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51. 发明申请

US20050009107A1 G-protein parathyroid hormone receptor HLTDG74 失效
标题翻译： G蛋白甲状旁腺激素受体HLTDG74
公开(公告)号：US20050009107A1
公开(公告)日：2005-01-13
申请号：US10921218
申请日：2004-08-19
申请人： Daniel Soppet , Yi Li , Craig Rosen , Steven Ruben
发明人： Daniel Soppet , Yi Li , Craig Rosen , Steven Ruben
IPC分类号： A61K48/00 , C07K14/72 , C12N15/12 , G01N33/53 , C12N5/06 , C12P21/04
CPC分类号： C07K14/723 , A61K48/00 , C12N2799/026
摘要： Human G-protein parathyroid hormone (PTH) receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the PTH receptor receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the PTH receptor receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host. Disclosed embodiments of the invention also include antibodies that bind Human G-Protein parathyroid hormone (PTH) receptor polypeptides and methods for making and using such antibodies.
摘要翻译：公开了人类G蛋白甲状旁腺激素（PTH）受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及在治疗上使用激动剂和拮抗剂治疗与PTH受体受体多肽的低表达和过表达相关的病症的方法。还公开了用于检测PTH受体受体核酸序列中的突变并检测衍生自宿主的样品中受体的可溶形式水平的诊断方法。本发明的公开的实施方案还包括结合人类G蛋白甲状旁腺激素（PTH）受体多肽的抗体以及制备和使用这些抗体的方法。

52. 发明申请

US20070154474A1 Human Prostate Specific G-Protein Receptor HPRAJ70 审中-公开
标题翻译：人前列腺特异性G蛋白受体HPRAJ70
公开(公告)号：US20070154474A1
公开(公告)日：2007-07-05
申请号：US11456261
申请日：2006-07-10
申请人： Daniel Soppet , Yi Li , Craig Rosen , Steven Ruben
发明人： Daniel Soppet , Yi Li , Craig Rosen , Steven Ruben
IPC分类号： A61K39/395 , C12Q1/68 , C12P21/06 , C07K14/72 , C07H21/04
CPC分类号： C07K16/28 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/705 , C07K2317/622
摘要： The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to PSGR polynucleotides and the polypeptides encoded by these polynucleotides, and the use of PSGR polynucleotides and polypeptides for detecting disorders of the reproductive system, including disorders of the prostate, particularly the presence of cancer. This invention relates to PSGR polynucleotides and polypeptides as well as vectors, host cells, antibodies directed to PSGR polynucleotides and polypeptides and recombinant and synthetic methods for producing the same. Also provided are methods for diagnosing, treating, preventing, and/or prognosing disorders related to the prostate, including cancer. The invention further relates to screening methods for identifying agonists and antagonists of PSGR polynucleotides and polypeptides of the invention and methods and/or compositions for inhibiting or enhancing the production and/or function of the PSGR polypeptides of the present invention.
摘要翻译：本发明涉及PSGR，一种与在前列腺癌中过表达的G蛋白偶联受体具有同源性的新型前列腺特异性基因。更具体地，本发明涉及PSGR多核苷酸和由这些多核苷酸编码的多肽，以及使用PSGR多核苷酸和多肽来检测生殖系统疾病，包括前列腺疾病，特别是癌症的存在。本发明涉及PSGR多核苷酸和多肽以及载体，宿主细胞，针对PSGR多核苷酸和多肽的抗体以及用于制备它的重组和合成方法。还提供了用于诊断，治疗，预防和/或预后与前列腺相关的疾病（包括癌症）的方法。本发明还涉及用于鉴定本发明的PSGR多核苷酸和多肽的激动剂和拮抗剂的筛选方法以及用于抑制或增强本发明的PSGR多肽的产生和/或功能的方法和/或组合物。

53. 发明申请

US20060140942A1 Human G-protein coupled receptor (HETGQ23) 审中-公开
标题翻译：人G蛋白偶联受体（HETGQ23）
公开(公告)号：US20060140942A1
公开(公告)日：2006-06-29
申请号：US11357204
申请日：2006-02-21
申请人： Daniel Soppet , Yi Li , Craig Rosen , Steven Ruben
发明人： Daniel Soppet , Yi Li , Craig Rosen , Steven Ruben
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/705
摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
摘要翻译：公开了人G-蛋白偶联受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

54. 发明申请

US20050064499A1 Human prostate specific G-protein receptor HPRAJ70 审中-公开
标题翻译：人前列腺特异性G蛋白受体HPRAJ70
公开(公告)号：US20050064499A1
公开(公告)日：2005-03-24
申请号：US10968294
申请日：2004-10-20
申请人： Daniel Soppet , Yi Li , Craig Rosen , Steven Ruben
发明人： Daniel Soppet , Yi Li , Craig Rosen , Steven Ruben
IPC分类号： A61K38/00 , A61K39/00 , C07K14/705 , C07K16/28 , C12Q1/68 , A61K38/17 , C07H21/04 , C07K14/72 , G01N33/574
CPC分类号： C07K16/28 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/705 , C07K2317/622
摘要： The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to PSGR polynucleotides and the polypeptides encoded by these polynucleotides, and the use of PSGR polynucleotides and polypeptides for detecting disorders of the reproductive system, including disorders of the prostate, particularly the presence of cancer. This invention relates to PSGR polynucleotides and polypeptides as well as vectors, host cells, antibodies directed to PSGR polynucleotides and polypeptides and recombinant and synthetic methods for producing the same. Also provided are methods for diagnosing, treating, preventing, and/or prognosing disorders related to the prostate, including cancer. The invention further relates to screening methods for identifying agonists and antagonists of PSGR polynucleotides and polypeptides of the invention and methods and/or compositions for inhibiting or enhancing the production and/or function of the PSGR polypeptides of the present invention.
摘要翻译：本发明涉及PSGR，一种与在前列腺癌中过表达的G蛋白偶联受体具有同源性的新型前列腺特异性基因。更具体地，本发明涉及PSGR多核苷酸和由这些多核苷酸编码的多肽，以及使用PSGR多核苷酸和多肽来检测生殖系统疾病，包括前列腺疾病，特别是癌症的存在。本发明涉及PSGR多核苷酸和多肽以及载体，宿主细胞，针对PSGR多核苷酸和多肽的抗体以及用于制备它的重组和合成方法。还提供了用于诊断，治疗，预防和/或预后与前列腺相关的疾病（包括癌症）的方法。本发明还涉及用于鉴定本发明的PSGR多核苷酸和多肽的激动剂和拮抗剂的筛选方法以及用于抑制或增强本发明的PSGR多肽的产生和/或功能的方法和/或组合物。

55. 发明申请

US20060008882A1 Antibodies to Chemokine Alpha-5 失效
标题翻译：趋化因子α-5抗体
公开(公告)号：US20060008882A1
公开(公告)日：2006-01-12
申请号：US11224076
申请日：2005-09-13
申请人： Ying-Fei Wei , Yi Li , Jian Ni , Craig Rosen , Steven Ruben
发明人： Ying-Fei Wei , Yi Li , Jian Ni , Craig Rosen , Steven Ruben
IPC分类号： C12P21/02 , C07H21/04 , C07K14/52 , C07K16/24
CPC分类号： C07K14/521 , A61K38/00 , C07K14/522 , C07K2319/00 , C12N2799/026 , Y02A50/423 , Y10T436/143333
摘要： The present invention relates to a novel CKα-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-5 protein. CKα-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CKα-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CKα-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及作为α趋化因子家族成员的新型CKalpha-5蛋白。特别地，提供编码人CKalpha-5蛋白的分离的核酸分子。还提供了CKalpha-5多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。还公开了特异性结合CKalpha-5多肽的抗体及其片段，以及制备这种抗体的组合物和方法。本发明还涉及鉴定CKalpha-5活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

56. 发明申请

US20060003378A1 Peptidoglycan recognition proteins 失效
标题翻译：肽聚糖识别蛋白
公开(公告)号：US20060003378A1
公开(公告)日：2006-01-05
申请号：US11214796
申请日：2005-08-31
申请人： Paul Young , Steven Ruben , Craig Rosen , Henrik Olsen
发明人： Paul Young , Steven Ruben , Craig Rosen , Henrik Olsen
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention related to three novel recognition protein expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-C polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.
摘要翻译：本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新型识别蛋白。更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。图1A-B，图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。还提供了PGRP-K，PGRP-W和PGRP-C多肽。进一步提供载体，宿主细胞和用于制备其的重组方法。本发明还涉及PGRP-K，PGRP-W和PGRP-C多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

57. 发明申请

US20060063924A1 Leukocyte regulatory factors 1 and 2 审中-公开
标题翻译：白细胞调节因子1和2
公开(公告)号：US20060063924A1
公开(公告)日：2006-03-23
申请号：US11272833
申请日：2005-11-15
申请人： Jian Ni , Jing-Shan Hu , Steven Ruben , Reiner Gentz
发明人： Jian Ni , Jing-Shan Hu , Steven Ruben , Reiner Gentz
IPC分类号： C07K14/475 , C07H21/02 , C12P21/06
CPC分类号： C07K14/4702
摘要： The present invention relates to novel LRF-1 and LRF-2 proteins which are related to the CRISP family and a protein called “Neutrophil Inhibitory Factor (NIF)” isolated from the canine hookworm (Ancylostoma caninum) that potently inhibits CD11/CD18-dependent neutrophil function. In particular, isolated nucleic acid molecules are provided encoding the human LRF-1 and LRF-2 proteins. LRF-1 and LRF-2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of LRF-1 or LRF-2 activity. Also provided are diagnostic methods for detecting immune system or other LRF-1- or LRF-2-related disorders and therapeutic methods for treating such disorders.
摘要翻译：本发明涉及与CRISP家族相关的新型LRF-1和LRF-2蛋白质，以及从犬钩虫（Ancylostoma caninum）中分离的称为“中性嗜中性粒细胞抑制因子（NIF）”的蛋白质，其有效抑制CD11 / CD18依赖性中性粒细胞功能。特别地，提供编码人LRF-1和LRF-2蛋白的分离的核酸分子。还提供了LRF-1和LRF-2多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。本发明还涉及用于鉴定LRF-1或LRF-2活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统或其他LRF-1或LRF-2相关疾病的诊断方法以及用于治疗这种疾病的治疗方法。

58. 发明申请

US20050090436A1 Human tumor necrosis factor receptors TR21 and TR22 审中-公开
标题翻译：人肿瘤坏死因子受体TR21和TR22
公开(公告)号：US20050090436A1
公开(公告)日：2005-04-28
申请号：US10620562
申请日：2003-07-17
申请人： Zhizhen Zeng , Steven Ruben , Craig Rosen
发明人： Zhizhen Zeng , Steven Ruben , Craig Rosen
IPC分类号： A61K38/00 , A61K38/17 , A61P29/00 , C07K14/47 , C07K14/715 , C07K16/28 , C07H21/04
CPC分类号： C07K14/7151 , A61K38/00 , A61K2039/505 , C07K16/2878 , C07K2317/622 , C07K2319/30 , G01N2333/70578
摘要： The present invention relates to two novel proteins, TR21 and TR22, which are members of the tumor necrosis factor (TNF) receptor. In particular, isolated nucleic acid molecules are provided encoding the human TR21 and TR22 protein. TR21 and TR22 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR21 and TR22 activity; and methods of treating immune disorders by administering TR21 and TR22 polynucleotides, polypeptides, agonists, and antagonists.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体成员的两种新型蛋白质TR21和TR22。特别地，提供编码人TR21和TR22蛋白的分离的核酸分子。还提供TR21和TR22多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定TR21和TR22活性的激动剂和拮抗剂的筛选方法; 以及通过施用TR21和TR22多核苷酸，多肽，激动剂和拮抗剂来治疗免疫疾病的方法。

59. 发明申请

US20080004432A1 HEMCM42 antibodies 有权
标题翻译： HEMCM42抗体
公开(公告)号：US20080004432A1
公开(公告)日：2008-01-03
申请号：US11801040
申请日：2007-05-07
申请人： Steven Ruben , Craig Rosen , Gregory Endress
发明人： Steven Ruben , Craig Rosen , Gregory Endress
IPC分类号： C07K16/00 , C07K16/18
CPC分类号： C07K14/47 , A61K38/00 , C07K16/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

60. 发明申请

US20050164366A1 Tissue plasminogen activator-like protease 审中-公开
标题翻译：组织纤溶酶原激活物样蛋白酶
公开(公告)号：US20050164366A1
公开(公告)日：2005-07-28
申请号：US11035988
申请日：2005-01-18
申请人： Paul Moore , Steven Ruben , Reinhard Ebner
发明人： Paul Moore , Steven Ruben , Reinhard Ebner
IPC分类号： C12N15/09 , A61K38/00 , A61P7/02 , A61P9/00 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/55 , C07H21/04 , C07K16/40
CPC分类号： C12N9/6421 , A61K38/00 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP protein. t-PALP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of t-PALP activity. Also provided are diagnostic methods for detecting circulatory system-related disorders and therapeutic methods for treating circulatory system-related disorders.
摘要翻译：本发明涉及一种作为丝氨酸蛋白酶家族成员的新型t-PALP蛋白。特别地，提供编码人t-PALP蛋白的分离的核酸分子。还提供t-PALP多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定t-PALP活性的激动剂和拮抗剂的筛选方法。还提供了用于检测循环系统相关疾病的诊断方法和用于治疗循环系统相关疾病的治疗方法。

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