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51. 发明申请

US20050277668A1 Chemokine receptor binding compounds 失效
标题翻译：趋化因子受体结合化合物
公开(公告)号：US20050277668A1
公开(公告)日：2005-12-15
申请号：US11152589
申请日：2005-06-14
申请人： Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
发明人： Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
IPC分类号： A61K31/4545 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C12N20060101 , C07D41/14
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D413/14
摘要： The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译：本发明涉及趋化因子受体结合化合物，药物组合物及其用途。更具体地，本发明涉及趋化因子受体活性的调节剂，优选CCR5的调节剂。这些化合物表现出对人体免疫缺陷病毒（HIV）感染靶细胞的保护作用。

52. 发明申请

US20050143205A1 Softball with great resilient coefficient 审中-公开
标题翻译：弹球系数很高的垒球
公开(公告)号：US20050143205A1
公开(公告)日：2005-06-30
申请号：US10746693
申请日：2003-12-29
申请人： Wen Yang
发明人： Wen Yang
IPC分类号： A63B37/02
CPC分类号： A63B37/02 , A63B2102/182
摘要： A softball associated with the game of softball comprises a core, an inner cover and an outer cover. The core is made by a mold and of either a cork material or a polyurethane material. The inner cover surrounds said core, being made of a material different from the core and selected from the group of a cork-type material and a polyurethane-type material. The outer cover surrounds both the core and the inner cover. The softball thus formed can sustain substantially constant hardness against variations in temperature and humidity. Further, by adjusting the ratio of thickness of the core and the inner cover, the softball can attain a higher coefficient of resilience as required.
摘要翻译：与垒球游戏相关联的垒球包括铁芯，内盖和外盖。芯由模具和软木材料或聚氨酯材料制成。内盖围绕所述芯，由不同于芯的材料制成，并且选自软木型材料和聚氨酯类材料。外盖包围芯和内盖。这样形成的垒球可以抵抗温度和湿度的变化来维持基本上恒定的硬度。此外，通过调整芯部和内罩的厚度比，垒球可以根据需要获得更高的弹性系数。

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