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51. 发明申请

US20070048277A1 HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29 有权
公开(公告)号：US20070048277A1
公开(公告)日：2007-03-01
申请号：US11549760
申请日：2006-10-16
申请人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
IPC分类号： A61K38/20 , C12P21/04 , C07K14/54
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.

52. 发明申请

US20070041936A1 HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29 有权
公开(公告)号：US20070041936A1
公开(公告)日：2007-02-22
申请号：US11550652
申请日：2006-10-18
申请人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人： Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
IPC分类号： A61K39/42 , C07H21/04 , C12P21/06 , C07K16/10 , C12N5/06
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.

53. 发明申请

US20060183851A1 Solvent free aqueous polyurethane dispersions and shaped articles therefrom 审中-公开
标题翻译：无溶剂的水性聚氨酯分散体和其成型制品
公开(公告)号：US20060183851A1
公开(公告)日：2006-08-17
申请号：US11351967
申请日：2006-02-10
申请人： Hong Liu , Carmen Covelli , Douglas Farmer
发明人： Hong Liu , Carmen Covelli , Douglas Farmer
IPC分类号： C08G18/08
CPC分类号： C08G18/0895 , A41B2500/54 , A41C3/0014 , A41D27/245 , B32B5/26 , B32B7/12 , B32B27/12 , B32B27/40 , B32B2255/02 , B32B2255/10 , B32B2255/26 , B32B2307/306 , B32B2307/51 , B32B2307/554 , B32B2437/00 , C08G18/0823 , C08G18/12 , C08G18/4808 , C08G18/4854 , C08G18/6692 , C08G18/7671 , C08G2170/80 , C08J3/05 , C08J2375/04 , D06M15/564 , D06M15/568 , D06M15/572 , D06M17/10 , D06N3/14 , C08G18/302
摘要： An article comprising an adhesive, a stretch member and a substrate wherein the adhesive is used to attach the stretch member to the fabric in a folded hem arrangement. The adhesive can be a tape made from an aqueous polyurethane dispersion and the stretch member can be a spandex fiber.
摘要翻译：一种包括粘合剂，拉伸构件和基底的制品，其中所述粘合剂用于以折叠的布置布置将拉伸构件附接到织物。粘合剂可以是由水性聚氨酯分散体制成的带，并且拉伸构件可以是氨纶纤维。

54. 发明授权

US07078408B2 [1,2,4]-Triazole bicyclic adenosine A2a receptor antagonists 有权
标题翻译： [1,2,4] - 三唑双环腺苷A2a受体拮抗剂
公开(公告)号：US07078408B2
公开(公告)日：2006-07-18
申请号：US10973642
申请日：2004-10-26
申请人： Bernard R. Neustadt , Hong Liu
发明人： Bernard R. Neustadt , Hong Liu
IPC分类号： C07D487/04 , A61K31/519 , A61P25/24 , A61P25/16
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds having the structural formula Iwherein: n is 0, 1, 2 or 3; A is C(R1) or N; R1 and R1a are H, (C1–C6)-alkyl, halo, CN or —CF3; X is —C(O)—, —O—, —SO0-2—, or optionally substituted methylene, imino, arylene or heteroaryldiyl; Y is —O—, —SO0-2—, or optionally substituted arylene, heteroaryldiyl, or nitrogen-containing heterocycloalkyl, or with certain provisos, a bond; R is optionally substituted-aryl or heteroaryl; and R2 is optionally substituted-aryl, heteroaryl, arylalkyl or heteroarylalkyl; or R2—Y is a fused piperidinyl, substituted piperazinyl or substituted piperidinyl; their use in the treatment of Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, pharmaceutical compositions comprising them and kits comprising the components of the combinations
摘要翻译：具有结构式I的化合物，其中：n为0,1,2或3; A是C（R 1）或N; R 1和R 2是H，（C 1 -C 6 -C 6） - 烷基，卤素，CN或 -CF 3 N 3; X是-C（O） - ， - O - ， - SO 2 - 或任选取代的亚甲基，亚氨基，亚芳基或杂芳基二基; Y是-O-，-SO 0-2 - 或任选取代的亚芳基，杂芳基二基或含氮杂环烷基，或具有一定条件的键; R是任选取代的 - 芳基或杂芳基; R 2是任选取代的 - 芳基，杂芳基，芳基烷基或杂芳基烷基; 或R 2 -Y是稠合的哌啶基，取代的哌嗪基或取代的哌啶基; 其用于治疗帕金森病，单独或与其他治疗帕金森病的药物组合，包含它们的药物组合物和包含组合的组分的试剂盒

55. 发明授权

US06984708B2 Spandex of a particular composition and process for making same 有权
标题翻译：特定组合物的氨纶和其制造方法
公开(公告)号：US06984708B2
公开(公告)日：2006-01-10
申请号：US10264742
申请日：2002-10-04
申请人： Hong Liu , Gregory L. Yoder , Robert O. Waldbauer, Jr.
发明人： Hong Liu , Gregory L. Yoder , Robert O. Waldbauer, Jr.
IPC分类号： C08G18/65
CPC分类号： D01F6/70 , C08G18/3228 , C08G18/3271 , C08G18/4854 , C08G18/7657 , Y10S528/906
摘要： The invention provides spandex having improved hysteresis and a method for making such spandex. The spandex of the invention comprises the polyurethaneurea reaction product of: (a) poly(tetramethylene ether) glycol (b) 1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene wherein the mole ratio of diisocyanate to glycol is from about 1.52 to about 2.04; and (c) a mixture of chain extenders comprising: from about 35 to about 55 mole percent ethylene diamine; and from about 45 to about 65 mole percent 1,2-propanediamine.
摘要翻译：本发明提供具有改善的滞后的氨纶和制造这种氨纶的方法。本发明的氨纶包含聚氨酯脲反应产物：（a）聚（四亚甲基醚）二醇（b）1-异氰酸酯基-4 - [（4-异氰酸基苯基）甲基]苯，其中二异氰酸酯与二醇的摩尔比为约 1.52至约2.04; 和（c）增链剂的混合物，其包含：约35至约55摩尔％的乙二胺; 和约45至约65摩尔％的1,2-丙二胺。

56. 发明授权

US06875772B2 [1,2,4]-Triazole bicyclic adeonsine A2a receptor antagonists 有权
标题翻译： Ä1,2,4'-三唑双环腺苷A2a受体拮抗剂
公开(公告)号：US06875772B2
公开(公告)日：2005-04-05
申请号：US10304939
申请日：2002-11-26
申请人： Bernard R. Neustadt , Hong Liu
发明人： Bernard R. Neustadt , Hong Liu
IPC分类号： A61K31/519 , A61P25/00 , A61P25/16 , A61P25/24 , A61P25/28 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds having the structural formula I wherein: n is 0, 1, 2 or 3; A is C(R1) or N; R1 and R1a are H, (C1-C6)-alkyl, halo, CN or —CF3; X is —C(O)—, —O—, —SO0-2—, or optionally substituted methylene, imino, arylene or heteroaryldiyl; Y is —O—, —SO0-2—, or optionally substituted arylene, heteroaryldiyl, or nitrogen-containing heterocycloalkyl, or with certain provisos, a bond; R is optionally substituted-aryl or heteroaryl; and R2 is optionally substituted aryl, heteroaryl, arylalkyl or heteroarylalkyl; or R2—Y is a fused piperidinyl, substituted piperazinyl or substituted piperidinyl; their use in the treatment of Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, pharmaceutical compositions comprising them and kits comprising the components of the combinations.
摘要翻译：具有结构式I的化合物，其中n为0,1,2或3; A为C（R 1）或N; R 1和R 1a为H，（C 1 -C 6） - 烷基，卤代，CN或-CF 3; X是-C（O） - ， - O - ， - SO 2 2-或任选取代的亚甲基，亚氨基，亚芳基或杂芳基二; Y是-O-，-SOO- 取代的亚芳基，杂芳基二基或含氮杂环烷基，或具有某些条件的键; R是任选取代的 - 芳基或杂芳基; R 2是任选取代的芳基，杂芳基，芳基烷基或杂芳基烷基; 或R 2 -Y是稠合的哌啶基，取代的哌嗪基或取代的哌啶基;它们用于治疗帕金森病，单独或与其它用于治疗帕金森病的药物组合，其包含它们的药物组合物和包含组合。

57. 发明授权

US06185519B2 Method and system for feature interaction detection in a telecommunication network 失效
标题翻译：电信网络中特征交互检测的方法和系统
公开(公告)号：US06185519B2
公开(公告)日：2001-02-06
申请号：US09204019
申请日：1998-12-01
申请人： Fuchun Joseph Lin , Abhrajit Ghosh , Hong Liu
发明人： Fuchun Joseph Lin , Abhrajit Ghosh , Hong Liu
IPC分类号： G06N500
CPC分类号： H04Q3/0041
摘要： Methods and systems disclosed efficiently detect potential interactions between features in a telecommunications network. The methods and systems specify AIN (Advanced Intelligent Network) and switch-based features and detect their interactions when present within a feature package provided to a single subscriber. The methodology supports the assumption that each feature is created without the knowledge of other features, and that each feature is specified as a “black box,” i.e., nothing is known about its internal logic except its input/output behaviors. The invention models a call environment, models two or more features, and combines the call variable usage for each feature. Methods then compare the combined call variable usages to detect potential feature interactions. The invention assists a service mediator in the tasks of detecting potential interactions among AIN features provided by different third party service providers, and detecting potential interactions between a third party service provider's AIN features and switch-based features.
摘要翻译：公开的方法和系统有效地检测电信网络中的特征之间的潜在交互。该方法和系统指定AIN（高级智能网络）和基于交换机的功能，并在提供给单个用户的功能包中存在时检测其交互。该方法支持假设每个特征是在没有其他特征的知识的情况下创建的，并且每个特征被指定为“黑匣子”，即，除了其输入/输出行为之外，其内部逻辑除外。本发明建模一个呼叫环境，建立两个或多个特征，并组合每个功能的呼叫变量使用。然后，方法比较组合的调用变量用法以检测潜在的特征相互作用。本发明有助于服务调解员检测由不同第三方服务提供商提供的AIN特征之间的潜在交互，并检测第三方服务提供商的AIN特征和基于交换机的功能之间的潜在交互。

58. 发明公开

US20230227441A1 2-OXO-OXAZOLIDINE-5-CARBOXAMIDES AS NAV1.8 INHIBITORS 审中-公开
公开(公告)号：US20230227441A1
公开(公告)日：2023-07-20
申请号：US18009306
申请日：2021-06-14
申请人： Ashok ARASAPPAN , Ian M. BELL , Christopher James BUNGARD , Christopher S. BURGEY , Jason M. COX , Deodial Guy GUIADEEN , Michael J. KELLY , Mark E. LAYTON , Hong LIU , Jian LIU , James T. OLSEN , James J. PERKINS , Jeffrey W. SCHUBERT , Akshay A. SHAH , Michael D. VANHEYST , Zhe WU , Shawn J. STACHEL , MERCK SHARP & DOHME CORP.
发明人： Ashok Arasappan , Ian M. Bell , Christopher James Bungard , Christopher S. Burgey , Jason Michael Cox , Deodial Guy Guiadeen, III , Michael J. Kelly, III , Mark E. Layton , Hong Liu , Jian Liu , James T. Olsen , James J. Perkins , Jeffrey W. Schubert , Akshay A. Shah , Shawn J. Stachel , Michael David VanHeyst , Zhe Wu
IPC分类号： C07D413/12 , C07D263/24 , C07D417/12
CPC分类号： C07D413/12 , C07D263/24 , C07D417/12
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

59. 发明授权

US10458218B2 Method of modelling hydrocarbon production from fractured unconventional formations 有权
$Method of modelling hydrocarbon production from fractured unconventional formations$
公开(公告)号：US10458218B2
公开(公告)日：2019-10-29
申请号：US14978037
申请日：2015-12-22
申请人： Xiangzeng Wang , Ruimin Gao , Fanhua Zeng , Shanshan Yao , Hong Liu , Quansheng Liang
发明人： Xiangzeng Wang , Ruimin Gao , Fanhua Zeng , Shanshan Yao , Hong Liu , Quansheng Liang
IPC分类号： G06F17/50 , E21B43/26 , G06F17/11
摘要： A method of modeling hydrocarbon flow from a fractured unconventional reservoir, where the formation has variability in stimulated reservoir properties caused by multi-stage fracturing treatment. A map is created which divides the formation into a plurality of closed production regions, each of which in turn is divided into a plurality of flow sub-systems extending between fractures in the formation. Production behavior is then calculated for each flow sub-system based on the geography and characteristics of the individual flow sub-system. Region hydrocarbon flow for each closed production region is determined by coupling the calculated production behavior of the flow sub-systems and the reservoir hydrocarbon flow can be modeled by aggregating the region hydrocarbon flows. Type curves showing the modeled hydrocarbon flow at selected points in time can then be plotted.

60. 发明申请

US20190218223A1 COMPOUNDS USEFUL FOR ALTERING THE LEVELS OF BILE ACIDS FOR THE TREATMENT OF DIABETES AND CARDIOMETABOLC DISEASE 审中-公开
公开(公告)号：US20190218223A1
公开(公告)日：2019-07-18
申请号：US16324596
申请日：2017-08-10
申请人： Jared N. CUMMING , Kevin D. DYKSTRA , Alan HRUZA , Derun LI , Hong LIU , Haiqun TANG , Brandon M. TAOKA , Andreas VERRAS , Shawn P. WALSH , Wen-Lian WU , Merck Sharp & Dohme Corp.
发明人： Jared N. Cumming , Kevin D. Dykstra , Alan Hruza , Derun Li , Hong Liu , Haiqun Tang , Brandon M. Taoka , Andreas Verras , Shawn P. Walsh , Wen-Lian Wu
IPC分类号： C07D487/04 , C07D519/00 , C07D471/04 , C07D498/04 , C07D513/04 , A61P3/10
CPC分类号： C07D487/04 , A61P3/10 , C07D471/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： Described herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.

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