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    • 56. 发明授权
    • Process for producing functional styrene copolymer
    • 制备功能性苯乙烯共聚物的方法
    • US06486272B1
    • 2002-11-26
    • US09926788
    • 2001-12-19
    • Tetsuya InoueMasanori Sera
    • Tetsuya InoueMasanori Sera
    • C08F4645
    • C08F212/04
    • A process for producing a styrenic copolymer having a functional group and a syndiotactic configuration is provided. The process comprises bringing a metal compound into interaction with a vinyl compound having a functional group to mask the functional group and copolymerizing the vinyl compound having the masked functional group with a styrenic compound in the presence of a polymerization catalyst comprising (A) a transition metal compound, (B) at least one compound selected from compounds having oxygen and compounds which can form ionic complex compounds by reaction with the transition metal compound and (C) an organometallic compound. A styrenic copolymer which is a random, block or graft copolymer, preferably a random copolymer, of a vinyl compound having a functional group and a styrenic compound and has the repeating units derived from the styrenic compound having the syndiotactic configuration can be produced efficiently. The above styrenic random copolymer exhibits excellent physical properties such as excellent adhesion with various adhesives and excellent compatibility with various rubbers and is advantageously used for various applications as various types of molded articles.
    • 提供了具有官能团和间同立构构型的苯乙烯类共聚物的制造方法。 该方法包括使金属化合物与具有官能团的乙烯基化合物相互作用以掩蔽该官能团并在具有(A)过渡金属的聚合催化剂的存在下将具有掩蔽官能团的乙烯基化合物与苯乙烯类化合物共聚 化合物,(B)至少一种选自具有氧的化合物的化合物和可以与过渡金属化合物反应形成离子络合物的化合物和(C)有机金属化合物。 可以有效地制造作为具有官能团的乙烯基化合物和苯乙烯类化合物的具有间同立构构型的苯乙烯类化合物的重复单元的随机,嵌段或接枝共聚物,优选无规共聚物的苯乙烯系共聚物。 上述苯乙烯类无规共聚物表现出优异的物理性能,例如与各种粘合剂的优异粘附性和与各种橡胶的优异相容性,并且有利地用于各种类型的模制品的各种应用。
    • 58. 发明授权
    • Aureobasidins
    • US5698670A
    • 1997-12-16
    • US505255
    • 1995-08-16
    • Toru KuromeTetsuya InoueKazutoh TakesakoKaoru InamiIkunoshin Kato
    • Toru KuromeTetsuya InoueKazutoh TakesakoKaoru InamiIkunoshin Kato
    • A61K38/00C07K11/02A61K38/12C07K5/00
    • C07K11/02A61K38/00
    • This invention relates to Aureobasidins useful as an antifungal agent having broader spectrum. The compound according to this invention includes a cyclic depsipeptide consisting of one hydroxy acid residue having A.sup.1, 3 amino acid residues having C.sup.1, F.sup.1 and H.sup.1, respectively, 4 N-methylamino acid residues having B.sup.1, D.sup.1, G.sup.1 and I.sup.1, respectively, and 1 cyclic amino acid residue having E.sup.1. The typical compound includes one wherein A.sup.1 is CH.sub.3 CH.sub.2 CH(CH.sub.3)--, B.sup.1 is (CH.sub.3).sub.2 CH--, C.sup.1 is benzyl, cyclohexylmethyl, p-fluorobenzyl, benzyloxymethyl, benzyloxybenzyl, methoxybenzyl, cyclohexylmethyloxybenzyl or the like, D.sup.1 is methyl, benzyl, hydroxymethyl or the like, E.sup.1 is --(CH.sub.2).sub.3 --, F.sup.1 is CH.sub.3 CH.sub.2 CH(CH.sub.3)--, G.sup.1 is (CH.sub.3).sub.2 CH--, H.sup.1 is (CH.sub.3).sub.2 CHCH.sub.2 -- and I.sup.1 is (CH.sub.3).sub.2 C(OH)--. The compound according to this invention has an excellent activity against not only Candida but also Cryptococcus and Aspergillus.
    • PCT No.PCT / JP94 / 02201 Sec。 371日期:1995年8月16日 102(e)日期1995年8月16日PCT 1994年12月26日PCT公布。 出版物WO95 / 18147 日期1995年7月6日本发明涉及可用作具有更宽光谱的抗真菌剂的Aureobasidins。 根据本发明的化合物包括由一个具有A1的羟基酸残基,具有C1,F1和H1的3个氨基酸残基,分别具有B1,D1,G1和I1的4个N-甲基氨基酸残基的环状缩肽,以及 1个具有E1的环状氨基酸残基。 典型的化合物包括其中A 1为CH 3 CH 2 CH(CH 3) - ,B 1为(CH 3)2 CH-,C 1为苄基,环己基甲基,对氟苄基,苄氧基甲基,苄氧基苄基,甲氧基苄基,环己基甲氧基苄基等的化合物,D1为甲基,苄基, 等等,E1是 - (CH 2)3 - ,F1是CH 3 CH 2 CH(CH 3) - ,G 1是(CH 3)2 CH-,H 1是(CH 3)2 CHCH 2 - 且I 1是(CH 3)2 C(OH) - 。 根据本发明的化合物对假丝酵母不仅具有优异的活性,而且对隐球菌和曲霉也具有优异的活性。