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51. 发明申请

US20060178515A1 Tetrahydroisoquinolyl acetamide derivatives for use as orexin receptor antagonists 审中-公开
标题翻译：用作食欲素受体拮抗剂的四氢异喹啉基乙酰胺衍生物
公开(公告)号：US20060178515A1
公开(公告)日：2006-08-10
申请号：US10549180
申请日：2004-03-23
申请人： Hamed Aissaoui , Martine Clozel , Thomas Weller , Ralf Koberstein , Thierry Sifferlen , Walter Fischli
发明人： Hamed Aissaoui , Martine Clozel , Thomas Weller , Ralf Koberstein , Thierry Sifferlen , Walter Fischli
IPC分类号： C07D217/12
CPC分类号： C07D217/02 , C07D217/04 , C07D217/16 , C07D217/18 , C07D217/20 , C07D405/06
摘要： The invention relates to novel acetamide derivatives of formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
摘要翻译：本发明涉及式（I）的新型乙酰胺衍生物及其在制备药物组合物中作为活性成分的用途。本发明还涉及包括制备这种化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为食欲素受体拮抗剂的用途的相关方面。

52. 发明授权

US07067519B2 7,8,9,10-tetrahydro-6H-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2H-pyrrolo[2,1-b]-quinazolinone derivatives 失效
标题翻译： 7,8,9,10-四氢-6H-吖庚因，6,7,8,9-四氢 - 吡啶并且2,3-二氢-2H-吡咯并[2,1-b] - 喹唑啉酮衍生物
公开(公告)号：US07067519B2
公开(公告)日：2006-06-27
申请号：US10489350
申请日：2003-07-08
申请人： Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Sifferlen , Thomas Weller
发明人： Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Sifferlen , Thomas Weller
IPC分类号： A61K31/517 , A61K31/536 , C07D487/04 , C07D498/04 , C07D513/04
CPC分类号： C07D471/04 , A61K31/519 , C07D487/04
摘要： The invention relates to novel 7,8,9,10-tetrahydro-6H-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2H-pyrrolo[2,1-b]-quinazolinone derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
摘要翻译：本发明涉及新的7,8,9,10-四氢-6H-吖庚因，6,7,8,9-四氢 - 吡啶并且2,3-二氢-2H-吡咯并[2,1-b] - 喹唑啉酮衍生物以及它们作为药物组合物制备中的活性成分的用途。本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为食欲素受体拮抗剂的用途的相关方面。

53. 发明申请

US20070043081A1 Novel pyridine derivatives 失效
标题翻译：新型吡啶衍生物
公开(公告)号：US20070043081A1
公开(公告)日：2007-02-22
申请号：US10573516
申请日：2004-09-21
申请人： Daniel Bur , Martine Clozel , Boris Mathys , Claus Mueller , Michael Scherz , Joerg Velker , Thomas Weller
发明人： Daniel Bur , Martine Clozel , Boris Mathys , Claus Mueller , Michael Scherz , Joerg Velker , Thomas Weller
IPC分类号： A61K31/4545 , A61K31/4439 , C07D401/02 , C07D403/02
CPC分类号： C07D401/12
摘要： The invention relates to novel pyridine derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.
摘要翻译：本发明涉及新型吡啶衍生物及其相关化合物及其在制备药物组合物中作为活性成分的用途。本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为神经激素拮抗剂的用途的相关方面。

54. 发明授权

US07750161B2 Pyridine derivatives 失效
标题翻译：吡啶衍生物
公开(公告)号：US07750161B2
公开(公告)日：2010-07-06
申请号：US10573516
申请日：2004-09-21
申请人： Daniel Bur , Martine Clozel , Boris Mathys , Claus Mueller , Michael Scherz , Joerg Velker , Thomas Weller
发明人： Daniel Bur , Martine Clozel , Boris Mathys , Claus Mueller , Michael Scherz , Joerg Velker , Thomas Weller
IPC分类号： A61K31/445
CPC分类号： C07D401/12
摘要： The invention relates to novel pyridine derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.
摘要翻译：本发明涉及新型吡啶衍生物及其相关化合物及其在制备药物组合物中作为活性成分的用途。本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为神经激素拮抗剂的用途的相关方面。

55. 发明申请

US20080076762A1 Novel 4-Aminopiperidine Derivatives 审中-公开
标题翻译：新型4-氨基哌啶衍生物
公开(公告)号：US20080076762A1
公开(公告)日：2008-03-27
申请号：US11720181
申请日：2005-11-21
申请人： Christoph Boss , Daniel Bur , Olivier Corminboeuf , Corinna Grisostomi , Lars Prade , Thomas Weller
发明人： Christoph Boss , Daniel Bur , Olivier Corminboeuf , Corinna Grisostomi , Lars Prade , Thomas Weller
IPC分类号： A61K31/541 , A61K31/4468 , A61K31/4523 , A61P33/06 , C07D241/04 , C07D295/00 , C07D221/00 , A61K31/496 , A61K31/5377
CPC分类号： C07D409/14 , C07D211/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14
摘要： Novel substituted 4-aminopiperidine derivatives of the formula I: wherein n, R1, Y, and are as defined in claim 1, and optically pure enantiomers, mixtures of enantiomers, racemates, diastereomers, mixtures of diastereomers, diastereomeric racemates, mixtures of diastereomeric racemates and meso-forms, as well as salts and solvent complexes of such compounds, and morphological forms, that exhibit useful parasite aspartic proteases inhibiting properties and can thus be used in the form of pharmaceutical compositions as antimalarial medicines.
摘要翻译：式I的新型取代的4-氨基哌啶衍生物：其中n，R 1，Y和如权利要求1中所定义，和光学纯对映异构体，对映异构体的混合物，外消旋体，非对映异构体，非对映异构体的混合物，非对映异构体外消旋体，非对映体外消旋体和内消旋体的混合物，以及这些化合物的盐和溶剂配合物，以及形态形式，其表现出有用的寄生虫天冬氨酸蛋白酶抑制性质，因此可以以药物组合物的形式用作抗疟药物。

56. 发明申请

US20150255196A1 Magneto-Dielectric Polymer Nanocomposites and Method of Making 有权
标题翻译：磁介电聚合物纳米复合材料及其制备方法
公开(公告)号：US20150255196A1
公开(公告)日：2015-09-10
申请号：US14685031
申请日：2015-04-13
申请人： Thomas Weller , Jing Wang , Hariharan Srikanth , Cesar A. Morales-Silva , Kristen L.S. Repa , Susmita Pal
发明人： Thomas Weller , Jing Wang , Hariharan Srikanth , Cesar A. Morales-Silva , Kristen L.S. Repa , Susmita Pal
IPC分类号： H01F1/00
CPC分类号： H01F1/0018 , C08J3/092 , C08J2300/24 , C08K9/04 , C08K2003/2275 , C08K2201/01 , C08K2201/011 , H01B3/006 , H01F1/0063 , H01F1/01 , H01F41/005
摘要： In accordance with the present invention, novel superparamagnetic magneto-dielectric polymer nanocomposites are synthesized using a novel process. The tunability of the dielectric/magnetic properties demonstrated by this novel highly-viscous solvent-free polymer nanocomposite that is amenable to building 3D electromagnetic structures/devices by using processes such as 3D printing, compression molding or injection molding, when an external DC magnetic field is applied, exceeds what has been previously reported for magneto-dielectric polymer nanocomposite materials.
摘要翻译：根据本发明，使用新颖的方法合成了新的超顺磁磁介电聚合物纳米复合材料。通过这种新型高粘度无溶剂聚合物纳米复合材料证明的电介质/磁性能的可调性，其适用于通过使用诸如3D印刷，压缩成型或注射成型的工艺来构建3D电磁结构/器件，当外部DC磁场被应用，超过了先前报道的磁介电聚合物纳米复合材料。

57. 发明授权

US08251895B2 Endoscope with an electric heating system 有权
标题翻译：具有电加热系统的内窥镜
公开(公告)号：US08251895B2
公开(公告)日：2012-08-28
申请号：US12762156
申请日：2010-04-16
申请人： Daniel Seeh , Armin Pfaff , Norbert Haeckl , Thomas Weller
发明人： Daniel Seeh , Armin Pfaff , Norbert Haeckl , Thomas Weller
IPC分类号： A61B1/00
CPC分类号： A61B1/127 , A61B1/002
摘要： An endoscope is provided, comprising a first tube whose distal end is sealed with a cover glass disposed in a mount and an electric heating system for heating the cover glass, with the heating system comprising two electric connections which can be connected with a power source, and an electrically conductive coating which is applied to the inside of the cover glass and comprises two mutually spaced contact sections, of which one each is electrically connected with one of the connections, and with the mount being electrically conductive and a first of the two contact sections being electrically connected via the mount with the associated connection.
摘要翻译：提供了一种内窥镜，其包括：第一管，其前端用设置在安装座中的盖玻璃密封，以及用于加热盖玻璃的电加热系统，所述加热系统包括可与电源连接的两个电连接，以及导电涂层，其被施加到盖玻璃的内部，并且包括两个相互间隔的接触部分，每个接触部分中的一个接触部分之一与连接中的一个电连接，并且安装件是导电的，并且两个接触中的第一个部分通过安装件与相关联的连接件电连接。

58. 发明申请

US20100204198A1 HYDROGENATED BENZO (C) THIOPHENE DERIVATIVES AS IMMUNOMODULATORS 有权
标题翻译：氢化苯甲酸（C）作为免疫调节剂的噻吩衍生物
公开(公告)号：US20100204198A1
公开(公告)日：2010-08-12
申请号：US12749180
申请日：2010-03-29
申请人： Martin Bolli , David Lehmann , Boris Mathys , Claus Mueller , Oliver Nayler , Jörg Velker , Thomas Weller
发明人： Martin Bolli , David Lehmann , Boris Mathys , Claus Mueller , Oliver Nayler , Jörg Velker , Thomas Weller
IPC分类号： A61K31/381 , C07D333/72 , C07D413/12 , C07D409/12 , C07D413/04 , A61K31/5377 , A61K31/4025 , A61K31/496 , A61K31/4245 , A61P37/00 , A61P37/06
CPC分类号： C07D409/12 , C07D333/72 , C07D333/78 , C07D413/04 , C07D413/14
摘要： The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
摘要翻译：本发明涉及新的噻吩衍生物，其制备及其作为药物活性化合物的用途。所述化合物特别充当免疫抑制剂。

59. 发明授权

US07720437B2 Zero-order energy smart antenna and repeater 有权
标题翻译：零级智能天线和中继器
公开(公告)号：US07720437B2
公开(公告)日：2010-05-18
申请号：US11608462
申请日：2006-12-08
申请人： Thomas Weller , Jeff Frolik
发明人： Thomas Weller , Jeff Frolik
IPC分类号： H04B7/185
CPC分类号： H01Q21/08
摘要： The invention is a new device that will improve the radio link quality for low power wireless devices. An example application is for low power, miniaturized wireless sensor nodes that are statically deployed in a slowly varying environment or that have limited mobility. The device is a reconfigurable antenna that is novel in that it operates with very low (zero-order) energy in contrast to existing system that required both significant computational and DC power.
摘要翻译：本发明是一种能够改善低功率无线设备的无线链路质量的新型设备。一个示例应用是用于低功率，小型化的无线传感器节点，其静态部署在缓慢变化的环境中或具有有限的移动性。该装置是可重新配置的天线，其新颖之处在于，与现有的系统相比，其具有非常低（零级）的能量，这需要显着的计算和DC功率。

60. 发明申请

US20100087063A1 NANOMETER-SCALE ELECTROMECHANICAL SWITCH AND FABRICATION PROCESS 有权
标题翻译：纳米尺度电化学开关和制造工艺
公开(公告)号：US20100087063A1
公开(公告)日：2010-04-08
申请号：US12266845
申请日：2008-11-07
申请人： Thomas Weller , Thomas Ketterl
发明人： Thomas Weller , Thomas Ketterl
IPC分类号： H01L21/283
CPC分类号： H01P1/12 , H01H1/0094
摘要： The present invention describes nano-scale fabrication technique used to create a sub-micron wide gap across the center conductor of a coplanar waveguide transmission line configured in a fixed-fixed beam arrangement, resulting in a pair of opposing cantilever beams that comprise an electro-mechanical switch. Accordingly, a nanometer-scale mechanical switch with very high switching speed and low actuation voltage has been developed. This switch is intended primarily for application in the RF/microwave/wireless industry.
摘要翻译：本发明描述了纳米尺度制造技术，其用于在以固定固定光束布置构造的共面波导传输线的中心导体上形成亚微米宽的间隙，从而产生一对相对的悬臂梁，机械开关因此，已经开发了具有非常高的开关速度和低致动电压的纳米级机械开关。该开关主要用于RF /微波/无线行业的应用。

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