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51. 发明申请

US20110224135A1 USE OF CONKUNITZIN-S1 FOR THE MODULATION OF GLUCOSE-INDUCED INSULIN SECRETION 审中-公开
标题翻译：用于调节葡萄糖诱导的胰岛素分泌的康宁嗪-S1
公开(公告)号：US20110224135A1
公开(公告)日：2011-09-15
申请号：US13057809
申请日：2009-08-10
申请人： Heinrich Terlau , Rocio Finol-Urdaneta , Stefan Becker , Walter Raasch
发明人： Heinrich Terlau , Rocio Finol-Urdaneta , Stefan Becker , Walter Raasch
IPC分类号： A61K38/17 , C07K14/435 , C12Q1/02 , C07K1/107 , A61P3/10 , A61P3/04 , A61P3/00 , A61P9/12
CPC分类号： C07K14/43504 , C07K14/8114
摘要： The present invention relates to a (poly)peptide or a peptidomimetic thereof having the biological activity of Conkunitzin-S1, wherein said (poly)peptide is selected from (a) a polypeptide comprising or having the amino acid sequence of SEQ ID NO: 1; (b) a polypeptide having at least 85% sequence identity to SEQ ID NO:1; or (c) a fragment of a) or b); wherein said (poly)peptide or peptidomimetic specifically modulates the activity of a channel having the activity of a Kv1.7 containing channel, for the treatment or prevention of metabolic diseases or conditions, or secondary diseases or conditions related to said metabolic diseases or conditions. The present invention furthermore relates to a method of screening for (poly)peptides derived from Conkunitzin-S1 suitable for specifically modulating the activity of a channel having the activity of a Kv1.7 containing channel, comprising: (a) altering the amino acid sequence of Conkunitzin-S1 represented by SEQ ID NO: 1 by deleting and/or inserting and/or replacing at least one amino acid; and (b) determining the modulatory effect of the (poly)peptide obtained in step (a) (i) on a channel having the activity of a Kv1.7 containing channel and (ii) on channels, preferably potassium channels, not having the activity of a Kv1.7 containing channel, which are optionally expressed on the same cell as the channel having the activity of a Kv1.7 containing channel.
摘要翻译：本发明涉及具有Conkunitzin-S1生物活性的（多）肽或其肽模拟物，其中所述（多）肽选自（a）包含或具有SEQ ID NO：1的氨基酸序列的多肽 ; （b）与SEQ ID NO：1具有至少85％序列同一性的多肽; 或（c）a）或b）的片段; 其中所述（多）肽或肽模拟物特异性调节具有Kv1.7含有通道活性的通道的活性，用于治疗或预防代谢疾病或病症，或与所述代谢疾病或病症有关的继发性疾病或病症。本发明还涉及一种筛选衍生自Conkunitzin-S1的（多）肽的方法，其适用于特异性调节含有Kv1.7含有通道活性的通道的活性，其包括：（a）改变氨基酸序列通过删除和/或插入和/或替换至少一个氨基酸的由SEQ ID NO：1表示的Conkunitzin-S1; （b）确定步骤（a）（i）中获得的（多）肽对具有Kv1.7含有通道活性的通道的调节作用，和（ii）在不具有包含Kv1.7的通道的活性，其任选地在与具有含有Kv1.7的通道的活性的通道相同的单元上表达。

52. 发明申请

US20100069532A1 PROCESS FOR PREPARING POLYMERIZABLE CARBOXYLIC ESTERS WITH ALKOXY GROUPS 审中-公开
标题翻译：用烷基聚合物制备可聚合羧酸酯的方法
公开(公告)号：US20100069532A1
公开(公告)日：2010-03-18
申请号：US12516628
申请日：2007-12-03
申请人： Paola Uribe Arocha , Joachim Pakusch , Stefan Becker , Thomas Goetz , Sylke Haremza , Rolf Gulden
发明人： Paola Uribe Arocha , Joachim Pakusch , Stefan Becker , Thomas Goetz , Sylke Haremza , Rolf Gulden
IPC分类号： C08K3/00 , C07C69/54 , C07C69/60 , C08F20/26 , C08F22/20
CPC分类号： C04B24/2647 , C04B2103/32 , C08F220/26 , C08G65/3324
摘要： A process for preparing free-radically polymerizable carboxylic esters by reacting ethyllenically unsaturated carboxylic acids, carboxylic anhydrides or carbonyl halides (referred to collectively as carboxylic acid component) with a hydroxyl compound composed of at least 60% by weight of C2 to C4 alkoxy groups (and referred to for short as polyalkoxy compound), which comprises said reacting taking place in the presence of a polymerization inhibitor and of a reducing agent.
摘要翻译：通过使不饱和羧酸，羧酸酐或羰基卤化物（统称为羧酸组分）与由至少60重量％的C 2至C 4烷氧基组成的羟基化合物反应制备可自由基聚合的羧酸酯的方法（简称为聚烷氧基化合物），其包括在聚合抑制剂和还原剂的存在下发生的所述反应。

53. 发明申请

US20090018240A1 Use of Water-Soluble or Water-Dispersible Polymers as Additives in Mineral Building Materials 审中-公开
标题翻译：使用水溶性或水分散性聚合物作为添加剂
公开(公告)号：US20090018240A1
公开(公告)日：2009-01-15
申请号：US10588194
申请日：2005-02-16
申请人： Stefan Becker , Ludwig Volkel , Thomas Gotz , Bernd Meyer-roscher , Markus Klumpe , Wolfgang Hansch , Arnold Burek , Stefanie Spilger
发明人： Stefan Becker , Ludwig Volkel , Thomas Gotz , Bernd Meyer-roscher , Markus Klumpe , Wolfgang Hansch , Arnold Burek , Stefanie Spilger
IPC分类号： C04B24/26 , C08G63/52
CPC分类号： C04B24/2647 , C04B24/26 , C04B24/2688 , C04B2103/408
摘要： The present invention relates to the use of water-soluble or water-dispersible polymers as additives in mineral building materials. The novel polymers are obtainable by polymerizing alkoxylated derivatives of 3-allyloxy-1,2-propanediol with ethylenically unsaturated mono- or dicarboxylic acids or the anhydrides, esters or mixtures thereof and, if appropriate, with one or more further ethylenically unsaturated monomers C.
摘要翻译：本发明涉及在矿物建筑材料中使用水溶性或水分散性聚合物作为添加剂。新型聚合物可通过聚合3-烯丙氧基-1,2-丙二醇与烯键式不饱和单羧酸或二羧酸的烷氧基化衍生物或其酸酐，酯或其混合物以及如果合适的话与一种或多种其它烯属不饱和单体C聚合而获得。

54. 发明申请

US20080275166A1 Method for Producing (Poly-C2-C4 Alkylene Glycol)-Mono(Meth)Acrylic Esters 有权
公开(公告)号：US20080275166A1
公开(公告)日：2008-11-06
申请号：US11574587
申请日：2005-09-02
申请人： Stefan Becker , Jorg Pastre , Joachim Pakusch , Thomas Gotz , Arnold Burek , Wolfgang Hansch , Stefanie Spilger
发明人： Stefan Becker , Jorg Pastre , Joachim Pakusch , Thomas Gotz , Arnold Burek , Wolfgang Hansch , Stefanie Spilger
IPC分类号： C04B24/28 , C08F4/30 , C08F120/08
CPC分类号： C08F299/065 , C08G65/3322
摘要： The present invention relates to a process for the preparation of poly-C2-C4-alkylene glycol monoacrylic acid esters and monomethacrylic acid esters, and a process for the preparation of copolymers of such poly-C2-C4-alkylene glycol mono(meth)acrylic acid esters with acrylic acid or methacrylic acid and the use of the polymers as a plasticizing additive in cement-containing preparations.The preparation of the poly-C2-C4-alkylene glycol monoacrylic acid esters and monomethacrylic acid esters is effected by reacting acrylic anhydride or methacrylic anhydride ((meth)acrylic anhydride A below) with a poly-C2-C4-alkylene glycol compound P carrying at least one OH group in the presence of a base, the base being selected from basic compounds which have a solubility in the poly-C2-C4-alkylene glycol compound P of not more than 10 g/l at 90° C., and the molar ratio of (meth)acrylic anhydride A to compound P (molar ratio A:P) being in the range from 1:1 to 1.095:1, preferably in the range from 1.005:1 to 1.09:1, in particular in the range from 1.01:1 to 1.085:1 and particularly preferably in the range from 1.02:1 to 1.08:1.The preparation of copolymers of (meth)acrylic acid with poly-C2-C4-alkylene glycol mono(meth)acrylic acid esters comprises: i) preparation of a poly-C2-C4-alkylene glycol mono(meth)acrylic acid ester by reacting (meth)acrylic anhydride A with a poly-C2-C4-alkylene glycol compound P carrying at least one OH group in the presence of a base by processes according to the invention, and ii) free radical copolymerization of the poly-C2-C4-alkylene glycol mono(meth)acrylic acid ester obtained in step i) with acrylic acid and/or methacrylic acid and, if appropriate, further ethylenically unsaturated monomers.

55. 发明申请

US20070191548A1 Polymers comprising diallylamines 审中-公开
标题翻译：包含二烯丙基胺的聚合物
公开(公告)号：US20070191548A1
公开(公告)日：2007-08-16
申请号：US10594959
申请日：2005-03-26
申请人： Lysander Chrisstoffels , Stefan Becker , Ludwig Volkel
发明人： Lysander Chrisstoffels , Stefan Becker , Ludwig Volkel
IPC分类号： C08F297/02
CPC分类号： A61K8/8182 , A61K8/817 , A61Q5/006 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/065 , A61Q5/12 , A61Q17/005 , A61Q17/04 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C08F8/44 , C08F226/04 , C08F226/10 , C08F226/12 , C08F226/00
摘要： The present invention relates to polymers which comprise, as monomeric building blocks, (poly)alkylene oxide-substituted diallylamines, ethylenically unsaturated monomers B, and, if appropriate, one or more further ethylenically unsaturated monomers and, if appropriate, crosslinkers, and to the use thereof as additives in cosmetic preparations.
摘要翻译：本发明涉及聚合物，其包含作为单体结构单元的（聚）环氧烷烃取代的二烯丙基胺，烯键式不饱和单体B，以及如果合适的话，一种或多种其它烯键式不饱和单体，以及如果合适的话，交联剂，以及其用作化妆品制剂中的添加剂。

56. 发明申请

US20060075585A1 Rylene dyes 失效
标题翻译：二烯染料
公开(公告)号：US20060075585A1
公开(公告)日：2006-04-13
申请号：US10522990
申请日：2003-07-25
申请人： Matthias Krieger , Arno Bohm , Lorenz Siggel , Stefan Becker , Klaus Mullen , Christopher Kohl
发明人： Matthias Krieger , Arno Bohm , Lorenz Siggel , Stefan Becker , Klaus Mullen , Christopher Kohl
IPC分类号： C09B49/00
CPC分类号： C09B5/62
摘要： Rylene dyes of the general formula I where the variables are defined as follows: R is hydrogen; optionally substituted C1-C30-alkyl, C5-C8-cycloalkyl, aryl or hetaryl; R′ is bromine; cyano; —NR32; optionally substituted aryloxy, arylthio, hetaryloxy or hetarylthio; optionally substituted C3-C18-alk-1-ynyl; X, Y are both hydrogen or together are a radical of the formula Ia n is 2, 3, 4 or additionally 1 when X and Y are a radical of the formula Ia; n′ is from 1 to 4; m is from 0 to 6.
摘要翻译：通式I的Rylene染料，其中变量定义如下：R是氢; 芳基或杂芳基;任选取代的C 1 -C 30 - 烷基，C 5 -C 8 - 环烷基，芳基或杂芳基; R'是溴; 氰基; -NR 3 3; 任选取代的芳氧基，芳硫基，杂芳氧基或杂芳硫基; 任选取代的C 3 -C 18 - 烷-1-基; 当X和Y是式Ia的基团时，X，Y都是氢或一起是式Ia n的基团是2,3,4或另外1， n'为1至4; m为0〜6。

57. 发明授权

US06916928B2 Functionalized perylene tetracarboxylic acid diimides 失效
标题翻译：官能化苝四羧酸二酰亚胺
公开(公告)号：US06916928B2
公开(公告)日：2005-07-12
申请号：US10343750
申请日：2001-08-11
申请人： Stefan Becker , Harm-Anton Klok , Juan Rodriguez-Hernandez , Falk Schuch , Klaus Müllen
发明人： Stefan Becker , Harm-Anton Klok , Juan Rodriguez-Hernandez , Falk Schuch , Klaus Müllen
IPC分类号： C08G73/06 , C07D471/06 , C08F2/44 , C08F4/00 , C08G63/685 , C08K5/00 , C09B5/62 , C09B69/10 , C07D471/02 , C08F2/00 , C09K11/06
CPC分类号： C07D471/06 , C08F4/00 , C08G63/6852 , C08K5/0041 , C09B5/62 , C09B69/102
摘要： The present invention relates to the use of functionalized perylene-3,4,9,10-tetracarboxylic acid diimides as initiator and/or co-reactant for polymerization reactions, to polymers prepared using the perylene-3,4,9,10-tetracarboxylic acid diimide compounds, to the use of these colored and/or fluorescent polymers, and to novel functionalized perylenetetracarboxylic acid diimides.
摘要翻译：本发明涉及使用官能化的苝-3,4,9,10-四羧酸二酰亚胺作为聚合反应的引发剂和/或共反应物，使用苝-3,4,9,10-四羧酸酸性二酰亚胺化合物，使用这些着色和/或荧光聚合物，以及新型官能化的苝四羧酸二酰亚胺。

58. 发明申请

US20050032948A1 Ethylene terpolymer waxes, their preparation and their use 审中-公开
标题翻译：乙烯三元共聚物蜡，其制备及其用途
公开(公告)号：US20050032948A1
公开(公告)日：2005-02-10
申请号：US10924053
申请日：2004-08-24
申请人： Andreas Fechtenkotter , Katrin Zeitz , Michael Ehle , Andreas Deckers , Stefan Becker
发明人： Andreas Fechtenkotter , Katrin Zeitz , Michael Ehle , Andreas Deckers , Stefan Becker
IPC分类号： B01F17/52 , B01F17/00 , C04B24/26 , C08F210/02 , C08F290/06 , C09G1/04 , C09G1/08 , C14C9/02 , C08L1/00
CPC分类号： C04B24/2647 , B01F17/0028 , C04B24/2611 , C04B24/2688 , C08F210/02 , C09G1/08 , C14C9/02 , C08F220/28 , C08F220/04 , C08F2500/17
摘要： An ethylene terpolymer wax comprising, as monomer building blocks, from 35 to 95% by weight of ethylene, from 0.1 to 40% by weight of at least one ester of the formula I where R1 is selected from hydrogen, C1-C10-alkyl, C3-C12-cycloalkyl and C6-C14-aryl R2 are identical or different and are selected from hydrogen and C1-C10-alkyl, R3 is selected from C1-C10-alkyl, C3-C12-cycloalkyl and C6-C14-aryl and n is an integer from 2 to 100, and from 0.1 to 25% by weight of at least one carboxylic acid of the formula II where R4 is selected from hydrogen, C1-C10-alkyl, C3-C12-cycloalkyl and C6-C14-aryl.
摘要翻译：一种乙烯三元共聚物蜡，其包含作为单体结构单元的35至95重量％的乙烯，0.1-40重量％的至少一种式I的酯，其中R 1选自氢，C 1 -C 10 - 烷基，C 3 -C 12 - 环烷基和C 6 -C 14 - 芳基R 2相同或不同，并且选自氢和C 1 -C 10 - 烷基，R 3选自C 1 -C 10 - 烷基，C 3 -C 12 环烷基和C 6 -C 14 - 芳基，n是2至100的整数，和0.1至25重量％的至少一种式II的羧酸，其中R 4选自氢，C 1 -C 10 - 烷基，C 3 -C 12 - 环烷基和C 6 -C 14 - 芳基。

59. 发明授权

US06606508B2 Method for handling phone numbers in mobile station and mobile station 有权
标题翻译：移动台和移动台处理电话号码的方法
公开(公告)号：US06606508B2
公开(公告)日：2003-08-12
申请号：US09141062
申请日：1998-08-27
申请人： Stefan Becker , Juha Kurkilahti
发明人： Stefan Becker , Juha Kurkilahti
IPC分类号： H04B138
CPC分类号： H04M19/041 , H04M1/57 , H04M1/663 , H04M1/72519
摘要： The invention relates to a method for handling phone numbers in a mobile station and a mobile station. According to the invention, numbers (3a, 3b, 3c) are handled in groups (1a, 1b, 1c) which have different attributes (2a, 2b, 2c). The attributes (2a, 2b, 2c) mean e.g. rights to generate a ringing tone. In a certain operating mode, only a call belonging to a group (1a, 1b, 1c) which in that operating mode has the right to call the mobile station, will generate a ringing tone. The attributes (2a, 2b, 2c) also mean group-specific ringing tones which represent the type of the group (1a, 1b, 1c). The attributes (2a, 2b, 2c) further mean symbols on the display of a mobile station.
摘要翻译：本发明涉及一种在移动台和移动台中处理电话号码的方法。根据本发明，数字（3a，3b，3c）以具有不同属性（2a，2b，2c）的组（1a，1b，1c）处理。属性（2a，2b，2c）表示例如。生成铃声的权利。在某种操作模式中，只有在该操作模式中有权呼叫移动台的组（1a，1b，1c）的呼叫将产生振铃音。属性（2a，2b，2c）也表示代表组（1a，1b，1c）的类型的组专用振铃音。属性（2a，2b，2c）还表示移动台的显示上的符号。

60. 发明授权

US11526560B2 Backwards-compatible method for retrieving data stored in a database using versioned reference perspectives of edges 有权
公开(公告)号：US11526560B2
公开(公告)日：2022-12-13
申请号：US16249541
申请日：2019-01-16
申请人： Stefan Becker
发明人： Stefan Becker
IPC分类号： G06F16/907 , G06F16/2458 , G06F16/21 , G06F16/22 , G06F16/25
摘要： As typical databases evolve and the schema defining the stored data changes, difficulties arise in interfacing with the database and compatibility to applications may be lost. Provided for are methods for retrieving data stored in a database using versioned reference perspectives of edges, which define relationships between nodes. The methods provide for backwards-compatibility in accessing node-data stored in accordance with a pre-defined schema based upon a request including a version identifier. Also provided for are backend systems, frontend systems, and industrial machines for the manipulation of work products.

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