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51. 发明授权

US07894899B2 Method and apparatus to terminate ventricular tachycardia via pacing 有权
标题翻译：通过起搏终止室性心动过速的方法和装置
公开(公告)号：US07894899B2
公开(公告)日：2011-02-22
申请号：US12393059
申请日：2009-02-26
申请人： Vinod Sharma
发明人： Vinod Sharma
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61N1/3962
摘要： An implantable device for terminating ventricular tachycardia is disclosed. The device includes a processor configured to determine a first antitachycardia pulse routine of N pulses. In the routine the first N−1 pulses are separated by a first cycle length and the Nth pulse is separated by a second cycle length that is shorter than the first cycle length. The device also comprises a lead coupled to the processor. The lead comprises an electrode configured to sense a tachycardia and further configured, under control of the processor, to administer the antitachycardia pulse routine.
摘要翻译：公开了用于终止室性心动过速的可植入装置。该装置包括被配置为确定N个脉冲的第一抗心动过速脉冲程序的处理器。在该例程中，第一N-1个脉冲被第一周期长度分开，并且第N个脉冲被分开比第一周期长度短的第二周期长度。该装置还包括耦合到处理器的引线。引线包括被配置为感测心动过速的电极，并且在处理器的控制下进一步配置以施用抗心动过速脉冲程序。

52. 发明申请

US20100076063A1 GENETIC MODIFICATION OF TARGETED REGIONS OF THE CARDIAC CONDUCTION SYSTEM 有权
标题翻译：心脏导管系统目标区域的遗传修饰
公开(公告)号：US20100076063A1
公开(公告)日：2010-03-25
申请号：US12578198
申请日：2009-10-13
申请人： Vinod Sharma , Walter H. Olson
发明人： Vinod Sharma , Walter H. Olson
IPC分类号： A61K31/7088 , A61P9/10
CPC分类号： C07K14/705 , A61K38/00 , A61K38/177
摘要： Disclosed are compositions, methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of cells of targeted regions of the cardiac conduction system. In particular, a bio-pacemaker composition is delivered to cardiac cells to increase the intrinsic pacemaking rate of the cells, wherein the bio-pacemaker composition increases expression of a channel or subunit thereof that produces funny current and a T-type Ca2+ channel or subunit thereof, and expresses one or more molecules that suppresses the expression of the wild type potassium channel.
摘要翻译：公开了用于预防或治疗心脏功能障碍的组合物，方法和系统，特别是心脏起搏功能障碍，通过心脏传导系统的靶向区域的细胞的遗传修饰。特别地，将生物起搏器组合物递送到心脏细胞以增加细胞的固有起搏速率，其中生物起搏器组合物增加产生滑稽电流的通道或其亚基的表达，以及T型Ca 2+通道或亚基并表达抑制野生型钾通道表达的一种或多种分子。

53. 发明申请

US20100047915A1 IDENTIFYING PATIENTS AT RISK FOR LIFE THREATENING ARRHYTHMIAS 审中-公开
标题翻译：识别患有ARRHYTHMIAS生命危险的患者
公开(公告)号：US20100047915A1
公开(公告)日：2010-02-25
申请号：US12606173
申请日：2009-10-26
申请人： Orhan Soykan , Amy C. Dearking , Timothy H. Robinson , Walter H. Olson , Vinod Sharma
发明人： Orhan Soykan , Amy C. Dearking , Timothy H. Robinson , Walter H. Olson , Vinod Sharma
IPC分类号： G01N33/00
CPC分类号： G01N33/6893 , G01N2800/326
摘要： The invention is a method for identifying proteins associated with sudden cardiac death (SCD) and for assessing a patient's risk of SCD by determining the amount of one or more SCD-associated proteins in the patient. Typically, the patient submits a sample, such as a blood sample, which is tested for one or more SCD-associated proteins. Based upon the results of the tests, the patient's risk of SCD may be assessed.
摘要翻译：本发明是鉴定与心脏猝死相关的蛋白质（SCD）的方法，并且通过确定患者中一种或多种与SCD相关的蛋白质的量来评估患者的SCD风险。通常，患者提交样品，例如血液样品，其被测试一种或多种与SCD相关的蛋白质。根据测试结果，可以评估患者SCD的风险。

54. 发明授权

US07608458B2 Identifying patients at risk for life threatening arrhythmias 失效
标题翻译：识别处于危及生命的心律失常风险的患者
公开(公告)号：US07608458B2
公开(公告)日：2009-10-27
申请号：US11157549
申请日：2005-06-21
申请人： Orhan Soykan , Amy C. Dearking , Timothy H. Robinson , Walter H. Olson , Vinod Sharma
发明人： Orhan Soykan , Amy C. Dearking , Timothy H. Robinson , Walter H. Olson , Vinod Sharma
IPC分类号： G01N33/00
CPC分类号： G01N33/6893 , G01N2800/326
摘要： The invention is a method for identifying proteins associated with sudden cardiac death (SCD) and for assessing a patient's risk of SCD by determining the amount of one or more SCD-associated proteins in the patient. Typically, the patient submits a sample, such as a blood sample, which is tested for one or more SCD-associated proteins. Based upon the results of the tests, the patient's risk of SCD may be assessed.
摘要翻译：本发明是鉴定与心脏猝死相关的蛋白质（SCD）的方法，并且通过确定患者中一种或多种与SCD相关的蛋白质的量来评估患者的SCD风险。通常，患者提交样品，例如血液样品，其被测试一种或多种与SCD相关的蛋白质。根据测试结果，可以评估患者SCD的风险。

55. 发明授权

US07415307B2 Ischemia detection based on cardiac conduction time 有权
标题翻译：基于心脏传导时间的缺血检测
公开(公告)号：US07415307B2
公开(公告)日：2008-08-19
申请号：US10284900
申请日：2002-10-31
申请人： Vinod Sharma , Walter H. Olson
发明人： Vinod Sharma , Walter H. Olson
IPC分类号： A61N1/00
CPC分类号： A61B5/05 , A61B5/7203 , A61N1/362
摘要： Methods and process for detection of myocardial ischemia involve detection and analysis of changes in electrical conduction velocity within the heart to monitor changes in the condition of the cardiac muscle and indicate possible ischemia. Conduction velocity slows considerably when oxygen supply to the heart is reduced. Analysis of electrical conduction velocity can be used to verify the occurrence of myocardial ischemia in a more reliable manner. Changes in conduction velocity may be monitored based on conduction time between electrodes positioned in the left and right ventricles of the heart. The electrodes may be endocardial or epicardial electrodes. In general, the techniques may involve launching a stimulation waveform at one electrode and sensing a local cardiac depolarization at another electrode to assess conduction time.
摘要翻译：用于检测心肌缺血的方法和过程涉及检测和分析心脏内电传导速度的变化，以监测心肌状况的变化并指示可能的缺血。当心脏供氧减少时，传导速度显着减慢。电传导速度分析可以更可靠地验证心肌缺血的发生。可以基于位于心脏左心室和右心室的电极之间的传导时间来监测传导速度的变化。电极可以是心内膜或心外膜电极。通常，这些技术可以涉及在一个电极处发射刺激波形并感测另一个电极处的局部心脏去极化以评估传导时间。

56. 发明申请

US20080103537A1 ELECTRONIC AND BIOLOGICAL PACEMAKER SYSTEMS 有权
标题翻译：电子与生物学系统
公开(公告)号：US20080103537A1
公开(公告)日：2008-05-01
申请号：US11554770
申请日：2006-10-31
申请人： Daniel C. Sigg , Timothy G. Laske , Vinod Sharma , Orhan Soykan
发明人： Daniel C. Sigg , Timothy G. Laske , Vinod Sharma , Orhan Soykan
IPC分类号： A61N1/00
CPC分类号： A61N1/362 , A61N1/3627
摘要： Heart pacing systems include at least one electronic or biological pacemaker as a primary pacemaker, and at least one electronic or biological pacemaker as a backup pacemaker. When implanted, the primary pacemaker(s) produce primary pacing stimuli that modulate cardiac function. The backup pacemaker(s) provide backup pacing stimuli when the electronic pacemaker is unable to modulate cardiac function at the predetermined pacing rate. The heart pacing systems are implemented by implantation in regions where they can provide pacing stimuli to cardiac tissue.
摘要翻译：心脏起搏系统包括至少一个电子或生物起搏器作为主要起搏器，以及至少一个电子或生物起搏器作为备用起搏器。当植入时，主起搏器产生调节心脏功能的主要起搏刺激。当电子起搏器不能以预定起搏速度调节心脏功能时，备用起搏器提供备用起搏刺激。心脏起搏系统通过植入在可以为心脏组织提供起搏刺激的区域中实现。

57. 发明申请

US20050266576A1 Identifying patients at risk for life threatening arrhythmias 失效
标题翻译：识别处于危及生命的心律失常风险的患者
公开(公告)号：US20050266576A1
公开(公告)日：2005-12-01
申请号：US11157549
申请日：2005-06-21
申请人： Orhan Soykan , Amy Dearking , Timothy Robinson , Walter Olson , Vinod Sharma
发明人： Orhan Soykan , Amy Dearking , Timothy Robinson , Walter Olson , Vinod Sharma
IPC分类号： G01N33/68 , G06F19/00 , G01N33/00
CPC分类号： G01N33/6893 , G01N2800/326
摘要： The invention is a method for identifying proteins associated with sudden cardiac death (SCD) and for assessing a patient's risk of SCD by determining the amount of one or more SCD-associated proteins in the patient. Typically, the patient submits a sample, such as a blood sample, which is tested for one or more SCD-associated proteins. Based upon the results of the tests, the patient's risk of SCD may be assessed.
摘要翻译：本发明是鉴定与心脏猝死相关的蛋白质（SCD）的方法，并且通过确定患者中一种或多种与SCD相关的蛋白质的量来评估患者的SCD风险。通常，患者提交样品，例如血液样品，其被测试一种或多种与SCD相关的蛋白质。根据测试结果，可以评估患者SCD的风险。

58. 发明申请

US20050091914A1 Antioxidant composition for motor gasoline 有权
标题翻译：汽油汽油的抗氧化剂组合物
公开(公告)号：US20050091914A1
公开(公告)日：2005-05-05
申请号：US10922659
申请日：2004-08-20
申请人： Anurag Gupta , Suresh Puri , Subhash Chand , Vinod Sharma , Rajagopal Manoharan , Rameshwar Prashad , Niranjan Raje , Akhilesh Bratnagar
发明人： Anurag Gupta , Suresh Puri , Subhash Chand , Vinod Sharma , Rajagopal Manoharan , Rameshwar Prashad , Niranjan Raje , Akhilesh Bratnagar
IPC分类号： C10L1/14 , C10L1/18 , C10L1/22
CPC分类号： C10L1/143 , C10L1/1832 , C10L1/223 , C10L1/238
摘要： An antioxidant composition effective for stabilizing gasoline and gasoline components contains from approximately 50-95% by weight of at least one Mannich base and from approximately 5-50% by weight of at least one amine. The Mannich base is derived from p-substituted phenols or from cashew nut shell liquid.
摘要翻译：用于稳定汽油和汽油组分的抗氧化剂组合物含有约50-95％重量的至少一种曼尼希碱和约5-50％重量的至少一种胺。曼尼希碱基来自对取代的酚类或来自腰果壳的液体。

59. 发明授权

US06813628B2 Method and apparatus for performing equality comparison in redundant form arithmetic 有权
标题翻译：用于在冗余形式算术中执行等式比较的方法和装置
公开(公告)号：US06813628B2
公开(公告)日：2004-11-02
申请号：US09746771
申请日：2000-12-22
申请人： Bharat Bhushan , Edward Grochowski , Vinod Sharma , John Crawford
发明人： Bharat Bhushan , Edward Grochowski , Vinod Sharma , John Crawford
IPC分类号： G06F704
CPC分类号： G06F7/5095 , G06F7/02 , G06F7/026 , G06F7/48 , G06F7/4824
摘要： A method and apparatus is disclosed to compare numbers for equality. The numbers represented in a redundant form, including numbers received from a bypass circuit are subtracted. More specifically, a complemented form is generated and supplied to an arithmetic circuit for at least one number represented in the redundant form. Input to the arithmetic circuit is adjusted to augment a result generated through the arithmetic circuit to generate a valid outcome represented in the redundant form as a result of a subtraction operation. Results of the subtraction operation are compared to zero in redundant form using a non-propagative circuit and without requiring carry propagation, thereby producing an equality comparison of the number in redundant form.
摘要翻译：公开了一种方法和装置，用于比较相等的数字。减去以冗余形式表示的数字，包括从旁路电路接收的数字。更具体地，产生补码形式并将其提供给用冗余形式表示的至少一个数字的运算电路。调整运算电路的输入以增加通过算术电路产生的结果，以产生作为减法运算的结果以冗余形式表示的有效结果。使用非传播电路将减法操作的结果与冗余形式进行比较，而不需要进位传播，从而产生冗余形式的数量的等式比较。

60. 发明授权

US06609209B1 Method and apparatus for reducing the power consumed by a processor by gating the clock signal to pipeline stages 有权
标题翻译：用于通过将时钟信号门控到流水线级来降低处理器消耗的功率的方法和装置
公开(公告)号：US06609209B1
公开(公告)日：2003-08-19
申请号：US09474461
申请日：1999-12-29
申请人： Vivek Tiwari , Vinod Sharma , Sivakumar Makineni , Suri B. Medapati
发明人： Vivek Tiwari , Vinod Sharma , Sivakumar Makineni , Suri B. Medapati
IPC分类号： G06F132
CPC分类号： G06F9/3869 , G06F1/3228 , G06F1/3243 , G06F9/3861 , Y02D10/152
摘要： A processor includes a pipeline having first and second stages and a shift register having first and second latches. An interface circuit is used to provide a clock signal from a clock signal line to the first and second stages based, at least in part, on first and second bits to be stored in the first and second latches, respectively.
摘要翻译：处理器包括具有第一和第二级的管线和具有第一和第二锁存器的移位寄存器。接口电路用于至少部分地基于要存储在第一和第二锁存器中的第一和第二位来从时钟信号线向第一和第二级提供时钟信号。

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