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51. 发明申请

US20110223618A1 ASSAYS USING CHIMERIC T1R POLYPEPTIDE 有权
标题翻译：测定使用CHIMERIC T1R多肽
公开(公告)号：US20110223618A1
公开(公告)日：2011-09-15
申请号：US13020068
申请日：2011-02-03
申请人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
发明人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
IPC分类号： G01N33/566
CPC分类号： C07K14/705 , G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/10
摘要： This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.
摘要翻译：本发明涉及包含一个T1R的细胞外部分或其变体或片段T1R1或T1R2的嵌合味觉感受器，以及T1R1或其变体或片段的跨膜部分，T1R1或T1R2，优选与T1R3相关多肽和合适的G蛋白。这些嵌合味觉受体和表达这种嵌合味觉受体的细胞可用于鉴定甜味和鲜味配体的测定以及用于鉴定甜味和鲜味增强剂的测定中。此外，这些嵌合味觉受体和表达相同的细胞可以用于绘制和确定特定甜味和鲜味配体与其各自受体相互作用的位置，并阐明受体活化的机制。

52. 发明授权

US07939671B2 Compounds that inhibit (block) bitter taste in composition and use thereof 有权
标题翻译：在组合物中抑制（阻断）苦味的化合物及其用途
公开(公告)号：US07939671B2
公开(公告)日：2011-05-10
申请号：US12222918
申请日：2008-08-19
申请人： Xiaodong Li , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
发明人： Xiaodong Li , Andrew Patron , Catherine Tachdjian , Hong Xu , Qing Li , Alexey Pronin , Guy Servant , Lan Zhang , Thomas Brady , Vincent Darmohusodo , Melissa Arellano , Victor Selchau , Brett Weylan Ching , Donald S. Karanewsky , Paul Brust , Jing Ling , Wen Zhao , Chad Priest
IPC分类号： C07D261/08 , C07D413/14 , A61K31/44 , A61K31/42
CPC分类号： C07C311/17 , A23L27/86 , A61K8/46 , A61K8/466 , A61K8/4933 , A61K8/494 , A61K8/4973 , A61K8/498 , A61K8/4986 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61Q11/00 , C07C233/73 , C07C311/04 , C07C311/13 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/29 , C07C311/46 , C07C323/49 , C07C335/16 , C07C335/18 , C07D213/42 , C07D213/71 , C07D217/08 , C07D223/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/34 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于例如咖啡中的特定苦味化合物的反应的发现。此外，本发明涉及含有作为苦味抑制剂的特定化合物和组合物的发现，以及其作为例如咖啡和咖啡风味食品，饮料和药物中的苦味抑制剂或风味调节剂的用途。此外，本发明涉及一种拮抗多种不同人类T2R的化合物的发现及其在测定中的用途以及用于摄取人类和动物的组合物中的苦味阻滞剂。

53. 发明授权

US07889810B2 Method and apparatus for a nonlinear feedback control system 有权
标题翻译：非线性反馈控制系统的方法和装置
公开(公告)号：US07889810B2
公开(公告)日：2011-02-15
申请号：US11639999
申请日：2006-12-15
申请人： Walid Khairy Mohamed Ahmed , Qing Li
发明人： Walid Khairy Mohamed Ahmed , Qing Li
IPC分类号： H04K1/02 , H04L25/03 , H04L25/49 , H04L27/00
CPC分类号： H03F1/3247
摘要： A method and apparatus for a nonlinear feedback control system is disclosed, such as for electrical and electronic systems, for pre-distorting a nonlinear device. A nonlinear feedback control system includes a nonlinear device having a first input and a first output. A detection stage is in communication with the first output of the nonlinear device. A derivation stage is in communication with the detection stage, and the derivation stage is in communication with the first input of the nonlinear device.
摘要翻译：公开了用于非线性反馈控制系统的方法和装置，例如用于电气和电子系统，用于对非线性装置进行预失真。非线性反馈控制系统包括具有第一输入和第一输出的非线性装置。检测级与非线性器件的第一输出端通信。导出级与检测级通信，导出级与非线性器件的第一输入端通信。

54. 发明授权

US07883856B2 Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators 有权
标题翻译：识别特异性激活人T2R受体的苦配体和相关测定法，用于鉴定人类苦味调节剂
公开(公告)号：US07883856B2
公开(公告)日：2011-02-08
申请号：US11766974
申请日：2007-06-22
申请人： Xiaodong Li , Hong Xu , Qing Li , Huixian Tang , Alexey Pronin
发明人： Xiaodong Li , Hong Xu , Qing Li , Huixian Tang , Alexey Pronin
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： G01N33/566 , G01N33/5008 , G01N33/5023 , G01N2500/00 , G01N2500/10
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. Also, the invention relates to the discovery of specific hT2R9 alleles and their disparate activity in functional assays with the same biter ligands. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands and related compounds. These compounds may be used as additives and/or removed from foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste. Also T2R ligands may be used as therapeutics to treat and modulate T2R associated gastrointestinal and metabolic functions as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味化合物的反应的发现。此外，本发明还涉及特异性hT2R9等位基因的发现及其在具有相同配体配体的功能测定中的不同活性。本发明还涉及这些T2R受体在用于鉴定通过特定的苦配体和相关化合物调节这些味觉受体的活化的配体的测定中的用途。这些化合物可以用作添加剂和/或从食品，饮料，化妆品和药物中去除，以便改变（阻断）T2R相关的苦味。也可以使用T2R配体作为治疗和调节T2R相关胃肠和代谢功能以及治疗胃肠道和代谢疾病如饮食失调，食物感觉，食物吸收，肥胖，糖尿病，克罗恩病，乳糜泻等的治疗剂。

55. 发明申请

US20100130908A1 METHOD OF USE OF PORPHYRINS IN PREPARING A MEDICAMENT FOR SONODYNAMIC THERAPY AND A METHOD OF SONODYNAMIC THERAPY USING PORPHYRINS 有权
标题翻译：在制备用于SONODYNAMIC治疗的药物中使用哌啶的方法和使用磷酸盐的SONODYNAMIC治疗方法
公开(公告)号：US20100130908A1
公开(公告)日：2010-05-27
申请号：US12323174
申请日：2008-11-25
申请人： Xiaohuai Wang , Jiangan Su , Qing Li , Guanglian Zhao , Yifan Luo , Bo Yu
发明人： Xiaohuai Wang , Jiangan Su , Qing Li , Guanglian Zhao , Yifan Luo , Bo Yu
IPC分类号： A61K31/555 , A61K31/40 , A61N7/00 , A61N1/30
CPC分类号： A61K41/0033 , A61K31/40 , A61K31/555 , A61N7/00
摘要： The invention provides method of use of a porphyrin compound as shown below in preparing a medicament for sonodynamic therapy, and a method of sonodynamic therapy using a porphyrin compound. Said therapy comprises administering a porphyrin compound to a patient and applying sonic wave to the patient, wherein each symbol has the meaning as defined in the description.
摘要翻译：本发明提供了如下所示的卟啉化合物的制备用于制备用于声动力学治疗的药物的方法，以及使用卟啉化合物的声波动力学治疗方法。所述治疗包括向患者施用卟啉化合物并向患者施加声波，其中每个符号具有如说明书中定义的含义。

56. 外观设计

USD608937S1 Reading lamp 有权
标题翻译：台灯
公开(公告)号：USD608937S1
公开(公告)日：2010-01-26
申请号：US29337550
申请日：2009-05-26
申请人： Qing Li , Shanliang Yao , Botao Wu , Min Hong
设计人： Qing Li , Shanliang Yao , Botao Wu , Min Hong

57. 外观设计

USD608936S1 Reading lamp 有权
公开(公告)号：USD608936S1
公开(公告)日：2010-01-26
申请号：US29337548
申请日：2009-05-26
申请人： Qing Li , Shanliang Yao , Botao Wu , Min Hong
设计人： Qing Li , Shanliang Yao , Botao Wu , Min Hong

58. 外观设计

USD605164S1 Media player 有权
公开(公告)号：USD605164S1
公开(公告)日：2009-12-01
申请号：US29328123
申请日：2008-11-19
申请人： Qing Li , Kok Chong Anthony Oh , Ai Wei Tan
设计人： Qing Li , Kok Chong Anthony Oh , Ai Wei Tan

59. 发明申请

US20090087866A1 HUMAN T2R RECEPTORS FOR RANITIDINE, STRYCHNINE AND DENATONIUM AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS 有权
标题翻译：人类T2R受体的RANITIDINE，STRYCHNINE和DENATONIUM及相关测定用于鉴定人体双歧杆菌调味剂
公开(公告)号：US20090087866A1
公开(公告)日：2009-04-02
申请号：US12166980
申请日：2008-07-02
申请人： Xiaodong LI , Hong Xu , Huixian Tang , Qing Li
发明人： Xiaodong LI , Hong Xu , Huixian Tang , Qing Li
IPC分类号： G01N33/567
CPC分类号： G01N33/74 , G01N33/566 , G01N2333/726 , G01N2500/02
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i.e., acetaminophen, ranitidine, strychnine and denatonium. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors and which may be used as additives in foods, beverages and medicinals for modifying (blocking) T2R-associated bitter taste.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味配体即对乙酰氨基酚，雷尼替丁，士的宁和丹那铵的反应的发现。本发明还涉及这些受体在用于鉴定调节这些味觉受体的活化的配体的测定中的用途，并且其可用作用于改变（阻断）T2R相关苦味的食品，饮料和药物中的添加剂。

60. 发明申请

US20090040926A1 System and Method of Traffic Inspection and Stateful Connection Forwarding Among Geographically Dispersed Network Appliances Organized as Clusters 有权
标题翻译：作为集群组织的地域分散网络设备之间的交通检查和状态连接转发系统与方法
公开(公告)号：US20090040926A1
公开(公告)日：2009-02-12
申请号：US11834576
申请日：2007-08-06
申请人： Qing Li , Preety Mordani , Yusheng Huang , Howard Chen
发明人： Qing Li , Preety Mordani , Yusheng Huang , Howard Chen
IPC分类号： G08C15/00
CPC分类号： H04L41/0893 , H04L29/12367 , H04L41/5003 , H04L43/12 , H04L61/2514 , H04L67/1002 , H04L67/1008 , H04L67/1014 , H04L67/1023 , H04L69/162
摘要： A peering relationship among two or more network appliances is established through an exchange of control messages among the network appliances. The peering relationship defines a cluster of peered network appliances, and at each network appliance of the cluster traffic flow state information for all the network appliances of the cluster is maintained. Network traffic associated with traffic flows of the network appliances of the cluster is managed according to the state information for the traffic flows. This managing of the network traffic may include forwarding among the network appliances of the cluster (i.e., to those of the appliances handling the respective flows) at least some of the network traffic associated with one or more of the traffic flows according to the state information for the one or more traffic flows. The traffic flows may be TCP connections or UDP flows.
摘要翻译：通过网络设备之间的交换控制消息建立两个或多个网络设备之间的对等关系。对等关系定义了一组对等网络设备，并且在群集的每个网络设备上维护集群的所有网络设备的流量状态信息。根据业务流的状态信息管理与集群网络设备的流量相关联的网络流量。网络流量的这种管理可以包括根据状态信息在集群的网络设备（即，处理各个流的设备的网络设备）之间转发与一个或多个业务流相关联的至少一些网络流量为一个或多个交通流量。流量可能是TCP连接或UDP流。

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