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51. 发明授权

US08642586B2 1,4-benzothiazepine-1-oxide derivative and pharmaceutical composition utilizing the same 有权
标题翻译： 1,4-苯并硫氮杂-1-氧化物衍生物和利用其的药物组合物
公开(公告)号：US08642586B2
公开(公告)日：2014-02-04
申请号：US13203188
申请日：2010-02-24
申请人： Noboru Kaneko , Mitsuru Takahashi
发明人： Noboru Kaneko , Mitsuru Takahashi
IPC分类号： A61P9/10 , A61K31/554 , C07D417/06
CPC分类号： C07D417/06
摘要： Provided are novel compound that is useful as a treatment agent or a prophylactic agent for cardiac failure, cardiac failure due to dystelectasis, left ventricular diastolic impairment, angina or cardiac infarct, hypertension, ischemic cardiac disease, and myocardial relaxation impairment recognized in cardiac failure, atrial fibrillation or ventricular arrhythmia, and a pharmaceutical composition containing the same. The invention pertains to a 1,4-benzothiazepine-1-oxide derivative represented by general formula [I] (In the formula, R represents a hydrogen atom or a hydroxyl group.) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same [I].
摘要翻译：提供可用作心脏衰竭的治疗剂或预防剂，由于心脏衰竭导致的心包衰竭引起的心脏衰竭，左心室舒张功能障碍，心绞痛或心肌梗塞，高血压，缺血性心脏病和心肌松弛障碍的新化合物，心房颤动或室性心律失常，以及含有它们的药物组合物。本发明涉及由通式[I]（式中，R表示氢原子或羟基）表示的1,4-苯并硫氮杂-1-氧化物衍生物或其药学上可接受的盐，以及含有相同[I]。

52. 发明授权

US08101774B2 Ester derivatives and medicinal use thereof 有权
标题翻译：酯衍生物及其药用
公开(公告)号：US08101774B2
公开(公告)日：2012-01-24
申请号：US11250636
申请日：2005-10-17
申请人： Atsushi Hagiwara , Taku Ikenogami , Kazunori Kurihara , Toshio Taniguchi , Mitsuru Takahashi , Akio Iida
发明人： Atsushi Hagiwara , Taku Ikenogami , Kazunori Kurihara , Toshio Taniguchi , Mitsuru Takahashi , Akio Iida
IPC分类号： C07D213/56 , A61K31/44
CPC分类号： C07D295/192 , C07C237/42 , C07C255/55
摘要： The present invention relates to an ester represented by the formula [1]: or its pharmaceutically acceptable salt, or use of the same. The compound represented by the formula [1] or its pharmaceutically acceptable salt is useful as an agent for the treatment or prophylaxis of hyperlipidemia or the like, since it disappears very rapidly in the living body and has an excellent MTP inhibitory activity.
摘要翻译：本发明涉及由式[1]表示的酯：或其药学上可接受的盐或其用途。由式[1]表示的化合物或其药学上可接受的盐可用作治疗或预防高脂血症等的药剂，因为其在生物体中消失非常迅速，具有优异的MTP抑制活性。

53. 发明授权

US07531554B2 4-oxoquinoline compound and use thereof as HIV integrase inhibitor 有权
标题翻译： 4-氧代喹啉化合物及其作为HIV整合酶抑制剂的用途
公开(公告)号：US07531554B2
公开(公告)日：2009-05-12
申请号：US11133470
申请日：2005-05-20
申请人： Motohide Satoh , Takashi Matsuda , Satoshi Okuda , Hiroshi Kawakami , Hisateru Aramaki , Hisashi Shinkai , Yuji Matsuzaki , Wataru Watanabe , Kazunobu Yamataka , Shinichi Kiyonari , Shuichi Wamaki , Mitsuru Takahashi , Naohito Yamada , Akemi Nagao
发明人： Motohide Satoh , Takashi Matsuda , Satoshi Okuda , Hiroshi Kawakami , Hisateru Aramaki , Hisashi Shinkai , Yuji Matsuzaki , Wataru Watanabe , Kazunobu Yamataka , Shinichi Kiyonari , Shuichi Wamaki , Mitsuru Takahashi , Naohito Yamada , Akemi Nagao
IPC分类号： C07D215/04 , A61K31/44
CPC分类号： C07D215/56 , C07D401/04 , C07D401/06 , C07D405/06 , C07D491/04
摘要： Provision of a compound having an anti-HIV activity, particularly an integrase inhibitory activity.A 4-oxoquinoline compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the specification. The present invention also relates to a pharmaceutical composition containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier; an integrase inhibitor, an antiviral agent, anti-HIV agent, and the like, which contains the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof as an active ingredient; an anti-HIV composition containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof, and one or more other kinds of anti-HIV activity substances as active ingredients; an anti-HIV agent containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof as an active ingredient, which is used for a multiple drug therapy with other anti-HIV agent(s), and the like.
摘要翻译：提供具有抗HIV活性的化合物，特别是整合酶抑制活性。由下式[I]表示的4-氧代喹啉化合物或其药学上可接受的盐：其中每个符号如说明书中所定义。本发明还涉及含有4-氧代喹啉化合物或其药学上可接受的盐和药学上可接受的载体的药物组合物; 含有4-氧代喹啉化合物或其药学上可接受的盐作为活性成分的整合酶抑制剂，抗病毒剂，抗HIV剂等; 含有4-氧代喹啉化合物或其药学上可接受的盐的抗HIV组合物和一种或多种其它类型的抗HIV活性物质作为活性成分; 含有4-氧代喹啉化合物或其药学上可接受的盐作为活性成分的抗HIV剂，其用于与其它抗HIV剂的多重药物治疗等。

54. 发明申请

US20060205726A1 Ester derivatives and medical use thereof 失效
标题翻译：酯衍生物及其医疗用途
公开(公告)号：US20060205726A1
公开(公告)日：2006-09-14
申请号：US11362375
申请日：2006-02-27
申请人： Atsushi Hagiwara , Taku Ikenogami , Yasuko Mera , Yukako Sumida , Akio Iida , Toshio Taniguchi , Mitsuru Takahashi
发明人： Atsushi Hagiwara , Taku Ikenogami , Yasuko Mera , Yukako Sumida , Akio Iida , Toshio Taniguchi , Mitsuru Takahashi
IPC分类号： A61K31/537 , A61K31/495 , A61K31/445
CPC分类号： C07D241/44 , C07C233/81 , C07D209/08 , C07D213/55 , C07D213/81 , C07D213/82 , C07D239/42 , C07D277/30 , C07D295/192 , C07D333/24 , C07D409/12 , C07D413/12
摘要： A therapeutic agent for hyperlipidemia which has no side effects on the liver unlike conventional MTP inhibitors and has excellent MTP inhibitory activity. Also, provided is an ester compound represented by the general formula (1): or a pharmaceutically acceptable salt thereof.
摘要翻译：与常规MTP抑制剂不同，对肝脏没有副作用且具有优异的MTP抑制活性的高脂血症治疗剂。此外，提供由通式（1）表示的酯化合物：或其药学上可接受的盐。

55. 发明授权

US07038800B2 Communication apparatus and processing method of the same 失效
公开(公告)号：US07038800B2
公开(公告)日：2006-05-02
申请号：US09855289
申请日：2001-05-15
申请人： Yoshiyuki Ono , Naoji Fujino , Mitsuru Takahashi , Kimihide Ono , Norikatsu Tokairin
发明人： Yoshiyuki Ono , Naoji Fujino , Mitsuru Takahashi , Kimihide Ono , Norikatsu Tokairin
IPC分类号： G06K1/00 , H04N1/32 , H04N1/00 , H04L12/50
CPC分类号： H04N1/00209 , H04N1/32 , H04N2201/0093 , H04N2201/3261 , H04N2201/33357
摘要： A communication apparatus for processing a fax signal and an audio signal includes an audio compression unit for compressing the audio signal, a fax-termination/switching control unit for terminating the fax signal and for executing control to prevent the fax signal from being compressed by the audio compression unit, a detection unit for detecting a predetermined negotiation signal used in a negotiation procedure for a fax communication from an input signal before compression within a fixed period of time starting at the beginning of the negotiation signal and an exclusion processing unit for carrying out an exclusion process on the negotiation signal upon detection of the negotiation signal.

56. 发明授权

US06990309B2 Method and apparatus for image forming performing improved cleaning and discharging operation on image forming associated members 失效
公开(公告)号：US06990309B2
公开(公告)日：2006-01-24
申请号：US10464537
申请日：2003-06-19
申请人： Shin Kayahara , Hideo Yu , Mitsuru Takahashi , Takeshi Shintani
发明人： Shin Kayahara , Hideo Yu , Mitsuru Takahashi , Takeshi Shintani
IPC分类号： G03G15/01 , G03G15/16
CPC分类号： G03G21/0005 , G03G15/161 , G03G15/162 , G03G2215/0174 , G03G2215/0177 , G03G2215/1661 , G03G2221/0005
摘要： An image forming apparatus includes an image carrying member, an intermediate transfer member, a charging member, a transfer mechanism, a discharging member, a direct current voltage source, and a direct current voltage controller. The intermediate transfer member is deposited at a position facing and in contact with the image carrying member rotatably carrying a toner image on a rotating surface, and receives the toner image therefrom during a first transfer operation. The charging member applies a charge to the intermediate transfer member to cause an electric field around a region where the image carrying member and the intermediate transfer member contact with each other, where the electric field generates a force for initiating the first transfer operation. The transfer mechanism performs a second transfer operation for transferring the toner image from the intermediate transfer member to a transfer sheet. The discharging member performs a discharging operation for discharging the charge remaining on the intermediate transfer member with contacting the intermediate transfer member after a completion of the second transfer operation. The direct current voltage source applies a direct current voltage to the discharging member to cause the discharging member to perform the discharging operation. The direct current voltage controller controls the direct current voltage in accordance with a volume resistivity of the intermediate transfer member.

57. 发明申请

US20050265755A1 Transfer device and image forming apparatus 有权
标题翻译：转印装置和图像形成装置
公开(公告)号：US20050265755A1
公开(公告)日：2005-12-01
申请号：US11118409
申请日：2005-05-02
申请人： Mitsuru Takahashi
发明人： Mitsuru Takahashi
IPC分类号： G03G15/16 , G03G15/01
CPC分类号： G03G15/167 , G03G2215/0119 , G03G2215/1614
摘要： In a transfer device, a driving roller that rotationally drives a belt member satisfies a condition “(R2−R1)π×(s−1)×p/(R1×π×2)≦0.15 millimeter”, where R1 is a diameter of the driving roller under an environment of a minimum temperature and a minimum moisture in a use environment range designed, R2 is a diameter of the driving roller under an environment of a maximum temperature and a maximum moisture in the use environment range at design, p is an arrangement pitch of the transfer units, s is a total number of the transfer units, and π is the circle ratio pi.
摘要翻译：在传送装置中，旋转地驱动传送带部件的驱动辊满足条件“（R 2→R 1）] pix（s-1）xp /（R < SUB> 1×x2×2）<= 0.15mm“，其中R 1是在设计的使用环境范围内的最低温度和最小湿度的环境下的驱动辊的直径， R 2是在设计时在使用环境范围内的最高温度和最大湿度的环境下的驱动辊的直径，p是转印单元的排列间距，s是总数的转移单位，pi是圆比pi。

58. 发明授权

US06828498B2 Audio signal outputting method, audio signal reproduction method, and computer program product 有权
标题翻译：音频信号输出方式，音频信号再现方式，计算机程序产品
公开(公告)号：US06828498B2
公开(公告)日：2004-12-07
申请号：US10267832
申请日：2002-10-10
申请人： Keiichi Sugiyama , Mitsuru Takahashi , Keiichi Noda
发明人： Keiichi Sugiyama , Mitsuru Takahashi , Keiichi Noda
IPC分类号： G10H700
CPC分类号： G10H1/0066 , G10H2210/026
摘要： An object of the present invention is to provide a technology for switching the output of an audio signal at timing where there is a musical break. To achieve this object, the present invention captures the musical piece progress timing for each MIDI message of multiple channels, mutually synchronized musically, and, upon detection of the occurrence of an event which changes the reproduced and outputted audio signal, reproduces and outputs an audio signal by selecting from above-mentioned plurality of MIDI messages a combination of MIDI messages corresponding to above-mentioned event, selection being made at a timing where there is a musical break.
摘要翻译：本发明的目的是提供一种用于在存在音乐突变的定时切换音频信号的输出的技术。为了达到这个目的，本发明为音频上相互同步的多个声道的每个MIDI信息捕获音乐作品进行定时，并且在检测到改变再现和输出的音频信号的事件的发生时，再现并输出音频通过从上述多个MIDI消息中选择与上述事件相对应的MIDI消息的组合来进行信号的选择，这是在存在音乐中断的时刻进行的。

59. 发明授权

US5983060A Image forming apparatus which removes a surface potential of an intermediate transfer member 失效
标题翻译：去除中间转印部件的表面电位的图像形成装置
公开(公告)号：US5983060A
公开(公告)日：1999-11-09
申请号：US50907
申请日：1998-03-31
申请人： Shin-Ichi Namekata , Hideo Yuu , Satoru Uchida , Mitsuru Takahashi , Katsuya Kawagoe , Hiroshi Ono , Toshiaki Motohashi
发明人： Shin-Ichi Namekata , Hideo Yuu , Satoru Uchida , Mitsuru Takahashi , Katsuya Kawagoe , Hiroshi Ono , Toshiaki Motohashi
IPC分类号： G03G15/16
CPC分类号： G03G15/161 , G03G15/162 , G03G2215/0177 , G03G2215/1623 , G03G2215/1661
摘要： An image forming apparatus which utilizes an intermediate transfer member. Plural toner images, for example of different colors, can be superimposed on the intermediate transfer member, and then can be transferred to a paper sheet. A discharging device is provided for discharging a charge applied to the intermediate transfer member. Further, a value of a voltage provided by this discharging device and/or a voltage provided for a transfer bias is proportional to an actual surface potential on the intermediate transfer member, which is proportional to the number of times toner images have been formed on the intermediate transfer member prior to transfer to the paper sheet. For example, if a full color toner image is formed on the intermediate transfer member, which may result from four operations of transferring individual toner images onto the intermediate transfer member, a voltage provided by the discharger and/or by a transfer bias device will be higher than that if only a monocolor image has been formed on the intermediate transfer member. Further, the image forming apparatus can be operable to form images on thicker paper, and in this instance a drive speed of devices in the image forming apparatus can be reduced, and a voltage applied to a pre-charger can also accordingly be reduced. The image forming apparatus can also include a cleaning device from the intermediate transfer belt, and the functions of both the intermediate transfer member discharging device and a cleaning device can be combined in one brush roller.
摘要翻译：一种利用中间转印部件的图像形成装置。可以将例如不同颜色的多种调色剂图像叠加在中间转印部件上，然后可以转印到纸张上。设置有用于对施加到中间转印部件的电荷进行放电的放电装置。此外，由该放电装置提供的电压值和/或为转印偏压提供的电压的值与中间转印部件上的实际表面电位成比例，该实际表面电位与在上述形成的调色剂图像的次数成正比在转印到纸张之前的中间转印部件。例如，如果在中间转印部件上形成全色调色剂图像，这可能由将各个调色剂图像转印到中间转印部件上的四个操作产生，则由放电器和/或转印偏压装置提供的电压将为高于在中间转印部件上仅形成单色图像的情况。此外，图像形成装置可以操作以在较厚的纸上形成图像，并且在这种情况下，可以减少图像形成装置中的装置的驱动速度，并且还可以相应地减小施加到预充电器的电压。图像形成装置还可以包括来自中间转印带的清洁装置，并且中间转印部件排出装置和清洁装置的功能可以组合在一个刷辊中。

60. 发明授权

US5870650A Image forming apparatus having a device to apply a release agent to a surface of a transfer roller 失效
公开(公告)号：US5870650A
公开(公告)日：1999-02-09
申请号：US891090
申请日：1997-07-10
申请人： Mitsuru Takahashi , Satoru Uchida
发明人： Mitsuru Takahashi , Satoru Uchida
IPC分类号： G03G15/16
CPC分类号： G03G15/168 , G03G2215/1652
摘要： An image forming apparatus includes a transfer device to transfer an image on an image carrier to a transfer sheet. The transfer device includes a transfer roller and transfers an image on the image carrier to a transfer sheet conveyed into a transfer area between the transfer roller and the image carrier by applying a bias voltage to the transfer roller. The transfer device includes a device to apply a release agent for an alien substance to a surface of the transfer roller. Toner and an alien substance, such as paper dust, thereby hardly adheres to the release agent applied on the surface of the transfer roller. Even if toner and/or an alien substance are put on the release agent applied on the surface of the transfer roller, such toner and/or an alien substance are easily removed by a cleaning device. Thus, lowering of an image quality due to insufficient cleaning of the transfer roller is avoided.

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