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51. 发明授权

US07323552B2 Variant integrin polypeptides and uses thereof 失效
标题翻译：变体整联蛋白多肽及其用途
公开(公告)号：US07323552B2
公开(公告)日：2008-01-29
申请号：US10144259
申请日：2002-05-10
申请人： M. Amin Arnaout , Rui Li , Jian-Ping Xiong
发明人： M. Amin Arnaout , Rui Li , Jian-Ping Xiong
IPC分类号： C07K1/107 , A61K38/04 , G01N33/53
CPC分类号： C07K14/70553 , A61K38/00 , C07K14/70546 , C07K16/2845
摘要： Polypeptides comprising all or part of a variant integrin α subunit A domain and its flanking region are described. In solution or in membrane-associated form, the A domain polypeptides of the invention exists predominantly in a high affinity conformation. In the polypeptides of the invention, referred to as variant integrin polypeptides, a crucial isoleucine or glutamic acid residue is altered. For example, the glutamic acid can be either deleted or replaced with different amino acids residue, e.g., glutamine, aspartic acid, or alanine The variant integrin polypeptides of the invention selectively impair binding of activation-dependent ligands, but not independent ligands. They are useful in screening assays for the identification of molecules that enhance binding of variant polypeptides with impaired binding. In addition, they are useful in distinguishing between activation-dependent ligands and activation-independent ligands. They are also useful for generating antibodies, e.g., monoclonal antibodies, which bind to the impaired form of an integrin. Some such antibodies recognize an epitope that is either not present or not accessible on an integrin that is in the high affinity conformation. The variant integrin polypeptides of the invention can be derived from any integrin α subunit that could be used therapeutically.
摘要翻译：描述了包含全部或部分变体整联蛋白α亚基A结构域及其侧翼区的多肽。在溶液或膜相关形式中，本发明的A结构域多肽主要存在于高亲和力构象中。在本发明的多肽中，称为变体整联蛋白多肽，关键的异亮氨酸或谷氨酸残基被改变。例如，谷氨酸可被删除或被不同氨基酸残基替代，例如谷氨酰胺，天冬氨酸或丙氨酸。本发明的变体整联蛋白多肽选择性地损害活化依赖性配体但不是独立配体的结合。它们可用于鉴定增强变异多肽与受损结合的结合的分子的筛选分析。此外，它们可用于区分活化依赖性配体和与激活无关的配体。它们也可用于产生结合受损形式的整联蛋白的抗体，例如单克隆抗体。一些这样的抗体识别在高亲和力构象的整联蛋白上不存在或不可接近的表位。本发明的变体整联蛋白多肽可以衍生自可以在治疗上使用的任何整联蛋白α亚基。

52. 外观设计

USD1002723S1 Business card holder 有权
公开(公告)号：USD1002723S1
公开(公告)日：2023-10-24
申请号：US29799936
申请日：2021-07-18
申请人： Rui Li
设计人： Rui Li
摘要： FIG. 1 is a perspective view of the business card holder showing my new design;
FIG. 2 is a front elevational view thereof;
FIG. 3 is a rear elevational view thereof;
FIG. 4 is a left side elevational view thereof;
FIG. 5 is a right side elevational view thereof;
FIG. 6 is a top plan view of thereof; and,
FIG. 7 is a bottom plan view of thereof.

53. 外观设计

USD1000519S1 Business card holder 有权
公开(公告)号：USD1000519S1
公开(公告)日：2023-10-03
申请号：US29800112
申请日：2021-07-19
申请人： Rui Li
设计人： Rui Li
摘要： FIG. 1 is a perspective view of the business card holder showing my new design;
FIG. 2 is a front elevational view thereof;
FIG. 3 is a rear elevational view thereof;
FIG. 4 is a left side elevational view thereof;
FIG. 5 is a right side elevational view thereof;
FIG. 6 is a top plan view of thereof; and,
FIG. 7 is a bottom plan view of thereof.

54. 发明申请

US20180336082A1 METHOD AND ARRANGEMENT FOR DETERMINING AN ABNORMAL STATE OF A SYSTEM 审中-公开
公开(公告)号：US20180336082A1
公开(公告)日：2018-11-22
申请号：US15985600
申请日：2018-05-21
申请人： Rui Li , Henning Ochsenfeld
发明人： Rui Li , Henning Ochsenfeld
IPC分类号： G06F11/07 , G06F11/00
CPC分类号： G06F11/079 , G05B23/0227 , G06F11/006 , G06F11/0736 , G06F2201/86 , G06Q10/0639
摘要： A similarity between a pattern distribution of selected state patterns of system state descriptions in a first set of system state descriptions and an average pattern distribution of the selected state patterns of the system state descriptions in a second set of system state description is determined. The similarity is compared with a plurality of such similarities between the pattern distributions within the second set of system state descriptions and the average pattern distribution in the second set of system state descriptions. An abnormal state of the system is determined using this comparison.

55. 发明授权

US09719953B2 System and process for determining and analysing surface property parameters of substance based on kinetic method 有权
公开(公告)号：US09719953B2
公开(公告)日：2017-08-01
申请号：US14359502
申请日：2012-01-20
申请人： Rui Li , Hang Li , Xinmin Liu , Zhenlun Li , Jie Hou , Hualing Zhu , Laosheng Wu
发明人： Rui Li , Hang Li , Xinmin Liu , Zhenlun Li , Jie Hou , Hualing Zhu , Laosheng Wu
IPC分类号： G01N27/26 , G01R29/24
CPC分类号： G01N27/26 , G01R29/24
摘要： A system and process for determining and analyzing surface property parameters of a substance based on kinetic method is provided. The system comprises a sample processing system and a detection system. The sample processing system includes a reactor (3), a collector for liquid to be tested (5), and a container for liquid to be tested (6). The detection system includes a detecting electrode (13), a concentration and activity operator, a kinetic data processor, a surface property operation module, and a result output module. The process comprises: having the substance to be tested to be treated with an electrolyte solution, measuring activity of liquid to be tested upon reaction at a pre-set time interval, and processing with the kinetic data processor and the surface property operation module, so as to obtain surface property parameters of the substance to be tested. The present invention adopts kinetic method of ion exchange to overcome the issues associated with long reaction equilibrium time, not easy to determine equilibrium and not easy to accurately determine the value of m. Five parameters of the substance surface property can be calculated with only intercept and gradient of the linear regression equation obtained from the kinetic data, and the total amount of surface charge can also be directly determined.

56. 发明授权

US09556009B2 Labor-saving device for detection of no-load hand hoist motion 有权
标题翻译：用于检测空载手动葫芦运动的省力装置
公开(公告)号：US09556009B2
公开(公告)日：2017-01-31
申请号：US13979833
申请日：2012-05-03
申请人： Rui Li , Liang Wang , Minbo Yu , Zhihua Zhu , Zhouxuan Li , Hongyun Yu , Qun Yuan
发明人： Rui Li , Liang Wang , Minbo Yu , Zhihua Zhu , Zhouxuan Li , Hongyun Yu , Qun Yuan
IPC分类号： B66D3/16 , B66D3/18
CPC分类号： B66D3/16 , B66D3/18
摘要： A labor-saving device for detection of no-load hand hoist motion, including a base, a stand pole, and a controller, a first cantilever beam, a second cantilever beam, a third cantilever beam, and a fourth cantilever beam being sequentially disposed in single vertical plane from top to bottom of the stand pole. Specifically, the electric hoist being disposed below the first cantilever beam; a pair of first guide unit being respectively disposed at two opposite laterals of the second cantilever beam; a driving unit including a motor, a stand plate, and an actuator being coaxially disposed in series from internal to external, being disposed above the third cantilever beam; and a pair of second guide unit are respectively disposed at two opposite laterals of the fourth cantilever beam.
摘要翻译：用于检测空载手动起重机运动的劳动节省装置，包括基座，立柱和控制器，顺序地布置有第一悬臂梁，第二悬臂梁，第三悬臂梁和第四悬臂梁在立柱从上到下的单一垂直平面。具体地说，电动葫芦设置在第一悬臂梁下方; 一对第一引导单元分别设置在第二悬臂梁的两个相对的侧面; 设置在所述第三悬臂梁的上方的包括马达，支架板和从内到外串联设置的致动器的驱动单元; 并且一对第二引导单元分别设置在第四悬臂梁的两个相对的侧面。

57. 发明申请

US20150135299A1 METHOD AND SYSTEM FOR ESTABLISHING IPSEC TUNNEL 审中-公开
标题翻译：建立IPSEC隧道的方法与系统
公开(公告)号：US20150135299A1
公开(公告)日：2015-05-14
申请号：US14402749
申请日：2012-07-24
申请人： Chaocai Liang , Junfeng Liao , Rui Li
发明人： Chaocai Liang , Junfeng Liao , Rui Li
IPC分类号： H04L29/06 , H04W76/02
CPC分类号： H04L63/0823 , H04L12/6418 , H04L63/0485 , H04L63/164 , H04W12/001 , H04W76/11
摘要： Provided are a method and system for establishing an IPSec tunnel. The method comprises: an base station requesting a first configuration parameter from a configuration server, and requesting a digital certificate from a CA server according to the first configuration parameter which is responded by the configuration server; the base station establishing a temporary IPSec tunnel to a security gateway according to the acquired digital certificate, and requesting a second configuration parameter from a background network management unit through the temporary IPSec tunnel; and after acquiring the second configuration parameter, the base station dismantling the temporary IPSec tunnel, and establishing a permanent IPSec tunnel between itself and the security gateway according to the second configuration parameter.
摘要翻译：提供了一种建立IPSec隧道的方法和系统。该方法包括：基站从配置服务器请求第一配置参数，并根据由配置服务器响应的第一配置参数从CA服务器请求数字证书; 所述基站根据获取的数字证书建立到安全网关的临时IPSec隧道，并通过所述临时IPSec隧道从后台网络管理单元请求第二配置参数; 并且在获取第二配置参数之后，基站拆除临时IPSec隧道，并根据第二配置参数在其自身与安全网关之间建立永久IPSec隧道。

58. 发明授权

US09013427B2 Method and terminal of displaying contact list 有权
标题翻译：显示联系人列表的方法和终端
公开(公告)号：US09013427B2
公开(公告)日：2015-04-21
申请号：US13592106
申请日：2012-08-22
申请人： Rui Li , Yong Liu , Yufeng Xu
发明人： Rui Li , Yong Liu , Yufeng Xu
IPC分类号： G06F3/041 , G06F3/042 , A63F9/24 , H04M1/2745 , G06F3/0482 , G06F3/0488
CPC分类号： H04M1/27455 , G06F3/0482 , G06F3/04886 , H04M1/274583 , H04M2250/22
摘要： The present disclosure relates to communication technologies and discloses a method and terminal of displaying a contact list. The method of displaying a contact list is applied on an apparatus with a touch sensitive display, comprising: detecting a touch on the touch sensitive display, after receiving an instruction for opening a contact list; determining a touch position, when detecting the touch on the touch sensitive display; and determining a large contact group corresponding to the touch position, and displaying contacts in the large contact group by the touch sensitive display. With the present disclosure, a user can find out a contact quickly, and the user's experience can be improved.
摘要翻译：本公开涉及通信技术，并且公开了显示联系人列表的方法和终端。显示联系人列表的方法被应用在具有触敏显示器的设备上，包括：在接收到打开联系人列表的指令之后，检测对触敏显示器的触摸; 当检测到所述触敏显示器上的触摸时，确定触摸位置; 以及确定对应于所述触摸位置的大接触组，以及通过所述触敏显示器显示所述大接触组中的触点。通过本公开，用户可以快速找到联系人，并且可以提高用户的体验。

59. 发明授权

US08856686B2 Method and apparatus for generating a menu display 有权
标题翻译：用于产生菜单显示的方法和装置
公开(公告)号：US08856686B2
公开(公告)日：2014-10-07
申请号：US13258518
申请日：2010-03-30
申请人： Rui Li
发明人： Rui Li
IPC分类号： G06F3/048 , G06F3/0482 , H04N5/445 , H04N21/431 , H04N21/45
CPC分类号： G06F3/0482 , H04N5/44543 , H04N21/4312 , H04N21/4532
摘要： A method of generating a menu display (203), the method comprising the steps of: selecting a plurality of menu items (205—1, 205—2, 205—3, 205—4) from a plurality of candidate menu items, the candidate menu items being arranged in a plurality of hierarchical levels, on the basis of most frequently used menu items and most difficult to access menu items within the plurality of hierarchical levels; and displaying the selected menu items simultaneously.
摘要翻译：一种生成菜单显示（203）的方法，所述方法包括以下步骤：从多个候选菜单项中选择多个菜单项（205-1,205-2,205-3,205-4），所述菜单显示基于最常使用的菜单项并且最难以访问多个层次级别内的菜单项，候选菜单项被排列成多个层次级别; 并同时显示所选择的菜单项。

60. 发明授权

US08782755B2 Systems and methods for selecting an authentication virtual server from a plurality of virtual servers 有权
标题翻译：用于从多个虚拟服务器中选择认证虚拟服务器的系统和方法
公开(公告)号：US08782755B2
公开(公告)日：2014-07-15
申请号：US12409223
申请日：2009-03-23
申请人： James Harris , Rui Li , Arkesh Kumar , Ravindranath Thakur , Puneet Agarwal , Akshat Choudhary
发明人： James Harris , Rui Li , Arkesh Kumar , Ravindranath Thakur , Puneet Agarwal , Akshat Choudhary
IPC分类号： G06F15/16 , G06F9/455 , G06F21/53 , G06F21/31 , H04L29/06 , H04L29/08
CPC分类号： H04L63/0876 , G06F21/31 , G06F21/53 , G06F2009/4557 , H04L63/08 , H04L63/0884 , H04L63/10 , H04L63/105 , H04L63/166 , H04L63/20 , H04L67/2814
摘要： The present invention provides a system and method for dynamically selecting an authentication virtual server from a plurality of authentication virtual servers. A traffic management virtual server may determine from a request received from a client to access content of a server that the client has not been authenticated. The traffic management virtual server can identify a policy for selecting an authentication virtual server to provide authentication of the client. Responsive to the identification, the traffic management virtual server can select, via the policy, an authentication virtual server of the plurality of authentication virtual servers to authenticate the client. Responsive to the request, the traffic management virtual server may transmit a response to the client The response includes an instruction to redirect to the selected authentication virtual server.
摘要翻译：本发明提供一种用于从多个认证虚拟服务器动态选择认证虚拟服务器的系统和方法。流量管理虚拟服务器可以根据从客户端接收的请求来确定访问客户端尚未认证的服务器的内容。流量管理虚拟服务器可以识别用于选择认证虚拟服务器以提供客户端认证的策略。响应于识别，流量管理虚拟服务器可以通过策略选择多个认证虚拟服务器的认证虚拟服务器来认证客户端。响应于该请求，流量管理虚拟服务器可以向客户端发送响应。该响应包括重定向到所选择的认证虚拟服务器的指令。

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