponding to the loudness level is greater than a maximum stimulation pulse amplitude allowed by a compliance voltage associated with a cochlear implant implanted within the patient, and 3) direct, in response to the determination that the stimulation pulse amplitude is greater than a maximum stimulation pulse amplitude allowed by the compliance voltage, the cochlear implant to represent the loudness level to the patient by directing the cochlear implant to generate and apply one or more stimulation pulses to the patient in accordance with at least one of a first encoding scheme that includes pulse density modulation and a second encoding scheme that includes a combination of pulse amplitude modulation and pulse width modulation.
摘要翻译：包括在与患者相关联的人工耳蜗植入系统中的示例性声音处理器可以1）识别呈现给患者的音频信号的响度水平，2）确定对应于响度水平的刺激脉冲幅度大于最大刺激脉冲通过与植入在患者体内的人工耳蜗植入物相关联的顺应性电压允许的幅度，以及3）响应于确定刺激脉冲幅度大于由顺应性电压允许的最大刺激脉冲幅度的确定，耳蜗植入物代表根据包括脉冲密度调制的第一编码方案和包括脉冲的组合的第二编码方案中的至少一个，通过引导耳蜗植入物产生并向患者施加一个或多个刺激脉冲，向患者施加响度，幅度调制和脉宽调制。

60. 发明申请

US20160082268A1 METHOD AND APPARATUS FOR CALIBRATING DORSAL HORN STIMULATION USING SENSORS 审中-公开
标题翻译：使用传感器校准背部刺激的方法和装置
公开(公告)号：US20160082268A1
公开(公告)日：2016-03-24
申请号：US14856364
申请日：2015-09-16
申请人： Boston Scientific Neuromodulation Corporation
发明人： Bradley Lawrence Hershey , Changfang Zhu
IPC分类号： A61N1/36
CPC分类号： A61N1/36189 , A61N1/0551 , A61N1/36071 , A61N1/36132 , A61N1/36139
摘要： An example of a system for applying neuromodulation to a patient includes a modulation output circuit and a modulation control circuit. The modulation output circuit may be configured to deliver dorsal horn stimulation. The modulation control circuit may be configured to control the delivery of the dorsal horn stimulation by executing a neuromodulation algorithm using modulation parameters. The modulation control circuit may include a response input and a parameter calibrator. The response input may be configured to receive response information indicative of one or more responses to the stimulation of the dorsal horn. The parameter calibrator may be configured to adjust one or more of the modulation parameters using the response information.
摘要翻译：用于向患者施加神经调节的系统的示例包括调制输出电路和调制控制电路。调制输出电路可以被配置为提供背角刺激。调制控制电路可以被配置为通过使用调制参数执行神经调制算法来控制背角刺激的传递。调制控制电路可以包括响应输入和参数校准器。响应输入可以被配置为接收指示对刺激背角的一个或多个响应的响应信息。参数校准器可以被配置为使用响应信息调整一个或多个调制参数。

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