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    • 54. 发明申请
    • ANTIGENIC POLYPEPTIDE USABLE AS THERAPEUTIC AGENT FOR MALIGNANT NEOPLASM
    • 抗恶性多糖可作为恶性肿瘤治疗药物使用
    • US20100034841A1
    • 2010-02-11
    • US12312232
    • 2007-10-02
    • Takashi Nishimura
    • Takashi Nishimura
    • A61K39/00C12N5/02C12N15/63C07K7/08C07K16/18C07H21/04
    • C07K14/4748A61K39/0011A61K2039/5158A61K2039/57C07K16/30C07K2317/34
    • This invention provides a new tumor antigen having an epitope that induces a Th1 cell (a CD4-positive T cell specific to MAGE-A4), and a method of application thereof.Specifically, this invention provides a polypeptide that includes an amino acid sequence having the following characteristic a), b), c), d), e) or f) and has a cytokine-producing activity in a Th cell specific to MAGE-A4: a) An amino acid sequence represented by SEQ ID No: 1 or No: 2; b) An amino acid sequence, wherein one to several tens of any amino acids are added to N terminus and/or C terminus of an amino acid sequence represented by SEQ ID No: 1 or No: 2; c) An amino acid sequence, wherein one to five amino acids from N terminus and/or C terminus of an amino acid sequence represented by SEQ ID No: 1 or No: 2 are deleted; d) An amino acid sequence, wherein one to several amino acid residues of an amino acid sequence represented by SEQ ID No: 1 or No: 2 are substituted and/or deleted; e) An amino acid sequence, wherein one to several tens of any amino acids are added to N terminus and/or C terminus of an amino acid sequence, wherein one to several amino acid residues of an amino acid sequence represented by SEQ ID No: 1 or No: 2 are substituted and/or deleted; and f) An amino acid sequence, wherein one to several amino acid residues are substituted in an amino acid sequence, wherein one to five amino acids from N terminus and/or C terminus of an amino acid sequence represented by SEQ ID No: 1 or No: 2 are deleted.
    • 本发明提供具有诱导Th1细胞(MAGE-A4特异性的CD4阳性T细胞)表位的新型肿瘤抗原及其应用方法。 具体而言,本发明提供了包含具有以下特征a),b),c),d),e)或f)特征的氨基酸序列的多肽,并且在特异于MAGE-A4的Th细胞中具有细胞因子产生活性 a)由SEQ ID No:1或No.2表示的氨基酸序列; b)氨基酸序列,其中在SEQ ID No:1或No.2所表示的氨基酸序列的N末端和/或C末端加入一至数十个氨基酸; c)缺失由SEQ ID No:1或No.2表示的氨基酸序列的N末端和/或C末端的一至五个氨基酸的氨基酸序列; d)氨基酸序列,其中由SEQ ID No:1或No:2表示的氨基酸序列的一个至几个氨基酸残基被取代和/或缺失; e)氨基酸序列,其中将一至几十个任何氨基酸加入氨基酸序列的N末端和/或C末端,其中SEQ ID NO:1所示的氨基酸序列的一个至多个氨基酸残基, 1或No:2被替换和/或删除; 和f)氨基酸序列,其中一个至几个氨基酸残基被氨基酸序列取代,其中由SEQ ID No:1表示的氨基酸序列的N末端和/或C末端的一至五个氨基酸或 否:2被删除。
    • 58. 发明申请
    • Image display device
    • 图像显示装置
    • US20060192480A1
    • 2006-08-31
    • US11416096
    • 2006-05-03
    • Satoshi IshikawaTakashi NishimuraSachiko Hirahara
    • Satoshi IshikawaTakashi NishimuraSachiko Hirahara
    • H01J63/04H01J1/62
    • H01J31/123H01J29/862H01J2329/861
    • In a flat image display device in which a first substrate having phosphor layers formed oh an inner surface thereof and a second substrate having electron emitting elements which excite the phosphor layers are located opposite each other with a gap therebetween, the plate thickness of the second substrate is made smaller than the plate thickness of the first substrate. The second substrate is formed thinner than the first substrate so that it is more flexible. Even if spacers are subject to variation in height, therefore, the first and second substrates can be securely brought into contact with the spacers, whereby gaps between the spacers and the substrates can be eliminated, and electric discharge between the first and second substrates can be restrained.
    • 在其中具有形成在其内表面上的荧光体层的第一基板和激发荧光体层的电子发射元件的第二基板彼此间隔开的平面图像显示装置中,第二基板的板厚度 被制成小于第一基板的板厚度。 第二基板被形成为比第一基板更薄,使得其更灵活。 即使间隔物的高度发生变化,也可以将第一基板和第二基板牢固地与间隔件接触,从而能够消除间隔物与基板之间的间隙,能够使第一基板与第二基板之间的放电 束缚