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51. 发明授权

US07098030B2 Polyampholytes for delivering polyions to a cell 有权
公开(公告)号：US07098030B2
公开(公告)日：2006-08-29
申请号：US10899509
申请日：2004-07-26
申请人： David B. Rozema , Vladimir G. Budker , James E. Hagstrom , Vladimir Trubetskoy , Jon A. Wolff , Sean D. Monahan , Paul M. Slattum
发明人： David B. Rozema , Vladimir G. Budker , James E. Hagstrom , Vladimir Trubetskoy , Jon A. Wolff , Sean D. Monahan , Paul M. Slattum
IPC分类号： C12N15/88
CPC分类号： C12N15/88 , A61K47/58 , A61K47/59 , A61K47/645
摘要： An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.

52. 发明授权

US07033607B2 pH-titratable polyampholytes for delivering polyions to a cell 失效
公开(公告)号：US07033607B2
公开(公告)日：2006-04-25
申请号：US10095789
申请日：2002-03-11
申请人： Vladimir S. Trubetskoy , James E. Hagstrom , Vladimir G. Budker , Jon A. Wolff , David B. Rozema , Sean D. Monahan
发明人： Vladimir S. Trubetskoy , James E. Hagstrom , Vladimir G. Budker , Jon A. Wolff , David B. Rozema , Sean D. Monahan
IPC分类号： A61K9/127 , A61K31/713
CPC分类号： C12N15/88 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041 , C12N15/87
摘要： A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.

53. 发明授权

US06977258B2 Piperazine derivatives and their use as anti-inflammatory agents 失效
标题翻译：哌嗪衍生物及其作为抗炎剂的用途
公开(公告)号：US06977258B2
公开(公告)日：2005-12-20
申请号：US10347530
申请日：2003-01-17
申请人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
发明人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
IPC分类号： A61K31/4965 , A61K31/497 , A61P29/00 , A61P43/00 , C07D241/04 , C07D261/14 , C07D295/185 , C07D307/52 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , A61K31/495
CPC分类号： C07D295/185 , C07D215/18 , C07D241/04 , C07D241/38 , C07D261/14 , C07D295/192 , C07D307/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12
摘要： This invention is directed to acyl piperazine derivatives of formula (Ia): wherein R1a, R2, R3, R4, R5 and R6 are defined herein, which are useful as anti-inflammatory agents. This invention is also directed to other acyl piperazine derivatives, pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
摘要翻译：本发明涉及式（Ia）的酰基哌嗪衍生物：其中R 1a，R 2，R 3，R 4，本文定义的R 5和R 6是有用的抗炎剂。本发明还涉及其它酰基哌嗪衍生物，含有本发明化合物的药物组合物，以及使用该化合物治疗人类炎性疾病的方法。

54. 发明授权

US06555537B2 Piperazine derivatives and their use as anti-inflammatory agents 失效
标题翻译：哌嗪衍生物及其作为抗炎剂的用途
公开(公告)号：US06555537B2
公开(公告)日：2003-04-29
申请号：US09726808
申请日：2000-11-29
申请人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
发明人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
IPC分类号： A61K31495
CPC分类号： C07D295/185 , C07D215/18 , C07D241/04 , C07D241/38 , C07D261/14 , C07D295/192 , C07D307/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12
摘要： This invention is directed to acyl piperazine derivatives, for example, of the following formula (Ia): wherein R1a, R2, R3, R4, R5, and R6 are described herein. These derivatives are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the derivatives, and methods of using the derivatives to treat inflammatory disorders in humans.
摘要翻译：本发明涉及例如下式（Ia）的酰基哌嗪衍生物：其中R1a，R2，R3，R4，R5和R6如本文所述。这些衍生物可用作抗炎剂。本发明还涉及含有衍生物的药物组合物，以及使用该衍生物治疗人类炎性疾病的方法。

55. 发明授权

US06534509B1 Piperazine derivatives and their use as anti-inflammatory agents 失效
标题翻译：哌嗪衍生物及其作为抗炎剂的用途
公开(公告)号：US06534509B1
公开(公告)日：2003-03-18
申请号：US09713881
申请日：2000-11-15
申请人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
发明人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Kenneth J. Shaw , Guo Ping Wei , Wei Xu , Zuchun Zhao , Wei Zheng
IPC分类号： A61K31495
CPC分类号： C07D295/185 , C07D215/18 , C07D241/04 , C07D241/38 , C07D261/14 , C07D295/192 , C07D307/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12
摘要： This invention is directed to acyl piperazine derivatives, for example, of the following formula (1a): wherein R1a, R2, R3, R4, R5, and R6are descried herein. These derivatives are useful as anti-inflammatory agents. This invention is also directed to pharmacetutical compostions containing the derivatives, and methods of using the derivatives to treat inflammatory disorders in humans.
摘要翻译：本发明涉及例如下式（1a）的酰基哌嗪衍生物：其中R1a，R2，R3，R4，R5和R6如本文所述。这些衍生物可用作抗炎剂。本发明还涉及含有衍生物的药物组合物，以及使用衍生物治疗人类炎症性疾病的方法。

56. 发明授权

US06207665B1 Piperazine derivatives and their use as anti-inflammatory agents 失效
标题翻译：哌嗪衍生物及其作为抗炎剂的用途
公开(公告)号：US06207665B1
公开(公告)日：2001-03-27
申请号：US09094397
申请日：1998-06-09
申请人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Guo Ping Wei , Wei Xu , Wei Zheng
发明人： John G. Bauman , Brad O. Buckman , Ameen F. Ghannam , Joseph E. Hesselgesser , Richard Horuk , Imadul Islam , Meina Liang , Karen B. May , Sean D. Monahan , Michael M. Morrissey , Howard P. Ng , Guo Ping Wei , Wei Xu , Wei Zheng
IPC分类号： A61K315377
CPC分类号： C07D295/185 , C07D215/18 , C07D241/04 , C07D241/38 , C07D261/14 , C07D295/192 , C07D307/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12
摘要： This invention is directed to acyl piperazine derivatives of formula (Ia): wherein R1a, R2, R3, R4, R5 and R6 are defined herein, which are useful as anti-inflammatory agents. This invention is also directed to other acyl piperazine derivatives, pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
摘要翻译：本发明涉及式（Ia）的酰基哌嗪衍生物：其中R1a，R2，R3，R4，R5和R6如本文所定义，其可用作抗炎剂。本发明还涉及其它酰基哌嗪衍生物，含有本发明化合物的药物组合物，以及使用该化合物治疗人类炎性疾病的方法。

57. 发明授权

US5866036A High tilt ferroelectric liquid crystal compounds and compositions 失效
公开(公告)号：US5866036A
公开(公告)日：1999-02-02
申请号：US190733
申请日：1994-02-02
申请人： Michael D. Wand , Rohini T. Vohra , David M. Walba , Sean D. Monahan
发明人： Michael D. Wand , Rohini T. Vohra , David M. Walba , Sean D. Monahan
IPC分类号： C07D303/23 , C09K19/18 , C09K19/34 , C07D239/02 , C07D303/12
CPC分类号： C09K19/18 , C09K19/3411
摘要： Chiral nonracemic molecules which are useful as high tilt, high polarization and/or high birefringence FLC materials or are useful as components of such FLC materials and which have the following general structure are provided:RO--(Ph.sub.1).sub.m --(A).sub.a --(Ph.sub.2).sub.n --(B).sub.b --(Ph.sub.3).sub.p --Twhere Ph.sub.1, Ph.sub.2 and Ph.sub.3 are, independently of one another, para-substituted aromatic ring groups selected from the group consisting of phenyl, monohalophenyl, pyridine, pyrimidine, diazine, or pyridizine; where m, n and p are either 0, 1 or 2, such that m+n+p=2 or 3; where A or B are either a triple bond or a --COO-- or --OOC-- group; where a and b are independently of one another either 1 or 0; where R is a branched alkyl or alkene group having from three to twenty carbon atoms; andwhere T is selected from the group consisting of --OR', --COOR', OR", COOR", or OOCR'": where R' is an alkyl, alkene, ether, thioether, or alkylsilyl group having from three to twenty carbon atoms wherein non-adjacent carbon atoms can be replaced with a double bond, --O--, --S--, or an (CH.sub.3).sub.2 --Si-- group; where R" is 2,3-alkylepoxide having four to twenty carbon atoms; where R'" is an alkyl, alkene or a monohaloalkyl group having from three to twenty carbon atoms and wherein at least one of R or T is a chiral nonracemic tail unit. Of particular use for increasing the tilt angle and birefringence of FLC mixtures are compounds in which the core contains a tolane moiety. Of particular use in high tilt, high polarization FLC mixtures are compounds in which T is a chiral nonracemic 2,3-epoxyester or 2,3-epoxyether tail unit. Certain of the compounds of this invention display a property of inducing a tilt angle greater than expected in FLC compositions in which they are combined. The invention includes methods of preparing high tilt FLC compounds and high tilt FLC compositions.

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