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    • 51. 发明申请
    • DEVICES, METHODS, AND SYSTEMS FOR ACCESSING NATIVE NEURONS THROUGH ARTIFICIAL NEURAL MEDIATORS (ANMS)
    • 通过人工神经介质(ANMS)接受原始神经元的装置,方法和系统
    • US20080299201A1
    • 2008-12-04
    • US12177606
    • 2008-07-22
    • James R. KozloskiStanislav Polonsky
    • James R. KozloskiStanislav Polonsky
    • A61K9/00C12Q1/02A61K38/02A61N1/00A61K31/7088
    • A45D27/46
    • The present invention relates to devices, methods, and systems for accessing native neurons in the nervous system of an animal. Specifically, one or more artificial neural mediators (ANMs) each comprising a neural cell are first formed, and neural connection is then established between the ANMs and one or more native neurons or collections of native neurons located in the nervous system. In this manner, the native neurons or collections of native neurons can be assessed through the ANMs. The neural connection between the ANMs and the native neurons is preferably established by guided axonal growth in the present invention, i.e., either an axon from one of the ANMs is grown into contact with one of the native neurons or collections of native neurons, or an axon from one of the native neurons or collections of native neurons is grown into contact with one of the ANMs.
    • 本发明涉及用于访问动物神经系统中的天生神经元的装置,方法和系统。 具体地,首先形成每个包含神经细胞的一个或多个人造神经介质(ANM),然后在ANM和位于神经系统中的一个或多个天然神经元或天然神经元的集合之间建立神经连接。 以这种方式,天然神经元或天然神经元的集合可以通过ANM进行评估。 ANM和天然神经元之间的神经连接优选通过本发明中的引导轴突生长来建立,即,来自一个ANM的轴突生长成与天然神经元之一或天然神经元的集合接触,或 来自其中一个天然神经元或天然神经元的集合的轴突生长成与ANM之一接触。
    • 53. 发明申请
    • Devices, methods, and systems for accessing native neurons through artificial neural mediators (ANMs)
    • 通过人造神经介质(ANM)访问本机神经元的设备,方法和系统
    • US20080014177A1
    • 2008-01-17
    • US11487810
    • 2006-07-17
    • James R. KozloskiStanislav Polonsky
    • James R. KozloskiStanislav Polonsky
    • A61K35/30C12N5/08
    • C12N5/0619A61K35/30A61L31/005
    • The present invention relates to devices, methods, and systems for accessing native neurons in the nervous system of an animal. Specifically, one or more artificial neural mediators (ANMs) each comprising a neural cell are first formed, and neural connection is then established between the ANMs and one or more native neurons or collections of native neurons located in the nervous system. In this manner, the native neurons or collections of native neurons can be assessed through the ANMs. The neural connection between the ANMs and the native neurons is preferably established by guided axonal growth in the present invention, i.e., either an axon from one of the ANMs is grown into contact with one of the native neurons or collections of native neurons, or an axon from one of the native neurons or collections of native neurons is grown into contact with one of the ANMs.
    • 本发明涉及用于访问动物神经系统中的天生神经元的装置,方法和系统。 具体地,首先形成每个包含神经细胞的一个或多个人造神经介质(ANM),然后在ANM和位于神经系统中的一个或多个天然神经元或天然神经元的集合之间建立神经连接。 以这种方式,天然神经元或天然神经元的集合可以通过ANM进行评估。 ANM和天然神经元之间的神经连接优选通过本发明中的引导轴突生长来建立,即,来自一个ANM的轴突生长成与天然神经元之一或天然神经元的集合接触,或 来自其中一个天然神经元或天然神经元的集合的轴突生长成与ANM之一接触。