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51. 发明申请

US20090188961A1 CONVEYING UNIT AND VACUUM DEPOSITION DEVICE 失效
标题翻译：输送单元和真空沉积装置
公开(公告)号：US20090188961A1
公开(公告)日：2009-07-30
申请号：US12363246
申请日：2009-01-30
申请人： Masami Nakagame , Hiroyuki Nishida , Hideaki Takeuchi
发明人： Masami Nakagame , Hiroyuki Nishida , Hideaki Takeuchi
IPC分类号： B65H20/02
CPC分类号： B65H20/02 , B65H27/00 , B65H2301/5114 , B65H2406/11 , B65H2601/2532 , B65H2701/1719 , B65H2801/61
摘要： The conveying unit conveys a long sheet-like subject in its longitudinal direction. The conveying unit includes a stepped roller which has large-diameter portions spaced apart from each other in a direction perpendicular to a direction of conveyance of the sheet-like subject and having a larger diameter than a remainder of the stepped roller being a small-diameter portion of the stepped roller, the large-diameter portions supporting and conveying the sheet-like subject, a closed space forming subunit between the small-diameter portion of the stepped roller and the sheet-like subject and a gas supply subunit for supplying a gas to the closed space. The vacuum deposition device forms a film on a surface of a long substrate by vacuum deposition. The vacuum deposition device includes a vacuum chamber, a conveying device which includes the conveying unit and a film forming unit.
摘要翻译：输送单元沿长度方向输送长片状物体。输送单元包括阶梯辊，该阶梯辊在与片状物体的输送方向垂直的方向上具有大直径部分，并且具有比剩余阶梯辊更小的直径阶梯辊的部分，支撑并输送片状物体的大直径部分，阶梯辊的小直径部分和片状物体之间的封闭空间形成子单元和用于供应气体的气体供应子单元到封闭的空间。真空沉积装置通过真空沉积在长基板的表面上形成膜。真空沉积装置包括真空室，包括输送单元和成膜单元的输送装置。

52. 发明授权

US07536940B2 Clean booth and sheet conveyor device 失效
标题翻译：清洁摊位和片材输送装置
公开(公告)号：US07536940B2
公开(公告)日：2009-05-26
申请号：US10321808
申请日：2002-12-18
申请人： Takehiko Nakayama , Hiroyuki Nishida , Hideyuki Uezono
发明人： Takehiko Nakayama , Hiroyuki Nishida , Hideyuki Uezono
IPC分类号： B26D7/06 , B65G45/22
CPC分类号： G03D3/00 , Y10T83/647 , Y10T83/6633
摘要： A clean booth has a conveyor area for carrying recording sheets, and a motor drive area for containing motor and mechanical parts that emit much dust. The conveyor area and the motor drive area are covered respectively, and separated by a frame plate. Moreover, fan filter units blow pressurized clean air into the conveyor area to discharge dust while a ventilation system exhausts air in the motor drive area. There is no airflow from motor drive area to the conveyor area because of the difference in air pressure. The recording sheets in the conveyor area are carried by belt conveyors with artificial suede belts. The artificial suede belt is suitable to be used as a conveyer belt because of low dust emission and sufficient flexibility to prevent flaw or pressure marks on the recording sheets.
摘要翻译：一个干净的展台有一个用于运送记录纸的输送机区域和一个电机驱动区域，用于容纳发出大量灰尘的电机和机械部件。输送机区域和电机驱动区域被分别覆盖，并被框架板隔开。此外，风扇过滤器单元将加压的清洁空气吹入输送机区域以排放灰尘，同时通风系统排出电动机驱动区域中的空气。由于空气压力的差异，电机驱动区域到输送机区域没有气流。传送带中的记录纸由带有人造麂皮皮带的皮带输送机承载。人造麂皮皮带适用于作为输送带使用，因为粉尘的排放少，而且足够的弹性防止记录纸上的瑕疵或压痕。

53. 发明授权

US06927408B2 Apparatus for and method of inspecting sheet body 失效
标题翻译：纸体检查方法及方法
公开(公告)号：US06927408B2
公开(公告)日：2005-08-09
申请号：US10176054
申请日：2002-06-21
申请人： Kazuo Onishi , Hiroyuki Nishida
发明人： Kazuo Onishi , Hiroyuki Nishida
IPC分类号： G01B11/06 , G01N21/89 , G01N21/892 , G01N21/88
CPC分类号： G01N21/8916
摘要： When a film is rewound, light is applied from light-emitting units to the film, and light that has passed through the film is detected by light-detecting units to detect a plurality of inclined defects in the film based on a change in the intensity of the light transmitted through the film. Slits oriented in the direction of the inclined defects are disposed in front of the light-emitting units and the light-detecting units. Detected signals outputted from the light-detecting units are transmitted to a processing device and processed thereby. The processing device processes the signals by approximating a maximum value array of extremal values of the signals in respective reference lengths of the film, with two functions in zones, and identifying a boundary between the zones as a position where a defect disappears.
摘要翻译：当薄膜重绕时，从发光单元向薄膜施加光，并且通过光检测单元检测已经通过薄膜的光，以基于强度的变化来检测薄膜中的多个倾斜缺陷透过薄膜的光线。在倾斜缺陷的方向上取向的狭缝设置在发光单元和光检测单元的前面。从光检测单元输出的检测信号被发送到处理装置并进行处理。处理装置通过在膜的各个参考长度中近似信号的极值的最大值阵列来处理信号，区域中具有两个功能，并且将区域之间的边界识别为缺陷消失的位置。

54. 发明授权

US06908728B2 Laser marking on photosensitive material and photosensitive material including the marking 失效
标题翻译：感光材料和感光材料上的激光标记，包括标记
公开(公告)号：US06908728B2
公开(公告)日：2005-06-21
申请号：US10413584
申请日：2003-04-15
申请人： Keisuke Endo , Hiroyuki Nishida
发明人： Keisuke Endo , Hiroyuki Nishida
IPC分类号： B41M5/28 , G03C5/60 , G03C11/02 , G03F7/004
CPC分类号： G03C5/60 , B41M5/288 , G03C11/02 , Y10S430/146
摘要： By irradiating a laser beam onto an X-ray film that includes a support layer having disposed thereon an emulsion layer, the emulsion layer is melted, numerous minute air bubbles are generated in the emulsion layer, and the emulsion layer becomes convex, whereby a visible dot pattern is formed. The irradiation time and wavelength of the laser beam are selected so that separation is not generated between the support layer and the emulsion layer. By defocusing and irradiating the laser beam, the X-ray film may substantially uniformly receives energy of the laser beam. Moreover, an undersurface layer may also be formed, and the laser beam may be irradiated onto the undersurface layer to form a dot pattern on the undersurface layer. A device and a method for forming a marking pattern representing identification information on a rolled photosensitive material and cutting the photosensitive material into sheets are disclosed.
摘要翻译：通过将激光照射到包含乳剂层上的支撑层的X射线胶片上，使乳剂层熔融，在乳剂层中产生许多微小的气泡，乳剂层变凸形，形成点图形。选择激光束的照射时间和波长，使得在支撑层和乳剂层之间不产生分离。通过散焦和照射激光束，X射线胶片可以基本均匀地接收激光束的能量。此外，还可以形成下表面层，并且可以将激光束照射到下表面层上以在下表面层上形成点图案。公开了一种用于形成表示轧制的感光材料上的识别信息并将感光材料切割成片材的标记图案的装置和方法。

55. 发明授权

US06391616B1 Oidiodendron strain for the production of terpenoid lactone compounds 失效
标题翻译：用于生产萜类内酯化合物的Oidiodendron菌株
公开(公告)号：US06391616B1
公开(公告)日：2002-05-21
申请号：US09596140
申请日：2000-06-16
申请人： Hiroyuki Nishida , Masaya Ikunaka , Nobuji Yoshikawa , Katsuomi Ichikawa , Nakao Kojima
发明人： Hiroyuki Nishida , Masaya Ikunaka , Nobuji Yoshikawa , Katsuomi Ichikawa , Nakao Kojima
IPC分类号： C12N114
CPC分类号： C07D307/92 , A61K31/365 , A61K31/366 , A61K31/4741 , C07D311/92 , C07D491/06 , C07D493/06 , Y02A50/411
摘要： This invention provides terpenoid lactone compounds, and processes for producing the terpenoid lactone compounds, which comprise cultivating Oidiodedron griseum FERM BP-5778 and then isolating the terpenoid lactone compounds from the fermentation broth. The present invention also provides a pharmaceutical composition comprising the terpenoid lactone compound, which is useful in the treatment of IL-1 and TNF mediated diseases or the like.
摘要翻译：本发明提供萜类内酯化合物，以及萜类内酯化合物的制备方法，其包括培育Oidiodedron griseum FERM BP-5778，然后从发酵液中分离萜类内酯化合物。本发明还提供了包含萜类内酯化合物的药物组合物，其可用于治疗IL-1和TNF介导的疾病等。

56. 发明授权

US06225339B1 Terpenoid lactone compounds and their production process 失效
标题翻译：萜类内酯化合物及其制备方法
公开(公告)号：US06225339B1
公开(公告)日：2001-05-01
申请号：US09232080
申请日：1999-01-15
申请人： Hiroyuki Nishida , Masaya Ikunaka , Nobuji Yoshikawa , Katsuomi Ichikawa , Nakao Kojima
发明人： Hiroyuki Nishida , Masaya Ikunaka , Nobuji Yoshikawa , Katsuomi Ichikawa , Nakao Kojima
IPC分类号： A61K3135
CPC分类号： C07D307/92 , A61K31/365 , A61K31/366 , A61K31/4741 , C07D311/92 , C07D491/06 , C07D493/06 , Y02A50/411
摘要： This invention provides terpenoid lactone compounds, and processes for producing the terpenoid lactone compounds, which comprise cultivating Oidiodedron griseum FERM BP-5778 and then isolating the terpenoid lactone compounds from the fermentation broth. The present invention also provides a pharmaceutical composition comprising the terpenoid lactone compound, which is useful in the treatment of IL-1 and TNF mediated diseases or the like.
摘要翻译：本发明提供萜类内酯化合物，以及萜类内酯化合物的制备方法，其包括培育Oidiodedron griseum FERM BP-5778，然后从发酵液中分离萜类内酯化合物。本发明还提供了包含萜类内酯化合物的药物组合物，其可用于治疗IL-1和TNF介导的疾病等。

57. 发明授权

US06187568B1 Macrocyclic lactone compounds and their production process 失效
标题翻译：大环内酯化合物及其生产工艺
公开(公告)号：US06187568B1
公开(公告)日：2001-02-13
申请号：US09378062
申请日：1999-08-20
申请人： Hiroyuki Nishida , Yuji Yamauchi , Taisuke Inagaki , Yasuhiro Kojima , Nakao Kojima
发明人： Hiroyuki Nishida , Yuji Yamauchi , Taisuke Inagaki , Yasuhiro Kojima , Nakao Kojima
IPC分类号： C12P1718
CPC分类号： C07D498/18 , C12P17/188
摘要： This invention provides a process for producing a macrocyclic lactone compound, which comprises cultivating Actinoplanes sp. FERM BP-3832, in the presence of L-proline, L-hydroxyproline or L-nipecotic acid, and then isolating a macrocylic lactone compound from the fermentation broth. The compounds produced by this process include a compound of the following formula: The present invention also relates to a pharmaceutical composition comprising the same, which is useful as immunosuppressive, antimycotic, antitumor agent or the like.
摘要翻译：本发明提供了一种制备大环内酯化合物的方法，其包括培养活性平板体。 FERM BP-3832，在L-脯氨酸，L-羟脯氨酸或L-乳酸的存在下，然后从发酵液中分离大环内酯化合物。通过该方法制备的化合物包括下式的化合物：本发明还涉及包含该化合物的药物组合物，其可用作免疫抑制，抗真菌剂，抗肿瘤剂等。

58. 发明授权

US6001998A Macrocyclic lactone compounds and their production process 失效
标题翻译：大环内酯化合物及其生产工艺
公开(公告)号：US6001998A
公开(公告)日：1999-12-14
申请号：US836213
申请日：1997-10-27
申请人： Hiroyuki Nishida , Yuji Yamauchi , Taisuke Inagaki , Yasuhiro Kojima , Nakao Kojima
发明人： Hiroyuki Nishida , Yuji Yamauchi , Taisuke Inagaki , Yasuhiro Kojima , Nakao Kojima
IPC分类号： B65B57/02 , A61K31/40 , A61K31/401 , A61K31/445 , A61K31/70 , A61K35/00 , A61P31/04 , A61P35/00 , A61P37/06 , B65G43/00 , C07D20060101 , C07D209/00 , C07D273/00 , C07D311/00 , C07D498/18 , C07H19/01 , C12P1/06 , C12P17/18 , C12R1/045 , G01B11/26 , G05B19/02 , G05B19/05 , G05D3/00 , G05D3/12
CPC分类号： C07D498/18 , C12P17/188
摘要： This invention provides a process for producing a macrocyclic lactone compound, which comprises cultivating Actinoplanes sp. FERM BP-3832, in the presence of L-proline, L-hydroxyproline or L-nipecotic acid, and then isolating a macrocyclic lactone compound from the fermentation broth. The compounds produced by this process include a compound of formula (I). The present invention also relates to a pharmaceutical composition comprising the same, which is useful as immunosuppressive, antimycotic, antitumor agent or the like.
摘要翻译： PCT No.PCT / IB95 / 00870 Sec。 371日期1997年10月27日第 102（e）1997年10月27日PCT PCT 1995年10月13日PCT公布。公开号WO96 / 15131 日期1996年5月23日本发明提供了一种制备大环内酯化合物的方法，其包括培养活性平板体。 FERM BP-3832，在L-脯氨酸，L-羟脯氨酸或L-乳酸的存在下，然后从发酵液中分离大环内酯化合物。通过该方法制备的化合物包括式（I）的化合物。本发明还涉及含有该组合物的药物组合物，其可用作免疫抑制，抗真菌剂，抗肿瘤剂等。

59. 发明授权

US5952562A Scanning probe microscope incorporating an optical microscope 失效
标题翻译：扫描显微镜并入光学显微镜
公开(公告)号：US5952562A
公开(公告)日：1999-09-14
申请号：US752390
申请日：1996-11-20
申请人： Akira Yagi , Hiroyuki Nishida
发明人： Akira Yagi , Hiroyuki Nishida
IPC分类号： G01Q20/02 , G01B11/30 , G01Q30/02 , G01Q70/02
CPC分类号： G01Q30/025 , B82Y35/00
摘要： A scanning probe microscope includes a cantilever having a probe on its free end, a displacement measuring unit for measuring a displacement of the cantilever caused by an interaction between a specimen and the probe, and a tube actuator for supporting the cantilever and the displacement measuring unit and controlling the position of the probe in a three-dimensional manner, the actuator and the probe being arranged coaxial with each other. The apparatus also includes a special microscopic optical system including a pupil modulating element and an oblique illumination optical system for obliquely illuminating the specimen, which together constitute an optical microscope capable of high-power observation of optically transparent specimens.
摘要翻译：扫描探针显微镜包括在其自由端具有探针的悬臂，用于测量由样本和探针之间的相互作用引起的悬臂的位移的位移测量单元和用于支撑悬臂和位移测量单元的管致动器并且以三维方式控制探针的位置，致动器和探针彼此同轴布置。该装置还包括特殊的微观光学系统，其包括瞳孔调制元件和用于倾斜照射样本的倾斜照明光学系统，它们共同构成能够大量观察光学透明样品的光学显微镜。

60. 发明授权

US5885959A Cyclic peptide compounds and their production process 失效
标题翻译：环肽化合物及其制备方法
公开(公告)号：US5885959A
公开(公告)日：1999-03-23
申请号：US999627
申请日：1997-12-03
申请人： Hideo Hirai , Nakao Kojima , Hiroyuki Nishida , Toshiyuki Saito , Nobuji Yoshikawa
发明人： Hideo Hirai , Nakao Kojima , Hiroyuki Nishida , Toshiyuki Saito , Nobuji Yoshikawa
IPC分类号： C12P21/04 , A61K38/00 , A61P25/04 , A61P25/30 , A61P39/02 , C07K5/12 , C12P21/02 , C12R1/645 , A61K38/12 , C07K5/00 , C07K7/00 , C07K16/00
CPC分类号： C07K5/126 , C12P21/02 , A61K38/00
摘要： This invention provides processes for producing novel cyclic peptide compounds, which comprise cultivating Ctenomyces serratus FERM BP-5731 and then isolating the cyclic peptide compounds from the fermentation broth. The compounds produced by these processes include a cyclic peptide compound of the following formula (I): ##STR1## The present invention also relates to a pharmaceutical composition comprising the same, which is useful in the treatment of severe pain, detoxication of narcotics dependency or acute narcotics intoxication or the like.
摘要翻译：本发明提供了生产新型环肽化合物的方法，其包括培养C ivating atus ERM FERM BP-5731，然后从发酵液中分离出环状肽化合物。通过这些方法制备的化合物包括下式（I）的环肽化合物：（I）本发明还涉及包含其的药物组合物，其可用于治疗严重疼痛，解毒麻醉品依赖或急性毒品中毒等。

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