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51. 发明授权

US09840526B1 Iridium(III)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent 有权
公开(公告)号：US09840526B1
公开(公告)日：2017-12-12
申请号：US15661288
申请日：2017-07-27
申请人： University of Macau , Hong Kong Baptist University , Kaohsiung Medical University
发明人： Chung-Hang Leung , Hai-Jing Zhong , Dik-Lung Ma , Hui-Min Wang
IPC分类号： C07F15/00 , A61K31/555
CPC分类号： C07F15/0033
摘要： Bromodomain-containing protein 4 (BRI)) has recently emerged as an attractive epigenetic target for anticancer therapy. Iridium(III) complexes are useful as irreversible inhibitor of BRD4. Complex 1a of the formula: is particularly useful.

52. 发明授权

US09655913B2 Anti-esophageal cancer compound and method of use thereof 有权
公开(公告)号：US09655913B2
公开(公告)日：2017-05-23
申请号：US15190367
申请日：2016-06-23
申请人： Hong Kong Baptist University , Changshu HKBU Technology Company Limited
发明人： Zhaoxiang Bian , Huaixue Mu , Chengyuan Lin , Jinjin Wang , Zhijun Yang , Aiping Lu , Albert Sun Chi Chan
IPC分类号： A61K31/7048 , A61K36/888 , A61K31/09 , A61K31/341 , A61K31/34 , A61K9/00 , A61K31/353
CPC分类号： A61K31/7048 , A61K9/0019 , A61K9/0053 , A61K31/09 , A61K31/34 , A61K31/341 , A61K31/353 , A61K36/888
摘要： The present invention relates to the bioactive components with the anti-proliferative property. In particular, the invention relates to one flavonol compound isolated from the root of Lasia spinosa Linn. Thwait or chemically synthesized and its specific anticancer/antitumor activity. This invention has a specific application in treating human esophageal cancer.

53. 发明申请

US20170057906A1 SKIN-PROTECTION COMPOSITION CONTAINING DENDROBIUM-BASED INGREDIENTS 有权
标题翻译：含有基于碳酸盐的成分的皮肤保护组合物
公开(公告)号：US20170057906A1
公开(公告)日：2017-03-02
申请号：US15352903
申请日：2016-11-16
申请人： Hong Kong Baptist University
发明人： Hongjie ZHANG , Siu Wai TSANG , Yu ZHU
IPC分类号： C07C69/80 , C07C43/205 , C07C43/215 , C07C69/34 , A61K8/34 , A61K8/37 , A61K8/33 , A61Q19/02 , A61Q17/04 , C07C39/21 , C07C69/736 , C07C69/753
CPC分类号： A61K8/347 , A61K8/33 , A61K8/37 , A61K9/0053 , A61K31/05 , A61K31/085 , A61K31/09 , A61Q17/04 , A61Q19/02 , C07C37/003 , C07C39/15 , C07C39/16 , C07C39/21 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C69/34 , C07C69/736 , C07C69/753 , C07C2601/08
摘要： A skin-protection composition is shown that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, the usage of Dendrobium ingredients and stilbenoids is shown to reduce the formation of melanin in melanocytes. The usage of Dendrobium ingredients and stilbenoids is also shown to reduce the generation of reactive oxygen species and oxidative free radicals. The use of Dendrobium-derived extracts or ingredients or stilbenoids is shown in the formulation of skin-protection, skin-whitening and/or anti-skin aging products.
摘要翻译：显示出一种皮肤保护组合物，其包含从石斛属植物获得的含有萜烯和/或芪类的提取物，例如石斛兰和石斛石斛用于管理黑素生成，皮肤变暗和皮肤老化。更具体地说，石斛成分和芪类化合物的使用被证明可以减少黑素细胞中黑色素的形成。还显示石斛粉成分和芪类化合物的使用可以减少活性氧和氧化自由基的产生。在皮肤保护，皮肤美白和/或抗皮肤衰老产品的配方中显示了使用石斛衍生的提取物或成分或芪类化合物。

54. 发明授权

US09511013B2 Herbal composition for skin-whitening and anti-skin-aging, method of preparation and the use thereof 有权
标题翻译：用于皮肤美白和抗皮肤老化的草药组合物，其制备方法及其用途
公开(公告)号：US09511013B2
公开(公告)日：2016-12-06
申请号：US14191470
申请日：2014-02-27
申请人： Hong Kong Baptist University
发明人： Zhiling Yu , Hua Yu
IPC分类号： A61K8/97 , A61Q19/08 , A61Q19/02
CPC分类号： A61K8/97 , A61K2800/5922 , A61Q19/02 , A61Q19/08
摘要： This invention provides a Chinese medicinal formula comprising Atractylodis Macrocephalae Rhizoma, Glycyrrhizae Radix et Rhizoma, Angelicae sinensis Radix, Paeoniae Radix Alba and Poria for skin care. It further relates to a method for preparing bioactive fraction of this formula and to the applications of the bioactive fraction in skin-whitening and anti-skin-aging.
摘要翻译：本发明提供了一种中药配方，其含有白术，大黄，甘草，当归，芍药，茯苓等。本发明进一步涉及制备该配方生物活性部分的方法以及生物活性级分在皮肤美白和抗皮肤老化中的应用。

55. 发明授权

US09403794B2 Imaging beta-amyloid peptides and inhibition of beta-amyloid peptide aggregation 有权
标题翻译：成像β-淀粉样蛋白肽和β-淀粉样肽聚集的抑制
公开(公告)号：US09403794B2
公开(公告)日：2016-08-02
申请号：US14231724
申请日：2014-03-31
申请人： Hong Kong Baptist University
发明人： Lei Guo , Di Xu , See-Lok Ho , Chung-Yan Poon , Olivia T. W. Ng , Hung Wing Li , Ken K. L. Yung , Daniel W. J. Kwong , Ricky M. S. Wong
IPC分类号： A61K49/10 , A61K49/00 , C07D401/06 , A61K49/08 , A61K31/4709 , A61K45/06
CPC分类号： C07D401/06 , A61K31/4709 , A61K45/06 , A61K49/0002 , A61K49/0021 , A61K49/0026 , A61K49/085 , A61K49/10 , A61K2300/00
摘要： The present invention is in the field of pharmaceuticals and chemical industries. In particular, the present invention relates to methods for labeling, imaging and detecting the beta-amyloid (Aβ) peptides, oligomers, and fibrils in vitro by using carbazole-based fluorophores. A further aspect of the present invention relates to a method of reducing and preventing aggregation of beta-amyloid peptides for Alzheimer's disease (AD) as well as of treating and/or preventing Alzheimer's disease by using carbazole-based fluorophores.
摘要翻译：本发明在医药和化学工业领域。特别地，本发明涉及通过使用咔唑类荧光团在体外标记，成像和检测β-淀粉样蛋白（Aβ）肽，寡聚体和原纤维的方法。本发明的另一方面涉及通过使用咔唑类荧光团来降低和预防β-淀粉样蛋白肽对阿尔茨海默病（AD）的聚集以及治疗和/或预防阿尔茨海默氏病的方法。

56. 发明授权

US09328007B2 Biogenic flocculant composition to enhance flocculation and dewaterability of chemically enhanced primary treatment sludge 有权
标题翻译：生物絮凝剂组合物，以增强化学增强的初级处理污泥的絮凝和脱水性能
公开(公告)号：US09328007B2
公开(公告)日：2016-05-03
申请号：US14192845
申请日：2014-02-27
申请人： Hong Kong Baptist University
发明人： Jonathan Woon-Chung Wong
IPC分类号： C02F3/34 , C02F11/02 , C02F1/52 , C02F11/12
CPC分类号： C02F11/02 , C02F1/5236 , C02F3/341 , C02F11/121 , C02F11/122 , C02F11/14 , Y02W10/27
摘要： The present invention discloses a composite biogenic flocculant for enhancing flocculation and dewaterability of chemically enhanced primary treatment (CEPT) sludge. The present invention also discloses method of conditioning CEPT sludge using the composite biogenic flocculant.
摘要翻译：本发明公开了一种用于增强化学增强初级处理（CEPT）污泥的絮凝和脱水性能的复合生物絮凝剂。本发明还公开了使用复合生物源絮凝剂调节CEPT污泥的方法。

57. 发明授权

US09252929B2 Method for achieving rendezvous for cognitive radio networks 有权
标题翻译：实现认知无线电网络会合的方法
公开(公告)号：US09252929B2
公开(公告)日：2016-02-02
申请号：US14036388
申请日：2013-09-25
申请人： Hong Kong Baptist University
发明人： Hai Liu , Zhiyong Lin , Xiaowen Chu , Yiu-Wing Leung
IPC分类号： H04W4/00 , H04L5/00
CPC分类号： H04L5/0012 , H04B1/7143 , H04W16/14
摘要： A method for achieving rendezvous in a multiple access network having two or more access channels includes the steps of generating channel access sequences in rounds for each user of the multiple access network, wherein each round includes at least one jump-pattern and at least one stay-pattern, performing the at least one jump-pattern alternated by the at least one stay-pattern in each round, and whereupon the at least one jump-pattern alternated by the stay-pattern in each round are performed, continuously generate at least one channel access sequence rounds and perform the jump-pattern of the channel access sequence rounds until a user in the network achieves rendezvous with its intended neighbor user or users.
摘要翻译：一种用于在具有两个或更多个接入信道的多址网络中实现会合的方法包括以下步骤：针对多址网络的每个用户生成轮回信道接入序列，其中每个轮包括至少一个跳跃模式和至少一个停留执行在每一轮中由所述至少一个停留模式交替的所述至少一个跳跃图案，并且由此执行由每轮中的停留图案交替的所述至少一个跳跃图案，连续地生成至少一个信道接入序列循环并执行信道接入序列轮次的跳跃模式，直到网络中的用户实现与其预定的邻居用户或用户的会合。

58. 发明授权

US09159321B2 Lip-password based speaker verification system 有权
标题翻译：基于口令的扬声器验证系统
公开(公告)号：US09159321B2
公开(公告)日：2015-10-13
申请号：US13776615
申请日：2013-02-25
申请人： Hong Kong Baptist University
发明人： Yiu-ming Cheung , Xin Liu
IPC分类号： G10L15/25 , G06K9/00
CPC分类号： G10L15/25 , G06K9/00335
摘要： A lip-based speaker verification system for identifying a speaker using a modality of lip motions; wherein an identification key of the speaker comprising one or more passwords; wherein the one or more passwords are embedded into lip motions of the speaker; wherein the speaker is verified by underlying dynamic characteristics of the lip motions; and wherein the speaker is required to match the one or more passwords embedded in the lip motions with registered information in a database. That is, in the case where the target speaker saying the wrong password or even in the case where an impostor knowing and saying the correct password, the nonconformities will be detected and the authentications/accesses will be denied.
摘要翻译：一种基于嘴唇的扬声器验证系统，用于使用唇形运动的方式识别扬声器; 其中所述扬声器的识别密钥包括一个或多个密码; 其中所述一个或多个密码被嵌入所述扬声器的唇部运动中; 其中通过唇部运动的潜在动态特性验证说话者; 并且其中要求说话者将嵌入在唇部运动中的一个或多个密码与数据库中的注册信息相匹配。也就是说，在目标讲话者说出错误的密码的情况下，甚至在冒名顶替者知道和说出正确的密码的情况下，将检测到不合格，并且拒绝认证/访问。

59. 发明授权

US09156814B2 Imaging beta-amyloid peptides and inhibition of beta-amyloid peptide aggregation 有权
标题翻译：成像β-淀粉样蛋白肽和β-淀粉样肽聚集的抑制
公开(公告)号：US09156814B2
公开(公告)日：2015-10-13
申请号：US13447127
申请日：2012-04-13
申请人： Wanggui Yang , Yi Wong , Olivia T. W. Ng , Hung Wing Li , Ken K. L. Yung , Daniel W. J. Kwong , Ricky M. S. Wong
发明人： Wanggui Yang , Yi Wong , Olivia T. W. Ng , Hung Wing Li , Ken K. L. Yung , Daniel W. J. Kwong , Ricky M. S. Wong
IPC分类号： A61K49/10 , A61K49/00 , C07D401/06 , A61K49/08 , A61K31/4439 , A61K31/4709 , A61K31/473
CPC分类号： C07D401/06 , A61K31/4439 , A61K31/4709 , A61K31/473 , A61K49/0002 , A61K49/0021 , A61K49/0026 , A61K49/085 , A61K49/10
摘要： The present invention relates to methods of detecting and monitoring aggregation of beta-amyloid peptides which are associated with neurodegenerative diseases as well as treating and/or preventing the neurodegenerative diseases by using carbazole-based fluorophores. In particular, the present invention provides methods for labeling and imaging the beta-amyloid (Aβ) peptides, oligomers, and fibrils in vitro and/or in vivo, as well as treating and/or preventing Alzheimer's disease by using the carbazole-based fluorophores of the present invention.
摘要翻译：本发明涉及检测和监测与神经变性疾病相关的β-淀粉样肽聚集以及通过使用咔唑类荧光团治疗和/或预防神经变性疾病的方法。特别地，本发明提供了用于在体外和/或体内标记和成像β-淀粉样蛋白（A＆bgr））肽，寡聚体和原纤维的方法，以及通过使用咔唑类治疗和/或预防阿尔茨海默氏病荧光团。

60. 发明申请

US20150261936A1 Method for Separating and Analyzing Overlapping Data Components with Variable Delays in Single Trials 审中-公开
标题翻译：在单次试验中分离和分析具有可变延迟的重叠数据组件的方法
公开(公告)号：US20150261936A1
公开(公告)日：2015-09-17
申请号：US14210321
申请日：2014-03-13
申请人： Hong Kong Baptist University
发明人： Changsong Zhou , Guang Ouyang , Werner Sommer
IPC分类号： G06F19/00 , A61B5/04 , A61B5/0476
CPC分类号： G16H10/20 , A61B5/04012 , A61B5/0484
摘要： The present invention relates to a method for separating and analyzing overlapping data components with variable delays in single trials. In particular, the present invention relates to a method for separating and analyzing overlapping data components consistently occur in multiple realizations but locked to different time markers with variable inter-marker delays using an extended residue iteration decomposition (RIDE) algorithm. The present invention has applications in separating and analyzing event-related brain potential (ERP) data derived from single-trial responses.
摘要翻译：本发明涉及在单次试验中分离和分析具有可变延迟的重叠数据分量的方法。特别地，本发明涉及一种用于分离和分析重叠数据分量的方法，其一致地出现在多个实现中，但是使用扩展残差迭代分解（RIDE）算法锁定到具有可变标记间延迟的不同时间标记。本发明具有分离和分析从单试验反应得出的事件相关脑电位（ERP）数据的应用。

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