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51. 发明授权

US07565284B2 Acoustic models with structured hidden dynamics with integration over many possible hidden trajectories 有权
标题翻译：具有结构化隐藏动力学的声学模型，并集成了许多可能的隐藏轨迹
公开(公告)号：US07565284B2
公开(公告)日：2009-07-21
申请号：US11071904
申请日：2005-03-01
申请人： Li Deng , Alejandro Acero , Dong Yu , Xiang Li
发明人： Li Deng , Alejandro Acero , Dong Yu , Xiang Li
IPC分类号： G10L15/14
CPC分类号： G10L15/02 , G10L2015/025
摘要： A method of producing at least one possible sequence of vocal tract resonance (VTR) for a fixed sequence of phonetic units, and producing the acoustic observation probability by integrating over such distributions is provided. The method includes identifying a sequence of target distributions for a VTR sequence corresponding to a phone sequence with a given segmentation. The sequence of target distributions is applied to a finite impulse response filter to produce distributions for possible VTR trajectories. Then these distributions are applied to a linearized nonlinear function to produce the acoustic observation probability for the given sequence of phonetic units. This acoustic observation probability is used for phonetic recognition.
摘要翻译：提供了一种用于固定语音单元序列的至少一个可能的声道共振（VTR）序列的方法，并且通过在这样的分布上积分来产生声学观察概率。该方法包括识别对应于具有给定分割的电话序列的VTR序列的目标分布序列。将目标分布的序列应用于有限脉冲响应滤波器，以产生可能的VTR轨迹的分布。然后将这些分布应用于线性化非线性函数，以产生给定的语音单元序列的声学观察概率。这种声学观测概率用于语音识别。

52. 再颁专利

USRE40733E1 Helical electrodeionization apparatus 有权
标题翻译：螺旋电去离子装置
公开(公告)号：USRE40733E1
公开(公告)日：2009-06-16
申请号：US10359060
申请日：2003-02-05
申请人： Xiang Li , Gou-Lin Luo
发明人： Xiang Li , Gou-Lin Luo
IPC分类号： B01D61/48
CPC分类号： C02F1/4695 , B01D61/46 , B01D61/48 , B01D2313/086 , B01D2313/146 , B01J47/08 , C02F1/42 , C02F1/4604 , C02F2201/46115
摘要： A helical electrodeionization apparatus is adapted to purify aqueous liquids to effect the production of high purity water. An insulated net-separating wall is positioned between a pair of anion and cation exchange membranes to form a special membrane bag type flow unit I, each flow unit I is linked up with a group of slots on the side walls of central pipe, and is rolled up to form cylinder structure which centers on central pipe as the helical axis, a conductive crust is formed by winding metal strip or wire outside the cylinder. Ion exchange resin is filled up between the adjacent membrane bags to form flow unit II. The present invention has less pressure drop and needs less power, and is suited to multiple-device series operation. Preferably, daily maintenance and renewal of the resin is convenient, and production cost is lower.
摘要翻译：螺旋电去离子装置适于净化含水液体以产生高纯度水。绝缘网分离壁位于一对阴离子交换膜和阳离子交换膜之间，形成一个特殊的膜袋型流量单元I，每个流量单元I与中心管侧壁上的一组槽口相连，卷起形成以中心管为中心的圆筒结构作为螺旋轴，通过将金属条或线缠绕在圆筒外部形成导电外壳。离子交换树脂填充在相邻的膜袋之间以形成流动单元II。本发明压降更小，功率更少，适用于多器件串联运行。优选地，树脂的日常维护和更新是方便的，并且生产成本更低。

53. 发明申请

US20090150369A1 METHOD AND APPARATUS TO PROVIDE MULTIMEDIA SERVICE USING TIME-BASED MARKUP LANGUAGE 有权
标题翻译：使用基于时间的标记语言提供多媒体服务的方法和设备
公开(公告)号：US20090150369A1
公开(公告)日：2009-06-11
申请号：US12329409
申请日：2008-12-05
申请人： Xiaosong Du , Yanlin Guan , Xiang Li
发明人： Xiaosong Du , Yanlin Guan , Xiang Li
IPC分类号： G06F17/30
CPC分类号： G06F17/30029 , G06F17/30044
摘要： A multimedia player and method is disclosed for displaying multimedia content on a video screen. A video stream and a markup language segment associated with the video stream are received, wherein the markup language segment comprising a time stamp identifying a target segment of the video stream, and at least one keyword associated with the time stamp. The keyword is transmitted over a network to a search engine, and related content is received from the search engine over the network, wherein the related content is related to the keyword. When the target segment of the video stream is displayed on the video screen, the related content is concurrently displayed on the video screen.
摘要翻译：公开了一种用于在视频屏幕上显示多媒体内容的多媒体播放器和方法。接收与视频流相关联的视频流和标记语言段，其中所述标记语言段包括标识所述视频流的目标段的时间戳以及与所述时间戳相关联的至少一个关键字。该关键字通过网络发送到搜索引擎，并且通过网络从搜索引擎接收相关内容，其中相关内容与该关键字相关。当视频流的目标段被显示在视频屏幕上时，相关内容被同时显示在视频屏幕上。

54. 发明申请

US20080146513A1 Synthetic Ion Channels 有权
标题翻译：合成离子通道
公开(公告)号：US20080146513A1
公开(公告)日：2008-06-19
申请号：US11959482
申请日：2007-12-19
申请人： Dan Yang , Xiang Li
发明人： Dan Yang , Xiang Li
IPC分类号： A61K38/07 , C07K17/02
CPC分类号： C07C239/20 , C07D213/63 , C07D213/79 , C07D213/81
摘要： Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also provided are methods of making and using the ion channels formed from a plurality of molecules of the self-assembling compounds. Further, provided are methods of treating or preventing conditions and diseases that are related to the dysfunction of ion channels, including chloride channels.
摘要翻译：本文提供了可以在脂质双层或细胞膜中形成离子通道的自组装化合物和包含自组装化合物的离子通道形成组合物。还提供了制造和使用由多个自组装化合物分子形成的离子通道的方法。此外，提供了治疗或预防与离子通道功能障碍（包括氯化物通道）相关的病症和疾病的方法。

55. 发明授权

US07368258B1 Devices and methods for profiling enzyme substrates 失效
公开(公告)号：US07368258B1
公开(公告)日：2008-05-06
申请号：US11447089
申请日：2006-06-06
申请人： Charles Bieberich , Xiang Li
发明人： Charles Bieberich , Xiang Li
IPC分类号： C12Q1/50
CPC分类号： C12Q1/00 , C12Q1/485 , G01N2500/02
摘要： The present invention relates to apparatus and methods for separating and detecting enzyme substrates using separation gels. For example, the apparatus and methods can be used to separate and detect kinase substrates for further analysis. The apparatus and methods can also be used to detect enzyme inhibitors, such as kinase inhibitors.

56. 发明申请

US20070191300A1 Methods for Modulating IKKalpha Activity 有权
标题翻译：调节IKKalpha活性的方法
公开(公告)号：US20070191300A1
公开(公告)日：2007-08-16
申请号：US11740438
申请日：2007-04-26
申请人： Jun Li , Xiang Li , Jianfei Yang , Kenneth Marcu
发明人： Jun Li , Xiang Li , Jianfei Yang , Kenneth Marcu
IPC分类号： A61K48/00 , C12Q1/48 , C07H21/02
CPC分类号： C12Q1/485 , A61K38/00 , C12N15/113 , C12N2310/14 , G01N2333/912 , G01N2500/00
摘要： A method for modulating NF-κB dependent gene transcription in a cell comprised of modulating IKKα protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-κB dependent gene transcription.
摘要翻译：一种调节细胞中NF-κB依赖性基因转录的方法，包括调节细胞中的IKKα蛋白活性。本发明还提供了用于调节NF-κB依赖性基因转录的siRNA组合物及其方法。

57. 发明授权

US07235654B2 Methods for modulating IKKα activity 有权
标题翻译：调节IKKalpha活性的方法
公开(公告)号：US07235654B2
公开(公告)日：2007-06-26
申请号：US10730614
申请日：2003-12-08
申请人： Jun Li , Xiang Li , Jianfei Yang
发明人： Jun Li , Xiang Li , Jianfei Yang
IPC分类号： C07H21/02 , C07H21/04
CPC分类号： C12Q1/485 , A61K38/00 , C12N15/113 , C12N2310/14 , G01N2333/912 , G01N2500/00
摘要： A method for modulating NF-κB dependent gene transcription in a cell comprised of modulating IKKα protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-κB dependent gene transcription.
摘要翻译：一种调节细胞中NF-κB依赖性基因转录的方法，包括调节细胞中的IKKα蛋白活性。本发明还提供了用于调节NF-κB依赖性基因转录的siRNA组合物及其方法。

58. 发明申请

US20070128648A1 Methods for the Identification of IKKalpha Function and other Genes Useful for Treatment of Inflammatory Diseases 审中-公开
标题翻译：用于鉴定IKKalpha功能和其他有助于治疗炎症疾病的基因的方法
公开(公告)号：US20070128648A1
公开(公告)日：2007-06-07
申请号：US11621029
申请日：2007-01-08
申请人： Jun Li , Adedeyo Hanidu , Xiang Li , Gregory Peet , Sheenah Mische , Kenneth Marcu
发明人： Jun Li , Adedeyo Hanidu , Xiang Li , Gregory Peet , Sheenah Mische , Kenneth Marcu
IPC分类号： A61K38/55 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/5023
摘要： The invention provides a method for identifying genes involved in the NF-κB pathway comprised of the steps of determining the level of expression of a gene in an experimental sample obtained from the cells having deficient levels of a component of the NF-κB pathway; determining the level of expression of said gene in a control sample obtained from wild type cells having levels of a component of a biological pathway; selecting genes having a level of expression that are modulated in said experimental sample relative to said wild type sample. The invention also provides a method of treating inflammatory related diseases by modulating the activity of IKKα.
摘要翻译：本发明提供了鉴定涉及NF-κB途径的基因的方法，其包括确定从具有NF-κB途径成分水平不足的细胞获得的实验样品中基因表达水平的步骤; 确定从具有生物学途径成分水平的野生型细胞获得的对照样品中所述基因的表达水平; 选择具有相对于所述野生型样品在所述实验样品中调节的表达水平的基因。本发明还提供了通过调节IKKα的活性来治疗炎性相关疾病的方法。

59. 发明授权

US07187794B2 Noise treatment of low-dose computed tomography projections and images 失效
标题翻译：低剂量计算机断层扫描投影和图像的噪声处理
公开(公告)号：US07187794B2
公开(公告)日：2007-03-06
申请号：US10273927
申请日：2002-10-18
申请人： Zhengrong Liang , Hongbing Lu , Xiang Li
发明人： Zhengrong Liang , Hongbing Lu , Xiang Li
IPC分类号： G06K9/00
CPC分类号： G06T11/005 , G06T5/002 , G06T5/10 , G06T5/20 , G06T2207/10081 , G06T2207/20192 , G06T2207/30004 , Y10S378/901
摘要： A method for treating noise in low-dose computed tomography projections and reconstructed images comprises acquiring raw data at a low mA value, applying a domain specific filter in a sinogram domain of the raw data, and applying an edge preserving smoothing filter in an image domain of the raw data after filtering in the sinogram domain.
摘要翻译：一种用于处理低剂量计算机断层摄影投影和重建图像中的噪声的方法，包括以低mA值获取原始数据，在原始数据的正弦图域中应用域特定滤波器，以及在图像域中应用边缘保持平滑滤波器的原始数据在sinogram域过滤后。

60. 发明授权

US07097753B2 Dilute support frame for an EDI device 有权
标题翻译： EDI设备的稀释支持框架
公开(公告)号：US07097753B2
公开(公告)日：2006-08-29
申请号：US10630338
申请日：2003-07-30
申请人： Xiang Li , Gou-Lin Luo
发明人： Xiang Li , Gou-Lin Luo
IPC分类号： B01D61/46
CPC分类号： B01D61/52 , B01D61/46 , B01D63/10 , B01J47/08 , C02F1/4695
摘要： The dilute support frame is made up of interphase longitude and latitude bars that preferably are hollow. The bars can be rectangular, rectangular with a rounded end, half-circular, triangular, polygonal or any combination thereof. The bars are sized to support the ion exchange resin in the dilute channel adjacent the concentrate membrane bag. The support frame also assures fluent water flow in the dilute channel. The support frames are arrayed on the membranes with interphase aisle to save the frame arrays and make water flow fluently. The membrane envelopes in turn with the support frames as both are preferably wound to form the cylinder module, and is covered by one plastic protecting net. This new type of support frame can assure fluent water flow in dilute channels and convenient resin filling.
摘要翻译：稀释的支撑框架由优选为中空的相间经纬线组成。杆可以是矩形的，具有圆形端，半圆形，三角形，多边形或其任何组合的矩形。这些条的尺寸被设计成支持邻近浓缩膜袋的稀释通道中的离子交换树脂。支撑框架还保证了稀释通道中流畅的水流。支撑框架通过相间通道排列在膜上，以节省框架阵列，并使水流畅流动。薄膜依次包围支撑框架，两者都优选地被卷绕以形成气缸模块，并被一个塑料保护网覆盖。这种新型支撑框架可以确保稀疏通道中的流动水流动，树脂填充方便。

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