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51. 发明授权

US08177805B2 Removable anchored lung volume reduction devices and methods 有权
标题翻译：可拆卸锚固肺体积减少装置及方法
公开(公告)号：US08177805B2
公开(公告)日：2012-05-15
申请号：US13198546
申请日：2011-08-04
申请人： Clifton A. Alferness
发明人： Clifton A. Alferness
IPC分类号： A61M29/00
CPC分类号： A61B17/12104 , A61B17/12022 , A61B17/1204 , A61B17/12159 , A61B17/12172 , A61B2017/1205 , A61B2017/22051 , A61B2017/22067 , A61F2002/043
摘要： An intra-bronchial device may be placed and anchored in an air passageway of a patient to collapse a lung portion associated with the air passageway. The device includes an obstructing member that prevents air from being inhaled into the lung portion, and an anchor that anchors the obstruction device within the air passageway. The anchor may piercingly engage the air passageway wall. The anchor may be releasable from the air passageway for removal of the obstructing member. The anchor may be releasable by collapsing a portion of the obstructing member, or by drawing the obstructing member toward the larynx. The obstructing member may be a one-way valve.
摘要翻译：可以将支气管内装置放置并锚定在患者的空气通道中以折叠与空气通道相关联的肺部分。该装置包括防止空气被吸入肺部的阻塞构件，以及将阻塞装置固定在空气通道内的锚固件。锚固件可以穿透空气通道壁。锚固件可以从空气通道释放以去除阻塞构件。锚固件可以通过塌缩阻塞构件的一部分，或者通过将阻塞构件拉向喉部来释放。阻塞构件可以是单向阀。

52. 发明授权

US08157837B2 Minimally invasive lung volume reduction device and method 有权
标题翻译：微创肺容积减少装置及方法
公开(公告)号：US08157837B2
公开(公告)日：2012-04-17
申请号：US11422047
申请日：2006-06-02
申请人： David Thompson , Nathan Aronson , Patrick Wu , Mark Mathis
发明人： David Thompson , Nathan Aronson , Patrick Wu , Mark Mathis
IPC分类号： A61B19/00 , A61B17/08 , A61M29/00
CPC分类号： A61M16/208 , A61B1/018 , A61B1/04 , A61B1/2676 , A61B5/06 , A61B6/032 , A61B6/12 , A61B6/485 , A61B17/00234 , A61B17/12022 , A61B17/12031 , A61B17/12104 , A61B17/12131 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B90/00 , A61B90/02 , A61B2017/00477 , A61B2017/00809 , A61B2017/00867 , A61B2017/12054 , A61F2/04 , A61F2002/043 , A61F2002/046 , A61M16/04 , A61M16/0406 , A61M16/0833 , A61M37/0069 , A61M2205/0266 , A61M2205/32
摘要： A lung volume reduction system is disclosed comprising an implantable device adapted to be delivered to a lung airway of a patient in a delivery configuration and to change to a deployed configuration to bend the lung airway. The invention also discloses a method of bending a lung airway of a patient comprising inserting a device into the airway in a delivery configuration and bending the device into a deployed configuration, thereby bending the airway.
摘要翻译：公开了一种肺容积减小系统，其包括可植入装置，其适于以递送配置递送到患者的肺气道并且改变为展开的配置以弯曲肺气道。本发明还公开了一种弯曲患者的肺气道的方法，包括将装置以输送构造插入气道并将装置弯曲成展开构型，从而弯曲气道。

53. 发明授权

US08136520B2 Occlusion device 有权
标题翻译：闭塞装置
公开(公告)号：US08136520B2
公开(公告)日：2012-03-20
申请号：US12687805
申请日：2010-01-14
申请人： Sabaratnam Sabanathan , Thirumani Sabanathan, legal representative
发明人： Sabaratnam Sabanathan
IPC分类号： A61M15/00 , A61M16/00 , A62B7/00 , A62B9/00 , A62B18/00
CPC分类号： A61B17/12172 , A61B17/12022 , A61B17/12104 , A61B17/12136 , A61B17/12159 , A61B17/12177 , A61B2017/1205 , A61F2002/043
摘要： An obturator for a bronchial tube or tubule of a human or animal lung includes a blocking element (92) and a securing element (90). The blocking element serves to seal the tube or tubule against the passage of fluid past the obturator when the obturator is disposed in a bronchial tube or tubule. The securing element serves to retain the blocking element in position. The blocking element comprises a substantially cylindrical plug of biocompatible, resiliently deformable closed-cell foamed plastics material, such as PVC. The securing element includes a stent having barbs (98) to engage and retain the blocking element. The stent also has anchors (100) to retain the stent in a bronchial tube or tubule. A method of treatment of emphysema or other lung conditions or diseases in human or animal patients comprises placing an obturator in a bronchial tube or tubule of the patient so as to seal the tube or tubule against the passage of fluid past the obturator.
摘要翻译：用于人或动物肺的支气管或小管的闭塞器包括阻塞元件（92）和固定元件（90）。当闭塞器设置在支气管或小管中时，阻塞元件用于密封管或小管抵抗流体经过闭孔器的通道。固定元件用于将阻挡元件保持在适当的位置。阻挡元件包括生物相容的，可弹性变形的闭孔发泡塑料材料（例如PVC）的基本上圆柱形的塞子。固定元件包括具有倒钩（98）以使接合和保持阻挡元件的支架。支架还具有将支架保持在支气管或小管中的锚固件（100）。治疗人或动物患者的肺气肿或其他肺病或疾病的方法包括将填塞物放置在患者的支气管或小管中，以密封管或小管以防止流体通过闭孔器。

54. 发明授权

US08100959B2 Loading device for a pulmonary implant 有权
标题翻译：用于肺部植入物的装载装置
公开(公告)号：US08100959B2
公开(公告)日：2012-01-24
申请号：US12043404
申请日：2008-03-06
申请人： Like Que , Hoang Nguyen , Son Gia , Ajitkumar Nair , Roger Farnholtz , George Surjan , Andrew Huffmaster , Jeffrey Lee
发明人： Like Que , Hoang Nguyen , Son Gia , Ajitkumar Nair , Roger Farnholtz , George Surjan , Andrew Huffmaster , Jeffrey Lee
IPC分类号： A61F2/06
CPC分类号： A61B17/12022 , A61B17/12104 , A61B17/12172 , A61B50/30 , A61B2017/0053 , A61B2017/00809 , A61B2017/00867 , A61B2017/12054 , A61F2/04 , A61F2/2436 , A61F2002/043 , A61F2002/9522
摘要： Devices for loading a collapsible implant onto a delivery catheter. In one aspect, a loading device comprises an outer tubular structure and an inner tubular structure. The outer tubular structure comprises a narrowing passage configured to receive a catheter at one end and a collapsible implant at another end. The inner tubular structure is configured to move slidably and co-axially within the outer tubular structure. The inner tubular structure comprises a carrier pin configured to move within the narrowing passage as the inner tubular structure slides into the outer tubular structure. The sliding of the inner tubular structure into the outer tubular structure causes an implant mounted on the carrier pin to collapse as the implant moves through the narrowing passage and into the distal end of a catheter. In an optional aspect, the outer tubular structure further comprises a grasper to stabilize the catheter for receipt of the collapsible implant, and the internal diameter of the inner tubular structure varies to cause the grasper to first contract and stabilize the catheter, and then expand and release the catheter, as the grasper moves into the inner tubular structure.
摘要翻译：用于将可折叠植入物装载到输送导管上的装置。在一个方面，装载装置包括外部管状结构和内部管状结构。外部管状结构包括被配置为在一端接收导管并在另一端容纳可折叠植入物的狭窄通道。内部管状结构构造成在外部管状结构内可滑动地和同轴地移动。内部管状结构包括承载销，其构造成随着内部管状结构滑入外部管状结构而在变窄的通道内移动。内部管状结构滑动到外部管状结构中，当植入物移动通过变窄的通道并进入导管的远端时，安装在承载销上的植入物塌陷。在可选方面，外部管状结构还包括抓紧器，用于稳定导管以接收可折叠植入物，并且内部管状结构的内径变化，使得抓紧器首先收缩和稳定导管，然后膨胀和释放导管，因为抓紧器移动到内部管状结构中。

55. 发明授权

US08079368B2 Bronchoscopic lung volume reduction method 有权
标题翻译：支气管镜减容方法
公开(公告)号：US08079368B2
公开(公告)日：2011-12-20
申请号：US12721426
申请日：2010-03-10
申请人： Steven C. Springmeyer
发明人： Steven C. Springmeyer
IPC分类号： A61B19/00 , A61M16/00 , A61M37/00 , A61M1/00 , A61M31/00 , A62B9/02 , A62B9/06 , A61F7/00
CPC分类号： A61M16/00 , A61B17/12022 , A61B17/12104 , A61B17/12186 , A61F2002/043
摘要： A method of minimally invasively reducing a volume of a hyper-inflated target section of diseased lung comprising the steps of introducing a bronchoscope into a patient's airway to a position adjacent the target section and equilibrating air within the target section with atmospheric air to at least partially deflate the target lung section; injecting an inflammation-causing substance into the target section to precipitate adhesion of the walls within the target lung section, preventing substantial re-inflation of the target section by occluding an airway upstream of the target section for a period of time, and removing the airway occlusion after the target section has substantially permanently been reduced in volume. The injected substance can be autologous blood or a constituent thereof.
摘要翻译：一种以最小限度地侵入性地减少患病肺的超充气靶区段的体积的方法，包括以下步骤：将支气管镜引入患者的气道中至邻近目标区段的位置，并将目标区段内的空气与大气空气平衡至少部分放气目标肺段; 将炎症引起物质注射到目标部分中以沉淀目标肺部分中的壁的粘附，通过在目标部分上游一段气道闭塞一段时间来防止目标部分的大量再膨胀，并且去除气道目标部分的体积基本上永久减小后的闭塞。注射的物质可以是自体血液或其组分。

56. 发明申请

US20110283998A1 REMOVABLE ANCHORED LUNG VOLUME REDUCTION DEVICES AND METHODS 有权
标题翻译：可拆卸的锚定式减压装置及方法
公开(公告)号：US20110283998A1
公开(公告)日：2011-11-24
申请号：US13198546
申请日：2011-08-04
申请人： CLIFTON A. ALFERNESS
发明人： CLIFTON A. ALFERNESS
IPC分类号： A61M16/00
CPC分类号： A61B17/12104 , A61B17/12022 , A61B17/1204 , A61B17/12159 , A61B17/12172 , A61B2017/1205 , A61B2017/22051 , A61B2017/22067 , A61F2002/043
摘要： An intra-bronchial device may be placed and anchored in an air passageway of a patient to collapse a lung portion associated with the air passageway. The device includes an obstructing member that prevents air from being inhaled into the lung portion, and an anchor that anchors the obstruction device within the air passageway. The anchor may piercingly engage the air passageway wall. The anchor may be releasable from the air passageway for removal of the obstructing member. The anchor may be releasable by collapsing a portion of the obstructing member, or by drawing the obstructing member toward the larynx. The obstructing member may be a one-way valve.
摘要翻译：可以将支气管内装置放置并锚定在患者的空气通道中以折叠与空气通道相关联的肺部分。该装置包括防止空气被吸入肺部的阻塞构件，以及将阻塞装置固定在空气通道内的锚固件。锚固件可以穿透空气通道壁。锚固件可以从空气通道释放以去除阻塞构件。锚固件可以通过塌缩阻塞构件的一部分，或者通过将阻塞构件拉向喉部来释放。阻塞构件可以是单向阀。

57. 发明申请

US20110226238A1 IMPLANTED BRONCHIAL ISOLATION DEVICES AND METHODS 有权
标题翻译：植入式隔离装置和方法
公开(公告)号：US20110226238A1
公开(公告)日：2011-09-22
申请号：US12885199
申请日：2010-09-17
申请人： Michael Barrett , Michael Hendricksen , Alan R. Rapacki , Ronald R. Hundertmark , Jeffrey J. Dolin , Robert M. George , Antony J. Fields , Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
发明人： Michael Barrett , Michael Hendricksen , Alan R. Rapacki , Ronald R. Hundertmark , Jeffrey J. Dolin , Robert M. George , Antony J. Fields , Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
IPC分类号： A61M16/20
CPC分类号： A61B17/12022 , A61B17/12104 , A61B17/12172 , A61F2/2412 , A61F2002/043
摘要： Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region.
摘要翻译：公开了用于调节流入和流出患者肺部区域的流体的方法和装置，例如在呼吸过程中实现期望的流体流动到肺部区域，和/或诱导一个或多个肺部区域的塌陷。根据示例性程序，确定的肺部区域被靶向用于治疗。然后将目标肺区域支气管分离，以通过一个或多个将空气送入目标肺部区域的支气管通路来调节进入和/或离开目标肺区域的气流。

58. 发明申请

US20110220104A1 COLLATERAL PATHWAY TREATMENT USING AGENT ENTRAINED BY ASPIRATION FLOW CURRENT 有权
标题翻译：使用通过吸入流量电流进入的药剂的阴道途径治疗
公开(公告)号：US20110220104A1
公开(公告)日：2011-09-15
申请号：US12883039
申请日：2010-09-15
申请人： Anthony Wondka , Peter Soltesz , John McCutcheon , Antony J. Fields
发明人： Anthony Wondka , Peter Soltesz , John McCutcheon , Antony J. Fields
IPC分类号： A61M16/10
CPC分类号： A61M25/10 , A61B17/12031 , A61B17/1204 , A61B17/12104 , A61B17/12136 , A61B2017/00809 , A61B2017/22067 , A61M2025/1052 , A61M2210/1039
摘要： A method and system for increasing the flow resistance of collateral pathways in the lung by employing aspiration to establish an artificial convective flow current between compartments in the lung in order to entrain and deliver a clogging agent preferentially to the collateral pathways. The method may sometimes be performed after lung has been assessed for the presence of collateral pathways.
摘要翻译：一种用于通过抽吸来增加肺内侧支路径的流阻的方法和系统，以在肺间隔室之间建立人造对流流动流，以夹带并将阻塞剂优先递送至旁路。有时可以在肺已经评估了侧支通路的存在后进行该方法。

59. 发明授权

US07992563B2 Methods and devices for improving breathing in patients with pulmonary disease 有权
标题翻译：改善肺部疾病患者呼吸的方法和装置
公开(公告)号：US07992563B2
公开(公告)日：2011-08-09
申请号：US12014060
申请日：2008-01-14
申请人： Rajiv Doshi
发明人： Rajiv Doshi
IPC分类号： A61M11/00
CPC分类号： A63B23/18 , A61B17/12036 , A61B17/12104 , A61B17/12172 , A61B17/12177 , A61B17/24 , A61F2/24 , A61F2002/043 , A61M16/0488 , A61M16/0493 , A61M16/06 , A61M16/20 , A61M16/208
摘要： Methods, apparatus, and kits for enhancing breathing in patients suffering from chronic pulmonary obstructive disease are described. The methods and apparatus rely on increasing flow resistance to expiration in a manner which mimics “pursed lip” breathing which has been found to benefit patients suffering from this disease. In a first example, a device is implanted in a trachea or bronchial passage to increase flow resistance, preferably selectively increase resistance to expiration relative to inspiration. In a second embodiment, a mouthpiece is provided, again to increase resistance to expiration, preferably with a lesser increase in flow resistance to inspiration. In a third embodiment, the patient's trachea or bronchial passage is modified by the application of energy in order to partially close the lumen therethrough.
摘要翻译：描述了用于增强患有慢性肺动脉阻塞性疾病的患者呼吸的方法，装置和试剂盒。方法和装置依赖于以模仿“追求唇”呼吸的方式增加流出阻力，已被发现有利于患有这种疾病的患者。在第一示例中，将装置植入气管或支气管通道中以增加流动阻力，优选地选择性地增加相对于吸气的抵抗力。在第二个实施例中，提供一个接口件，以再次增加对呼气的阻力，优选地，对吸气的流动阻力的增加较小。在第三实施例中，通过施加能量来改变患者的气管或支气管通道，以便部分地关闭通过其中的内腔。

60. 发明授权

US07942931B2 Device and method for intra-bronchial provision of a therapeutic agent 有权
标题翻译：用于支气管内给药治疗剂的装置和方法
公开(公告)号：US07942931B2
公开(公告)日：2011-05-17
申请号：US11204383
申请日：2005-08-15
申请人： Hugo X. Gonzalez , Steven Chase Springmeyer , Richard O. Shea , John H. Wang , Lauri J. DeVore
发明人： Hugo X. Gonzalez , Steven Chase Springmeyer , Richard O. Shea , John H. Wang , Lauri J. DeVore
IPC分类号： A61F2/20 , A61M31/00
CPC分类号： A61M31/002 , A61B17/12022 , A61B17/12036 , A61B17/1204 , A61B17/12104 , A61B17/12159 , A61B17/12172 , A61B2017/1205 , A61B2017/22051 , A61B2017/22067 , A61B2017/242 , A61B2217/005 , A61F2002/043 , A61M1/0023 , A61M25/04 , A61M31/00 , A61M2025/0076 , A61M2210/1035 , A61N5/1027 , A61N2005/1021
摘要： The present invention includes an intra-bronchial device, system, and method for providing a therapeutic agent to a patient. A device includes a flow control member for placement in an air passageway communicating with a lung portion, and when deployed in the air passageway inhibits a therapeutic agent distal of the control member from moving proximal of the control member, and includes the therapeutic agent associated with the flow control member. The control member may inhibit movement of the therapeutic agent by limiting airflow, and may include a one-way valve limiting exhalation of air from the lung portion. The control member may include a flexible membrane impervious to air flow, or a separator arranged to inhibit the movement of the therapeutic agent. The control member may include at least one anchor, and the anchor may be releasable from the air passageway for removal of the intra-bronchial device.
摘要翻译：本发明包括用于向患者提供治疗剂的支气管内装置，系统和方法。一种装置包括用于放置在与肺部连通的空气通道中的流量控制构件，并且当部署在空气通道中时，阻止远离控制构件的治疗剂移动到控制构件的近侧，并且包括与流量控制构件。控制构件可以通过限制气流来抑制治疗剂的移动，并且可以包括限制从肺部呼出空气的单向阀。控制构件可以包括不透气体的柔性膜，或者设置成抑制治疗剂运动的隔膜。控制构件可以包括至少一个锚固件，并且锚固件可以从空气通道释放以去除支气管内装置。

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