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51. 发明申请

US20080058349A1 New Compounds 318 审中-公开
标题翻译：新化合物318
公开(公告)号：US20080058349A1
公开(公告)日：2008-03-06
申请号：US11761120
申请日：2007-06-11
申请人： Stefan Berg , Jorg Holenz , Katharina Hogdin , Jacob Kihlstrom , Karin Kolmodin , Johan Lindstrom , Niklas Plobeck , Didier Rotticci , Fernando Sehgelmeble , Maria Wirstam
发明人： Stefan Berg , Jorg Holenz , Katharina Hogdin , Jacob Kihlstrom , Karin Kolmodin , Johan Lindstrom , Niklas Plobeck , Didier Rotticci , Fernando Sehgelmeble , Maria Wirstam
IPC分类号： A61K31/519 , A61K31/4164 , A61P25/00 , A61P43/00 , C07D235/02 , C07D487/00
CPC分类号： C07D487/04
摘要： This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译：本发明涉及具有以下结构式I的新化合物及其药学上可接受的盐，组合物和使用方法。这些新化合物提供了认知障碍，阿尔茨海默病，神经变性和痴呆症的治疗或预防。

52. 发明授权

US06534652B2 Intermediates for the preparation of substituted 1,2,3,4-tetrahydronaphthalene derivatives 失效
标题翻译：用于制备取代的1,2,3,4-四氢萘衍生物的中间体
公开(公告)号：US06534652B2
公开(公告)日：2003-03-18
申请号：US09902123
申请日：2001-07-10
申请人： Stefan Berg , Svante Ross , Seth-Olov Thorberg
发明人： Stefan Berg , Svante Ross , Seth-Olov Thorberg
IPC分类号： C07D26530
CPC分类号： C07D295/192 , C07C237/24 , C07C2602/10 , C07D295/135 , C07D295/155 , C07D295/205
摘要： The present invention relates to new piperidyl- or piperazinyl-substituted-1,2,3,4-tetrahydronaphthalene derivatives having the formula I wherein X is N or CH; Y is NR2CH2, CH2—NR2, NR2—CO, CO—NR2 or NR2SO2 wherein R2 is H or C1-C6 alkyl; R1 is H, C1-C6 alkyl or C3-C6 cycloalkyl; R3 is C1-C6 alkyl, C3-C6 cycloalkyl or (CH2)n-aryl, wherein aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted n is 0-4; R9 is C1-C6 alkyl, C3-C6 cycloalkyl OCF3, OCHF2, OCH2F, halogen, CN, CF3, OH, C1-C6 alkoxy, C1-C6 alkoxy-C1-C6 alkyl, NR6R7, SO3CH3, SO3CF3, SO2NR6R7, an unsubstituted or substituted heterocyclic or heteroaromatic ring containing one or two heteroatoms selected from N and O, wherein the substituent(s) is(are) C1-C6 alkyl; or COR8; wherein R6, R7 and R8 are as defined above, as (R)- enantiomers, (S)-enantiomers or racemates in the form of a free base or pharmaceutically acceptable salts thereof, a process for their preparation, pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds in therapy.
摘要翻译：本发明涉及具有式I的新的哌啶基或哌嗪基取代的-1,2,3,4-四氢萘衍生物，其中X是N或CH; Y是NR2CH2，CH2-NR2，NR2-CO，CO-NR2或NR2SO2，其中 R2是H或C1-C6烷基; R1是H，C1-C6烷基或C3-C6环烷基; R3是C1-C6烷基，C3-C6环烷基或（CH2）n-芳基，其中芳基是苯基或杂芳环含有一个或两个选自N，O和S的杂原子，其可以是单取代或二取代的是0-4; R9是C1-C6烷基，C3-C6环烷基OCF3，OCHF2，OCH2F，卤素，CN，CF3， OH，C1-C6烷氧基，C1-C6烷氧基-C1-C6烷基，NR6R7，SO3CH3，SO3CF3，SO2NR6R7，含有一个或两个选自N和O的杂原子的未取代或取代的杂环或杂芳环，是（C 1 -C 6）烷基; 或COR8; 其中R6，R7和R8如上定义，为游离碱形式的（R） - 对映异构体，（S） - 对映异构体或外消旋物或其药学上可接受的盐，其制备方法，含有所述治疗活性的药物组合物化合物和所述活性化合物在治疗中的用途。

53. 发明授权

US6159970A Combination of a monoamine oxidase inhibitor and a h5-HT.sub.1B antagonist or partial agonist 失效
标题翻译：单胺氧化酶抑制剂和h5-HT1B拮抗剂或部分激动剂的组合
公开(公告)号：US6159970A
公开(公告)日：2000-12-12
申请号：US171578
申请日：1998-10-21
申请人： Stefan Berg , Svante Ross , Seth-Olov Thorberg
发明人： Stefan Berg , Svante Ross , Seth-Olov Thorberg
IPC分类号： A61K45/00 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5355 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , A61K31/135 , A61K31/50
CPC分类号： A61K31/495 , A61K31/535 , A61K31/15 , A61K2300/00
摘要： The invention relates to a combination of a first component (a) which is a monoamine oxidase inhibitor and a second component (b) which is selective h5-HT.sub.1B antagonist or partial agonist having the formula I ##STR1## wherein X is CH.sub.2, O; Y is CONH, NHCO;R.sub.1 is H, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl;R.sub.2 is H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halogen;R.sub.3 is ##STR2## R.sub.4 and R.sub.5 independently are H or C.sub.1 -C.sub.4 alkyl, as racemate, R-enantiomer or S-enantiomer, and said components (a) and (b) being in the form of free bases, solvates or pharmaceutically acceptable salts thereof, the preparation thereof, pharmaceutical formulations containing said combination, use of and method of treatment of affective disorders such as depression, anxiety and OCD with said combination as well as a kit containing said combination.
摘要翻译： PCT No.PCT / SE98 / 01602 Sec。 371日期：1998年10月21日 102（e）1998年10月21日PCT PCT 1998年9月9日PCT公布。出版物WO99 / 13878 日期1999年3月25日本发明涉及作为单胺氧化酶抑制剂的第一组分（a）和作为选择性h5-HT1B拮抗剂的第二组分（b）或其中X为CH 2的具有式I的部分激动剂的组合， O; Y为CONH，NHCO; R1是H，C1-C6烷基，C3-C6环烷基; R2是H，C1-C6烷基，C1-C6烷氧基，卤素; R 3是R 4和R 5独立地是H或C 1 -C 4烷基，作为外消旋物，R-对映体或S-对映异构体，所述组分（a）和（b）是游离碱，溶剂合物或其药学上可接受的盐，其制备方法，含有所述组合的药物制剂，使用和使用所述组合治疗情感障碍如抑郁症，焦虑和OCD的方法以及含有所述组合的试剂盒。

54. 发明授权

US08492584B2 Process and apparatus for oxidizing organic compounds 有权
标题翻译：氧化有机化合物的方法和设备
公开(公告)号：US08492584B2
公开(公告)日：2013-07-23
申请号：US12674466
申请日：2008-08-18
申请人： Joaquim Henrique Teles , Steffen Oehlenschläger , Kai Gumlich , Martin Schäfer , Stephan Lamm , Stefan Berg , Michael Nilles , Hans-Peter Schildberg , Tilo John , Peter Zehner
发明人： Joaquim Henrique Teles , Steffen Oehlenschläger , Kai Gumlich , Martin Schäfer , Stephan Lamm , Stefan Berg , Michael Nilles , Hans-Peter Schildberg , Tilo John , Peter Zehner
IPC分类号： C07C51/215
CPC分类号： C07C51/235 , Y02P20/582 , C07C53/126 , C07C53/122
摘要： The invention relates to a process for oxidizing at least one organic substance with oxygen, which comprises the following steps: (a) adding the at least one organic substance as a liquid and an oxygenous gas stream to a first reaction stage to form a reaction mixture, at least some of the oxygen reacting with the organic compound to form a reaction product, (b) adding the reaction mixture from the first reaction stage to an adiabatically operated reaction stage in which the unconverted organic substance reacts further at least partly to give the product. The invention further relates to an apparatus for performing the process.
摘要翻译：本发明涉及用氧氧化至少一种有机物质的方法，其包括以下步骤：（a）将至少一种有机物质作为液体和含氧气流加入到第一反应阶段以形成反应混合物，至少一些氧与有机化合物反应以形成反应产物，（b）将反应混合物从第一反应阶段加入至绝热操作的反应阶段，其中未转化的有机物质至少部分地进一步反应，得到产品。本发明还涉及一种用于执行该过程的装置。

55. 发明授权

US08251676B2 Axial-flow fan for a vehicle radiator 有权
标题翻译：用于车辆散热器的轴流风扇
公开(公告)号：US08251676B2
公开(公告)日：2012-08-28
申请号：US12515960
申请日：2007-11-15
申请人： Karl-Heinz Fleischmann , Stefan Berg , Alexander Gass
发明人： Karl-Heinz Fleischmann , Stefan Berg , Alexander Gass
IPC分类号： F04B17/00 , F04B35/00 , F04B39/06 , F04B39/02 , H02K9/00 , H02K9/06 , F01D5/06 , F01D1/04 , F03B3/04 , F03D11/00 , F04D3/00 , F04D19/00 , F04D29/32
CPC分类号： F04D25/082
摘要： An axial-flow fan for a vehicle radiator includes a fan wheel that delivers the main air flow and is driven by a hub motor coupled to the fan wheel. The vehicle radiator is on the intake side of the fan wheel, the hub motor during operation is cooled by a secondary air flow, and the cooling air flow of the hub motor flowing out from an air outlet opening is on the intake side in the hub area of the fan wheel. An air baffle device including a propeller is assigned to the hub motor and the cooling air flow passing through the air baffle device is led out of the air outlet opening, avoiding disturbances of the main air flow delivered by the fan wheel.
摘要翻译：用于车辆散热器的轴流风扇包括传递主空气流并由耦合到风扇叶轮的轮毂马达驱动的风扇叶轮。车辆散热器位于风扇轮的进气侧，运转中的轮毂电机被二次空气流冷却，从排气口流出的轮毂电机的冷却风流在轮毂的进气侧风扇轮的区域。包括螺旋桨的空气挡板装置被分配给轮毂马达，并且通过空气挡板装置的冷却空气流从出气口引出，从而避免由风扇轮传递的主空气流的干扰。

56. 发明授权

US07761600B2 Method and apparatus for distributing application server addresses in an IMS 有权
标题翻译：在IMS中分发应用服务器地址的方法和装置
公开(公告)号：US07761600B2
公开(公告)日：2010-07-20
申请号：US11995879
申请日：2005-08-15
申请人： Stephen Terrill , Bo Åström , Hubert Przybysz , Anders Ryde , Stefan Berg
发明人： Stephen Terrill , Bo Åström , Hubert Przybysz , Anders Ryde , Stefan Berg
IPC分类号： G06F15/16
CPC分类号： H04L29/12009 , H04L29/12188 , H04L61/1588 , H04L65/1016 , H04L65/4076 , H04W8/04 , H04W80/00
摘要： A method of distributing application server addresses in an IP Multimedia Subsystem. Upon allocation of an application server to a subscriber, the allocated or another application server sends at least one application server address to a Home Subscriber Server (HSS). The HSS stores the address(es) in association with the subscriber identity and sends the address(es) to a Serving Call/Session State Control Function (S-CSCF) allocated to the subscriber. The S-CSCF caches the address(es) in association with the subscriber identity and uses the address(es) to send subscriber-related messages to the allocated application server.
摘要翻译：一种在IP多媒体子系统中分发应用服务器地址的方法。在将应用服务器分配给用户时，所分配的或另一个应用服务器向归属订户服务器（HSS）发送至少一个应用服务器地址。 HSS存储与用户身份相关联的地址，并将地址发送到分配给用户的服务呼叫/会话状态控制功能（S-CSCF）。 S-CSCF缓存与订户身份相关联的地址，并使用该地址向用户分配的应用服务器发送与订户相关的消息。

57. 发明申请

US20080319948A1 Xml Document Manager Server Method and Apparatus 审中-公开
标题翻译： Xml Document Manager服务器方法和设备
公开(公告)号：US20080319948A1
公开(公告)日：2008-12-25
申请号：US12097577
申请日：2005-12-16
申请人： Stefan Berg , Bo Astrom , Christer Boberg , Anders Ryde , Stephen Terrill , Hubert Przybysz
发明人： Stefan Berg , Bo Astrom , Christer Boberg , Anders Ryde , Stephen Terrill , Hubert Przybysz
IPC分类号： G06F17/30 , G06F7/06 , G06F15/16
CPC分类号： G06F16/80
摘要： A method is disclosed of providing an XML Document Manager Server function to an XML Document Manager Client (2-1). The XML Document Manager Server function is enabled by a database component for storing at least one XML document and a logic component for causing at least one operation to be performed on one or more of the at least one XML documents. In the method, the logic component is provided by a first network entity (60-1), with which the XML Document Manager Client (2-1) communicates directly or indirectly to receive the XML Document Manager Server function, and the database component is provided by a second network entity (70) different to the first network entity (60-1).
摘要翻译：公开了一种向XML文档管理器客户机（2-1）提供XML文档管理器服务器功能的方法。 XML文档管理器服务器功能由数据库组件启用，用于存储至少一个XML文档和用于使所述至少一个XML文档中的一个或多个XML文档执行至少一个操作的逻辑组件。在该方法中，逻辑组件由第一网络实体（60-1）提供，XML文档管理器客户端（2-1）直接或间接地与之通信以接收XML文档管理器服务器功能，数据库组件由与第一网络实体（60-1）不同的第二网络实体（70）提供。

58. 发明申请

US20080232352A1 Method and Apparatus for Distributing Application Server Addresses in an Ims 有权
标题翻译：在Ims中分发应用服务器地址的方法和设备
公开(公告)号：US20080232352A1
公开(公告)日：2008-09-25
申请号：US11995879
申请日：2005-08-15
申请人： Stephen Terrill , Bo Astrom , Hubert Przybysz , Anders Ryde , Stefan Berg
发明人： Stephen Terrill , Bo Astrom , Hubert Przybysz , Anders Ryde , Stefan Berg
IPC分类号： H04L12/66
CPC分类号： H04L29/12009 , H04L29/12188 , H04L61/1588 , H04L65/1016 , H04L65/4076 , H04W8/04 , H04W80/00
摘要： A method of distributing application server addresses in an IP Multimedia Subsystem. Upon allocation of an application server to a subscriber, the allocated or another application server sends at least one application server address to a Home Subscriber Server (HSS). The HSS stores the address(es) in association with the subscriber identity and sends the address(es) to a Serving Call/Session State Control Function (S-CSCF) allocated to the subscriber. The S-CSCF caches the address(es) in association with the subscriber identity and uses the address(es) to send subscriber-related messages to the allocated application server.
摘要翻译：一种在IP多媒体子系统中分发应用服务器地址的方法。在将应用服务器分配给用户时，所分配的或另一个应用服务器向归属订户服务器（HSS）发送至少一个应用服务器地址。 HSS存储与用户身份相关联的地址，并将地址发送到分配给用户的服务呼叫/会话状态控制功能（S-CSCF）。 S-CSCF缓存与订户身份相关联的地址，并使用该地址向用户分配的应用服务器发送与订户相关的消息。

59. 发明申请

US20080215736A1 Method and Apparatus for Allocating a Server in an Ims Network 审中-公开
标题翻译：在Ims网络中分配服务器的方法和装置
公开(公告)号：US20080215736A1
公开(公告)日：2008-09-04
申请号：US11995652
申请日：2006-07-19
申请人： Bo Astrom , Anders Ryde , Stefan Berg , Hubert Przybysz , Stephen Terrill , Jesus-Javier Arauz-Rosado
发明人： Bo Astrom , Anders Ryde , Stefan Berg , Hubert Przybysz , Stephen Terrill , Jesus-Javier Arauz-Rosado
IPC分类号： G06F15/173
CPC分类号： H04L29/06027 , H04L65/1006 , H04L65/1016 , H04L65/1063 , H04L65/1073
摘要： A method, apparatus, and application server for dynamically allocating an application server within an IP Multimedia Subsystem (IMS). A Serving Call/Session Control Function (S-CSCF) receives a user request and queries a central database to determine whether the user is allocated to an application server. If so, the S-CSCF forwards the request to the allocated application server. If the user is not already allocated to a server, the S-CSCF allocates the user to an application server and forwards the request to the newly allocated application server. The S-CSCF or the newly allocated application server sends a request to the central database to record the allocation.
摘要翻译：一种用于在IP多媒体子系统（IMS）内动态分配应用服务器的方法，装置和应用服务器。服务呼叫/会话控制功能（S-CSCF）接收用户请求并查询中央数据库以确定用户是否被分配给应用服务器。如果是，则S-CSCF将该请求转发给所分配的应用服务器。如果用户尚未分配给服务器，则S-CSCF将用户分配给应用服务器，并将该请求转发给新分配的应用服务器。 S-CSCF或新分配的应用服务器向中央数据库发送请求以记录分配。

60. 发明申请

US20080212569A1 Method and Apparatus for Allocating Application Servers in an Ims 有权
标题翻译：在Ims中分配应用服务器的方法和设备
公开(公告)号：US20080212569A1
公开(公告)日：2008-09-04
申请号：US11995871
申请日：2005-08-15
申请人： Stephen Terrill , Bo Astrom , Hubert Przybysz , Anders Ryde , Stefan Berg
发明人： Stephen Terrill , Bo Astrom , Hubert Przybysz , Anders Ryde , Stefan Berg
IPC分类号： H04L12/66 , H04L29/06
CPC分类号： H04L29/12009 , H04L29/12188 , H04L61/1588 , H04L65/1016 , H04L65/4076 , H04W8/04 , H04W80/00
摘要： A method, application server, and Serving Call/Session Control Function (S-CSCF) for allocating a SIP Application Server to a subscriber in an IP Multimedia Subsystem. A Home Subscriber Server (HSS) identifies for the subscriber, a set of provisioned initial filter criteria, which contains at least one generic SIP Application Server identity. The HSS sends the filter criteria to an S-CSCF allocated to the subscriber. The S-CSCF resolves the generic SIP Application Server identity into a plurality of application server addresses, with one of the addresses being allocated to the subscriber for use in provisioning a service to the subscriber. The S-CSCF caches the address allocated to the subscriber for subsequent use.
摘要翻译：一种用于向IP多媒体子系统中的用户分配SIP应用服务器的方法，应用服务器和服务呼叫/会话控制功能（S-CSCF）。归属订户服务器（HSS）为订户识别一组提供的初始过滤标准，其包含至少一个通用SIP应用服务器标识。 HSS将过滤标准发送给分配给用户的S-CSCF。 S-CSCF将通用SIP应用服务器身份解析为多个应用服务器地址，其中一个地址被分配给用户以用于向订户提供服务。 S-CSCF缓存分配给订户的地址以供后续使用。

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