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51. 发明申请

US20020165301A1 Plasticized polymer compositions 失效
标题翻译：增塑聚合物组合物
公开(公告)号：US20020165301A1
公开(公告)日：2002-11-07
申请号：US10095701
申请日：2002-03-13
申请人： UCB, S.A.
发明人： August Van Gysel , Jean-Claude Van Overvelt , Andre Nannan , Pierre Godard , Jean-Jacques Biebuyck , Philippe De Groote
IPC分类号： C08K005/43
CPC分类号： C08K5/435 , C08L77/00
摘要： The invention relates to compositions comprising at least one polymer and at least one plasticizer, in which compositions the polymer is semi-crystalline and exhibits a processing temperature equal to or greater than 220null C., preferably 250null C., and the plasticizer is an aromatic benzenesulphonamide represented by the general formula (I) 1 in which R1 represents a hydrogen atom, a C1-C4 alkyl group or a C1-C4 alkoxy group, X represents a linear or branched C2-C10 alkylene group, or a cycloaliphatic group, or an aromatic group, Y represents one of the groups OH or 2 R2 representing a C1-C4 alkyl group or an aromatic group, these groups optionally themselves being substituted by an OH or C1-C4 alkyl group. The aromatic benzenesulphonamides have little volatility and exhibit good thermal stability, which makes it possible to effectively plasticize polyamides which are processed at high temperatures, such as polyamides-6, -6,6, -4,6, -6,9, -6,10, -6,12 and MDX-6 and polyketones, but also polyamides-11 and -12, polyoxymethylene and poly(vinylidene fluoride).
摘要翻译：本发明涉及包含至少一种聚合物和至少一种增塑剂的组合物，其中聚合物为半结晶的组合物，其处理温度等于或大于220℃，优选250℃，增塑剂为由通式（I）表示的芳族苯磺酰胺，其中R 1表示氢原子，C 1 -C 4烷基或C 1 -C 4烷氧基，X表示直链或支链C 2 -C 10亚烷基或脂环族基，或芳基，Y表示OH或R2中的一个代表C1-C4烷基或芳族基团，这些基团任选地本身被OH或C 1 -C 4烷基取代。芳香族苯磺酰胺具有很小的挥发性并表现出良好的热稳定性，这使得有可能有效地增塑在高温下加工的聚酰胺，例如聚酰胺-6,6,6，-4,6，-6,9，-6 ，10,6-12和MDX-6和聚酮，还有聚酰胺-11和-12，聚甲醛和聚（偏二氟乙烯）。

52. 发明授权

US5272026A Negative image process utilizing photosensitive compositions containing aromatic fused polycyclic sulfonic acid and partial ester or phenolic resin with diazoquinone sulfonic acid or diazoquinone carboxylic acid, and associated imaged article 失效
标题翻译：使用含有芳族稠合多环磺酸和部分酯或酚醛树脂的光敏组合物与重氮醌磺酸或重氮醌羧酸的负影像处理方法，以及相关成像制品
公开(公告)号：US5272026A
公开(公告)日：1993-12-21
申请号：US833724
申请日：1992-02-11
申请人： Bruno Roland , Jan Vandendriessche , Catherine Jakus
发明人： Bruno Roland , Jan Vandendriessche , Catherine Jakus
IPC分类号： G03F7/022 , G03F7/36 , G03F7/38
CPC分类号： G03F7/0226
摘要： A photosensitive composition having contrast and selectivity, useful in forming high resolution patterns.The composition comprises a phenolic resin, a diazoquinone compound and an aromatic fused polycyclic sulfonic or carboxylic acid, in the form of the free acid and/or an ammonium salt and/or an acid halide, the cation component of the ammonium salt having the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, each represent hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -hydroxyalkyl.In forming a negative pattern, the composition is coated on a substrate and exposed imagewise to ultraviolet radiation, thereafter treated with a silicon compound, whereby the silicon compound is selectively absorbed into the irradiated portions and the non-irradiated portions are then removed by dry etching.
摘要翻译：具有对比度和选择性的光敏组合物，可用于形成高分辨率图案。该组合物包含游离酸和/或铵盐和/或酰卤形式的酚醛树脂，重氮醌化合物和芳族稠合多环磺酸或羧酸，铵盐的阳离子组分具有式其中R 1，R 2，R 3和R 4各自代表氢，C 1 -C 4 - 烷基或C 1 -C 4 - 羟基烷基。在形成负图案时，将组合物涂布在基板上并以成像方式暴露于紫外线照射，然后用硅化合物处理，由此将硅化合物选择性地吸收到照射部分中，然后通过干蚀刻除去未照射部分。

53. 发明申请

US20090156607A1 2-OXO-1-PYRROLIDINE DERIVATIVES 有权
标题翻译： 2-氧代-1-吡咯烷衍生物
公开(公告)号：US20090156607A1
公开(公告)日：2009-06-18
申请号：US11916231
申请日：2006-05-31
申请人： Benoit Kenda , Yannick Quesnel , Ali Ates , Philippe Michel , Laurent Turet , Joel Mercier
发明人： Benoit Kenda , Yannick Quesnel , Ali Ates , Philippe Michel , Laurent Turet , Joel Mercier
IPC分类号： A61K31/5025 , C07D471/04 , C07D403/02 , C07D209/04 , A61K31/4162 , A61P25/14 , A61K31/4353 , C07D487/04 , A61K31/437
CPC分类号： C07D513/04 , C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06 , C07D471/04 , C07D473/00 , C07D487/04
摘要： The present invention concerns 2-oxo-1-pyrrolidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
摘要翻译：本发明涉及2-氧代-1-吡咯烷衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途。

54. 发明授权

US07473697B2 2-Oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives for the treatment of epilepsy and other neurological disorders 失效
标题翻译：用于治疗癫痫和其他神经系统疾病的2-氧代 - 哌啶基和2-氧代 - 氮杂环己烷基链烷酸衍生物
公开(公告)号：US07473697B2
公开(公告)日：2009-01-06
申请号：US11453088
申请日：2006-06-15
申请人： Philippe Michel , Benoît Kenda
发明人： Philippe Michel , Benoît Kenda
IPC分类号： A61K31/45
CPC分类号： C07D409/04 , C07D211/76 , C07D211/78 , C07D223/10
摘要： This invention relates to new 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives of formula (1) having anticonvulsant activity which are useful as therapeutic agents for the treatment or prevention of epilepsy and other neurological disorders. The invention also concerns processes for preparing these derivatives and novel intermediates used in the preparation of these derivatives.
摘要翻译：本发明涉及具有抗惊厥活性的式（1）的新的2-氧代 - 哌啶基和2-氧代 - 氮杂螺环烷酸衍生物，其可用作治疗或预防癫痫和其它神经障碍的治疗剂。本发明还涉及制备这些衍生物的方法和用于制备这些衍生物的新型中间体。

55. 发明申请

US20070299118A1 Benzoxazolone Derivatives, Processes For Preparing Them And Their Uses 有权
标题翻译：苯并恶唑酮衍生物，其制备方法及其用途
公开(公告)号：US20070299118A1
公开(公告)日：2007-12-27
申请号：US11569605
申请日：2005-05-24
申请人： Jean-Philippe Starck , Benoit Kenda
发明人： Jean-Philippe Starck , Benoit Kenda
IPC分类号： A61K31/421 , A61P25/14 , A61P25/16 , C07D263/58
CPC分类号： C07D263/58
摘要： The present invention relates to benzoxazolone derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals, in the treatment of movement disorders, in particular in Parkinson's disease.
摘要翻译：本发明涉及苯并恶唑酮衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途，用于治疗运动障碍，特别是帕金森氏病。

56. 发明授权

US07112612B2 N-alkylated GABA compounds, processes for their preparation and their use as medicaments 失效
标题翻译： N-烷基化GABA化合物，其制备方法及其作为药物的用途
公开(公告)号：US07112612B2
公开(公告)日：2006-09-26
申请号：US10432115
申请日：2001-11-14
申请人： Benoit Kenda , Philippe Michel , Luc Quere
发明人： Benoit Kenda , Philippe Michel , Luc Quere
IPC分类号： A61K31/16 , A61K31/21 , A61K31/275 , A61K31/195 , C07C233/05
CPC分类号： C07C327/22 , C07C237/06 , C07C2601/08 , C07C2603/74
摘要： The present invention relates to N-alkylated GABA (Gamma-aminobutyric acid) compounds, to processes for their preparation, to their use in therapy and to pharmaceutical compositions containing them. More particularly these compounds are useful for treatment of disorders of the central and/or peripheral nervous system. Of particular interest is their potent anticonvulsant activity.
摘要翻译：本发明涉及N-烷基化的GABA（γ-氨基丁酸）化合物，其制备方法，其在治疗中的应用和含有它们的药物组合物。更特别地，这些化合物可用于治疗中枢和/或周围神经系统的病症。特别令人感兴趣的是它们有效的抗惊厥活性。

57. 发明申请

US20060183903A1 Piperazine derivatives and their use as synthesis intermediates 失效
标题翻译：哌嗪衍生物及其作为合成中间体的用途
公开(公告)号：US20060183903A1
公开(公告)日：2006-08-17
申请号：US10548709
申请日：2004-01-20
申请人： Celal Ates , Emile Cavoy , Didier Bouvy
发明人： Celal Ates , Emile Cavoy , Didier Bouvy
IPC分类号： C07D241/04
CPC分类号： C07D271/07 , C07D295/15
摘要： The present invention relates to new enantiomerically pure piperazine derivatives of formula (I) wherein Y represents hydroxy or a leaving group and n is 1, 2, 3, 4 or 5, and to their use as synthesis intermediates, especially for the preparation of pharmaceutically active compounds.
摘要翻译：本发明涉及式（I）的新的对映体纯的哌嗪衍生物，其中Y代表羟基或离去基团，n是1,2,3,4或5，并且它们用作合成中间体，特别是用于制备药学上活性化合物。

58. 发明授权

US07083807B2 Pharmaceutical compositions for the controlled release of active substances 有权
标题翻译：用于控释活性物质的药物组合物
公开(公告)号：US07083807B2
公开(公告)日：2006-08-01
申请号：US10607047
申请日：2003-06-27
申请人： Domenico Fanara , Monique Berwaer , Anne Bouquelle , Michel Deleers
发明人： Domenico Fanara , Monique Berwaer , Anne Bouquelle , Michel Deleers
IPC分类号： A61K9/14 , A61K9/20 , A61K9/22 , A61K9/24
CPC分类号： A61K9/2009 , A61K9/2054 , A61K9/209
摘要： The invention relates to pharmaceutical compositions which can be administrated orally, allowing the controlled release of at least one active substance comprising a) the said at least one active substance, b) between 5 and 60% by weight, relative to the total weight of the composition, of at least one excipient, selected from inert matrices, hydrophilic matrices, lipid matrices, mixtures of inert matrices and of lipid matrices, mixtures of hydrophilic matrices and of inert matrices, with the exception of mixtures comprising a polyacrylic acid and at least one hydrophilic matrix of the cellulose type; c) between 5 and 50% by weight, relative to the total weight of the composition, of at least one alkalinizing agent soluble in an aqueous phase under physiological pH conditions, selected from alkali or alkaline-earth metal hydroxidcs, carbonates, bicarbonates and phosphates, sodium borate as well as the basic salts of organic acids. It also relates to processes for the preparation of said compositions, multi-layered pharmaceutical compositions comprising at least one layer with this composition, as well as processes for the preparation of said multi-layered composition.
摘要翻译：本发明涉及可以口服给药的药物组合物，允许控制释放至少一种活性物质，所述活性物质包含a）所述至少一种活性物质，b）相对于所述至少一种活性物质的总重量为5至60重量％至少一种赋形剂，选自惰性基质，亲水基质，脂质基质，惰性基质和脂质基质的混合物，亲水基质和惰性基质的混合物，除了包含聚丙烯酸和至少一种纤维素类型的亲水基质; c）在生理pH条件下，选自碱金属或碱土金属氢氧化物，碳酸盐，碳酸氢盐和磷酸盐的至少一种可溶于水相的至少一种碱化剂，相对于组合物的总重量为5至50重量％，硼酸钠以及有机酸的碱性盐。它还涉及制备所述组合物的方法，包含至少一层具有该组合物的多层药物组合物，以及制备所述多层组合物的方法。

59. 发明申请

US20060074068A1 Chemical compounds with dual activity, processes for their preparation and pharmaceutical compositions 失效
公开(公告)号：US20060074068A1
公开(公告)日：2006-04-06
申请号：US10511660
申请日：2003-03-29
申请人： Laurent Provins , Berend Van Keulen , John Surtees , Patrice Talaga , Bernard Christophe
发明人： Laurent Provins , Berend Van Keulen , John Surtees , Patrice Talaga , Bernard Christophe
IPC分类号： A61K31/506 , A61K31/505 , C07D403/02
CPC分类号： C07D239/42 , C07D239/48 , C07D239/50 , C07D239/60 , C07D401/04 , C07D403/04 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04
摘要： The present invention concerns chemical compounds combining affinity and antagonism against the human m3 muscarinic receptor with activity as selective phosphodiesterase IV (PDE IV) inhibitors, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

60. 发明授权

US06894059B1 Compounds and methods for treatment of asthma, allergy and inflammatory disorders 失效
标题翻译：用于治疗哮喘，过敏和炎性疾病的化合物和方法
公开(公告)号：US06894059B1
公开(公告)日：2005-05-17
申请号：US09937667
申请日：2000-03-23
申请人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmund Differding , James Ellis , Marie-Agnes Lassoie , Michelle Young , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
发明人： Ralph Scannell , Pierre Chatelain , Anna Toy-Palmer , Edmund Differding , James Ellis , Marie-Agnes Lassoie , Michelle Young , Xiong Cai , Sajjat Hussoin , Gurmit Grewal , Timothy Lewis
IPC分类号： C07D295/084 , C07D295/088 , C07D295/092 , C07D295/096 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/15 , C07D307/52 , A61K31/44 , A61K31/445
CPC分类号： C07D295/096 , C07D295/084 , C07D295/088 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/15 , C07D307/52
摘要： The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obsructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.
摘要翻译：本发明提供了1,4取代的哌嗪，1,4-取代的哌啶和1-取代的4-亚烷基哌啶化合物。本发明的化合物是具有白细胞三烯抑制性质以及抗组胺能性质的双作用分子。本发明的化合物可用于治疗可能存在组胺和/或白三烯组分的病症。这些病症优选包括哮喘，季节性和常年性过敏性鼻炎，窦炎，结膜炎，食物过敏，鲭鱼中毒，牛皮癣，荨麻疹，瘙痒，湿疹，类风湿性关节炎，炎性肠病，慢性损伤性肺病，血栓性疾病和中耳炎。还提供了通过向有需要的受试者施用有效的哮喘和减轻炎症的量的化合物来治疗哮喘和鼻炎的方法。

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