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51. 发明授权

US5785701A Sterile vial connector assembly for efficient transfer of liquid 失效
标题翻译：无菌小瓶连接器组件，用于有效转移液体
公开(公告)号：US5785701A
公开(公告)日：1998-07-28
申请号：US714873
申请日：1996-09-17
申请人： Bernard Sams , Colin James Matthews , Jean Claude Thibault , Hubert Jansen
发明人： Bernard Sams , Colin James Matthews , Jean Claude Thibault , Hubert Jansen
IPC分类号： A61J1/05 , A61J1/00 , A61J1/10 , A61J1/20 , A61J3/00
CPC分类号： A61J1/2089 , A61J1/201 , A61J1/2041 , A61J1/2055 , A61J1/2072
摘要： A connector assembly is provided for efficient flow of liquid into and/or out of a vial, such as a vial containing a lyophilized drug. The connector assembly includes a spike and a stopper sleeve, both slidably mounted in the open top of the vial. The connector assembly includes a stopper affixed to the stopper sleeve and sealingly engaged in the open top of the vial. The stopper is slidably moveable in response to axial movement of the stopper sleeve. Movement of the stopper sleeve relative to the vial will move the stopper into or out of sealing engagement with the vial. The connector assembly further includes a spring for generating a small amount of axial movement of the spike, stopper sleeve and stopper after the stopper has been moved into the opened position in the vial. Movement of the spike, stopper sleeve and stopper generated by the spring will cause a sufficient change in pressure to overcome surface tension and initiate an efficient flow of fluid into or out of the vial.
摘要翻译：提供连接器组件用于有效地将液体流入和/或从小瓶中，例如含有冻干药物的小瓶中。连接器组件包括尖头和塞子套筒，两者均可滑动地安装在小瓶的开口顶部。连接器组件包括固定到止动套筒上并密封地接合在小瓶的开口顶部的止动件。止动器响应于止动套筒的轴向运动而可滑动地移动。止动器套筒相对于小瓶的移动将使止动器移动到与小瓶密封接合中。连接器组件还包括弹簧，用于在塞子已经移动到小瓶中的打开位置之后产生尖钉，止动套筒和塞子的少量轴向运动。由弹簧产生的尖钉，止动套筒和止动器的移动将导致压力的充分变化以克服表面张力并引发流体有效地流入或流出小瓶。

52. 发明授权

US09022990B2 Needle safety shield 有权
标题翻译：针安全盾
公开(公告)号：US09022990B2
公开(公告)日：2015-05-05
申请号：US14009814
申请日：2011-04-04
申请人： Stéphane Chevallier , Jean-Michel Chevallier , Hubert Jansen , Alain Feret
发明人： Stéphane Chevallier , Jean-Michel Chevallier , Hubert Jansen , Alain Feret
IPC分类号： A61M5/32
CPC分类号： A61M5/326 , A61M2005/3264
摘要： A needle safety shield 10 for use with a syringe 10 having a barrel 14, a needle and a plunger rod 16. The safety shield 10 has a first tube 22. A second tube 26 is arranged for sliding movement within the first tube 22. A pin 46 is connected to one of the first and second tubes 22, 26. An activation ring 32 has a stop 72. A drive spring 34 biases the activation ring 32 in a proximal direction to place the stop 72 in engagement with the pin 46 to retain the first and second tubes 22, 26 in a retracted configuration. The movement of the plunger rod 16 to engage the activation ring 32 compresses the drive spring 34, moving the activation ring 32 distally, and moving the stop 72 out of engagement with the pin 46, allowing the drive spring 34 to move the first and second tubes 22, 26 into an extended configuration.
摘要翻译：用于具有筒体14，针头和柱塞杆16的注射器10的针安全护罩10.安全护罩10具有第一管22.第二管26被布置用于在第一管22内滑动。销46连接到第一和第二管22,26中的一个。激活环32具有止动件72.驱动弹簧34沿近端方向偏压激活环32以使止动件72与销46接合到将第一和第二管22,26保持在缩回构型中。活塞杆16与活动环32接合的运动压缩驱动弹簧34，使活塞环32向远侧移动，并使止动件72与销46脱离接合，从而允许驱动弹簧34移动第一和第二管22,26成为延伸构造。

53. 发明授权

US08056719B2 Multipurpose packages for sterile products or products to be sterilized 有权
标题翻译：用于灭菌产品或消毒产品的多用途包装
公开(公告)号：US08056719B2
公开(公告)日：2011-11-15
申请号：US10485931
申请日：2001-11-16
申请人： Jean-Yves Porret , Hubert Jansen
发明人： Jean-Yves Porret , Hubert Jansen
IPC分类号： A61B17/06 , B65D83/10
CPC分类号： C07K14/62 , A61K38/00 , A61K47/548 , A61L2/20 , A61L2/206 , A61L2/26 , A61L2202/182 , A61L2202/24 , C07F9/091 , C07F9/5537
摘要： The invention concerns a package (2) for sterilized products or products to be sterilized comprising a plastic box (4) and a lid (16) fixed on the box (4) to seal the latter with a tight sealing zone. The invention is characterized in that the lid (16) comprises: a plastic cover sheet (20) transparent for electronic irradiation and for light radiation; at least a window (22) provided in the cover sheet (20); at least a sheet of selectively sealing material (24) integral with said cover sheet (20) and closing the window (22); and an opaque screen (26, 126) for at least an electronic irradiation passing through the cover sheet or the selectively sealing material, said screen extending inside the package (2), proximate to the cover sheet (20), so as to allow through a sterilizing gas, for example ethylene oxide (ETO) or water vapor, through the selectively sealing material (24).
摘要翻译：本发明涉及一种用于灭菌产品或灭菌产品的包装（2），包括固定在盒（4）上的塑料盒（4）和盖（16），以密封密封区。本发明的特征在于，盖（16）包括：用于电子照射和光辐射的透明塑料盖片（20）至少设置在所述盖片（20）中的窗（22）。至少一块选片密封材料（24）与所述盖片（20）成一体并且关闭所述窗（22）; 和用于至少通过所述覆盖片或所述选择性密封材料的电子照射的不透明屏幕（26,126），所述屏幕在所述封装（2）内延伸，靠近所述覆盖片（20），以允许通过灭菌气体，例如环氧乙烷（ETO）或水蒸汽，通过选择性密封材料（24）。

54. 发明申请

US20100270197A1 MULTIPURPOSE PACKAGES FOR STERILE PRODUCTS OR PRODUCTS TO BE STERILISED 有权
标题翻译：用于无菌产品或产品灭菌的多用途包装
公开(公告)号：US20100270197A1
公开(公告)日：2010-10-28
申请号：US10485931
申请日：2001-11-16
申请人： Jean-Yves Porret , Hubert Jansen
发明人： Jean-Yves Porret , Hubert Jansen
IPC分类号： B65D25/54 , B65D51/00
CPC分类号： C07K14/62 , A61K38/00 , A61K47/548 , A61L2/20 , A61L2/206 , A61L2/26 , A61L2202/182 , A61L2202/24 , C07F9/091 , C07F9/5537
摘要： The invention concerns a package (2) for sterilised products or products to be sterilised comprising a plastic box (4) and a lid (16) fixed on the box (4) to seal the latter with a tight sealing zone. The invention is characterised in that the lid (16) comprises: a plastic cover sheet (20) transparent for electronic irradiation and for light radiation; at least a window (22) provided in the cover sheet (20); at least a sheet of selectively sealing material (24) integral with said cover sheet (20) and closing the window (22); and an opaque screen (26, 126) for at least an electronic irradiation passing through the cover sheet or the selectively sealing material, said screen extending inside the package (2), proximate to the cover sheet (20), so as to allow through a sterilising gas, for example ethylene oxide (ETO) or water vapour, through the selectively sealing material (24).
摘要翻译：本发明涉及一种用于灭菌产品或灭菌产品的包装（2），包括固定在盒（4）上的塑料盒（4）和盖（16），以密封密封区。本发明的特征在于，盖（16）包括：用于电子照射和光辐射的透明塑料盖片（20）至少设置在所述盖片（20）中的窗（22）。至少一块选片密封材料（24）与所述盖片（20）成一体并且关闭所述窗（22）; 和用于至少通过所述覆盖片或所述选择性密封材料的电子照射的不透明屏幕（26,126），所述屏幕在所述封装（2）内延伸，靠近所述覆盖片（20），以允许通过灭菌气体，例如环氧乙烷（ETO）或水蒸汽，通过选择性密封材料（24）。

55. 发明授权

US07431157B2 Package for sterile products 有权
标题翻译：无菌产品包装
公开(公告)号：US07431157B2
公开(公告)日：2008-10-07
申请号：US10485929
申请日：2001-11-16
申请人： Jean-Yves Porret , Hubert Jansen
发明人： Jean-Yves Porret , Hubert Jansen
IPC分类号： A61B19/02
CPC分类号： A61L2/206 , A61L2/08 , A61L2/087 , A61L2/20 , A61L2/26 , A61L2202/182 , A61L2202/24 , A61M5/002 , A61M5/008
摘要： This packaging for sterile products or products intended to be sterilized by a gas, for example a gas of the ETO type, comprises a tub (2) made of plastic and a cover sheet (14) made of selectively impervious material, fixed to the tub (2) so as to seal the latter imperviously.According to the invention, the packaging comprises a screen (20, 22; 24, 26; 26) against electron radiation (E), placed along the cover sheet (14) on the inside of the tub (2) and dimensioned in such a way as to extend above the products (10) to be sterilized and so as to delimit on the cover sheet (14) a peripheral zone (14a) for fixing this cover sheet (14) to the tub (2).
摘要翻译：这种用于无菌产品或旨在由气体灭菌的产品（例如ETO类型的气体）的包装包括由塑料制成的桶（2）和由选择性不透水材料制成的覆盖片（14），固定到桶（2），以便不可见地密封它。根据本发明，包装包括抵抗电子辐射（E）的屏幕（20,22; 24,26; 26），沿着覆盖片（14）放置在洗涤桶（2）的内部并且尺寸设置在这样的方式延伸到待消毒的产品（10）上方，以便在覆盖片（14）上限定用于将该覆盖片（14）固定到洗涤桶（2）的周边区域（14a）。

56. 发明申请

US20060016156A1 Vacuum package system and method 审中-公开
标题翻译：真空包装系统及方法
公开(公告)号：US20060016156A1
公开(公告)日：2006-01-26
申请号：US11171814
申请日：2005-06-30
申请人： Edward Bush , Robert Nase , Hiroshi Togashi , Hubert Jansen , John Paproski
发明人： Edward Bush , Robert Nase , Hiroshi Togashi , Hubert Jansen , John Paproski
IPC分类号： B65B31/00 , B65B5/06
CPC分类号： B65B31/06 , A61M5/002 , A61M2207/00 , A61M2209/06 , B65B5/067 , B65D77/0446 , B65D81/203
摘要： A vacuum packaging system for transporting a plurality of medical containers including a tray that supports the medical containers and an air impervious flexible film defining an internal cavity. The air impervious flexible film completely surrounds the tray and the medical containers. The internal cavity is evacuated to a predetermined vacuum level below atmospheric pressure. A method for packaging the plurality of medical containers for transportation in the tray includes inserting the medical containers into the tray, inserting the tray filled with medical containers into the internal cavity, evacuating the internal cavity to a predetermined vacuum pressure and sealing the flexible film such that the predetermined vacuum pressure is generally maintained in the internal cavity.
摘要翻译：一种用于运输多个医疗容器的真空包装系统，包括支撑医疗容器的托盘和限定内腔的不透气的柔性膜。不透气的柔性膜完全包围托盘和医疗容器。将内腔抽真空至低于大气压的预定真空度。用于将多个用于在托盘中运输的医疗容器进行包装的方法包括将医疗容器插入托盘，将填充有医疗容器的托盘插入内腔中，将内腔排空到预定的真空压力并将柔性膜密封预定的真空压力通常保持在内腔中。

57. 发明授权

US06945417B2 Resealable medical transfer set 有权
标题翻译：可再密封医疗转移套
公开(公告)号：US06945417B2
公开(公告)日：2005-09-20
申请号：US10723531
申请日：2003-11-26
申请人： Hubert Jansen , Jean-Claude Thibault
发明人： Hubert Jansen , Jean-Claude Thibault
IPC分类号： A61J1/00 , A61J1/14 , A61J1/20 , B65D51/00 , B65D39/00 , B65D41/10 , B65D47/04
CPC分类号： A61J1/1406 , A61J1/201 , A61J1/2096 , B65D51/002 , Y10S215/03
摘要： A transfer set for transferring fluid, including drugs, vaccines, medicaments, solutions and the like, between a first container, such as a conventional vial, and a second container, such as a conventional syringe having a unique multipurpose resealable member. The transfer set assembly includes an elastomeric tubular fluid transfer and resealable valve member preferably including an open end mounted on the pierceable closure or stopper of a vial and a generally closed distal end having a longitudinal slit and a piercing member is telescopically received within the fluid transfer valve member having a piercing end opposite the pierceable closure. The fluid transfer valve member is preferably formed of silicone and is surrounded by a generally tubular luer connector member having an open end mounted on the pierceable closure and a distal end having male luer threads. This assembly is enclosed within a cup-shaped closure and the assembly is retained to the first container or vial by a collar preferably secured to the vial by crimping. Upon removal of the cup-shaped closure, fluid communication between the vial and a second container, such as a syringe, is achieved by threading the luer connector of the syringe on the luer threads of the tubular luer connector member, which drives the tip through the slit of the elastomeric fluid transfer valve member against the distal end of the piercing member, driving the piercing end through the pierceable closure. In the preferred embodiment, the piercing member includes a generally longitudinal channel which establishes communication between the vial and the syringe through the tubular fluid transfer valve member.
摘要翻译：用于在诸如常规小瓶的第一容器和具有独特的多用途可再密封构件的常规注射器的第二容器之间传送流体的转移装置，包括药物，疫苗，药物，溶液等。传送组件包括弹性体管状流体传送和可重新密封的阀构件，其优选地包括安装在小瓶的可刺穿的封闭件或塞子上的开口端，以及具有纵向狭缝的通常封闭的远端，并且穿孔构件可伸缩地容纳在流体传递阀构件具有与可刺破的封闭件相对的穿刺端。流体转移阀构件优选地由硅树脂形成，并且由通常管状的鲁尔连接器构件围绕，该连接器构件具有安装在可刺穿闭合件上的开口端和具有阳性鲁尔螺纹的远端。该组件被封闭在杯形封闭件内，并且组件通过优选通过卷曲固定到小瓶的套环而保持在第一容器或小瓶中。在移除杯形封闭件时，小瓶和第二容器（例如注射器）之间的流体连通通过将注射器的鲁尔连接器穿过管状鲁尔连接器构件的鲁尔螺纹上来实现，该管路式鲁尔连接器构件驱动尖端通过弹性体流体转移阀构件的狭缝抵靠穿孔构件的远端，将刺穿端驱动穿过可刺穿的闭合件。在优选实施例中，刺穿构件包括大致纵向通道，其通过管状流体转移阀构件在小瓶和注射器之间建立连通。

58. 发明授权

US06685676B2 Safety shield system for prefilled syringes 有权
标题翻译：预充式注射器的安全防护系统
公开(公告)号：US06685676B2
公开(公告)日：2004-02-03
申请号：US10057978
申请日：2002-01-17
申请人： Hubert Jansen , Samuel Gagnieux
发明人： Hubert Jansen , Samuel Gagnieux
IPC分类号： A61M532
CPC分类号： A61M5/326 , A61M2005/3247 , A61M2005/3261
摘要： A medical device is provided which includes a shield system and a syringe which is coupled to the shield system. The shield system includes a syringe holder and a shield which is slidably coupled to the holder. A spring resiliently urges the shield from a retracted position to an extended position. Stop members are provided on the holder and shield for maintaining the shield in the retracted position. The syringe is slidably coupled to the holder, and extends within the shield. Axial movement of the syringe with respect to the holder causes disengagement of the stop members, allowing the spring to move the shield to the extended position. Detents are provided on the holder for maintaining the shield in the extended position.
摘要翻译：提供了一种医疗装置，其包括屏蔽系统和联接到屏蔽系统的注射器。屏蔽系统包括注射器保持器和可滑动地联接到保持器的护罩。弹簧弹性地将护罩从缩回位置推向延伸位置。止动构件设置在保持器和护罩上，用于将护罩保持在缩回位置。注射器可滑动地联接到保持器，并且在护罩内延伸。注射器相对于保持器的轴向运动导致止动件的脱离，允许弹簧将护罩移动到延伸位置。在保持器上设置有用于将护罩保持在延伸位置的凹处。

59. 发明授权

US06638256B2 Lockable safety shield assembly for a prefillable syringe 有权
标题翻译：可预充注射器的可锁定安全防护罩组件
公开(公告)号：US06638256B2
公开(公告)日：2003-10-28
申请号：US09767470
申请日：2001-01-23
申请人： Hubert Jansen , Claude Imbert
发明人： Hubert Jansen , Claude Imbert
IPC分类号： A61M5132
CPC分类号： A61M5/3243 , A61M5/3135 , A61M5/3202 , A61M5/3271 , A61M5/502 , A61M2005/3109 , A61M2005/3247 , A61M2205/581 , A61M2205/582
摘要： A lockable safety shield assembly for a prefillable syringe is provided. The design of the lockable safety shield assembly enhances pharmaceutical manufacturers' ease of assembling the various components as part of its filling or processing of the prefillable syringes in normal practice, while at the same time minimizes difficulties in mating parts made from different materials. A tube is placed around the outside surface of the syringe barrel and affixed thereto. A collar is provided on the tube adjacent the distal end of the syringe barrel. A safety shield is axially slidable over the tube between a retracted position, wherein the distal end of the piercing element associated with the prefillable syringe is exposed, and an extended position, wherein the safety shield is locked to the collar to protectively cover the distal end of the piercing element. The safety shield includes locking structure configured so that the shield can be easily fitted over the tube. The locking structure includes at least one deflectable arm provided on the body of the shield. The deflectable arm includes a proximal end deflectable towards the interior of the shield. A stop member is provided on the interior of a shield in spaced relation to the proximal end of the deflectable arm. A ring is axially slidable over the shield to deflect the arm towards the interior of the shield to activate the locking structure. The safety shield is slid distally by an end user such that the collar is lockingly retained between the stop member and the proximal end of the deflectable arm. The collar, the stop member, and the deflectable arm may be configured to provide tactile as well as audible indication of locking to the end user.
摘要翻译：提供了一种用于可预充注射器的可锁定安全屏蔽组件。可锁定安全护罩组件的设计增强了药物制造商在常规实践中作为其预填充注射器的填充或加工的一部分而组装各种部件的容易性，同时最小化了由不同材料制成的配合部件的困难。将管放置在注射器筒的外表面周围并固定到其上。管子靠近注射器筒的远端设置在管子上。安全护罩可以在缩回位置之间在管子之间轴向滑动，在缩回位置，其中与可预充注射器相关联的穿刺元件的远端被暴露，并且延伸位置，其中安全护罩被锁定到套环以保护性地覆盖远端的穿孔元件。安全护罩包括锁定结构，其构造使得护罩可以容易地装配在管上。锁定结构包括设置在护罩主体上的至少一个可偏转臂。可偏转臂包括可朝向屏蔽件内部偏转的近端。在与可偏转臂的近端间隔开的屏蔽件的内部设有止动件。环可以在屏蔽件上轴向滑动以使臂朝向屏蔽件的内部偏转以启动锁定结构。安全护罩由终端使用者向远侧滑动，使得套环被锁定地保持在止动构件和可偏转臂的近端之间。套环，止动构件和可偏转臂可以被配置为向最终用户提供触觉以及可听见的锁定指示。

60. 发明授权

US06601721B2 Transferset for vials and other medical containers 有权
公开(公告)号：US06601721B2
公开(公告)日：2003-08-05
申请号：US10060628
申请日：2002-01-30
申请人： Hubert Jansen , Jean-Claude Thibault
发明人： Hubert Jansen , Jean-Claude Thibault
IPC分类号： B65D3900
CPC分类号： A61J1/2096 , A61J1/14 , A61J1/1406 , A61J1/1425 , A61J1/201 , A61J1/2086 , B65D51/002 , Y10S215/03
摘要： An improved transferset assembly for transferring fluids between a first container, such as a medicament vial and a second container, such as a syringe, which includes an integral polymeric transfer assembly having a tubular collar portion, a radial portion overlying the rim of the first container, an outer tubular portion and an inner tubular portion which is integrally joined to the outer tubular portion by a radial intermediate web portion, a piercing member telescopically received in the inner tubular portion having a piercing end to pierce the closure sealing the open end of the first container and a removable closure which seals the open ends of the outer and inner tubular portions of the transfer assembly. The tubular collar portion, which may be separate from the inner and outer tubular portions, is formed of composite polymer including a relatively soft polymer and a relatively rigid polymer, such that the free end of the collar portion may be deformed radially inwardly or crimped into the neck of the first container, yet sufficiently rigid to retain its shape following deformation and resistant to creep to maintain a seal between the transfer assembly and the first container. The proximate end of the inner tubular portion includes a sharp edge which seals against the closure of the first container. The preferred embodiment of the closure is frangibly connected to the free end of the outer tubular portion of the transfer assembly and provides a biological seal.

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