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51. 发明申请

US20100249627A1 Detecting A Condition Of A Patient Using A Probability-Correlation Based Model 有权
标题翻译：使用概率相关模型检测患者的病情
公开(公告)号：US20100249627A1
公开(公告)日：2010-09-30
申请号：US12415445
申请日：2009-03-31
申请人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
发明人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
IPC分类号： A61B5/0464
CPC分类号： A61B5/0452 , A61B5/7203 , A61N1/3621 , A61N1/3702 , A61N1/3962
摘要： Techniques are described for detecting a condition of a patient using a probability-correlation based model that integrates a plurality of parameters associated with the condition. A medical device that operates in accordance with the techniques obtains a plurality of parameters associated with the condition of the patient. The medical device obtains probabilities that the condition of the patient exists based on each single parameter separately and correlations between each of the parameters and the other ones of the parameters. After obtaining the probabilities and correlations associated with each of the parameters, the medical device determines whether the condition of the patient exists based on the determined probabilities and correlations. Such techniques may be particularly effective for use in distinguishing whether a rhythm of a patient is treatable, e.g., VT or VF, or non-treatable, e.g., SVT.
摘要翻译：描述了用于使用集成了与条件相关联的多个参数的基于概率相关的模型来检测患者的状况的技术。根据技术操作的医疗装置获得与患者状况相关联的多个参数。医疗设备根据每个单独的参数获得病人的状况存在的概率，以及每个参数与其他参数之间的相关性。在获得与每个参数相关联的概率和相关性之后，医疗设备基于所确定的概率和相关性来确定患者的状况是否存在。这种技术可能特别有效地用于区分患者的节律是否可治疗，例如VT或VF，或不可治疗的，例如SVT。

52. 发明授权

US08437842B2 Method and apparatus for detecting and discriminating tachycardia 有权
标题翻译：用于检测和辨别心动过速的方法和装置
公开(公告)号：US08437842B2
公开(公告)日：2013-05-07
申请号：US12768917
申请日：2010-04-28
申请人： Xusheng Zhang , Robert W. Stadler , Saul E. Greenhut , Mark L. Brown , Troy E. Jackson , Teresa A. Whitman
发明人： Xusheng Zhang , Robert W. Stadler , Saul E. Greenhut , Mark L. Brown , Troy E. Jackson , Teresa A. Whitman
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/04525 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61B5/7203 , A61N1/3621
摘要： A medical device and associated method obtaining cardiac event intervals corresponding to a tachycardia interval. Evidence of a rhythm breaking point is obtained in response to sensing a cardiac event having a morphology corresponding to a supraventricular beat. A non-treatable rhythm is detected in response to the plurality of cardiac event intervals and the evidence of the rhythm breaking point.
摘要翻译：获得对应于心动过速间隔的心脏事件间隔的医疗装置和相关方法。响应于感测具有对应于室上搏动的形态的心脏事件而获得节律断点的证据。响应于多个心脏事件间隔和节律断点的证据来检测不可治疗的节律。

53. 发明申请

US20110270103A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 有权
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：US20110270103A1
公开(公告)日：2011-11-03
申请号：US12768807
申请日：2010-04-28
申请人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
发明人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
IPC分类号： A61B5/0464 , A61B5/0452
CPC分类号： A61B5/0464 , A61B5/0245 , A61B5/7203 , A61N1/3622 , A61N1/3962
摘要： A medical device and associated method for discriminating cardiac events includes determining whether a first match score is within a first match zone having a first correlation with a non-treatable cardiac event, a second match zone having a second correlation with the non-treatable cardiac event less than the first correlation with the non-treatable event, a third match zone having a first correlation with a treatable cardiac event, and a fourth match zone having a second correlation with the treatable cardiac event greater than the first correlation with the treatable cardiac event. A determination is made as to whether a second match score and a third match score are within the first match zone, the second match zone, the third match zone and the fourth match zone to generate a first adjusting factor, and cardiac event evidence is accumulated in response to the first adjusting factor for discriminating cardiac events.
摘要翻译：用于鉴别心脏事件的医疗装置和相关联的方法包括确定第一匹配得分是否在与不可治疗心脏事件具有第一相关性的第一匹配区域内，与不可治疗心脏事件具有第二相关性的第二匹配区域小于与不可治疗事件的第一相关性，具有与可治疗心脏事件的第一相关性的第三匹配区，以及与可治疗心脏事件具有大于与可治疗心脏事件的第一相关性的第二相关性的第四匹配区。确定第二匹配分数和第三匹配分数是否在第一匹配区域，第二匹配区域，第三匹配区域和第四匹配区域内，以产生第一调整因子，并且累积心脏事件证据响应于用于区分心脏事件的第一调整因子。

54. 发明申请

US20110270102A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 审中-公开
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：US20110270102A1
公开(公告)日：2011-11-03
申请号：US12768773
申请日：2010-04-28
申请人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
发明人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
IPC分类号： A61B5/0464 , A61B5/0452
CPC分类号： A61N1/36514 , A61B5/02405 , A61B5/04525 , A61B5/7203 , A61N1/3621 , A61N1/3962
摘要： A medical device and associated method for discriminating cardiac events includes sensing a cardiac signal spatially located across approximately a full duration of a predetermined sensing window. A match score is determined corresponding to the sensed cardiac signal. A beat feature of multiple beat features across less than the full duration of the sensing window is determined, the beat feature being selected from the multiple beat features in response to the match score. Cardiac event evidence is accumulated in response to the match score and the determined beat feature, and cardiac events are discriminated in response to the accumulated cardiac evidence.
摘要翻译：用于鉴别心脏事件的医疗装置和相关联的方法包括感测在预定感测窗口的大约整个持续时间上空间定位的心脏信号。根据感测的心脏信号确定匹配分数。确定在小于感测窗口的整个持续时间的多个拍子特征的拍子特征，响应于匹配分数，从多拍特征中选择节拍特征。响应于匹配得分和确定的搏动特征累积心脏事件证据，并且响应于累积的心脏证据来区分心脏事件。

55. 发明申请

US20100274148A1 DISTINGUISHING BETWEEN TREATABLE AND NON-TREATABLE HEART RHYTHMS 有权
标题翻译：可治疗和不可治疗心脏疾病之间的差异
公开(公告)号：US20100274148A1
公开(公告)日：2010-10-28
申请号：US12430301
申请日：2009-04-27
申请人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
发明人： Xusheng Zhang , Robert W. Stadler , Jeffrey M. Gillberg
IPC分类号： A61B5/046 , A61B5/0464 , A61N1/365
CPC分类号： A61N1/3621 , A61B5/04525 , A61B5/046 , A61B5/0464 , A61B5/726 , A61B5/7264 , A61N1/36507 , A61N1/3962 , G06F19/00
摘要： Techniques are described for distinguishing between treatable and non-treatable heart rhythms. A medical device that operates in accordance with the techniques analyzes characteristics over several cardiac event intervals to detect initiation of a sudden rate onset. After detection of the initiation of the sudden rate onset, the IMD analyzes a morphology of an EGM associated with a selected cardiac event within the first several beats after the initiation of sudden rate onset. In one example, the IMD analyzes the morphology of the EGM associated with the first cardiac event immediately subsequent to the initiation of the sudden rate onset. If the morphology of the EGM of the selected cardiac event is abnormal compared to template EGM, the rhythm is classified as treatable. Otherwise, the rhythm is classified as non-treatable.
摘要翻译：描述了用于区分可治疗和不可治疗的心脏节律的技术。根据该技术操作的医疗装置分析几个心脏事件间隔的特征，以检测突然发生率的起始。在检测到突发性发作起始之后，IMD分析在突然发病起始之后的前几次心跳中与所选心脏事件相关的EGM的形态。在一个实例中，IMD分析与突然发病起始之后紧接着的第一次心脏事件相关的EGM的形态。如果所选心脏事件的EGM的形态与模板EGM相比异常，则将节律分类为可治疗的。否则，节奏被分类为不可治疗。

56. 发明授权

US09480844B2 Method and apparatus for reducing noise in a medical device 有权
标题翻译：减少医疗装置噪音的方法和装置
公开(公告)号：US09480844B2
公开(公告)日：2016-11-01
申请号：US12915093
申请日：2010-10-29
申请人： Robert W. Stadler , Richard P. M. Houben , Tim Dirk Jan Jongen
发明人： Robert W. Stadler , Richard P. M. Houben , Tim Dirk Jan Jongen
IPC分类号： A61N1/37 , A61N1/36 , A61N1/362
CPC分类号： A61N1/3702 , A61N1/3621
摘要： A method and apparatus for detecting a cardiac event in a medical device that includes sensing a cardiac signal, detecting a cardiac event in response to the sensed signal, determining whether an interval associated with the cardiac signal is less than an interval threshold, determining a noise metric in response to an interval associated with the cardiac signal being less than the interval threshold, determining whether the noise metric is greater than a noise metric threshold, and determining whether to inhibit detecting in response to determining whether an interval associated with the cardiac signal is less than the interval threshold and determining whether the noise metric is greater than the noise metric threshold.
摘要翻译：一种用于检测医疗设备中的心脏事件的方法和装置，包括感测心脏信号，响应于感测信号检测心脏事件，确定与心脏信号相关联的间隔是否小于间隔阈值，确定噪声响应于与所述心脏信号相关联的间隔小于所述间隔阈值的度量，确定所述噪声度量是否大于噪声度量阈值，以及响应于确定与所述心脏信号相关联的间隔是否是禁止检测小于间隔阈值并确定噪声度量是否大于噪声度量阈值。

57. 发明授权

US09180300B2 Left-ventricular pacing site selection guided by electrogram morphology analysis 有权
标题翻译：通过电描记图形态分析指导左心室起搏部位选择
公开(公告)号：US09180300B2
公开(公告)日：2015-11-10
申请号：US13598784
申请日：2012-08-30
申请人： Aleksandre T. Sambelashvili , Robert W. Stadler
发明人： Aleksandre T. Sambelashvili , Robert W. Stadler
IPC分类号： A61N1/00 , A61N1/362 , A61B5/00 , A61B5/0452 , A61N1/368
CPC分类号： A61N1/3627 , A61B5/04525 , A61B5/7264 , A61N1/362 , A61N1/3684 , A61N1/3686
摘要： A medical device and associated method classify candidate pacing electrode sites for delivering pacing pulses to a patient's heart. A first morphology template is established and stored in memory of the device. A processor is configured to determine a cardiac signal morphology in response to delivering pacing pulses at a candidate pacing site in a first heart chamber. The processor compares the determined cardiac signal morphology to the first morphology template. The pacing site in the first heart chamber is classified in response to the comparing of the determined cardiac signal morphology and the first morphology template.
摘要翻译：医疗装置和相关联的方法对候选起搏电极位置进行分类，以将起搏脉冲输送到患者的心脏。建立第一形态学模板并存储在设备的存储器中。处理器被配置为响应于在第一心室中的候选起搏部位处输送起搏脉冲来确定心脏信号形态。处理器将确定的心脏信号形态与第一形态学模板进行比较。响应于确定的心脏信号形态与第一形态学模板的比较，将第一心室中的起搏部位分类。

58. 发明授权

US08948869B2 Criteria for optimal electrical resynchronization derived from multipolar leads or multiple electrodes during biventricular pacing 有权
标题翻译：在双心室起搏期间从多极引线或多个电极获得的最佳电再同步的标准
公开(公告)号：US08948869B2
公开(公告)日：2015-02-03
申请号：US13464181
申请日：2012-05-04
申请人： Subham Ghosh , Robert W. Stadler
发明人： Subham Ghosh , Robert W. Stadler
IPC分类号： A61N1/00 , A61N1/368
CPC分类号： A61N1/3686 , A61N1/3622 , A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/371
摘要： Generally, the disclosure is directed one or more methods or systems of cardiac pacing employing a right ventricular electrode and a plurality of left ventricular electrodes. Pacing using the right ventricular electrode and a first one of the left ventricular electrodes and measuring activation times at other ones of the left ventricular electrodes. Pacing using the right ventricular electrode and a second one of the ventricular electrodes and measuring activation times at other ones of the left ventricular electrodes. Employing sums of the measured activation times to select one of the left ventricular electrodes for delivery of subsequent pacing pulses.
摘要翻译：通常，本公开涉及使用右心室电极和多个左心室电极的一个或多个心脏起搏方法或系统。使用右心室电极和左心室电极中的第一个进行起搏，并测量其他左心室电极的活化时间。使用右心室电极和第二个心室电极进行起搏，并测量其他左心室电极的活化时间。使用所测量的激活时间的总和来选择一个左心室电极用于递送随后的起搏脉冲。

59. 发明授权

US08862212B2 Aggregating cardiac resynchronization therapy data 有权
标题翻译：聚集心脏再同步治疗数据
公开(公告)号：US08862212B2
公开(公告)日：2014-10-14
申请号：US13316177
申请日：2011-12-09
申请人： Helen W. Otto , Kevin T. Ousdigian , Julian Sanchez , Sean R. Landman , Robert W. Stadler
发明人： Helen W. Otto , Kevin T. Ousdigian , Julian Sanchez , Sean R. Landman , Robert W. Stadler
IPC分类号： A61B5/0402 , G06F19/00
CPC分类号： G06F19/3443 , G06F19/00 , G16H50/70
摘要： Cardiac resynchronization therapy (CRT) performance data for a number of patients in which an implantable medical device (IMD) is implanted is aggregated and reports of the aggregated data are generated, e.g., for review by organizations or individual clinicians treating the patients. In one example, a method includes collecting CRT performance data correlated to cardiac rhythm event data for a first group of patients in which an IMD configured to deliver CRT is implanted, aggregating, with a computing device, the CRT performance data correlated to the cardiac rhythm event data for a second group of patients from among the first group of patients, and generating, with the computing device, a report comprising the aggregation of the CRT performance data correlated to the cardiac rhythm event data for the second group of patients.
摘要翻译：对植入了植入式医疗装置（IMD）的许多患者的心脏再同步治疗（CRT）性能数据进行聚合，并且生成聚合数据的报告，例如用于治疗患者的组织或个体临床医师的审查。在一个示例中，一种方法包括收集与其中植入用于递送CRT的IMD相关的第一组患者的与心律事件数据相关的CRT性能数据，与计算设备聚合与心律相关的CRT性能数据生成来自第一组患者的第二组患者的事件数据，并且与计算设备一起生成包括与第二组患者的心律事件数据相关的CRT性能数据的聚集的报告。

60. 发明授权

US08694099B2 Criteria for optimal electrical resynchronization derived from multipolar leads or multiple electrodes during biventricular pacing 有权
标题翻译：在双心室起搏期间从多极引线或多个电极获得的最佳电再同步的标准
公开(公告)号：US08694099B2
公开(公告)日：2014-04-08
申请号：US13464279
申请日：2012-05-04
申请人： Subham Ghosh , Robert W. Stadler
发明人： Subham Ghosh , Robert W. Stadler
IPC分类号： A61N1/00
CPC分类号： A61N1/3686 , A61N1/3622 , A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/371
摘要： Generally, the disclosure is directed one or more methods or systems of cardiac pacing employing a right ventricular electrode and a plurality of left ventricular electrodes. Pacing using the right ventricular electrode and a first one of the left ventricular electrodes and measuring activation times at other ones of the left ventricular electrodes. Pacing using the right ventricular electrode and a second one of the ventricular electrodes and measuring activation times at other ones of the left ventricular electrodes. Employing sums of the measured activation times to select one of the left ventricular electrodes for delivery of subsequent pacing pulses.
摘要翻译：通常，本公开涉及使用右心室电极和多个左心室电极的一个或多个心脏起搏方法或系统。使用右心室电极和左心室电极中的第一个进行起搏，并测量其他左心室电极的活化时间。使用右心室电极和第二个心室电极进行起搏，并测量其他左心室电极的活化时间。使用所测量的激活时间的总和来选择一个左心室电极用于递送随后的起搏脉冲。

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