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51. 发明授权

US08759619B2 AXMI218, AXMI219, AXMI220, AXMI226, AXMI227, AXMI228, AXMI229, AXMI230, and AXMI231, delta-endotoxin genes and methods for their use 有权
标题翻译： AXMI218，AXMI219，AXMI220，AXMI226，AXMI227，AXMI228，AXMI229，AXMI230和AXMI231，δ-内毒素基因及其使用方法
公开(公告)号：US08759619B2
公开(公告)日：2014-06-24
申请号：US13030399
申请日：2011-02-18
申请人： Kimberly Sampson , Daniel Tomso
发明人： Kimberly Sampson , Daniel Tomso
IPC分类号： A01H5/00 , C12N15/82 , C12P1/00 , C07K1/00 , C07H21/02
CPC分类号： C07K14/325 , A01N37/46 , A01N63/02 , C12N15/8285 , C12N15/8286 , Y02A40/162 , Y02A40/164
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated toxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:13-30, or the nucleotide sequence set forth in SEQ ID NO:1-12, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含毒素多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的毒素核酸分子。另外，包括对应于多核苷酸的氨基酸序列，以及与这些氨基酸序列特异性结合的抗体。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：13-30所示的氨基酸序列的核苷酸序列或SEQ ID NO：1-12所示的核苷酸序列，以及变体和片段。

52. 发明申请

US20140051837A1 AXMI-205 PESTICIDAL GENE AND METHOD FOR ITS USE 审中-公开
公开(公告)号：US20140051837A1
公开(公告)日：2014-02-20
申请号：US14057250
申请日：2013-10-18
申请人： Athenix Corp.
发明人： Nalini Manoj Desai , Jill Hinson , Deepa Balasubramanian , Kimberly S. Sampson , Daniel J. Tomso , Duane Alan Lehtinen , Nicholas B. Duck , Rong Guo , Volker Heinrichs
IPC分类号： C07K16/12
CPC分类号： C07K14/195 , C07K14/22 , C07K16/1203 , C12N15/8285 , C12N15/8286 , C12Q1/6876 , Y02A40/162 , Y02A40/164
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2, 3, or 4, the nucleotide sequence set forth in SEQ ID NO:1, 9, 10, or 11, as well as variants and fragments thereof.

53. 发明申请

US20140046049A1 AXMI-205 PESTICIDAL GENE AND METHOD FOR ITS USE 审中-公开
公开(公告)号：US20140046049A1
公开(公告)日：2014-02-13
申请号：US14057282
申请日：2013-10-18
申请人： Athenix Corp.
发明人： Nalini Manoj Desai , Jill Hinson , Deepa Balasubramanian , Kimberly S. Sampson , Daniel J. Tomso , Duane Alan Lehtinen , Nicholas B. Duck , Rong Guo , Volker Heinrichs
IPC分类号： C07K14/22
CPC分类号： C07K14/195 , C07K14/22 , C07K16/1203 , C12N15/8285 , C12N15/8286 , C12Q1/6876 , Y02A40/162 , Y02A40/164
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2, 3, or 4, the nucleotide sequence set forth in SEQ ID NO:1, 9, 10, or 11, as well as variants and fragments thereof.

54. 发明授权

US08461415B2 AXMI-192 family of pesticidal genes and methods for their use 有权
标题翻译： AXMI-192系列杀虫基因及其使用方法
公开(公告)号：US08461415B2
公开(公告)日：2013-06-11
申请号：US12846900
申请日：2010-07-30
申请人： Kimberly S. Sampson , Daniel John Tomso , Rong Guo
发明人： Kimberly S. Sampson , Daniel John Tomso , Rong Guo
IPC分类号： C12N15/32 , C12N15/82 , C12N5/10 , C12N1/21 , A01H5/00 , A01H5/10
CPC分类号： C07K2/00 , C07K14/325 , C12N15/8285 , C12N15/8286 , Y02A40/162 , Y02A40/164
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated toxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:28-62, or the nucleotide sequence set forth in SEQ ID NO:1-27, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含毒素多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的毒素核酸分子。另外，包括对应于多核苷酸的氨基酸序列，以及与这些氨基酸序列特异性结合的抗体。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：28-62所示氨基酸序列的核苷酸序列或SEQ ID NO：1-27所示的核苷酸序列，以及变体和片段。

55. 发明授权

US08299217B2 Variant AXMI-R1 delta endotoxin genes and methods for their use 有权
标题翻译：变体AXMI-R1δ内毒素基因及其使用方法
公开(公告)号：US08299217B2
公开(公告)日：2012-10-30
申请号：US12701058
申请日：2010-02-05
申请人： Volker Heinrichs
发明人： Volker Heinrichs
IPC分类号： C07K14/235 , A01N37/44 , A01P7/04
CPC分类号： C12N15/8286 , C07K14/325 , Y02A40/162
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, nucleic acid molecules encoding variant AXMI-R1 sequences are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含杀虫多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了编码变体AXMI-R1序列的核酸分子。另外，包括对应于多核苷酸的氨基酸序列。

56. 发明授权

US08175813B2 Computational methods for synthetic gene design 有权
标题翻译：合成基因设计的计算方法
公开(公告)号：US08175813B2
公开(公告)日：2012-05-08
申请号：US12248750
申请日：2008-10-09
申请人： Daniel J. Tomso
发明人： Daniel J. Tomso
IPC分类号： G01N33/48 , C12Q1/68 , G06F7/60 , G06G7/58
CPC分类号： G06F19/22 , G06F19/24
摘要： The present invention is drawn to methods for designing synthetic nucleotide sequences encoding polypeptides of interest. The methods involve organizing a database of sequences as a set of N-length oligomer sequences and compiling a list of probability scores for each N-length sequence. The probability scores are used to substitute one or more higher-scoring sequences into the parent nucleotide sequence to generate an optimized sequence. The nucleotide sequence of interest may be further optimized by removing either or both of unintended open reading frames or undesired short DNA elements, and/or substituting oligomer sequences to achieve a specific G:C content. These methods may be used for optimizing expression of heterologous genes in any organism, particularly in plants. The method generates synthetic sequences with a composition similar to that of a target database. These synthetic sequences may be used, for example, for regulating pesticidal activity or herbicide resistance in organisms, particularly plants or plant cells.
摘要翻译：本发明涉及用于设计编码目标多肽的合成核苷酸序列的方法。所述方法包括将序列数据库组织为一组N长度寡聚体序列，并编制每个N长度序列的概率分数列表。概率分数用于将一个或多个更高分数的序列替换到母体核苷酸序列中以产生优化的序列。可以通过去除非预期的开放阅读框或不需要的短DNA元件中的任一个或两者，和/或取代低聚物序列以获得特定的G：C含量来进一步优化目的核苷酸序列。这些方法可用于优化异源基因在任何生物体中的表达，特别是在植物中。该方法生成具有类似于目标数据库的组成的合成序列。这些合成序列可用于例如调节生物体，特别是植物或植物细胞中的杀虫活性或除草剂抗性。

57. 发明授权

US08133858B2 AXMI-008, a delta-endotoxin gene and methods for its use 有权
标题翻译： AXMI-008，一种δ-内毒素基因及其使用方法
公开(公告)号：US08133858B2
公开(公告)日：2012-03-13
申请号：US12026427
申请日：2008-02-05
申请人： Nadine Carozzi , Tracy Hargiss , Michael G. Koziel , Nicholas B. Duck , Brian Carr
发明人： Nadine Carozzi , Tracy Hargiss , Michael G. Koziel , Nicholas B. Duck , Brian Carr
IPC分类号： C07K14/325 , A01N37/18
CPC分类号： C07K14/325 , C12N15/8286 , Y02A40/162
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin and delta-endotoxin-associated polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin and delta-endotoxin-associated nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequences shown in SEQ ID NOS:3, 5, and 7, and the nucleotide sequences set forth in SEQ ID NO:1, 2, 4, and 6, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含δ-内毒素和δ-内毒素相关多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的δ-内毒素和δ-内毒素相关的核酸分子。另外，包括对应于多核苷酸的氨基酸序列。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：3,5和7所示氨基酸序列的核苷酸序列，以及SEQ ID NO：和6，以及其变体和片段。

58. 发明申请

US20110263488A1 FAMILY OF PESTICIDAL PROTEINS AND METHODS FOR THEIR USE 有权
标题翻译：杀虫蛋白家族及其使用方法
公开(公告)号：US20110263488A1
公开(公告)日：2011-10-27
申请号：US13168454
申请日：2011-06-24
申请人： Nadine Carozzi , Michael G. Koziel , Nicholas B. Duck , Nalini M. Desai , Rong Guo , Daniel John Tomso , Rebekah Deter , Tracy Hargiss
发明人： Nadine Carozzi , Michael G. Koziel , Nicholas B. Duck , Nalini M. Desai , Rong Guo , Daniel John Tomso , Rebekah Deter , Tracy Hargiss
IPC分类号： A01N63/02 , C12N15/63 , C12N1/21 , A01H5/10 , A01H5/00 , C07K14/325 , A01P5/00 , A01P7/04 , C07H21/04 , C12N5/10
CPC分类号： C12N15/8286 , A01N37/44 , C07K14/325 , C12P21/02 , Y02A40/162
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2, 4, 6, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37 or 61, the nucleotide sequence set forth in SEQ ID NO:1, 3, 5, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or 60, or the nucleotide sequence deposited in a bacterial host as Accession No. NRRL B-30961, B-30955, B-30956, B-30957, B-30958, B-30942, B-30939, B-30941, B-50047, B-30959, B-30960, B-30943, or B-50048, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀虫活性的组合物和方法。提供了包含杀虫多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的杀虫核酸分子。另外，包括对应于多核苷酸的氨基酸序列。特别地，本发明提供了分离的核酸分子，其包含编码SEQ ID NO： 25，27，29，31，33，35，37或61所述的核苷酸序列，所述核苷酸序列如SEQ ID NO：1,3,5,8,10,12,14,16,18,20,22,24， 26,28,30,32,34,36或60个核苷酸序列，或作为保藏号NRRL B-30961，B-30955，B-30956，B-30957，B-30958，B -30942，B-30939，B-30941，B-50047，B-30959，B-30960，B-30943或B-50048，以及其变体和片段。

59. 发明申请

US20110252502A1 GRG23 EPSP SYNTHASES: COMPOSITIONS AND METHODS OF USE 有权
公开(公告)号：US20110252502A1
公开(公告)日：2011-10-13
申请号：US12856058
申请日：2010-08-13
申请人： Laura C. Schouten , Brian Vande Berg , Volker Heinrichs
发明人： Laura C. Schouten , Brian Vande Berg , Volker Heinrichs
IPC分类号： A01H5/10 , C12N15/63 , C12N1/21 , A01G1/00 , A01H5/00 , C12N9/00 , C12N15/82 , C12N15/52 , C12N5/10
CPC分类号： C12N15/8275 , C12N9/1085 , C12N9/1092
摘要： Compositions and methods for conferring herbicide resistance or tolerance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions include polynucleotides encoding herbicide resistance or tolerance polypeptides, vectors comprising those polynucleotides, and host cells comprising the vectors. The nucleotide sequences of the invention can be used in DNA constructs or expression cassettes for transformation and expression in organisms, including microorganisms and plants. Compositions also include transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated polynucleotides encoding glyphosate resistance or tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated polynucleotides containing nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, or 35, or the nucleotide sequence set forth in SEQ ID NO:6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, or 34.

60. 发明申请

US20110232179A1 GRG23 EPSP SYNTHASES: COMPOSITIONS AND METHODS OF USE 有权
公开(公告)号：US20110232179A1
公开(公告)日：2011-09-29
申请号：US12856072
申请日：2010-08-13
申请人： Laura C. Schouten , Brian Vande Berg , Volker Heinrichs
发明人： Laura C. Schouten , Brian Vande Berg , Volker Heinrichs
IPC分类号： A01G1/00 , C12N15/52 , C12N15/63 , C12N1/21 , C12N5/10 , A01H5/00 , A01H5/10 , C12N9/00 , C12N15/82
CPC分类号： C12N15/8275 , C12N9/1085 , C12N9/1092
摘要： Compositions and methods for conferring herbicide resistance or tolerance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions include polynucleotides encoding herbicide resistance or tolerance polypeptides, vectors comprising those polynucleotides, and host cells comprising the vectors. The nucleotide sequences of the invention can be used in DNA constructs or expression cassettes for transformation and expression in organisms, including microorganisms and plants. Compositions also include transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated polynucleotides encoding glyphosate resistance or tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated polynucleotides containing nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, or 35, or the nucleotide sequence set forth in SEQ ID NO:6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, or 34.

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