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51. 发明申请

US20090049876A1 SECURITY APPARATUS WITH STABILIZING ELEMENT 审中-公开
标题翻译：安全装置与稳定元件
公开(公告)号：US20090049876A1
公开(公告)日：2009-02-26
申请号：US12192516
申请日：2008-08-15
申请人： Ryan White , John Hung , Guillermo Andres , Robert Mahaffey
发明人： Ryan White , John Hung , Guillermo Andres , Robert Mahaffey
IPC分类号： E05B65/48
CPC分类号： E05B73/0082 , E05B73/0005 , Y10T70/5009
摘要： A security apparatus for use with a portable electronic device with an aperture. The security apparatus includes a head including a housing, an engagement element extending from the housing, a first stabilizing element extending from the housing, and can have a second stabilizing element extending from the housing. The first stabilizing element extends out of the housing a first length and the second stabilizing element extends out of the housing a second length. The first and second lengths are different, and a security device is coupled to the head
摘要翻译：一种用于具有孔径的便携式电子设备的安全装置。该安全装置包括：头部，其包括壳体，从壳体延伸的接合元件，从壳体延伸的第一稳定元件，并且可以具有从壳体延伸的第二稳定元件。第一稳定元件从壳体延伸出第一长度，并且第二稳定元件从壳体延伸出第二长度。第一和第二长度不同，并且安全装置耦合到头部

52. 发明申请

US20080249090A1 Substituted pyridone compounds and methods of use 失效
标题翻译：取代的吡啶酮化合物和使用方法
公开(公告)号：US20080249090A1
公开(公告)日：2008-10-09
申请号：US11879830
申请日：2007-07-18
申请人： Essa Hu , Jason Brooks Human , Roxanne Kunz , Andrew Tasker , Ryan White
发明人： Essa Hu , Jason Brooks Human , Roxanne Kunz , Andrew Tasker , Ryan White
IPC分类号： A61K31/5377 , A61K31/517 , C07D471/04 , A61P35/04 , A61P35/00 , C07D403/02
CPC分类号： C07D471/04 , C07D401/04
摘要： The present invention comprises a new class of compounds capable of modulating the c-kit receptor and, accordingly, useful for treatment of c-kit mediated diseases, including various inflammatory, fibrotic and/or mast cell mediated diseases such as mastocytosis. The compounds have a general Formula I wherein A0-3 and R1-6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of c-kit mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译：本发明包括能够调节c-kit受体的新一类化合物，因此可用于治疗c-kit介导的疾病，包括各种炎性，纤维化和/或肥大细胞介导的疾病如肥大细胞增多症。这些化合物具有通式I，其中A 0-3和R 6-16在本文中定义。本发明还包括药物组合物，用于治疗c-kit介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。

53. 发明申请

US20070072851A1 Pyrazolopyridine and pyrazolopyrimidine compounds 有权
标题翻译：吡唑并吡啶和吡唑并嘧啶化合物
公开(公告)号：US20070072851A1
公开(公告)日：2007-03-29
申请号：US11506381
申请日：2006-08-18
申请人： John Buchanan , William Buckner , Mario Cardozo , Erin DiMauro , Jiasheng Fu , Xiaolin Hao , Xian Jiao , Frank Kayser , David Kopecky , Craig Masse , Susan Tomlinson , Ryan White , Xiaotian Zhu
发明人： John Buchanan , William Buckner , Mario Cardozo , Erin DiMauro , Jiasheng Fu , Xiaolin Hao , Xian Jiao , Frank Kayser , David Kopecky , Craig Masse , Susan Tomlinson , Ryan White , Xiaotian Zhu
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/519 , A61K31/503 , A61K31/498 , A61K31/497 , A61K31/496 , C07D487/02 , C07D471/02
CPC分类号： C07D403/06 , C07D231/56 , C07D401/14 , C07D405/06 , C07D487/04
摘要： The present invention relates to compounds of Formula I or a stereomer, a tautomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof, pharmaceutical formulations containing the compounds, methods of treatments using the compounds, for example, protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders and methods of preparing medicaments comprising the compounds.
摘要翻译：本发明涉及式I化合物或立体异构体，互变异构体，溶剂合物，药学上可接受的盐或前药，含有化合物的药物制剂，使用该化合物的治疗方法，例如蛋白质酪氨酸激酶相关诸如免疫学和肿瘤学障碍的疾病以及制备包含该化合物的药物的方法。

54. 发明申请

US20050219685A1 Microscope with adjustable stage 失效
标题翻译：显微镜可调阶段
公开(公告)号：US20050219685A1
公开(公告)日：2005-10-06
申请号：US10815967
申请日：2004-03-31
申请人： Alison Swift , David Copeland , Daniel Nelsen , Aidan Petrie , Ryan White , Robert Garay , Jacques Valiquette
发明人： Alison Swift , David Copeland , Daniel Nelsen , Aidan Petrie , Ryan White , Robert Garay , Jacques Valiquette
IPC分类号： G02B21/00 , G02B21/24 , G02B21/26
CPC分类号： G02B21/0008 , G02B21/248
摘要： Systems and techniques relating to a microscope with an adjustable stage are described. A microscope includes a base, a support arm attached to and extending upwardly from the base, a head attached to the support arm, the head including a lens, and an eyepiece attached to the head. A stage is releasably attachable to the support arm between the head and the base at multiple locations, providing multiple working distances between a lower surface of the head and an upper surface of the stage. When the stage is attached to the support arm at a location, a working distance between the lower surface of the head and the upper surface of the stage is further adjustable to an either greater or lesser working distance. In another embodiment, microscopic and macroscopic viewing can both be provided using a lens changer with multiple lens positioned radially about an axis of rotation.
摘要翻译：描述与具有可调节级的显微镜相关的系统和技术。显微镜包括底座，从底座附接并向上延伸的支撑臂，附接到支撑臂的头部，头部包括透镜，以及附接到头部的目镜。舞台可在多个位置处可释放地附接到头部和底座之间的支撑臂，从而在头部的下表面和舞台的上表面之间提供多个工作距离。当舞台在一个位置附接到支撑臂时，头部的下表面和舞台的上表面之间的工作距离进一步可调节到更大或更小的工作距离。在另一个实施例中，可以使用具有围绕旋转轴径向放置的多个透镜的透镜更换器来提供微观和宏观的观察。

55. 发明授权

US08962859B2 Spiro-amino-imidazo-fused heterocyclic compounds as beta-secretase modulators and methods of use 有权
标题翻译：螺氨基 - 咪唑稠合杂环化合物作为β-分泌酶调节剂和使用方法
公开(公告)号：US08962859B2
公开(公告)日：2015-02-24
申请号：US13982096
申请日：2012-02-13
申请人： Oleg Epstein , Ryan White , Vinod F. Patel , Jason Brooks Human
发明人： Oleg Epstein , Ryan White , Vinod F. Patel , Jason Brooks Human
IPC分类号： C07D487/10 , C07D313/00 , C07D491/20 , A61K31/353
CPC分类号： C07D491/20 , A61K31/353
摘要： The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A1, A3, A5, A6, A8, R2, R7, X, Y and Z of Formula I are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to plaque formation and deposition, resulting from the activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits and impairments, schizophrenia and other central nervous system conditions and disorders. The invention further provides compounds of Formulas II and III, and of sub-formulas of Formulas I, II and III, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.
摘要翻译：本发明提供了一类可用于调节β-分泌酶（BACE）活性的化合物。化合物具有通式I：其中式I的变量A1，A3，A5，A6，A8，R2，R7，X，Y和Z如本文所定义。本发明还提供包含该化合物的药物组合物，以及用于治疗由于BACE的活性而导致的斑块形成和沉积相关疾病和/或病症的化合物和组合物的相应用途。这种BACE介导的病症包括例如阿尔茨海默病，认知缺陷和损伤，精神分裂症和其他中枢神经系统病症和障碍。本发明还提供了式II和III的化合物和式I，II和III的分子式，可用于制备式I-III化合物的中间体和方法和方法。

56. 发明授权

US08842422B2 Security apparatus 有权
标题翻译：安全装置
公开(公告)号：US08842422B2
公开(公告)日：2014-09-23
申请号：US12446560
申请日：2007-10-22
申请人： John Hung , Ryan White , Guillermo Andres , David Thomas Dobson , Jacque Gagne
发明人： John Hung , Ryan White , Guillermo Andres , David Thomas Dobson , Jacque Gagne
IPC分类号： H05K5/00 , E05B73/00
CPC分类号： G06F1/1656 , E05B73/00 , E05B73/0005 , E05B73/0082 , G06F1/16 , Y10T70/402 , Y10T70/413 , Y10T70/50 , Y10T70/5009 , Y10T70/8973
摘要： A security apparatus is disclosed. The security apparatus is used with a lock interface member attached to a housing of a portable electronic device. The security apparatus may include an engagement element as well as a stabilizing element. The engagement element and the stabilizing element may secure the security apparatus to the lock interface member, and therefore to the housing of the portable electronic device.
摘要翻译：公开了一种安全装置。安全装置与附接到便携式电子装置的壳体的锁定接口构件一起使用。安全装置可以包括接合元件以及稳定元件。接合元件和稳定元件可以将安全装置固定到锁定接口构件，并因此固定到便携式电子设备的壳体。

57. 发明授权

US08842118B1 Automated image replacement using deformation and illumination estimation 有权
标题翻译：使用变形和照明估计自动图像替换
公开(公告)号：US08842118B1
公开(公告)日：2014-09-23
申请号：US11866401
申请日：2007-10-02
申请人： Ryan White , David Forsyth
发明人： Ryan White , David Forsyth
IPC分类号： G06T15/50 , G06T15/60
CPC分类号： G06T15/50 , G06T7/30 , G06T15/205
摘要： A method which makes it possible to replace a reference pattern (aka texture) on a video of clothing is described. For example, a video of a T-shirt with the text “UCLA” could be edited to say “UC Berkeley” with minimal user intervention. The method is novel because it separates the problem into two parts: erasing the old texture (while properly accounting for lighting) and adding the new texture (properly deformed to appear on the shirt. This decomposition creates realistic images with simple tracking models of the cloth. It is believed that this method may be used for targeted audience sales techniques, with static or dynamic replacement images replacing images on warping or otherwise deforming surfaces, in addition to other perspective deformations. Potentially, real-time image replacements using the techniques taught here could be used for live activities or real-time video feeds.
摘要翻译：描述了可以在服装视频上替换参考图案（又称纹理）的方法。例如，具有文本“UCLA”的T恤的视频可以用最少的用户干预来编辑来说“UC Berkeley”。该方法是新颖的，因为它将问题分为两部分：擦除旧纹理（同时适当地计算照明），并添加新纹理（正确变形出现在衬衫上），这种分解用布的简单跟踪模型创建逼真的图像相信这种方法可以用于目标观众销售技术，除了其他透视变形之外，还可以使用静态或动态替换图像替换曲面上的图像或其他变形曲面。潜在地，使用本教学中的技术进行实时图像替换可用于实时活动或实时视频馈送。

58. 发明申请

US20140031340A1 5-Amino-Oxazepine and 5-Amino-Thiazepane Compounds as Beta Secretase Antagonists and Methods of Use 有权
标题翻译： 5-氨基 - 氧氮杂和5-氨基 - 噻吖烷化合物作为β-分泌酶拮抗剂和使用方法
公开(公告)号：US20140031340A1
公开(公告)日：2014-01-30
申请号：US13982222
申请日：2012-02-06
申请人： Thomas Dineen , Matthew Weiss , Vinod F. Patel , Xiao Mai Zheng , Ryan White
发明人： Thomas Dineen , Matthew Weiss , Vinod F. Patel , Xiao Mai Zheng , Ryan White
IPC分类号： C07D498/20 , C07D498/10
CPC分类号： C07D498/20 , C07D498/10 , C07D513/10
摘要： The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I); wherein variables A1, A3, A4, A5, A6, A8, R2, R7, X and Y of Formula (I) are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas (II) and sub-formula embodiments of Formula (I) and (II), intermediates and processes and methods useful for the preparation of compounds of Formulas (I)-(II).
摘要翻译：本发明提供了一类可用于调节β-分泌酶（BACE）活性的化合物。该化合物具有通式（I）; 其中式（I）的变量A1，A3，A4，A5，A6，A8，R2，R7，X和Y在本文中定义。本发明还提供包含该化合物的药物组合物，以及用于治疗由BACE的生物学活性产生的A-β斑块形成和沉积相关的病症和/或病症的化合物和组合物的相应用途。这种BACE介导的疾病包括例如阿尔茨海默病，认知缺陷，认知障碍，精神分裂症和其他中枢神经系统疾病。本发明进一步提供式（I）和（II）的式（II）和亚式实施方案的化合物，可用于制备式（I） - （II）化合物的中间体和方法和方法。

59. 发明申请

US20130288923A1 Nucleotide-Based Probes and Methods for the Detection and Quantification of Macromolecules and Other Analytes 有权
标题翻译：基于核苷酸的探针和大分子和其他分析物的检测和定量方法
公开(公告)号：US20130288923A1
公开(公告)日：2013-10-31
申请号：US13988487
申请日：2011-11-21
申请人： Alexis Vallée-Bélisle , Francesco Ricci , Ryan White , Andrew J. Bonham , Kevin W. Plaxco
发明人： Alexis Vallée-Bélisle , Francesco Ricci , Ryan White , Andrew J. Bonham , Kevin W. Plaxco
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , C12Q1/6818 , C12Q2525/301 , C12Q2565/1015 , C12Q2565/1025 , C12Q2545/113 , C12Q2563/131
摘要： Provided are unimolecular oligonucleotide probes for detecting a target in a sample. The probes use target binding-induced structural changes to detect the presence of the target in the sample. Also provided are methods of using the probes to detect a target in a sample.
摘要翻译：提供了用于检测样品中靶标的单分子寡核苷酸探针。探针使用靶结合诱导的结构变化来检测样品中目标物的存在。还提供了使用探针来检测样品中的靶的方法。

60. 发明授权

US08404694B2 Aurora kinase modulators and method of use 失效
标题翻译：极光激酶调节剂和使用方法
公开(公告)号：US08404694B2
公开(公告)日：2013-03-26
申请号：US12933400
申请日：2009-03-19
申请人： Ryan White , Jason Brooks Human
发明人： Ryan White , Jason Brooks Human
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： The present invention relates to chemical compounds having a general formula I wherein A1-5 and 7-8, D′, L1, L2, R1, R3, R6-8, n and o are defined herein, and synthetic intermediates, which are capable of modulating the activity of Aurora kinase proteins and, thereby, influencing various disease states and conditions related to the activities of Aurora kinases. For example, the compounds are capable of influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.
摘要翻译：本发明涉及具有通式I的化合物，其中A1-5和7-8，D'，L1，L2，R1，R3，R6-8，n和o如本文所定义，和合成中间体，其能够调节极光激酶蛋白的活性，从而影响与极光激酶活性相关的各种疾病状态和状况。例如，化合物能够影响细胞周期和细胞增殖的过程，以治疗癌症和与癌症有关的疾病。本发明还包括药物组合物，包括该化合物，以及治疗与Aurora激酶活性有关的疾病状态的方法。

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